Monday, June 18, 2012
!"#$%&%$#($)*+,$)"&-$,.,/)&0,1$Monday, June 18, 2012
!"#$%&%$#($)*+,$)"&-$,.,/)&0,1$           !"#$%&%()%*+,*-$%$%.*#/01%Monday, June 18, 2012
!"#$%&%$#($)*+,$)"&-$,.,/)&0,1$           !"#$%&%()%*+,*-$%$%.*#/01%          !"#$%"$&"$#()!$*"$+,-./$)*00$               ...
BIOLOGY 151             (INTRODUCTION TO IMMUNOLOGY) 1. Orientation 2. Overview of Immunology    a. History of Immunology ...
ORIENTATION                COURSE DESCRIPTION: Structure and Function of the                Immune System; Antigen-Antibod...
ORIENTATIONMonday, June 18, 2012
ORIENTATION           COURSE OBJECTIVESMonday, June 18, 2012
ORIENTATION           COURSE OBJECTIVES                 Describe and differentiate the general properties and components o...
ORIENTATION           COURSE OBJECTIVES                 Describe and differentiate the general properties and components o...
ORIENTATION           COURSE OBJECTIVES                 Describe and differentiate the general properties and components o...
ORIENTATION           COURSE OBJECTIVES                 Describe and differentiate the general properties and components o...
ORIENTATION           COURSE OBJECTIVES                 Describe and differentiate the general properties and components o...
ORIENTATION           COURSE OBJECTIVES                 Describe and differentiate the general properties and components o...
CALENDAR OF ACTIVITIES                      DATE                                           ACTIVITY June 19 (2 hours)     ...
COURSE REQUIREMENT                A. Lecture (60%)              B. Laboratory (40%)                Lecture exams (3)!!    ...
EXAMS & QUIZZES                EXAMS                        sit-down, written exam; class hours                        obj...
CLASS plenary            CONFERENCE-TYPE OF PAPER            PRESENTATIONS            3 PAPERS: VACCINE CHALLENGES (HIV,  ...
your grade                PFG = lecture (60%) + laboratory (40%) rating                        NOTE: This will be the final...
OUR TEXTBOOK                Abbas, Abul K. and                Andrew H. Lichtman.                2004. Basic              ...
POLICIES                The student should be able to pass (PFG = 3.0) both lecture and                laboratory componen...
QUESTIONS???Monday, June 18, 2012
RECALL from BIOLOGY 120                        THE WAR WITH                         MICROBES...Monday, June 18, 2012
HOW WE FIGHT       INFECTIONS...                        www.youtube.com/watch?v=T_4TrNRa3v8Monday, June 18, 2012
TODAY....             Looking back.........                   famous personalities                   how it all started   ...
Monday, June 18, 2012
Monday, June 18, 2012
International Journal of Infectious Diseases                        Volume 3, Issue 1, July-September 1998, Pages 54-60Mon...
Monday, June 18, 2012
Monday, June 18, 2012
Monday, June 18, 2012
Monday, June 18, 2012
Monday, June 18, 2012
Monday, June 18, 2012
Monday, June 18, 2012
Monday, June 18, 2012
! ▪! 2001 – Discovery of FOXP3 – the gene directing regulatory T cell development ! ▪! 2005 – Development of human papillo...
CELLS & ORGANS OF THE                          IMMUNE SYSTEMMonday, June 18, 2012
INNATE                HUMORAL                        complement system                CELLULAR                        mono...
Monday, June 18, 2012
Monday, June 18, 2012
Monday, June 18, 2012
ADAPTIVE                HUMORAL                        antibodies                        complement system                ...
Monday, June 18, 2012
organs of the immune systemMonday, June 18, 2012
MUST KNOW...          ANTIGEN          ANTIBODIESMonday, June 18, 2012
OJT: IMMUNE CELLSMonday, June 18, 2012
OJT: IMMUNE CELLSMonday, June 18, 2012
OUR IMMUNE SYSTEM           Physiologic function of the immune system:                 prevent infections                 ...
OUR IMMUNE SYSTEM                vaccines: stimulation of our Immune SystemMonday, June 18, 2012
overview: host defense                                 mechanisms              INNATE: immunity which mediates the initial...
overview: host defense                            mechanismsMonday, June 18, 2012
Monday, June 18, 2012
OVERVIEW: HUMORAL & CELL-                          MEDIATED IMMUNITYMonday, June 18, 2012
NOTE: ADAPTIVE RESPONSE  Immunity may be induced in an individual by infection or  vaccination (active immunity) or confer...
SPECIFICITY & MEMORYMonday, June 18, 2012
OVERVIEW: PHASES OF ADAPTIVE                          IMMUNITYMonday, June 18, 2012
MAJOR CHARACTERS OF THE                          IMMUNE SYSTEMMonday, June 18, 2012
THE EFFECTOR FUNCTIONSMonday, June 18, 2012
When naive lymphocytes                        recognize microbial antigens                        and also receive additio...
END OF LECTURE 1Monday, June 18, 2012
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Biology 151 lecture 1 2012 2013

  1. 1. Monday, June 18, 2012
  2. 2. !"#$%&%$#($)*+,$)"&-$,.,/)&0,1$Monday, June 18, 2012
  3. 3. !"#$%&%$#($)*+,$)"&-$,.,/)&0,1$ !"#$%&%()%*+,*-$%$%.*#/01%Monday, June 18, 2012
  4. 4. !"#$%&%$#($)*+,$)"&-$,.,/)&0,1$ !"#$%&%()%*+,*-$%$%.*#/01% !"#$%"$&"$#()!$*"$+,-./$)*00$ !,.,1$Monday, June 18, 2012
  5. 5. BIOLOGY 151 (INTRODUCTION TO IMMUNOLOGY) 1. Orientation 2. Overview of Immunology a. History of Immunology & Famous Personalities b. General Properties & Components of the Immune SystemMonday, June 18, 2012
  6. 6. ORIENTATION COURSE DESCRIPTION: Structure and Function of the Immune System; Antigen-Antibody Reactions; Genetic Control of the Immune System and Basic Immunological Techniques COURSE CREDIT: 3 units (2 units lecture and 1 unit laboratory) PREREQUISITES: Biology 10, 21, 22; Chemistry 40 and 40.1Monday, June 18, 2012
  7. 7. ORIENTATIONMonday, June 18, 2012
  8. 8. ORIENTATION COURSE OBJECTIVESMonday, June 18, 2012
  9. 9. ORIENTATION COURSE OBJECTIVES Describe and differentiate the general properties and components of the immune system with focus on antigens and antibodies;Monday, June 18, 2012
  10. 10. ORIENTATION COURSE OBJECTIVES Describe and differentiate the general properties and components of the immune system with focus on antigens and antibodies; Distinguish and compare innate and adaptive immune responses of the body during a pathogenic or non-pathogenic challenge;Monday, June 18, 2012
  11. 11. ORIENTATION COURSE OBJECTIVES Describe and differentiate the general properties and components of the immune system with focus on antigens and antibodies; Distinguish and compare innate and adaptive immune responses of the body during a pathogenic or non-pathogenic challenge; Recognize and demonstrate which diagnostic procedures will best detect antigens and antibodies;Monday, June 18, 2012
  12. 12. ORIENTATION COURSE OBJECTIVES Describe and differentiate the general properties and components of the immune system with focus on antigens and antibodies; Distinguish and compare innate and adaptive immune responses of the body during a pathogenic or non-pathogenic challenge; Recognize and demonstrate which diagnostic procedures will best detect antigens and antibodies; Be familiar with the mechanisms of the different immunodeficiencies;Monday, June 18, 2012
  13. 13. ORIENTATION COURSE OBJECTIVES Describe and differentiate the general properties and components of the immune system with focus on antigens and antibodies; Distinguish and compare innate and adaptive immune responses of the body during a pathogenic or non-pathogenic challenge; Recognize and demonstrate which diagnostic procedures will best detect antigens and antibodies; Be familiar with the mechanisms of the different immunodeficiencies; Define and differentiate the types of vaccines and their uses; andMonday, June 18, 2012
  14. 14. ORIENTATION COURSE OBJECTIVES Describe and differentiate the general properties and components of the immune system with focus on antigens and antibodies; Distinguish and compare innate and adaptive immune responses of the body during a pathogenic or non-pathogenic challenge; Recognize and demonstrate which diagnostic procedures will best detect antigens and antibodies; Be familiar with the mechanisms of the different immunodeficiencies; Define and differentiate the types of vaccines and their uses; and Determine the ethical considerations in the study and applications of Immunology in researchMonday, June 18, 2012
  15. 15. CALENDAR OF ACTIVITIES DATE ACTIVITY June 19 (2 hours) ORIENTATION & OVERVIEW OF IMMUNOLOGY History of Immunology and Famous Personalities General properties and components: the cells and their function June 26 (2 hours) ANTIGENS AND ANTIBODIES July 3-10 (4 hours) INNATE & ADAPTIVE IMMUNITY July 17-24 (4 hours) HUMORAL & CELLULAR IMMUNITY July 31 EXAMINATION 1 EXAM 1: JULY 31, 2012 August 7 (2 hours) PATHOGENESIS OF BACTERIAL INFECTIONS a. Immunity to bacteria b. Important bacterial infections c. Serological diagnosis to detect antigens and antibodies August 14 (2 hours) PATHOGENESIS OF VIRAL INFECTIONS a. Immunity to viruses b. Important viral infections c. Serological diagnosis to detect antigens and antibodies August 21-24 BIOWEEK CELEBRATION: CLASS POSTER PRESENTATION August 28 (2 hours) PATHOGENESIS OF FUNGAL INFECTIONS a. Immunity to fungi b. Important fungal infections c. Serological diagnosis to detect antigens and antibodies September 4 (2 hours) PATHOGENESIS OF PARASITIC INFECTIONS a. Immunity to parasites b. Important parasitic infections c. Serological diagnosis to detect antigens and antibodies September 11 EXAMINATION 2 EXAM 2: SEPT 11, 2012 September 18 ( 2hours) IMMUNODEFICIENCIES a. Immunologic tolerance and hypersensitivities b. Selected immunodeficiencies (e.g. HIV, etc) VACCINES a. types of vaccines and their design b. Philippine laws on vaccination c. vaccine challenges September 25 CLASS PLENARY REPORT: VACCINE CHALLENGES (HIV, pandemics, vector- borne or zoonotic diseases) EXAM 3: OCT 2, 2012 October 2 EXAMINATION 3Monday, June 18, 2012
  16. 16. COURSE REQUIREMENT A. Lecture (60%) B. Laboratory (40%) Lecture exams (3)!! 60% Laboratory exams (2)! ! 50% Quizzes! ! ! 20% Laboratory reports! ! 10% Plenary Report! ! 20% Journal report! ! ! 10% Quizzes! ! ! 10% Laboratory performance! 10%Monday, June 18, 2012
  17. 17. EXAMS & QUIZZES EXAMS sit-down, written exam; class hours objective and critical thinking type QUIZZES individual, pair, group, class quizzes written, oral or take-home no make-up for missed quizzes!Monday, June 18, 2012
  18. 18. CLASS plenary CONFERENCE-TYPE OF PAPER PRESENTATIONS 3 PAPERS: VACCINE CHALLENGES (HIV, pandemics, vector-borne or zoonotic diseases) TASKS: Speakers, Master of Ceremonies, Moderator, Reactors, Technical Group, Logistics Group, Refreshments Group, Press Group, etc CLASS GRADE: Absent during the presentation is given a ZERO (0) markMonday, June 18, 2012
  19. 19. your grade PFG = lecture (60%) + laboratory (40%) rating NOTE: This will be the final grade when exempted to take the final exams. If the student will take the finals the rating will be computed as follows, which should be no lower than 60% or 3.0: RATING = PFG (80%) + Score in Finals Exam (20%)Monday, June 18, 2012
  20. 20. OUR TEXTBOOK Abbas, Abul K. and Andrew H. Lichtman. 2004. Basic Immunology: Function and Disorders of the Immune System. 2nd ed.Monday, June 18, 2012
  21. 21. POLICIES The student should be able to pass (PFG = 3.0) both lecture and laboratory component to pass the course There will be no make-up exams, missed exams will qualify students to take the final examination. The score in the final exam may replace the missed exam. However, in the case of two missed exams, the other exam will have a score of zero (0) The student should be able to incur a PFG of 2.0 or better to be exempted to take the written final exam Should the student fail the final exam, an oral removal exam to satisfy the course competencies will be given to pass the course. The grade to be given here shall only be a “pass” (3.0) or “fail” (5.0)Monday, June 18, 2012
  22. 22. QUESTIONS???Monday, June 18, 2012
  23. 23. RECALL from BIOLOGY 120 THE WAR WITH MICROBES...Monday, June 18, 2012
  24. 24. HOW WE FIGHT INFECTIONS... www.youtube.com/watch?v=T_4TrNRa3v8Monday, June 18, 2012
  25. 25. TODAY.... Looking back......... famous personalities how it all started Who’s who of our immune system... cells general functionsMonday, June 18, 2012
  26. 26. Monday, June 18, 2012
  27. 27. Monday, June 18, 2012
  28. 28. International Journal of Infectious Diseases Volume 3, Issue 1, July-September 1998, Pages 54-60Monday, June 18, 2012
  29. 29. Monday, June 18, 2012
  30. 30. Monday, June 18, 2012
  31. 31. Monday, June 18, 2012
  32. 32. Monday, June 18, 2012
  33. 33. Monday, June 18, 2012
  34. 34. Monday, June 18, 2012
  35. 35. Monday, June 18, 2012
  36. 36. Monday, June 18, 2012
  37. 37. ! ▪! 2001 – Discovery of FOXP3 – the gene directing regulatory T cell development ! ▪! 2005 – Development of human papillomavirus vaccine (Ian Frazer)Monday, June 18, 2012
  38. 38. CELLS & ORGANS OF THE IMMUNE SYSTEMMonday, June 18, 2012
  39. 39. INNATE HUMORAL complement system CELLULAR monocytes (macrophages, dendritic cells) NKC (natural killer cells) granulocytes (mast cells and , basophils, eosinophils, neutrophils)Monday, June 18, 2012
  40. 40. Monday, June 18, 2012
  41. 41. Monday, June 18, 2012
  42. 42. Monday, June 18, 2012
  43. 43. ADAPTIVE HUMORAL antibodies complement system CELLULAR B cells T cellsMonday, June 18, 2012
  44. 44. Monday, June 18, 2012
  45. 45. organs of the immune systemMonday, June 18, 2012
  46. 46. MUST KNOW... ANTIGEN ANTIBODIESMonday, June 18, 2012
  47. 47. OJT: IMMUNE CELLSMonday, June 18, 2012
  48. 48. OJT: IMMUNE CELLSMonday, June 18, 2012
  49. 49. OUR IMMUNE SYSTEM Physiologic function of the immune system: prevent infections eradicate established infectionsMonday, June 18, 2012
  50. 50. OUR IMMUNE SYSTEM vaccines: stimulation of our Immune SystemMonday, June 18, 2012
  51. 51. overview: host defense mechanisms INNATE: immunity which mediates the initial protection against infections always present in health individuals block the entry of microbes and rapidly eliminate microbes that do succeed in entering host tissues ADAPTIVE: immunity which!develop more slowly and mediates innate immunity more effective defense against infections specific or acquired stimulated by microbes that invade tissues adapts to the presence of microbial invadersMonday, June 18, 2012
  52. 52. overview: host defense mechanismsMonday, June 18, 2012
  53. 53. Monday, June 18, 2012
  54. 54. OVERVIEW: HUMORAL & CELL- MEDIATED IMMUNITYMonday, June 18, 2012
  55. 55. NOTE: ADAPTIVE RESPONSE Immunity may be induced in an individual by infection or vaccination (active immunity) or conferred on an individual by transfer of antibodies or lymphocytes from an actively immunized individual (passive immunity)Monday, June 18, 2012
  56. 56. SPECIFICITY & MEMORYMonday, June 18, 2012
  57. 57. OVERVIEW: PHASES OF ADAPTIVE IMMUNITYMonday, June 18, 2012
  58. 58. MAJOR CHARACTERS OF THE IMMUNE SYSTEMMonday, June 18, 2012
  59. 59. THE EFFECTOR FUNCTIONSMonday, June 18, 2012
  60. 60. When naive lymphocytes recognize microbial antigens and also receive additional ("second) signals induced by microbes, the antigen-specific lymphocytes proliferate and differentiate into effector cells and memory cells Naive lymphocytes express receptors for antigens but do not perform the functions that are required to eliminate antigens Differentiation into effector cells and memory cells is initiated by antigen recognition, thus ensuring that the immune response that develops is specific for the antigenMonday, June 18, 2012
  61. 61. END OF LECTURE 1Monday, June 18, 2012

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