Beating Brain Fog - by Louis B. Cady, MD

Beating Brain Fog! Louis B. Cady, MD – CEO & Founder – Cady Wellness Institute Adjunct Professor – University of Southern Indiana Adjunct Clinical Lecturer – Indiana University School of Medicine Department of Psychiatry Child, Adolescent, Adult & Forensic Psychiatry – Evansville, Indiana

“ All truth passes through three phases:
First, it is ridiculed.
Second, it is violently opposed, and…
Third, it is accepted as self-evident.”
Arthur Shopenhauer, 1788-1860

Health is a state of complete physical, mental and social well-being, and not merely the absence of disease or infirmity. - World Health Organization

Today’s Medical Practice Challenges
Obesity, diabetes, auto-immune, inflammatory and chronic diseases increasing
Inflammatory triggers increasing
Novel viruses and infective organisms
Animal infections non-responsive to any therapy
Unresponsive/resistant infections
Weakened immune systems
GI decline/inflammation
Poor quality medicinals/foods/nutritionals

February 26, 2009 6 a.m.

2001 estimated age by appearance of 387 sets of twins
2003, 49 deaths
The surviving twin was rated as being approximately 1.15 years younger
Evidence indicates appearance may reflect how long we live Christensen K, Iachina M, Rexbye H, Tomassini C, Frederiksen H, McGue M, Vaupel JW. Epidemiology. 2004 Mar;15(2):251-2

Nutrients linked to fewer lines and wrinkles and overall health Am J Clin Nutr. 2007 Oct;86(4):1225-31. Higher intakes of Vitamin C and lenoleic acid and lower intakes of fats & carbohydrates are associated with better skin-aging appearance.

% of Adults Achieving the Recommended Dietary Intakes of Fruits and Vegetables Centers for Disease Control MMWR 56 (10);2007. Dietary advice seems simple – but we don’t do it! What we should be eating What we are eating BIG GAP!!!!

= 2 apples (fruits) & 3 - 4 vegetables – per CDC

16,103 people – 1994 – 1996.
ZERO got 100% of all required vitamins and nutrients
- Highest – B12 =- 82.8% got enough
66.8% - had adequate folate
Lowest – Zinc – only 26.6% got enough .

Assessment of lifestyle effects on the overall antioxidant capacity of healthy subjects Lesgards JF et al. Environ Health Perspect. 2002 May;110(5):479-86.
INCREASED antioxidant status:
Nonsmoking
Vitamin/mineral supplementation
Regular physical activity
DECREASED antioxidant status:
Smoking
Psychological stress
Alcohol consumption
Moderate vegetable , LOW FRUIT , LOW FISH consumption
High natural UV light

“ The Complete Idiot’s Guide to Free Radicals and What They Do”
Rob you of energy.
Kill you with heart attacks and strokes.
Give you cancer because of altered DNA.
Age your skin before your time.

Mitochondrial Damage: Loss of Energy
Mitochondria
Free radical damage alters their energy production capability. Plus, they “breathe their own exhaust.”

ENERGY!

Power to the people!
2 ATP – glucose
36 ATP – Krebs
29.85 ATP/glucose most recent
Mitochondria AGE.
Treatment with antioxidants extends their life and function. (Science, 2000).

Glutathione: drops 8 – 12 % per decade after 20
Oxidative stress: toxins, inadequate nutrition, stress

Trends in Pharmacological Sciences (2008) Jul; 29(7):351. Epub 2008 Jun 4

Oxidation (“Rusting”) of LDL: Loss of LIFE
Blood and tissue Lipids
Free radicals cause lipid peroxidation (“spoilage of fats”).
“ Spoiled” LDL cholesterol = Lip(a). It becomes sticky and can clog arteries and cause macrophages to become foam cells. This causes arteriosclerosis . Too much = stroke or MI.

Oxidative stress [DAMAGE] on DNA: Cancer & Loss of Life
Free radicals in the nucleus of the cell can attack a gene and damage the chemical bonds and alter the information transcribed , or they can cause cross-linking (shutting down replication).

Free radical stress: “ You’re not getting older, just your DNA” (Headline from an article in Popular Science, August 2002, p.44)

Nutrition, Disease, & Longevity
" The amount of Antioxidants that you maintain in your body is directly related to how long you will live "
Richard Cutler, PhD, NIH
" Antioxidants are substances that may protect cells from the damage caused by unstable molecules known as free radicals . Free radical damage may lead to cancer. Antioxidants interact with and stabilize free radicals and may prevent some of the damage free radicals otherwise might cause . Examples of antioxidants include beta-carotene, lycopene, vitamins C, E, and A , and other substances." - National Cancer Institute, "Antioxidants and Cancer Prevention: Fact Sheet", 28 July 2004

Today’s salad:
-mixed greens, peppers, onions, tomato, olive oil
it has nearly 63% less nutrient compared to 1940
plus residues of pesticides and nitrates
Nutrition on the farm (not found in 1940)
Courtesy of Arden Andersen, DO, FS.

% Mineral depletion from the soil during the past 100 years, by continent Source: UN Earth Summit Report 1992 North America 85% South America 76% Asia 76% Africa 74% Europe 72% Australia 55%

Cf: http://www.veganforum.com/forums/showthread.php?t=3532

Jrnl of Amer. College of Nutrition Vol 23, No. 6, 669-682 (2004). Objective: evaluate possible changes in USDA nutrient content data for 43 crops between 1950 – 1999; consider potential causes Methods: ratios calculated for “R” 1999/1950 Results: as a group, the 43 foods showed apparently, statistically reliable declines for 6 nutrients: protein, Ca, P, Fe, riboflavin, and ascorbic acid . - 6% decrease in protein - 38% decrease in riboflavin CONCLUSIONS: trade off between yield and nutrient content

Source: Jerry Brunetti – www.agri-dyanmics.com

CONFOUNDS
Too much of the wrong things.
Erroneous [holdover] paradigms
Deliberate bias in literature

http://fnic.nal.usda.gov/interactiveDRI

“ Pending strong evidence of effectiveness from randomized trials, it appears prudent for all adults to take vitamin supplements.” Fletcher & Fairfield, JAMA vol. 287, No. 23 – June 19, 2002

What should we be taking?

Evansville Courier & Press : May 29, 2006

Lymphocytes are used for FIA

“ Harold was impressed with the cells’ performance.”

Rational notions of vitamin supplementation Council for Responsible Nutrition 1828 L Street, NW, Suite 510 • Washington, DC

Some Multivitamin options A B complex C, Se, ZN D Copper 22 vitamins/minerals Cu – skin, hair, nails Chromium, Calcium Se (?cancer reduction) Black cohosh Chasteberry, Dong Quai Extra Zinc, Magnesium, and Calcium

Bacopa monieri & memory
Potent cognitive enhancer and neuroprotectant (rats)–
J Ethnopharmacol. 2010 Jan 8;127(1):26-31. Epub 2009 Oct 4. Uabundit, Wattanathorn, et al.
Rasayana – Aryuvedic remedies for rejuvenation & nutrition (Bacopa & Ashwaghanda cited) – the Medhya Rasayana are specific for brain regions.
Biogerontology. 2008 Dec;9(6):369-74. Epub 2008 Oct 1, Singh & Narsimhamurthy

6 week placebo run in; 12 weeks of treatment
54 participants, >/= 65 years of age, w/o signs of dementia
48 completed the study; 24 in each group – placebo or Bacopa
Bacopa (300 mg / day) participants:
enhanced Auditory Verbal Learning Test scores
Improved ability on Stroop
CESD-10 depression scores decreased
Anxiety scores decreased, as well as heart rate
“ This study provides further evidence that B. monnieri has potential for safely enhancing cognitive performance in the aging.”

www.cwimetagenics.com

Bacopa – available in a Medhya Rasayana formulation Ashwaghanda Rasyana herb. An adoptgen that allegedly normalizes the HPA axis and neuroendocrine system. Bacopa leaf Antioxidant. Nootropic effects (cognitve enhancing). Rat studies show improved memory and learning. Human studies confirmatory Amia Fruit “ Indian gooseberry” – contains 30 X the Vitamin C found in oranges . Indian and Tibetan healers bnelieve it has anti-ageing and immune system enhancing properties Holy Basil Aryuvedic. Anti-inflammatory and anti-oxidant.

Combination MVI + Antioxidant from Metagenics Two tabs 3X/day - $35.25 One tablet 2X/day - $23.50 Multivitamin, multimineral, antioxidants More Vitamin A, C, and E. Quercetin, Turmeric Grape Seed Extract, ALA, Crptoxanthin, Zeaxanthin, Lutein

Study of several nootropics, as well as VINPOCETINE.
Vinpocetine:
Increases blood circulation and metabolism in the brain
Three studies of adults with dementia related disease, showed significant effects on:
Global cognitive tests reflecting attention
Concentration
Memory

November 2009 “Alpha Male” issue
Observational study of randomly selected men – Boston
3 cohorts of men: 1987-1989; 1995-1997; 2002 -2004.
1374, 906, and 489 men, respectively.
“ Age independent decline in T that does not appear to be attributable to observed changes in explanatory factors, including lifestyle characteristics such as smoking and obesity.”
“ Recent years have seen a SUBSTANTIAL , and as yet UNRECOGNIZED age-independent population-level decrease in T in American men.” Travison, Araujo, et al. Jrnl of Clin. Endocrinol & Metabol 92:1; 196-202.

Fast food (low Zn) is bad for you.
Fast food = high energy density = low essential micronutrient density, ESPECIALLY ZINC
Antioxidant processes are dependent on Zn
Fast food = severe decrease in antioxidant vitamins and zinc, correlating with inflammation in testicular tissue – with underdevelopment of testicular tissue and decreased testosterone levels

Special needs - Zinc
Low Zinc- associated with low testosterone
Per USDA, 60% of US men between 20 – 49 years of age do not get enough.
N.B.: Do not supplement with > 50 mg daily (can interfere with Cu+ metabolism)
Tsai, E.C., Boyko, E.J., Leonetti, D.L., & Fujimoto, W.Y. (2000). Low serum testosterone level as a predictor of increased visceral fat in Japanese-American men. International Journal of Obesity and Related Metabolic Disorders, 24, 485-491

The Paul Revere of Anti-Aging has Arrived Archives of Gerontology and Geriatrics, Volume 48, Issue 3, May-June 2009, 271-275

Dr. Zs-Nagy, MD, continued:
"[The] gerontological elite has instead sought to obfuscate the facts ... the reason for this is nothing less than an abject fear ... to avert their loss of control, power, prestige, and position in the multi-billion dollar industry of gerontological medicine .”
Prof. Dr. Imre Zs.-Nagy, MD - part of the gerontology movement for four decades; founder and Editor-in-Chief of the Archives of Gerontology and Geriatrics

There is no “complimentary” biochemistry

Cady Wellness Institute Synergy: The Five Point Plan
GET ALL THE LABS YOU NEED.
Rx: Hormones, if needed.
MONITOR ANTIOXIDNAT LEVELS AND SUPPLEMENT, AS NEEDED.
RATIONAL EATING
RATIONAL EXERCISING.
Mind Body Actions

Jim Rohn
Success – “A few good disciplines, practiced each day.”
Failure – “A few errors in judgement, repeated each day.”

Aging in America - 80 – The 3 rd Half of Life! www.bobdelmonteque.com

What can you do at 100?
Rita Levi Montalcini, MD
Nobel Prize – Medicine 1986
Birthday – April 18, 1909
“ At 100, I have a mind that is superior – thanks to experience – than when I was 20.”
“ Above all, don’t fear difficult moments. The best comes from them.”

"If I hadn't believed it, I wouldn't have seen it." - Yogi Berra Personal collection Louis B. Cady, M.D.

Thanks for coming! Contact Dr. Cady at (812) 429 – 0772 or [email_address] . For listing of presentations and for color frame by frame view of this presentation – go to www.cadywellness.com/presentations

Beating Brain Fog - by Louis B. Cady, MD

by Louis Cady, MD

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