1. Reporter:
Camille Joy Llarinas Guarin

2.  The fatty acids must be activated by conversion to
fatty acyl SCoA.
 It occurs in cytosl and serves the same purpose as
the few steps in oxidation of glucose by glycolysis
O
ll
R—C—O + HSCoA + ATP R—C—SCoA+ AMP+ P2

3.  The fatty acyl-SCoA must be
transported into the
mitochondrial matrix where
energy generation will occur.

4.  The fatty acyl-SCoA must be oxidized by
enzymes in the mitochondrial matrix to
produce acetyl-SCoA plus the reduced
coenzymes to be used in ATP generation.
The oxidation occurs by repetition of
series of four reactions which make up
the BETA OXIDATION PATHWAY.

5.  It is the repetitive series of four
biochemical reactions that degrades
acyl CoA to acetyl CoA by removing
two carbon atoms at a time, with
FADH2 and NADH also being
produced.

6.  It involves the ff. functional groups:
Alkane alkene  secondary alcohol  ketone

7. 1. OXIDATION
Hydrogen atoms are removed from the α and β
carbons, creating a double bond between these two
carbon atoms. FAD is the oxidizing agent and a
FADH2 molecule is a product.
H H O H O
l l ll l ll
R—C—C—C—S—CoA-------> R—C=C—S—CoA
l l l
H H H

8.  A molecule of water is added across the trans
double bond, producing a secondary alcohol at
the β- carbon position.
H O OH H O
l ll l l ll
R—C=C—C—S—CoA R—C—C—C—S—CoA
l l l
H H2O H H

9.  The β-hydroxy group is oxidized to a ketone
functional group with NAD+ serving the
oxidizing agent.
OH H O O O
l l ll ll ll
R—C—C—C—S—CoAR—C—CH2—C—S—CoA
l l
H H

10.  The fatty acid chain is broken between the α and β
carbons by reaction with a coenzyme A molecule.
O O O
ll ll ll
R—C—CH2—C—S—CoA R—C—S—CoA +
O
ll
CH3—C—S—CoA