Transcription in prokaryotes and eukaryotes def

7,749 views
7,294 views

Published on

1 Comment
3 Likes
Statistics
Notes
No Downloads
Views
Total views
7,749
On SlideShare
0
From Embeds
0
Number of Embeds
6
Actions
Shares
0
Downloads
301
Comments
1
Likes
3
Embeds 0
No embeds

No notes for slide

Transcription in prokaryotes and eukaryotes def

  1. 1. Transcription in prokaryotes and eukaryotes; gene Regulation. <br />Lina Marcela Laverde Preciado<br />Medicine Third semester<br />2010-2<br />
  2. 2. FOLDING<br />
  3. 3. FOLDING<br />
  4. 4. INTRODUCTION<br />
  5. 5. New waydiseases can develop: previouslyunknownmechanismdirects gene expression in cells<br />
  6. 6. The DPF3b is a protein that recognizes a gene activator chemical marks on histones in the transcription is crucial for muscle growth and heart development<br />
  7. 7.
  8. 8. This discovery has broad implications in the field of epigenetic to human biology in health and disease<br />Science of heritable changes that do not depend on the sequence of DNA bases<br />
  9. 9. Brodomains are the protein domains that recognize acetylated lysine residues and are often essential for an association that may occur between proteins and histones and can rearrange the chromatin<br />
  10. 10. OBSERVATION<br />
  11. 11. ROLE OF RNA POLYMERASE IN GENE TRANSCRIPTION DEMONSTRATED<br />
  12. 12. RNA polymerase plays an important role in the formation of the transcription bubble and in the process of bending the DNA to facilitate entry of DNA into the active site.<br />
  13. 13. Sequence, structure and function of RNA polymerase is universally conserved from bacteria to humans, this facilitates the study of this.<br />
  14. 14. The stage of transcription initiation of RNA polymerase consists of three steps<br />The RNA polymerase binds with transcription promoting regions of DNA<br />Through interactions with the RNA polymerase, the DNA helix then unwinds<br />Forming an open "bubble" that allows the polymerase access to the exposed DNA sequence to begin transcription.<br />
  15. 15. OBSERVATION<br />
  16. 16. MEDICAL UTILITY<br />
  17. 17. The expression of our genes is given by a combination of environmental factors, feeding radiation etc, when we come to understand the mechanism of expression can create new more effective treatments and also in terms of prevention<br />
  18. 18. The discovery of new regulatory proteins may serve as biomarkers for certain diseases and acquire predictive value<br />
  19. 19. BIBLIOGRAPHY<br />Lei Zeng, Qiang Zhang, SiDe Li, Alexander N. Plotnikov, Martin J. Walsh, Ming-Ming Zhou. Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b. Nature, 2010; 466 (7303): 258 DOI: 10.1038/nature09139 available http://www.sciencedaily.com/releases/2010/07/100708152101.htm<br />Chen et al. From the Cover: Promoter melting triggered by bacterial RNA polymerase occurs in three steps. Proceedings of the National Academy of Sciences, 2010; 107 (28): 12523 DOI: 10.1073/pnas.1003533107 aviable http://www.sciencedaily.com/releases/2010/07/100715111559.htm<br />Martínez LM. Transcripción genética, 5. ed. Medellín: Universidad Pontificia Bolivariana; 2009. p. 103-108.<br />
  20. 20. Thanks…<br />

×