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The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation
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The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation

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In this presentation, delivered at the 2nd Health Care Professional Summit in Los Angeles, CA - 9 24 2011 - Dr. Cady reviews the critical points in the Cady White Paper on the Biophotonic Scanner, as …

In this presentation, delivered at the 2nd Health Care Professional Summit in Los Angeles, CA - 9 24 2011 - Dr. Cady reviews the critical points in the Cady White Paper on the Biophotonic Scanner, as well as a cogent explanation from the literature about the need to monitor antioxidant status and supplement appropriately.

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  • FROM WIKIPEDIA - Epidermis Epidermis , "epi" coming from the Greek meaning "over" or "upon", is the outermost layer of the skin. It forms the waterproof, protective wrap over the body's surface and is made up of stratified squamous epithelium with an underlying basal lamina. The epidermis contains no blood vessels, and cells in the deepest layers are nourished by diffusion from blood capillaries extending to the upper layers of the dermis. The main type of cells which make up the epidermis are Merkel cells, keratinocytes, with melanocytes and Langerhans cells also present. The epidermis can be further subdivided into the following strata (beginning with the outermost layer): corneum, lucidum (only in palms of hands and bottoms of feet), granulosum, spinosum, basale. Cells are formed through mitosis at the basale layer. The daughter cells (see cell division) move up the strata changing shape and composition as they die due to isolation from their blood source. The cytoplasm is released and the protein keratin is inserted. They eventually reach the corneum and slough off (desquamation). This process is called keratinization and takes place within about 27 days. This keratinized layer of skin is responsible for keeping water in the body and keeping other harmful chemicals and pathogens out, making skin a natural barrier to infection. From WIKIpedia
  • Based on clinical studies with the biophotonic scanner, we have identified a number of factors that may influence your score. The average skin carotenoid score for Europeans is 26,673, those who eat the recommended 5-9 fruits and vegetables or take lifepak regularly have even higher scores. What is really exciting is that people with the best lifestyles - eat the recommended 5-9 fruits and vegetables, take LifePak regularly, avoid cigarettes, and so on, have the very highest scores, in the 40,000 range. Therefore, the effects of a good lifestyle are cumulative when it comes to Antioxidant protection. The other point I would like to make is that people with known oxidative stress such as smokers, have lower scanner scores, just as we would predict, but people who are overweight or obese tend to have even lower scores than smokers! Thus it appears that obesity depletes antioxidant levels even more than smoking.
  • Dr. Greenblatt treats anyone at less than 600. “Serum levels don’t accurately reflect what’s in the CSF.”
  • When repleted - results pretty quickly. “If if spasms, think magnesium” – bowel, bronchial.
  • Transcript

    • 1. A Review of the Pharmanex Biophotonic Scanner, Supplementation and the “Cady White Paper” An Educational Presentation for Health Care Practitioners September 24, 2011 – Los Angeles, CA Louis B. Cady, MD – CEO & Founder – Cady Wellness Institute Adjunct Professor – University of Southern Indiana Adjunct Clinical Lecturer – Indiana University School of Medicine Department of Psychiatry Child, Adolescent, Adult & Forensic Psychiatry – Evansville, Indiana Disclaimer: Pharmanex/NuSkin products are not FDA approved for the diagnosis or treatment of ANY disease or “medical condition.”
    • 2. “ There are two objects of medical education: to heal the sick and to advance the science. ” - Dr. Charles H. Mayo, MD “ The glory of medicine is that it is always moving forward, that there is always more to learn.” - Dr. William J. Mayo
    • 3. Is this any way to take care of the health of a nation? 3.4 Billion Prescriptions 307 million People <ul><li>3.4 billion prescriptions are written every year 1 </li></ul><ul><li>307 million people in US 2 </li></ul><ul><li>$630 billion to top 12 pharmaceutical companies (profits!) 3 </li></ul><ul><li>The majority are due to “silent syndromes” and modifiable disease risk factors . </li></ul>1. Ukens C. How mail order pharmacy gained in market share in 2003. Drug Topics Mar 22, 2004; 148. 2. U.S. Census Bureau, Jul 2009 3. CNN Money, May 3, 2010; http://money.cnn.com/magazines/fortune/ ortune500/2010/industries/21/index.html accessed August 17, 2011 3.4 * 10 9 Rx 3.1 * 10 8 Peeps
    • 4. CURRENT PRACTICE OF MEDICINE: What a patient had to say about her “specialists”: <ul><li>“ They just monitor my degeneration.” </li></ul>
    • 5.  
    • 6. Cady Wellness Institute – July 2005 The Reasons: <ul><li>Conventional medical practice had failed me twice. </li></ul><ul><li>A lot of “psychiatric cases” WEREN’T “psychiatric.” </li></ul><ul><li>Nobody was integrated. </li></ul><ul><li>Nobody was looking at ALL of the peer-reviewed literature. </li></ul>
    • 7.  
    • 8. Evansville Courier & Press : May 29, 2006
    • 9. “ Real doctoring”: The Chance to Change Patient’s BRAINS
    • 10. “ But my patients don’t know about this and aren’t asking for it….” <ul><li>“ It’s not the consumers’ job to know what they want.” </li></ul><ul><li>- Steve Jobs </li></ul>
    • 11. How not to get overwhelmed in this presentation:
    • 12. What causes oxidative stress? <ul><li>Environmental Toxins </li></ul><ul><ul><li>Heavy metals </li></ul></ul><ul><ul><li>Pesticides/herbicides </li></ul></ul><ul><ul><li>Preservatives </li></ul></ul><ul><ul><li>PCB ’s, Dioxins, Phthalates </li></ul></ul><ul><li>Toxins produced in the body </li></ul><ul><ul><li>Yeast and bacteria </li></ul></ul><ul><ul><li>Products of cellular metabolism </li></ul></ul><ul><li>Emotional Stress </li></ul><ul><ul><li>Anxiety/Tension </li></ul></ul><ul><ul><li>Fear </li></ul></ul><ul><ul><li>Anger </li></ul></ul>
    • 13. Why is the brain so susceptible to oxidative stress?
    • 14. Why is the brain so susceptible to oxidative stress? <ul><li>Burns glucose – generates free radicals. </li></ul><ul><ul><li>Uses 20% of total oxygen and energy consumed by the body. </li></ul></ul><ul><ul><ul><li>½ of this is for electrochemical nerve transmission. </li></ul></ul></ul><ul><li>Contains IRON </li></ul><ul><li>Contains essential fatty acids, which can be OXIDIZED (“rancid fat”) </li></ul><ul><li>Limited supply of own antioxidants </li></ul><ul><li>Limited ability to regenerate/repair damage </li></ul>
    • 15. What are some consequences of oxidative stress? <ul><li>Impaired cognitive function </li></ul><ul><li>Decreased memory </li></ul><ul><li>Depressed immune system </li></ul><ul><li>Increased inflammation </li></ul><ul><li>DNA damage </li></ul><ul><li>cancer </li></ul><ul><li>Behavioral deterioration </li></ul>
    • 16.  
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    • 26. Where to read more…
    • 27. The fastest, cheapest, most painless way to measure antioxidants…. <ul><li>US patent 6,205,354 – March 20, 2001 – Werner Gellerman, et al. Univ. of Utah </li></ul><ul><li>“ A method and apparatus are provided for the determination of levels of carotenoids and similar chemical compounds in biological tissue such as living skin.” </li></ul>
    • 28. Psst. Hey buddy. Wanna buy a portable Raman spectrometer?
    • 29. “ The Complete Idiot’s Guide to the “Cady White Paper” <ul><li>Pp 1-3 Patent claim synthesis: assessing the overall antioxidant status in human tissue via Raman spectroscopy via measuring carotenoids </li></ul><ul><ul><li>Carotenoids are antioxidants </li></ul></ul><ul><ul><ul><li>Identified in 1992 </li></ul></ul></ul><ul><ul><ul><li>Potent antioxidants </li></ul></ul></ul><ul><ul><ul><li>Lycopenes and carotenoids appear to diminish risk of prostate CA. </li></ul></ul></ul><ul><li>P 4 Further discussion of prostate CA </li></ul>
    • 30. Carotenoid correlation with other antioxidants (pp 4-6) <ul><li>Correlation between carotenoids and other antioxidants, esp. tocopherols, previously noted. </li></ul><ul><ul><li>Cited: carotenoids as chemopreventive agents* </li></ul></ul><ul><ul><li>Carotenoids as first line of defense, associated with “antioxidant network” – with Vitamins C, E, Coenzyme Q10, ALA, and SE. ** </li></ul></ul><ul><ul><li>Yeum et al: need to measure water AND fat soluble vitamins identified.* ** </li></ul></ul>*Peng YM et al. Concentrations and plasma-tissue-diet relationships of carotenoids, retinoids, and tocopherols in humans. Nutr Cancer. 1995;23(3):233-46. ** Packet, Lester. The Antioxidant Miracle. John Wiley & Sons, Inc. © 1999 ***Yeum et al. Biomarkers of antioxidant capacity in the hydrophilic and lipophilic compartments of human plasma. Arch Biochem Biophys. 2004 Oct 1; 430(1):97-103.
    • 31. Relationships of carotenoids to other more conventionally measured antioxidants (p 6 -7) <ul><li>Svilaas et al (2004): </li></ul><ul><ul><li>2, 670 adults studied with serum carotenoids measured and correlated with vitamin consumption </li></ul></ul><ul><ul><li>serum carotenoids were stronger predictors of other antioxidants than were alpha, beta, delta, and gamma tocopherols, as well as glutathione .* </li></ul></ul>* Svilaas A, et al. Intakes of antioxidants in coffee, wine, and vegetables are correlated with plasma carotenoids in humans. J Nutr. 2004 Mar;134(3):562-7.
    • 32. Missing point: Vitamin E as antioxidant predictor Jaques PF, et al. Antioxidant status in persons with and without senile cataract. Arch Opthalmol. 1988;106(3):337-340. <ul><li>N=112, ages 40 – yo yoa. </li></ul><ul><li>77 subjects had at least one cataract. </li></ul><ul><li>Antioxidant status: superoxide dismutase, glutathione peroxidase, G6PD, Vit E, Vit C and carotenoids. </li></ul><ul><li>Grouped by low, moderate, or high enzymes and antioxidant status. </li></ul><ul><li>Subjects with at least 2/3 – vitamins E & C, and carotenoids – were at reduced risk. </li></ul>
    • 33. Higher Vitamin E lowers oxidative stress in Alzheimer’s disease <ul><li>“ Oxidative stress (OS) may be involved in the neurodegenerative process in Alzheimer’s disease.” </li></ul><ul><li>MEASURED: </li></ul><ul><ul><li>8-iso-PGF2alpha (lipid-peroxidation product) </li></ul></ul><ul><ul><li>Methylated and non-methylated telomeres </li></ul></ul><ul><li>Oral administration of 400 mg (IU) Vitamin E partly reverses AD-associated alterations in OS markers. </li></ul>Guan, JZ et al. Effect of Vitamin E Adminsitration on the Elevated Oxygen Stress and the Telomeric and Subtelomeric status in Alzheimer’s Disease. Gerontology. 2011, Sept 7 (epub ahead of print)
    • 34. Vitamin E as antioxidant – a molecular biology assessment <ul><li>25 ESRD patients under chronic dialysis. </li></ul><ul><li>Effects of vitamin E-coated dialyzer noted to have positive effect on antioxidant state. </li></ul><ul><li>“ Treatment with VitabranE significnatly decreases the expression of proteins and markers relevant to oxidative stress and inflammation tightly associated with cardiovascular disease….” </li></ul>Calo LA et al. Molecular biology-based assessment of vitamin E-coated dialyzer effects on oxidative stress, inflammation, and vascular remodeling. Artif Organs. 2011 Feb;35(2):E33-9. doi:10.1111/j. 1525-1594.2010.01125.x
    • 35. Convenience of carotenoids as antioxidant measurement: from the eye to the skin (pp7-11) <ul><li>Bernstein P et al (1998) - Carotenoids useful as measure of antioxidant status in human retina* </li></ul><ul><li>Hata, et al (2000) – correlated skin carotenoids (Raman) with carotenoid levels from skin from abdominoplasty patients (HPLC). </li></ul><ul><ul><li>“ Our technique can be used…for assessing antioxidant status and the risk for diseases related to oxidative stress.” </li></ul></ul><ul><ul><li>Previous use in skin, retina, oral cavity and other tissues cited. Palm of skin = highest carotenoid location </li></ul></ul>*Bernstein P et al. Raman detection of macular carotenoids pigments in intact human retina. Invest Opthalmol Vis Sc. 1998 Oct;39(11):2003-11. **Hata et al. Non-invasive Raman spectroscopic detection of carotenoids in human skin. J Invest Dermatol. 2000 Sep; 115(3):441-8.
    • 36. Dissolved carotenoids in stratum corneum 27 days
    • 37. The Svilaas/Hata Syllogism: <ul><li>Svilaas (2004) – skin carotenoids = better predictor of antioxidant status than mixed tocopherols and glutathione </li></ul><ul><li>Hata (2000) – Raman measurements of carotenoid == HPLC skin measurements </li></ul><ul><li>THEREFORE [Cady]: Raman spectroscopy is a better measure of antioxidant status than mixed tocopherols and glutathione. </li></ul>
    • 38. Time warp – News Flash!
    • 39. High oxidative stress = low skin carotenoids (p 11) <ul><li>Ermakov IV et al (2005) – “carotenoids are a good indicator of antioxidant status.” </li></ul><ul><ul><li>Smokers and high sunlight exposure – have reduced skin carotenoid levels, independent of their dietary carotenoid consumption. </li></ul></ul><ul><ul><ul><li>[Cady – “bad stuff trumps reasonable diet”] </li></ul></ul></ul>Ermakov IV, et al. Resonance Raman detection of carotenoids antioxidants in living human tissue. J Biomed Opt. 2005 Nov-Dec;10(6):064028
    • 40. Pharmanex research (pp 12-13), or, “Taking the Scanner Out to Play” <ul><li>Smidt C (2002) – study of 1,375 NUS employees </li></ul><ul><ul><li>Mean score of 19,072 </li></ul></ul><ul><ul><ul><li>Range from 1,556 – 73,416 </li></ul></ul></ul><ul><ul><ul><li>68% in range of {10,244 – 27,900} </li></ul></ul></ul><ul><ul><li>562 subjects – provided urine for MDA </li></ul></ul>Smidt, C. Clinical screening study: use of the Pharmanex ® BioPhotonic scanner to assess skin carotenoids as a marker of antioxidant status. Pharmanex, LCC, 75 West Center Street, Provo, UT. 2002
    • 41. Biophotonic Scan scores as function of # of servings of fruits and vegetables (p 12) Smidt, C. Clinical screening study: use of the Pharmanex ® Biophotonic scanner to assess skin carotenoids as a marker of antioxidant status. 2002
    • 42. Fun footnotes (p 13) <ul><li>MDA subjects (n=562) demonstrated LINEAR inverse correlation between urine MDA levels and Biophotonic scan scores </li></ul><ul><li>Inverse correlation between #of cigarettes smoked and scan score. </li></ul><ul><li>Strong and obvious correlation between use of LifePak & SCS </li></ul><ul><ul><li>One pack twice daily use showed 61% higher SCS than non users (p<0.001) </li></ul></ul>Smidt, C. , 2002, loc cit.
    • 43. More fun with LifePak supplementation, prescanner (1999) p. 14 <ul><li>Changes measured in: </li></ul><ul><ul><li>Ascorbic acid, beta-carotene, alpha-carotene, and alpha tocopherol </li></ul></ul><ul><ul><li>FUNCTIONAL MEASURMENET: decreased LDL oxidation </li></ul></ul><ul><li>Study of 50 healthy non smoker, crossover </li></ul><ul><ul><li>25 on either for six weeks, then crossed over for six weeks, then on alternate for six weeks </li></ul></ul>Smidt, CR et al. The effects of a nutritionally complete dietary supplement (LifePak®) on antioxidant status and LDL-oxidation in healthy non-smokers. Federation of American Society for Experimental Biology. 1999;13(4). Pharmanex Clinical Study Report published February 23, 2000.
    • 44. More fun with LifePak supplementation, prescanner (1999) p. 14 RESULTS <ul><li>LP supplementation prolonged LDL oxidation 18% </li></ul><ul><li>Increase of: </li></ul><ul><ul><li>Ascorbic acid – 38% </li></ul></ul><ul><ul><li>Alpha-carotene – 678% </li></ul></ul><ul><ul><li>Beta-carotene – 114% </li></ul></ul><ul><ul><li>Alpha-tocopherol – 84% </li></ul></ul><ul><li>“ LP significantly increased antioxidant status, and decreased LDL oxidizability in healthy non-smokers.” </li></ul>Smidt, CR et al. (1999, 2000 loc cit)
    • 45. How are we doing? 2006 Data Histogram: N =2,591,667 Mean SCS = 26,673 Skin Carotenoid Score Frequency THE LIFE PAKERS! Source: data reported by Pharmanex 5-9 Fruits & Vegetables Smokers Average (2-3 Fruits & Vegetables) Obesity LifePak LifePak + 5-9 Fruits & Vegetables
    • 46. Clinical opportunities – p. 16 <ul><li>1996 USDA survey of 5,188 – ZERO people got recommended daily allowances for all vitamins and nutrients. * </li></ul><ul><li>1994-1996 – 16,103 people studied – ZERO got 100% of all nutrients required* </li></ul><ul><ul><li>82.8% of the population got enough B12 </li></ul></ul><ul><ul><li>66.8% got enough folate. </li></ul></ul><ul><ul><li>26.6% got enough Zinc. </li></ul></ul>* http://www.ars.usda.gov /Services/docs.htm?docid=7716
    • 47. Final aspects of Cady White Paper <ul><li>pp 16-20 – review of products and opportunity </li></ul><ul><li>P 21 – Article on “The Raman Effect” </li></ul>
    • 48. What’s new since the 2006 “Cady Report”? <ul><li>Epidemiology of Vascular Ageing (EVA) study </li></ul><ul><ul><li>N=1,389; age range {59-71 yoa} </li></ul></ul><ul><ul><li>9 year study </li></ul></ul><ul><li>Relative risks: </li></ul><ul><ul><li>all cause mortality at 2.94X in men in lowest quintile (95% CI, P=0.03) </li></ul></ul><ul><ul><li>cancer 1.72X in men (95% CI, P=0.01 </li></ul></ul><ul><li>“ Total plasma carotenoids levels were independently associated with mortality risk in men.” </li></ul>
    • 49. Harvesting more data: Akbaraly and dysglycemia <ul><li>Akbaraly TN, et al. Used same data set. </li></ul><ul><li>127 cases of dysglycemia at 9 years. </li></ul><ul><li>“ After controlling for sociodemographic variables, lifestyle habits, cardiovascular disease, blood pressure, BMI , and lipid profile, risk of dysglycemia remained significantly lower in participants in the highest quartile of total plasma carotenoid compared with …. The lowest quartile.” </li></ul>Akbaraly TN et al. Plasma carotenoids and onset of dysglycemia in an elderly population: results of the Epidemiology of Vascular Ageing Study. Diabetes Care. 2008 Jul;31(7):1355-9.
    • 50. More data: a mad dash through the literature <ul><li>September 24, 2011 – 6:30 a.m. Pacific Time </li></ul>One more time… no supplement, under the DSHEA act, may be represented to treat, cure, mitigate or prevent any disease. No such “health claims” are being advanced for any Pharmanex/NuSkin supplement or product. The following slides represents a LITERATURE REVIEW. Louis B. Cady, MD
    • 51.  
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    • 59. But what about other things besides carotenoids and “Antioxidants”?? B12, Magnesium, Zinc, fish oil…
    • 60. <ul><li>Irritability </li></ul><ul><li>Apathy </li></ul><ul><li>Personality changes </li></ul><ul><li>Depression </li></ul><ul><li>Memory loss </li></ul><ul><li>Dementia </li></ul><ul><li>Hallucinations </li></ul><ul><li>Violent behavior </li></ul><ul><li>Anxiety </li></ul>Symptoms of B 12 Deficiency <ul><li>Diminished sense of touch and pain </li></ul><ul><li>Clumsiness </li></ul><ul><li>Weakness </li></ul><ul><li>Pernicious anemia </li></ul><ul><li>Chronic fatigue </li></ul><ul><li>Tremors </li></ul><ul><li>GI problems </li></ul>Mental Physical
    • 61. <ul><li>“ Although reference range for vitamin B12 is 200-1100 pg/ml, it has been reported that between 5 and 10% of patients with values between 200 and 400 pg/ml may experience neuropsychiatric and hematologic abnormalities due to occult B12 deficiency : less than 1% of patients with values above 400 pg/ml will have symptoms.” </li></ul><ul><li>- Quest Diagnostic Laboratories </li></ul>B12
    • 62. <ul><li>Levitt and Joffe, Brit J Psychiatry, 1988 </li></ul><ul><ul><li>B 12 deficiency seen in those with psychotic depression </li></ul></ul><ul><li>Penninx, et al., Am J Psychiatry, 2000 </li></ul><ul><ul><li>B 12 deficiency doubled the risk of severe depression in physically disabled older women </li></ul></ul>B 12 Deficiency <ul><li>Catalano, et al., Ann Clin Psychiatry, 2001 </li></ul><ul><ul><li>Nearly 1/3 (of 115) patients with depression or mood disorders had low B 12 </li></ul></ul><ul><li>Silver, Israeli J Psychiatry and Related Sciences, 2000 </li></ul><ul><ul><li>20% of psychiatric patients were B 12 deficient </li></ul></ul>
    • 63. Magnesium mementos <ul><li>One of the first minerals to disappear with: </li></ul><ul><ul><li>Processed food </li></ul></ul><ul><ul><li>Stress </li></ul></ul><ul><li>Decreased by EtOH , caffeine , sodas , meds </li></ul><ul><li>Considered “anti-stress” mineral </li></ul><ul><ul><li>Decreases cortisol (rel to sleep disruption) </li></ul></ul><ul><ul><li>Relaxes muscles, prevents cramps (sleep disruption) </li></ul></ul><ul><ul><li>Decreases anxiety ; improves sleep </li></ul></ul>
    • 64. Symptoms of Magnesium Deficiency <ul><li>PSYCHIATRIC ISSUES: </li></ul><ul><li>Difficulty with memory and concentration </li></ul><ul><li>Depression, apathy </li></ul><ul><li>Emotional lability </li></ul><ul><li>Irritability, nervousness, anxiety </li></ul><ul><li>Insomnia </li></ul><ul><li>Autism </li></ul><ul><li>ADHD </li></ul><ul><li>Migraine headaches </li></ul><ul><li>PMS </li></ul><ul><li>Dysmenorrhea </li></ul><ul><li>Fibromyalgia </li></ul><ul><li>Fatigue </li></ul><ul><li>CONSTIPATION </li></ul>Health Conditions Associated with Magnesium Deficiency
    • 65. November 2009 “Alpha Male” issue <ul><li>Observational study of randomly selected men – Boston </li></ul><ul><li>3 cohorts of men: 1987-1989; 1995-1997; 2002 -2004. </li></ul><ul><li>1374, 906, and 489 men, respectively. </li></ul><ul><li>“ Age independent decline in T that does not appear to be attributable to observed changes in explanatory factors, including lifestyle characteristics such as smoking and obesity.” </li></ul><ul><li>“ Recent years have seen a SUBSTANTIAL , and as yet UNRECOGNIZED age-independent population-level decrease in T in American men.” Travison, Araujo, et al. Jrnl of Clin. Endocrinol & Metabol 92:1; 196-202. </li></ul>
    • 66. Fast food (low Zn) is bad for you. <ul><li>Fast food = high energy density = low essential micronutrient density, ESPECIALLY ZINC </li></ul><ul><li>Antioxidant processes are dependent on Zinc </li></ul><ul><li>Fast food = severe decrease in antioxidant vitamins and zinc, correlating with inflammation in testicular tissue – with underdevelopment of testicular tissue and decreased testosterone levels </li></ul>
    • 67. Special needs - Zinc <ul><li>Low Zinc- associated with low testosterone </li></ul><ul><ul><li>Per USDA, 60% of US men between 20 – 49 years of age do not get enough . </li></ul></ul><ul><ul><li>N.B.: Do not supplement with > 50 mg daily (can interfere with Cu+ metabolism) </li></ul></ul><ul><ul><ul><li>Tsai, E.C., Boyko, E.J., Leonetti, D.L., & Fujimoto, W.Y. (2000). Low serum testosterone level as a predictor of increased visceral fat in Japanese-American men. International Journal of Obesity and Related Metabolic Disorders, 24, 485-491 </li></ul></ul></ul>
    • 68. Essential Fatty Acids – relevant for: <ul><li>“ Psych” </li></ul><ul><li>Depression </li></ul><ul><li>Bipolar depression </li></ul><ul><li>Schizophrenia </li></ul><ul><li>Autism </li></ul><ul><li>AD(H)D </li></ul><ul><li>Learning disabilities </li></ul><ul><li>“ Medical” </li></ul><ul><li>Seizures </li></ul><ul><li>Rheumatoid arthritis (& anything with inflammation) </li></ul><ul><li>Coronary heart disease (or health maintenance) </li></ul>
    • 69. Do YOU Need Fish Oil?
    • 70. c. 15-20X Omega 6:3
    • 71.  
    • 72. How to lie about vitamins and antioxidants…
    • 73. How to Lie about Vitamins & Antioxidants
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    • 84. “ If you’re going to be thinking anyway, you might as well thing big.” - Donald Trump
    • 85. “ For me, the practice of medicine has opened the door to the greatest adventure in life. Medicine is like a hallway lined with doors, each door opening into a different room, and each room opening into another hallway, again lined with doors. Medicine is always wonderful and never will be finished. ” - Charles H. Mayo, M.D.

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