A Review of the Pharmanex Biophotonic Scanner,  Supplementation and the “Cady White Paper”         Newport Beach, Californ...
Disclaimer: Pharmanex    supplementation and the  BioPhotonic Scanner are notFDA approved for the diagnosis,treatment, pre...
Tech Rules…. Please turnyour phones ON      (just       silenced).• Shoot photos!• Tweet! ( @LouisCadyMD )
Cady Wellness Institute – July 2005                The Reasons:•   Conventional medical practice had failed me twice.•   A...
CURRENT PRACTICE OF MEDICINE:What a patient had to say about her “specialists”:“They just monitor my    degeneration.”
A TALE OF THREE WOMEN
Evansville Courier & Press: May 29,2006
As of 5/31/2012
Could it happen to you?
What causes oxidative stress?• Environmental Toxins  –   Heavy metals – including Mercury (fillings!)  –   Pesticides/herb...
Oxidative stress in the BRAIN
Why is the brain so    susceptible to oxidative stress?• Burns glucose – generates free radicals.   • Uses 20% of total ox...
What are some consequences of           oxidative stress?•   Impaired cognitive function•   Decreased memory•   Depressed ...
Center for Biomedical Optics – Dixon Laser Institute, University of Utah• Werner Gellermann, Ph.D. – Research  Professor• ...
“A method and apparatus are providedfor the determination of levels ofcarotenoids and similar chemicalcompounds in biologi...
Scientific Validation: Peer-reviewed by the    medical & research communities• Society of Investigative Dermatology, May 2...
“RSS spectroscopy is a reliablemethod for non-invasivemeasurement of B-carotenelevels in skin, and may be usedas an import...
Where to read more…
“The Complete Idiot’s Guide to the          “Cady White Paper”• Pp 1-3 Patent claim synthesis: assessing  the overall anti...
Carotenoid correlation with other              antioxidants (pp 4-6)• Cited: carotenoids as chemopreventive agents*• Carot...
Relationships of carotenoids to other more conventionally measured antioxidants (p 6 -7)• Svilaas et al (2004):   – 2, 670...
Convenience of carotenoids as antioxidant measurement: from the eye to the skin (pp7-11)• Bernstein P et al (1998) - Carot...
The Svilaas/Hata Syllogism:• Hata (2000) – Raman measurements of  carotenoid == HPLC skin measurements• Svilaas (2004) – s...
Dissolved carotenoids in stratum corneum        27 days
BTW – what does that “SCS” actuallymean in REAL LAB MEASUREMENTS?• Y = 12703 * X + 5891.7  – Where Y is the SCS, and X is ...
Original study Skin carotenoid score             distribution                                                       • N=1,...
How are we doing? 2006 Data Histogram:                        N =2,591,667      Skin Carotenoid Score            Source: d...
16,103 people – 1994 – 1996.ZERO got 100% of all required vitamins andnutrients- Highest – B12 =- 82.8% got enough- 66.8% ...
What’s New since the “cadyreport” (2006 & 2008)?
Lipid peroxidation, antioxidant status& survival in institutionalized elderly• Plasma MDA  predicted mortality  independen...
Angela Mastaloudis Ph.D.Senior Scientist, Global Research &    Development, Pharmanex
“RS accurately measures total carotenoids in human skinwith less intra-individual variability than measurement ofserum car...
Epidemiology of Vascular Aging (EVA)• Study population:  – N=1,389; age range {59-71 yoa}  – 9 year study• Relative risks:...
Vitamin/mineral supplementation & cancer,  cardiovascular, and all-cause mortality   (EPIC-Heidelberg) Li K, Kaaks R., et ...
Antioxidants and brain tumors?• “free radicals are another etiological factor  of brain tumor and are removed by cellular ...
Conclusions• “It is concluded that  administration of antioxidants  could reduce the incidence of  brain tumors and probab...
Oxidative damage in DNA in lymphocytes:     correlation with CA and CV disease                    • 8-oxodeoxyguanosine (8...
The GREAT news about a BAD study Conclusions: “In older women, several commonly used dietary vitamin and mineral supplemen...
Not so fast!• 18 year duration; 38,000 “older” white  women in Iowa• Supplements: MVI’s, A, D, E, Beta-  carotene, B –vita...
A real hatchet job on MVI’s• Study measured “who dies over 18 years?”   – Average age at start – 61 yoa   – Average age at...
More hatcheting – poor controls• Hormones (Premarin/provera)                  Nearly   – 13.5% of supplement users        ...
“Pending strong evidence …from randomized trials, itappears prudent for all adults to take vitaminsupplements.” Fletcher &...
So why do you need aSYSTEM in your vitaminsupplement/mineralcomplex?? And what’s a‘nano’?
What does “Nano” mean?• Cylcodextrin ring – benign, digestable• Feeds the gut microflora
How do nano-nutrients work?Fat-soluble nutrients like   Nano-encapsulated nutrients docarotenoids and coenzyme Q10 not clu...
The Nanotechnology Difference                                       5-fold increase in absorption!   pmol/mg protein      ...
The train has left the station…
what about otherthings besides carotenoidsand “Antioxidants”?? B12, Magnesium, Selenium, Zinc, fish oil…
3                        ega - s                   O m c id                    fa tty a                                 nt...
Symptoms of B12 Deficiency      Mental               Physical•   Irritability•                         • Diminished sense ...
LifePak Nano factoids - % RDA in 2              packets• B12    -   1,000% (as 60 MICROgrams  cyanocobalamin)• Magnesium 7...
Magnesium mementos• One of the first minerals to disappear with:  – Processed food  – Stress• Decreased by EtOH, caffeine,...
Symptoms of Magnesium DeficiencyPSYCHIATRIC ISSUES: Health Conditions Associated•Difficulty with memory with Magnesium Def...
SELENIUM DEFICIENCY in FASEB:                             • “Adaptive dysfunction of                               selenop...
Negative downstream effects from         selenium deficiency: “…cancer, heart disease, and immune dysfunction are prospect...
Se+    “the foot soldier”LifePak Nano has 200% of    RDA of selenium.
Fast food (low Zn) is bad for you.• Fast food = high energy density = low essential  micronutrient density, ESPECIALLY ZIN...
Special needs - Zinc• Low Zinc- associated with low testosterone  – Per USDA, 60% of US men between 20 – 49    years of ag...
Essential Fatty Acids – relevant for:“Psych”                     “Medical”•   Depression              • Seizures•   Bipola...
Do YOU Need Fish Oil?           5X reduction
What happens with biotin       deficiency?Two LifePak Nano packets have100% of recommended dailyrequirements of Biotin.“Ou...
Putting it all together…
LifePak Nano Contains60+ Antioxidants, plus complete nutritional system    • All 8 forms of natural vitamin E    • Buffere...
The Effects of high dose B vitamins           on stress at workStrough C et al. The effect of 90 day administration of a h...
The Effects of high dose B vitamins            on stress at work• “Occupational stress is increasing in Western societies....
Erectile dysfunction& antioxidants with      MVI’s??
Way to improve erectile quality           (LP Nano concentrations in parentheses)• Holistic: physical exercise, improved n...
Contact information:                                                   Louis B. Cady, M.D.                                ...
Two thinkers: - Yoshida Kenko – (1283?-1350?)“Life Frail & Fleeting”          • Risk reversal                             ...
How do you want to age?
Success and Failure (Jim Rohn)  What about you? You’ve only got one body.• “Errors in judgement” - High glycemic eating,  ...
Perhaps the ability not only to acquirethe confidence of the patient, but todeserve it, to see what the patientdesires and...
The Biophotonic Scanner, Supplementation & The "Cady White Paper"
The Biophotonic Scanner, Supplementation & The "Cady White Paper"
The Biophotonic Scanner, Supplementation & The "Cady White Paper"
The Biophotonic Scanner, Supplementation & The "Cady White Paper"
The Biophotonic Scanner, Supplementation & The "Cady White Paper"
The Biophotonic Scanner, Supplementation & The "Cady White Paper"
The Biophotonic Scanner, Supplementation & The "Cady White Paper"
The Biophotonic Scanner, Supplementation & The "Cady White Paper"
The Biophotonic Scanner, Supplementation & The "Cady White Paper"
The Biophotonic Scanner, Supplementation & The "Cady White Paper"
The Biophotonic Scanner, Supplementation & The "Cady White Paper"
The Biophotonic Scanner, Supplementation & The "Cady White Paper"
The Biophotonic Scanner, Supplementation & The "Cady White Paper"
The Biophotonic Scanner, Supplementation & The "Cady White Paper"
The Biophotonic Scanner, Supplementation & The "Cady White Paper"
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The Biophotonic Scanner, Supplementation & The "Cady White Paper"

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This is Dr. Cady's third presentation to health care professionals in California, this time with updated news from the peer reviewed literature and a wide-ranging discussion of Pharmanex supplements and products: not just for "antioxidant" benefit, but for a complete, balance, systems-focused approach toward wellness.

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The Biophotonic Scanner, Supplementation & The "Cady White Paper"

  1. 1. A Review of the Pharmanex Biophotonic Scanner, Supplementation and the “Cady White Paper” Newport Beach, California – June 2, 2012 Louis B. Cady, MD – CEO & Founder – Cady Wellness Institute Adjunct Professor – University of Southern Indiana Adjunct Clinical Lecturer – Indiana University School of Medicine Department of Psychiatry Child, Adolescent, Adult & Forensic Psychiatry – Evansville, IndianaThis presentation is © Louis B. Cady M.D. and may not be reproduced in part or whole, in any form, or used without permission.
  2. 2. Disclaimer: Pharmanex supplementation and the BioPhotonic Scanner are notFDA approved for the diagnosis,treatment, prevention, or cure of ANY disease or “medical condition.”They ARE appropriate to support the structureand function of the human body.
  3. 3. Tech Rules…. Please turnyour phones ON (just silenced).• Shoot photos!• Tweet! ( @LouisCadyMD )
  4. 4. Cady Wellness Institute – July 2005 The Reasons:• Conventional medical practice had failed me twice.• A lot of “psychiatric cases” WEREN’T “psychiatric.”• Nobody was integrated.• Nobody was looking at ALL of the peer-reviewed literature.
  5. 5. CURRENT PRACTICE OF MEDICINE:What a patient had to say about her “specialists”:“They just monitor my degeneration.”
  6. 6. A TALE OF THREE WOMEN
  7. 7. Evansville Courier & Press: May 29,2006
  8. 8. As of 5/31/2012
  9. 9. Could it happen to you?
  10. 10. What causes oxidative stress?• Environmental Toxins – Heavy metals – including Mercury (fillings!) – Pesticides/herbicides – Preservatives – PCB’s, Dioxins, Phthalates• Toxins produced in the body – Yeast and bacteria – Products of cellular metabolism• Emotional Stress – Anxiety/Tension – Fear – Anger
  11. 11. Oxidative stress in the BRAIN
  12. 12. Why is the brain so susceptible to oxidative stress?• Burns glucose – generates free radicals. • Uses 20% of total oxygen and energy consumed by the body. • ½ of this is for electrochemical nerve transmission.• Contains IRON• Contains essential fatty acids, which can be OXIDIZED (“rancid fat”)• Limited supply of own antioxidants• Limited ability to regenerate/repair damage
  13. 13. What are some consequences of oxidative stress?• Impaired cognitive function• Decreased memory• Depressed immune system• Increased inflammation• DNA damage• cancer• Behavioral deterioration
  14. 14. Center for Biomedical Optics – Dixon Laser Institute, University of Utah• Werner Gellermann, Ph.D. – Research Professor• Colleague – Igor Ermakov, Ph.D., et al.• Technologies – “Novel Raman Spectroscopy and Raman Imaging.”• Funding: – National Institutes of Health – State of Utah – Spectrotek, LLC
  15. 15. “A method and apparatus are providedfor the determination of levels ofcarotenoids and similar chemicalcompounds in biological tissue suchas living skin.”
  16. 16. Scientific Validation: Peer-reviewed by the medical & research communities• Society of Investigative Dermatology, May 25, 2000. – Non-Invasive Raman Spectroscopic Detection of Carotenoids in Human Skin.• Arch Biochem Biophys. 2010 Dec 1;504(1):40-9. Epub 2010 Aug 1. – Validation model for Raman based skin carotenoid detection• J Eur Acad Dermatol Ven. 2011 Aug;25(8):945-9. – Skin carotenoid levels in adult patients with psoriasis.
  17. 17. “RSS spectroscopy is a reliablemethod for non-invasivemeasurement of B-carotenelevels in skin, and may be usedas an important biomarker ofantioxidant status in nutritionaland health studies in humans.”Ramirez-Velez, et al. Endocrinol Nutr. 2012 April
  18. 18. Where to read more…
  19. 19. “The Complete Idiot’s Guide to the “Cady White Paper”• Pp 1-3 Patent claim synthesis: assessing the overall antioxidant status in human tissue via Raman spectroscopy via measuring carotenoids – Carotenoids are antioxidants • Identified in 1992 • Potent antioxidants • Lycopenes and carotenoids appear to diminish risk of prostate CA.• P 4 Further discussion of prostate CA
  20. 20. Carotenoid correlation with other antioxidants (pp 4-6)• Cited: carotenoids as chemopreventive agents*• Carotenoids as first line of defense, associated with “antioxidant network” – with Vitamins C, E, Coenzyme Q10, ALA, and SE. **• Yeum et al: need to measure water AND fat soluble vitamins identified.*** *Peng YM et al. Concentrations and plasma-tissue-diet relationships of carotenoids, retinoids, and tocopherols in humans. Nutr Cancer. 1995;23(3):233-46. ** Packet, Lester. The Antioxidant Miracle. John Wiley & Sons, Inc. © 1999 ***Yeum et al. Biomarkers of antioxidant capacity in the hydrophilic and lipophilic compartments of human plasma. Arch Biochem Biophys. 2004 Oct 1; 430(1):97-103.
  21. 21. Relationships of carotenoids to other more conventionally measured antioxidants (p 6 -7)• Svilaas et al (2004): – 2, 670 adults studied with serum carotenoids measured and correlated with vitamin consumption – serum carotenoids were stronger predictors of other antioxidants than were alpha, beta, delta, and gamma tocopherols, as well as glutathione.** Svilaas A, et al. Intakes of antioxidants in coffee, wine, andvegetables are correlated with plasma carotenoids in humans. JNutr. 2004 Mar;134(3):562-7.
  22. 22. Convenience of carotenoids as antioxidant measurement: from the eye to the skin (pp7-11)• Bernstein P et al (1998) - Carotenoids useful as measure of antioxidant status in human retina*• Hata, et al (2000) – correlated skin carotenoids (Raman) with carotenoid levels from skin from abdominoplasty patients (HPLC). – “Our technique can be used…for assessing antioxidant status and the risk for diseases related to oxidative stress.” – Previous use in skin, retina, oral cavity and other tissues cited. Palm of skin = highest carotenoid location*Bernstein P et al. Raman detection of macular carotenoids pigments in intact humanretina. Invest Opthalmol Vis Sc. 1998 Oct;39(11):2003-11.**Hata et al. Non-invasive Raman spectroscopic detection of carotenoids in humanskin. J Invest Dermatol. 2000 Sep; 115(3):441-8.
  23. 23. The Svilaas/Hata Syllogism:• Hata (2000) – Raman measurements of carotenoid == HPLC skin measurements• Svilaas (2004) – skin carotenoids = better predictor of antioxidant status than mixed tocopherols and glutathione• THEREFORE [Cady]: Raman spectroscopy is a better measure of antioxidant status than mixed tocopherols and glutathione.
  24. 24. Dissolved carotenoids in stratum corneum 27 days
  25. 25. BTW – what does that “SCS” actuallymean in REAL LAB MEASUREMENTS?• Y = 12703 * X + 5891.7 – Where Y is the SCS, and X is the carotenoid concentration in MICROgrams/ml, viz: • 25,000 = 12703X + 5891.7 • 25,000 – 5891.7 = 12703 * X • 19,108.3 = 12703 * X • 19,108.3 /12703 = X • X = 1.50 MICROgrams /ml• Rule of thumb: 1,000 on SCS = .06 ug carotenoid/ ml blood serum• (e.g., SCS of 40,000 = 2.4 ug carotenoid/ml) Source: NuSkin/Pharmanex
  26. 26. Original study Skin carotenoid score distribution • N=1,375 April 2012 - – SCS ranges: Columbia • 1500 – cancer patient • 73,000 – two month old baby. – Mean: 19,281Smidt, C. Clinical screening study: use of the Pharmanex ® Biophotonic scanner to assess skin carotenoids as a marker of antioxidant status. 2002
  27. 27. How are we doing? 2006 Data Histogram: N =2,591,667 Skin Carotenoid Score Source: data reported by Pharmanex Mean SCS = 26,673 Obesity Smokers Average (2-3 Fruits & Vegetables)Frequency 5-9 Fruits & Vegetables LifePak LifePak + 5-9 Fruits & Vegetables
  28. 28. 16,103 people – 1994 – 1996.ZERO got 100% of all required vitamins andnutrients- Highest – B12 =- 82.8% got enough- 66.8% - had adequate folate- Lowest – Zinc – only 26.6% got enough.
  29. 29. What’s New since the “cadyreport” (2006 & 2008)?
  30. 30. Lipid peroxidation, antioxidant status& survival in institutionalized elderly• Plasma MDA predicted mortality independently of all other variables.• B-carotene and alpha tocopherol were independently associated with survival. Huerta JM et al. Free Radical Research 2006, vol 40, no 6. pp 571-578.
  31. 31. Angela Mastaloudis Ph.D.Senior Scientist, Global Research & Development, Pharmanex
  32. 32. “RS accurately measures total carotenoids in human skinwith less intra-individual variability than measurement ofserum carotenoids by HPLC analysis. RS technologyis a valid and reliable noninvasive methodto rapidly assess carotenoid nutritionalstatus in humans.” (J Am. Coll Nutr 2009)
  33. 33. Epidemiology of Vascular Aging (EVA)• Study population: – N=1,389; age range {59-71 yoa} – 9 year study• Relative risks: – all cause mortality at 2.94X in men in lowest quintile (95% CI, P=0.03) – cancer 1.72X in men (95% CI, P=0.01• “Total plasma carotenoids levels were independently associated with mortality risk in men.”
  34. 34. Vitamin/mineral supplementation & cancer, cardiovascular, and all-cause mortality (EPIC-Heidelberg) Li K, Kaaks R., et al. Eur J Nutri July 2011• Purpose: evaluate vitamin/mineral supplementation with CA, CV dz, and mortality• Methods: – 23,943 healthy participants, followed x 11 years – Baseline and “new-use” supplementation noted• Results: 513 CA deaths, 264 CV deaths – “No MVI supplement had any significant effect” – Baseline users of antioxidant supplements had significantly reduced risk of cancer [HR 0.52] and all cause mortality [0.58]• “sick user” phenomenon discussed.
  35. 35. Antioxidants and brain tumors?• “free radicals are another etiological factor of brain tumor and are removed by cellular antioxidants in the human body.”• Inverse correlation between: – antioxidant levels and oxidative DNA damage – Grades of malignancy• Decrease in antioxidants are associated with severity of malignancy
  36. 36. Conclusions• “It is concluded that administration of antioxidants could reduce the incidence of brain tumors and probably other types of cancer.”• - Shewelta SA , Sheikh, BY Curr Drug Metab. 2011 Jul;12(6):587-93. (Dept.of Biosciences & Technology, Alexandria University, Egypt.)
  37. 37. Oxidative damage in DNA in lymphocytes: correlation with CA and CV disease • 8-oxodeoxyguanosine (8- oxo-dG) concentration measured in lymphocytes • Vitamin C in plasma • Vitamin E & carotenoids by HPLC • Mortality correlations with oxidative damage: – Heart dz, males (r= 0.95) – Colorectal CA, malesCollin AR , et al. FASEB J.1998 Oct;12(13):1397-400. (r=0.91)
  38. 38. The GREAT news about a BAD study Conclusions: “In older women, several commonly used dietary vitamin and mineral supplements may be associated with increased total mortality risk; this association is strongest with supplemental iron.”
  39. 39. Not so fast!• 18 year duration; 38,000 “older” white women in Iowa• Supplements: MVI’s, A, D, E, Beta- carotene, B –vitamins, iron, calcium, copper, magnesium selenium, and zinc.• The real results: – Early results showed women who used C, D, E, and Calcium had significantly lower rates of death – Iron supplementation was highly correlated to death rates (but these results were mixed in)
  40. 40. A real hatchet job on MVI’s• Study measured “who dies over 18 years?” – Average age at start – 61 yoa – Average age at end of study 82 yoa – Average mortality for all women – 80 yoa in 2003 (during the study)• Conclusion: Over 50% of the women in the Iowa study lived longer than the average life expectancy.Mursu, Harnack et al – Dietary supplements and mortality rate inolder women…. Arch Intern Med 2011 Oct 10;171(18):1625-33.
  41. 41. More hatcheting – poor controls• Hormones (Premarin/provera) Nearly – 13.5% of supplement users 2X as – 7.2% of non-supplement users many!!• No explanation as to why so many women were taking iron.• Excess levels of vitamin A in some MVI brands• No evaluation of the quality or potency of the supplementsMursu, Harnack et al – Dietary supplements and mortality rate inolder women…. Arch Intern Med 2011 Oct 10;171(18):1625-33.
  42. 42. “Pending strong evidence …from randomized trials, itappears prudent for all adults to take vitaminsupplements.” Fletcher & Fairfield, JAMA 2002
  43. 43. So why do you need aSYSTEM in your vitaminsupplement/mineralcomplex?? And what’s a‘nano’?
  44. 44. What does “Nano” mean?• Cylcodextrin ring – benign, digestable• Feeds the gut microflora
  45. 45. How do nano-nutrients work?Fat-soluble nutrients like Nano-encapsulated nutrients docarotenoids and coenzyme Q10 not clump; they DISPERSE.CLUMP in watery milieu.
  46. 46. The Nanotechnology Difference 5-fold increase in absorption! pmol/mg protein γ-cyclodextrinAdapted from Craft et al, FASEB Journal. 2005; 19(4): Abstract #281.6, A449. complex
  47. 47. The train has left the station…
  48. 48. what about otherthings besides carotenoidsand “Antioxidants”?? B12, Magnesium, Selenium, Zinc, fish oil…
  49. 49. 3 ega - s O m c id fa tty a nts mi ns onu trievita P hyt s nts ine ral xid a m ntio lth) A hea (b one
  50. 50. Symptoms of B12 Deficiency Mental Physical• Irritability• • Diminished sense Apathy of touch and pain• Personality changes • Clumsiness• Depression • Weakness• Memory loss • Pernicious anemia• Dementia • Chronic fatigue• Hallucinations • Tremors• Violent behavior • GI problems• Anxiety
  51. 51. LifePak Nano factoids - % RDA in 2 packets• B12 - 1,000% (as 60 MICROgrams cyanocobalamin)• Magnesium 76% (as 300 Mg amino acid chelate)• Zinc 100% (15 mg as zinc chelate)• Selenium 200% (L-selenomethionine & NaSeO3)
  52. 52. Magnesium mementos• One of the first minerals to disappear with: – Processed food – Stress• Decreased by EtOH, caffeine, sodas, meds• Considered “anti-stress” mineral – Decreases cortisol (rel to sleep disruption) – Relaxes muscles, prevents cramps (sleep disruption) – Decreases anxiety; improves sleep
  53. 53. Symptoms of Magnesium DeficiencyPSYCHIATRIC ISSUES: Health Conditions Associated•Difficulty with memory with Magnesium Deficiencyand concentration  Migraine headaches•Depression, apathy  PMS•Emotional lability  Dysmenorrhea•Irritability, nervousness,  Fibromyalgiaanxiety  Fatigue•Insomnia  CONSTIPATIONAutismADHD
  54. 54. SELENIUM DEFICIENCY in FASEB: • “Adaptive dysfunction of selenoproteins from the perspective of the ‘triage’ theory: why modest selenium deficiency may increase risk of diseases of aging.”Foundation of American McCann, J, Ames BM. FASEB J.Societies for Experimental 2011 Jun;25(6):1793-814.Biology
  55. 55. Negative downstream effects from selenium deficiency: “…cancer, heart disease, and immune dysfunction are prospectively associated with modest selenium deficiency…. suggesting that Se deficiency could be a CAUSATIVE factor”McCann, J, Ames BM. FASEB J. 2011 Jun;25(6):1793-814.
  56. 56. Se+  “the foot soldier”LifePak Nano has 200% of RDA of selenium.
  57. 57. Fast food (low Zn) is bad for you.• Fast food = high energy density = low essential micronutrient density, ESPECIALLY ZINC• Antioxidant processes are dependent on Zinc• Fast food = severe decrease in antioxidant vitamins and zinc, correlating with inflammation in testicular tissue – with underdevelopment of testicular tissue and decreased testosterone levels
  58. 58. Special needs - Zinc• Low Zinc- associated with low testosterone – Per USDA, 60% of US men between 20 – 49 years of age do not get enough. – N.B.: Do not supplement with > 50 mg daily (can interfere with Cu+ metabolism) • Tsai, E.C., Boyko, E.J., Leonetti, D.L., & Fujimoto, W.Y. (2000). Low serum testosterone level as a predictor of increased visceral fat in Japanese- American men. International Journal of Obesity and Related Metabolic Dis 24, 485-491
  59. 59. Essential Fatty Acids – relevant for:“Psych” “Medical”• Depression • Seizures• Bipolar depression • Rheumatoid arthritis• Schizophrenia (& anything with• Autism inflammation)• • Coronary heart AD(H)D disease (or health• Learning disabilities maintenance)
  60. 60. Do YOU Need Fish Oil? 5X reduction
  61. 61. What happens with biotin deficiency?Two LifePak Nano packets have100% of recommended dailyrequirements of Biotin.“Our results suggest that biotin deficiencypromotes hyperglycemic mechanisms…anddecreased insulin secretion and sensitivity tocompensate for reduced blood glucoseconcentrations.”
  62. 62. Putting it all together…
  63. 63. LifePak Nano Contains60+ Antioxidants, plus complete nutritional system • All 8 forms of natural vitamin E • Buffered vitamin C, Alpha lipoic acid • Nano Carotenoids: – as found in 5-10 fruits & vegetables per day • Over 20 Flavonoids: – green tea catechins, quercetin, citrus bioflavonoids, grape seed polyphenols, resveratrol • Selenium, Copper, Zinc, Mg++, Mb++ • B-vitamins complex, Biotin, D3 (150%) • 4 GRAMS fish oil (incl. 600mg EPA/400 mg DHA)
  64. 64. The Effects of high dose B vitamins on stress at workStrough C et al. The effect of 90 day administration of a high dose vitamin B-coplex on work stress. Hum Psyhopharmacol. 2011 Sept 8. doi10.1002/hup.1229 (Swinburne University of Techbnology – Hawhorn, Victoria,Australia.)
  65. 65. The Effects of high dose B vitamins on stress at work• “Occupational stress is increasing in Western societies.”• 3 month, double blind, placebo control, randomized study• Measured: Personality, work demands, mood, anxiety, and strain• After variances in personality and work demands were controlled, the vitamin B complex treated group reported significantly lower personal strain and a reduction in confusion and depressed/dejected mood after 12 weeks. Strough C et al. The effect of 90 day administration of a high dose vitamin B- coplex on work stress. Hum Psychopharmacol. 2011 Sept 8. doi 10.1002/hup.1229 (Swinburne University of Techbnology – Hawhorn, Victoria, Australia.)
  66. 66. Erectile dysfunction& antioxidants with MVI’s??
  67. 67. Way to improve erectile quality (LP Nano concentrations in parentheses)• Holistic: physical exercise, improved nutrition, weight control• Supplements: adequate intake – Omega 3 fatty acids ( ~4 grams/ day in LP Nano) – Antioxidants {+++} – Calcium (600 mg = 60%) – Folic acid (folate – 600 ug = 150%)• RX: Replacement of any T deficiencyMeldrum DR et al. The link between erectile and cardiovascular health: thecanary in the coal mine. Am J Cardiol. 2011 Aug 15;108(4):599-606
  68. 68. Contact information: Louis B. Cady, M.D. www.cadywellness.com www.indianaTMS-cadywellness.com Office: 812-429-0772 E-mail: lcady@cadywellness.com 4727 Rosebud Lane – Suite F Interstate Office Park Newburgh, IN 47630 (USA) Download fromiTunes or Android App stores now!
  69. 69. Two thinkers: - Yoshida Kenko – (1283?-1350?)“Life Frail & Fleeting” • Risk reversal • “USP” • Defining the buying criteria
  70. 70. How do you want to age?
  71. 71. Success and Failure (Jim Rohn) What about you? You’ve only got one body.• “Errors in judgement” - High glycemic eating, no exercise, poor nutrition, lousy or no supplementation, high stress lifestyle.- “Good disciplines” – appropriate diet, supplementation, exercise, hormones. Stress management. Decent lifestyle.
  72. 72. Perhaps the ability not only to acquirethe confidence of the patient, but todeserve it, to see what the patientdesires and needs, comes through thesixth sense we call intuition, which inturn comes from wide experience anddeep sympathy for and devotion tothe patient, giving to the possessorremarkable ability to achieve results. ...William J. Mayo, 1935

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