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A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science

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In his return to the Orange County, CA area, Dr. Cady quickly reviews the key points of his previous presentation and integrates new science and citations about wellness and the key concepts of …

In his return to the Orange County, CA area, Dr. Cady quickly reviews the key points of his previous presentation and integrates new science and citations about wellness and the key concepts of nutritional supplementation with balanced products. He then turns his attention to new developments in genomic science, reviews key scientific milestones, and describes how the NuSkin/Pharmanex line of AgeLOC products have profound implications for the improvement of energy, sexual functioning, mental focus, and weight loss through the optimization of the function of the human body.

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  • Dr. Cady did an outstanding presentation at the Pharmanex Biophotonic Scanner Meeting yesterday in Orange County. Thank You Dr. Cady for sharing all your knowledge and white pages. Such a wealth of information.
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  • Speaker note – transition– of tale of three women.
  • FROM WIKIPEDIA - Epidermis
    Epidermis, "epi" coming from the Greek meaning "over" or "upon", is the outermost layer of the skin. It forms the waterproof, protective wrap over the body's surface and is made up of stratified squamous epithelium with an underlying basal lamina.
    The epidermis contains no blood vessels, and cells in the deepest layers are nourished by diffusion from blood capillaries extending to the upper layers of the dermis. The main type of cells which make up the epidermis are Merkel cells, keratinocytes, with melanocytes and Langerhans cells also present. The epidermis can be further subdivided into the following strata (beginning with the outermost layer): corneum, lucidum (only in palms of hands and bottoms of feet), granulosum, spinosum, basale. Cells are formed through mitosis at the basale layer. The daughter cells (see cell division) move up the strata changing shape and composition as they die due to isolation from their blood source. The cytoplasm is released and the protein keratin is inserted. They eventually reach the corneum and slough off (desquamation). This process is called keratinization and takes place within about 27 days. This keratinized layer of skin is responsible for keeping water in the body and keeping other harmful chemicals and pathogens out, making skin a natural barrier to infection. From WIKIpedia
  • METHODS:
    In the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg), which was recruited in 1994-1998, 23,943 participants without pre-existing cancer and myocardial infarction/stroke at baseline were included in the analyses. Vitamin/mineral supplementation was assessed at baseline and during follow-up. Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).
    RESULTS:
    After an average follow-up time of 11 years, 1,101 deaths were documented (cancer deaths = 513 and cardiovascular deaths = 264). After adjustment for potential confounders, neither any vitamin/mineral supplementation nor multivitamin supplementation at baseline was statistically significantly associated with cancer, cardiovascular, or all-cause mortality. However, baseline users of antioxidant vitamin supplements had a significantly reduced risk of cancer mortality (HR: 0.52; 95% CI: 0.28, 0.97) and all-cause mortality (HR: 0.58; 95% CI: 0.38, 0.88). In comparison with never users, baseline non-users who started taking vitamin/mineral supplements during follow-up had significantly increased risks of cancer mortality (HR: 1.74; 95% CI: 1.09, 2.77) and all-cause mortality (HR: 1.58; 95% CI: 1.17, 2.14).
    CONCLUSIONS:
    Based on limited numbers of users and cases, this cohort study suggests that supplementation of antioxidant vitamins might possibly reduce cancer and all-cause mortality. The significantly increased risks of cancer and all-cause mortality among baseline non-users who started taking supplements during follow-up may suggest a "sick-user effect," which researchers should be cautious of in future observational studies.
  • When repleted - results pretty quickly. “If if spasms, think magnesium” – bowel, bronchial.
  • From the study: We and others have previously hypothesized that defects in mitochondrial oxidative and phosphorylation capacity might be a contributing factor to the increased triglyceride content in muscle and the liver. To test this hypothesis, we assessed in vivo rates of mitochondrial oxidative activity in skeletal muscle by 13C NMR and phosphorylation activity by 31P NMR. Using this approach, we found that rates of mitochondrial oxidative and phosphorylation activity were both reduced by ~40% in the elderly participants as compared with the young controls.
  • This heatmap illustrates gene expression of three groups from a pre-clinical test with one of the ageLOC Vitality ingredients: young (column 1), old (column 2), and old with ageLOC science (column 3). Each row represents one of 52 genes comprising the mitochondrial Youth Gene Cluster (mtYGC). Columns 1 and 2 show that each of the 52 genes became more or less active during the aging process. In column 3, the YGC activity pattern of the old with ageLOC science group has been reset to a gene expression pattern similar to the young group in column 1.1
  • Site Source
  • Transcript

    • 1. A Review of the Pharmanex Biophotonic Scanner, Supplements, the “Cady White Paper,” & Relevant Genomic Science in New AgeLOC Products Santa Ana, California – November 9, 2013 Louis B. Cady, MD – CEO & Founder – Cady Wellness Institute Adjunct Professor – University of Southern Indiana Adjunct Clinical Lecturer – Indiana University School of Medicine Department of Psychiatry Child, Adolescent, Adult & Forensic Psychiatry – Evansville, Indiana
    • 2. Background for this presentation: • There are no “drug claims” made for any products from NuSkin/Pharmanex • No NuSkin/Pharmanex product– nor any other “OTC” vitamin or supplement – is designed to treat, prevent, mitigate, diagnose or do anything else to or for any disease. • Pharmanex nutritional supplements & weight control products are designed to support the structure and function of the human body. (c) 2013 Louis B. Cady, M.D. - all rights reserved
    • 3. CURRENT PRACTICE OF MEDICINE: What a patient had to say about her “specialists”: “They just monitor my degeneration.”
    • 4. Cady Wellness Institute – July 2005 The Reasons: • • • • Conventional medical practice had failed me twice. A lot of “psychiatric cases” WEREN’T “psychiatric.” Nobody was integrated. Nobody was looking at ALL of the peer-reviewed literature.
    • 5. Today: A Tale of FOUR Guys…
    • 6. Learning objectives • Importance of antioxidants (with refs) • Origins and validity of the Biophotonic Scanner • The critical “three points” of the “Cady White Paper” • AgeLOC technology and “YGC’s” (??) • Vitality and TR90
    • 7. “Streaking”, or….. Better Buckle Up!!! • Definition: Streaking is the act of taking off one's clothes and running naked through a public place. [ref: http://en.wikipedia.org/wiki/Streaking - accessed 09 02 2013] • “In 1973, what the press called a ‘streaking epidemic’ hit Stephen F. Austin State University in Nacogdoches, TX, with streakers being seen in residence halls, at football games and at various other on-campus locations and events, including Spring graduation.” (Harvard-Yale game, 2006)
    • 8. www.slideshare.net/lcadymd
    • 9. Here it is again… :) www.slideshare.net/lcadymd
    • 10. Evansville Courier & Press: May 29, 2006
    • 11. As of 11/8/2013
    • 12. As of 11/8/2013
    • 13. As of 11/8/2013
    • 14. Could it happen to you?
    • 15. What causes oxidative stress? • Environmental Toxins – – – – Heavy metals – including Mercury (fillings!) Pesticides/herbicides Preservatives PCB’s, Dioxins, Phthalates • Toxins produced in the body – Yeast and bacteria – Products of cellular metabolism • Emotional Stress – Anxiety/Tension – Fear – Anger
    • 16. Oxidative stress in the BRAIN – why you should “know your numbers”
    • 17. Why is the brain so susceptible to oxidative stress? • Burns glucose – generates free radicals. • Uses 20% of total oxygen and energy consumed by the body. • ½ of this is for electrochemical nerve transmission. • Contains IRON • Contains essential fatty acids, which can be OXIDIZED (“rancid fat”) • Limited supply of own antioxidants • Limited ability to regenerate/repair damage
    • 18. • • • • What are some consequences of oxidative stress? Behavioral deterioration Impaired cognitive function Decreased memory Psychiatric symptoms • Increased inflammation • Depressed immune system • DNA damage • cancer
    • 19. Antioxidant assessment Reference: www.cadywellness.com/cadyw
    • 20. Center for Biomedical Optics – Dixon Laser Institute, University of Utah • Werner Gellermann, Ph.D. – Research Professor • Colleague – Igor Ermakov, Ph.D., et al. • Technologies – “Novel Raman Spectroscopy and Raman Imaging.” • Funding: – National Institutes of Health – State of Utah – Spectrotek, LLC
    • 21. “A method and apparatus are provided for the determination of levels of carotenoids and similar chemical compounds in biological tissue such as living skin.”
    • 22. Dissolved carotenoids in stratum corneum 27 days
    • 23. Scientific Validation: Peer-reviewed by the medical & research communities • Society of Investigative Dermatology, May 25, 2000. – Non-Invasive Raman Spectroscopic Detection of Carotenoids in Human Skin. • Arch Biochem Biophys. 2010 Dec 1;504(1):40-9. Epub 2010 Aug 1. – Validation model for Raman based skin carotenoid detection • J Eur Acad Dermatol Ven. 2011 Aug;25(8):945-9. – Skin carotenoid levels in adult patients with psoriasis.
    • 24. “RSS spectroscopy is a reliable method for non-invasive measurement of B-carotene levels in skin, and may be used as an important biomarker of antioxidant status in nutritional and health studies in humans.” Ramirez-Velez, et al. Endocrinol Nutr. 2012 April
    • 25. “But is the scanner really valid and dependable?”
    • 26. • “The totality of the evidence supports the use of skin carotenoid status as an objective biomarker of fruits/vegetable intake…” • “..skin carotenoids may effectively serve as an integrated biomarker of health…” • “Thus, this biomarker holds promise as both a health biomarker and an objective indicator of fruits & vegetables intake….”
    • 27. Scamo S et al. Br J Nutr. 2013 Sep 14;110(5):911-7. • Good agreement between single and multiple measures (95% CI) • + association with intake of total carotenoids • “A single RRS measure was reasonably accurate at classifying usual skin carotenoid state.”
    • 28. So where do I find this “white paper”? • www.google.com • www.cadywellness.com/ cadywhitepaper2008.pdf
    • 29. Relationships of carotenoids to other more conventionally measured antioxidants (p 6 -7) • Svilaas et al (2004): – 2, 670 adults studied with serum carotenoids measured and correlated with vitamin consumption – serum carotenoids were stronger predictors of other antioxidants than were alpha, beta, delta, and gamma tocopherols, as well as glutathione.* * Svilaas A, et al. Intakes of antioxidants in coffee, wine, and vegetables are correlated with plasma carotenoids in humans. J Nutr. 2004 Mar;134(3):562-7.
    • 30. Convenience of carotenoids as antioxidant measurement (pp7-11) • Hata, et al* (2000) – correlated skin carotenoids (Raman) with carotenoid levels from skin from abdominoplasty patients (HPLC). • “Our technique can be used…for assessing antioxidant status and the risk for diseases related to oxidative stress.” [Palm of skin = highest carotenoid location] *Hata et al. Non-invasive Raman spectroscopic detection of carotenoids in human skin. J Invest Dermatol. 2000 Sep; 115(3):441-8.
    • 31. The Svilaas/Hata Syllogism: • Hata (2000) – Raman measurements of carotenoid == HPLC skin measurements • Svilaas (2004) – skin carotenoids = better predictor of antioxidant status than mixed tocopherols and glutathione • THEREFORE [Cady]: Raman spectroscopy is a better measure of antioxidant status than mixed tocopherols and glutathione.
    • 32. BTW – what does that “SCS” actually mean in REAL LAB MEASUREMENTS? • Y = 12703 * X + 5891.7 – Where Y is the SCS, and X is the carotenoid concentration in MICROgrams/ml, viz: • • • • • 25,000 = 12703X + 5891.7 25,000 – 5891.7 = 12703 * X 19,108.3 = 12703 * X 19,108.3 /12703 = X X = 1.50 MICROgrams /ml • Rule of thumb: 1,000 on SCS = .06 ug carotenoid/ml blood serum • (e.g., SCS of 40,000 = 2.4 ug carotenoid/ml) Source: NuSkin/Pharmanex
    • 33. “You don’t need vitamins: (a) you can get’em in your food; (b)they just make expensive urine.” “I don’t believe in antioxidants.” – from an MD!!
    • 34. “Inadequate intakes may result in chronic metabolic disruption, including mitochondrial decay.” “[They] cause DNA damage, such as chromosome breaks, in cultured human cells or in vivo.” “triage theory
    • 35. 16,103 people – 1994 – 1996. ZERO got 100% of all required vitamins and nutrients - Highest – B12 =- 82.8% got enough - 66.8% - had adequate folate - Lowest – Zinc – only 26.6% got enough.
    • 36. Seismic shift in the medical literature - 2002 “Pending strong evidence …from randomized trials, it appears prudent for all adults to take vitamin supplements.” Fletcher & Fairfield, JAMA 2002
    • 37. What’s New since the “cady report” (2006 & 2008)?
    • 38. Angela Mastaloudis Ph.D. Senior Scientist, Global Research & Development, Pharmanex
    • 39. “RS accurately measures total carotenoids in human skin with less intra-individual variability than measurement of serum carotenoids by HPLC analysis. RS technology is a valid and reliable noninvasive method to rapidly assess carotenoid nutritional status in humans.” (J Am. Coll Nutr 2009)
    • 40. Epidemiology of Vascular Aging (EVA)
    • 41. Epidemiology of Vascular Aging (EVA) • Study population: – N=1,389; age range {59-71 yoa} – 9 year study • Relative risks: – all cause mortality at 2.94X in men in lowest quintile (95% CI, P=0.03) – cancer 1.72X in men (95% CI, P=0.01 • “Total plasma carotenoids levels were independently associated with mortality risk in men.”
    • 42. Vitamin/mineral supplementation & cancer, cardiovascular, and all-cause mortality (EPIC-Heidelberg) Li K, Kaaks R., et al. Eur J Nutri July 2011 • Purpose: evaluate vitamin/mineral supplementation with CA, CV dz, and mortality • Methods: – 23,943 healthy participants, followed 11 years – Baseline and “new-use” supplementation noted • Results: 513 CA deaths, 264 CV deaths – “No MVI supplement had any significant effect” • “sick user” phenomenon discussed. • Baseline users of antioxidant supplements had significantly reduced risk of cancer [HR 0.52] and all cause mortality [0.58]
    • 43. Antioxidants and brain tumors? • “free radicals are another etiological factor of brain tumor and are removed by cellular antioxidants in the human body.” • Inverse correlation between: – antioxidant levels and oxidative DNA damage – Grades of malignancy • Decrease in antioxidants are associated with severity of malignancy
    • 44. Conclusions • “It is concluded that administration of antioxidants could reduce the incidence of brain tumors and probably other types of cancer.” • - Shewelta SA , Sheikh, BY Curr Drug Metab. 2011 Jul;12(6):587-93. (Dept.of Biosciences & Technology, Alexandria University, Egypt.)
    • 45. So why do you need a SYSTEM in your vitamin supplement/mineral complex?? And what’s a ‘nano’?
    • 46. A SYSTEMS approach to nutritional optimization 3 ega- s Om cid tty a fa nts trie ns mi onu vita hyt P nts s a ral xid ine ntio m lth) A hea one (b
    • 47. What does “Nano” mean? • Cylcodextrin ring – benign, digestable • Feeds the gut microflora
    • 48. How do nano-nutrients work? Fat-soluble nutrients like Nano-encapsulated nutrients do carotenoids and coenzyme Q10 not clump; they DISPERSE. CLUMP in watery milieu.
    • 49. The Nanotechnology Difference pmol/mg protein 5-fold increase in absorption! Adapted from Craft et al, FASEB Journal. 2005; 19(4): Abstract #281.6, A449. γ-cyclodextrin complex
    • 50. The train has left the station…
    • 51. Can you relax with an 81,000 scan score??
    • 52. Total organic fruits/vegetables intake, 9 – 12 servings per day. No supplements.
    • 53. 74,000
    • 54. what about other things besides carotenoids and “Antioxidants”?? Or… why can’t you just “juice” your way to complete and optimal health???
    • 55. Essential Fatty Acids – relevant for: “Psych” “Medical” • • • • • • • Seizures • Rheumatoid arthritis (& anything with inflammation) • Coronary heart disease (or health maintenance) Depression Bipolar depression Schizophrenia Autism AD(H)D Learning disabilities
    • 56. Do YOU Need Fish Oil? 5X reduction
    • 57. Symptoms of B12 Deficiency Mental • • • • • • • • • Irritability Apathy Personality changes Depression Memory loss Dementia Hallucinations Violent behavior Anxiety Physical • Diminished sense of touch and pain • Clumsiness • Weakness • Pernicious anemia • Chronic fatigue • Tremors • GI problems
    • 58. LifePak Nano - % RDA in 2 packets • B12 1,000% (as 60 MICROgrams cyanocobalamin) • B6 500% • Folic acid/folate - 150% • Magnesium 76% (as 300 Mg amino acid chelate) • Zinc 100% (15 mg as zinc chelate) • Selenium 200% (L-selenomethionine & NaSeO3) • Iodine 76% • Chromium 166% • Vitamin C 834% • Vitamin A 300% (83% as Beta carotene and plant extracts)
    • 59. Why there is an epidemic of B12 deficiency?? • Gastric intrinsic factor produced by parietal cells of stomach;. H1 blockers shut them down • Can’t absorb B-12 without it. • Complex goes to last portion of small intestine, where complex is absorbed and B12 liberated.
    • 60. Your brain and B12 • If you are in the bottom 1/3rd for B-12 levels…. • SIX TIMES increase risk of brain volume loss (Odds ratio = 6.17, 95% CI) – Vogiatzoglou A et al. Vitamin B12 status and rate of brain volume loss in community-dwellers. Neurology. 2008 Sep 9;71(11):826-32. – (107 volunteers aged 61-87 years of age)
    • 61. BRAIN SHRINKAGE… CONCLUSIONS: “The accelerated rate of brain atrophy in elderly with MCI can be slowed by treatment with homocysteine-lowering Bvitamins.” Smith AD, Smith SM, de Jager CA, Whitbread P, et al. (2010) Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial. PLoS ONE 5(9): e12244. doi:10.1371/journal.pone.0012244 http://www.plosone.org/article/info:doi/10.1371/journal.pone.0012244
    • 62. LifePak Nano - % RDA in 2 packets • B12 1,000% (as 60 MICROgrams cyanocobalamin) HOMOCYSTEINE • B6 500% lowering • Folic acid/folate - 150% • Magnesium 76% (as 300 Mg amino acid chelate) • Zinc 100% (15 mg as zinc chelate) • Selenium 200% (L-selenomethionine & NaSeO3) • Iodine 76% • Chromium 166% • Vitamin C 834% • Vitamin A 300% (83% as Beta carotene and plant extracts)
    • 63. OK. It slows shrinkage. But are they sharper? [deJager CA et al. Int J Geriatr Psychiatry. 2012 June;27(6):592-600] “B-vitamins appear to slow cognitive and clinical decline in people with MCI.”
    • 64. The Effects of high dose B vitamins on stress at work • 3 month, double blind, placebo control, randomized study – Measured: Personality, work demands, mood, anxiety, and strain • The vitamin B complex treated group reported significantly lower personal strain and a reduction in confusion and depressed/dejected mood after 12 weeks. Strough C et al. The effect of 90 day administration of a high dose vitamin Bcomplex on work stress. Hum Psychopharmacol. 2011 Sept 8. doi 10.1002/hup.1229 (Swinburne University of Technology – Hawthorn, Victoria, Australia.)
    • 65. “Micronutrient supplementation has a beneficial effect on perceived stress, mild psychiatric symptoms, and aspects of mood in apparently healthy individuals. Supplements containing high doses of B vitamins may be more effective in improving mood states.”
    • 66. What happens with biotin deficiency? Two LifePak Nano packets have 100% of recommended daily requirements of Biotin. “Our results suggest that biotin deficiency promotes hyperglycemic mechanisms…and decreased insulin secretion and sensitivity to compensate for reduced blood glucose concentrations.”
    • 67. One more time… no supplement, under the DSHEA act, may be represented to treat, cure, mitigate or prevent any disease. No such “health claims” are being advanced for any Pharmanex/NuSkin supplement or product. The following slides represents a LITERATURE REVIEW It correlates antioxidants, carotenoids and various conditions described in the peer reviewed medical literature. - Louis B. Cady, MD On November 8th, 2013 More data: a mad dash through the literature
    • 68. “Chile has an increased cancer prevalence which is associated with poor quality diets, rising mean body mass index and a sedentary behavior.”
    • 69. 100 more citations in the last year!
    • 70. OK. So I’ll just drink carrot juice and pop some high potency B’s. What me worry?
    • 71. 20 years ago - a hint of bad things to come… • North Americans, unfortunately, obtain about one-third of their total calories from nutrient-poor junk food. Even well-educated… adults…. fall short in their consumption of important minerals, like magnesium, iron, zinc, and calcium. Hallfrishch, J., Muller, D. 1993. Experimental Gerontology, v28 : 473-83.
    • 72. Magnesium mementos • One of the first minerals to disappear with: – Processed food – Stress • Decreased by EtOH, caffeine, sodas, meds • Considered “anti-stress” mineral – Decreases cortisol (rel to sleep disruption) – Relaxes muscles, prevents cramps – Decreases anxiety; improves sleep
    • 73. Symptoms of Magnesium Deficiency PSYCHIATRIC ISSUES: •Difficulty with memory and concentration •Depression, apathy •Emotional lability •Irritability, nervousness, anxiety •Insomnia Autism ADHD Health Conditions Associated with Magnesium Deficiency  Migraine headaches  PMS  Dysmenorrhea  Fibromyalgia  Fatigue  CONSTIPATION
    • 74. SELENIUM DEFICIENCY in FASEB: • “Adaptive dysfunction of selenoproteins from the perspective of the ‘triage’ theory: why modest selenium deficiency may increase risk of diseases of aging.” Foundation of American Societies for Experimental Biology McCann, J, Ames BM. FASEB J. 2011 Jun;25(6):1793-814.
    • 75. I+ Se+  “the foot soldier” LifePak Nano has 200% of RDA of selenium. And 76%of RDA of iodine.
    • 76.  “Recent years have seen a SUBSTANTIAL, and as yet UNRECOGNIZED ageindependent population-level decrease in T in American men.” November 2009 Travison, Araujo, et al. Jrnl of Clin. Endocrinol & Metabol 92:1; 196-202. 3 cohorts of men: 1987-1989; 1995-1997; 2002 -2004. “Alpha Male” issue
    • 77. Fast food (low Zinc) is bad for you. • Fast food = high energy density = low essential micronutrient density, ESPECIALLY ZINC • Antioxidant processes are dependent on Zinc • Fast food = severe decrease in antioxidant vitamins and zinc, correlating with inflammation in testicular tissue – with underdevelopment of testicular tissue and decreased testosterone levels
    • 78. Low Zinc associated with low testosterone • Per USDA, 60% of US men between 20 – 49 years of age do not get enough. – [N.B.: Do not supplement with > 50 mg daily (can interfere with Cu+ metabolism); rationale for SYSTEMS approach] • Tsai, E.C., Boyko, E.J., Leonetti, D.L., & Fujimoto, W.Y. (2000). Low serum testosterone level as a predictor of increased visceral fat in JapaneseAmerican men. International Journal of Obesity and Related Metabolic Disorders, 24, 485-491 LifePak Nano has 100% of daily RDA for Zinc.
    • 79. Erectile dysfunction & antioxidants with MVI’s??
    • 80. Ways to improve erectile quality (LP Nano concentrations in parentheses) • Holistic: physical exercise, improved nutrition, weight control (R90 & TR90) • Supplements: adequate intake – Omega 3 fatty acids ( ~4 grams/ day in LP Nano) – Antioxidants {+++} – Calcium (600 mg = 60%) – Folic acid (folate – 600 ug = 150%) • RX: Replacement of any T deficiency Meldrum DR et al. The link between erectile and cardiovascular health: the canary in the coal mine. Am J Cardiol. 2011 Aug 15;108(4):599-606
    • 81. New Partners, New Products
    • 82. LifeGen acquisition: Why? • Owns all current and future genetic data on aging – monopolizes the genetic knowledge on aging • Applies LifeGen science to all products – Unrestricted access • Builds barrier to entry • Enhances Nu Skin product innovation in antiaging (“Apple” of the industry) 99
    • 83. Is it safe to Influence Genes? ageLOC is NOT: gene therapy genetic engineering gene splicing ageLOC is: • NuSkin/Pharmanex - novel approach to developing products designed to support youthful gene expression.
    • 84. An Entirely New Class of Anti-aging Products
    • 85. BEFORE AFTER 6 MONTHS *Twice daily usage of ageLOC Transformation, and twice weekly usage of ageLOC Galvanic Spa and Facial Gels.
    • 86. Mitochondrial Damage: Loss of Energy Mitochondria Free radical damage alters their energy production capability. Plus, they “breathe their own exhaust.”
    • 87. MITOCHONDRIAL ACTIVITY DECLINES WITH AGE 8 6 - 40% 4 2 18~39 61~84 ”Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance” Science 16 May 2003:Vol. 300. no. 5622, pp. 1140 – 1142
    • 88. “Transcriptional Biomarkers of Mitochondrial Aging and Modulation by Cordyceps sinensis CS-4.” Muscle Brain R Weindruch, A Mastaloudis, SB Ferguson et al. Presented at Biology of Aging, Determinants of Health-Span. Switzerland August 22-27,2010
    • 89. TARGET & RESET YOUTH GENE CLUSTERS Young Gene Expression TARGET Old Gene Expression Old Gene Expression RESET Transcriptional Biomarkers of Mitochondrial Aging and Modulation by Cordyceps Sinensis Cs-4. Gordon Research Conference, Biology of Aging, Determinants of Health-Span: From Cells to Humans, August 22-27, 2010. Les Diablerets Conference Center, Les Diablerets, Switzerland. 1
    • 90. “Youth Gene Clusters” – bogus or bonanza? Yeast species SPECIFIC genes Comparative genomics of fungal allergens and epitopes show widespread distribution of closely related allergen and epitope orthologues. Bower P, et al, BMC Genomics. 2006; 7:251.
    • 91. Prostate Cancer – more relevant? Pre-invention gene expression Post-intervention gene expression Changes in prostate gene expression in men undergoing an intensive nutrition and lifestyle intervention. Ornish, Dean Proc Natl Acad Sci USA 2008 June 17; 105(24):8369-8374 et al.
    • 92. Active mitochondrial research on energy
    • 93. http://www.nature.com/scitable/topicpage/mtdna-andmitochondrial-diseases-903
    • 94. Three active botanicals: •Cordyceps •Pomegranate extract •Panax ginseng Promotes Three Dimensions of Vitality:* •Physical Vigor •Mental Acuity •Sexual Health * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
    • 95. Week 12 = +20% P=0.021 Vitality vs. Placebo “Targeting Age-related gene expression improves mental and physical vitality” Ferguson SB SM et al. Paper presented at 1st World Congress on Targeting Mitochondria, Strategies, Innovations & Clinical Applications. Berlin, German. November 18-19, 2010.
    • 96. “Excess body weight is correlated with excess morbidity and mortality. In particular, Grade 2 or higher obesity (BMI>35) significantly increases the risk of death.” (c) 2013 Louis B. Cady, M.D. - all (www.cdc.gov/nchs/data/hus/hus11_InBrief.pdf) rights reserved
    • 97. Obesity – a national crisis A $586 Billion Market in 2014 Fortune Magazine Feb 3, 2003
    • 98. How do you lose it?
    • 99. • TBL: It’s the INSULIN RESPONSE • RX: EAT LESS CARBS AND SUGAR!! NEW APPROACH: -Turn on your genes in your fat cells to burn more fat and store less fat!! - Change hunger signaling to brain by changing gene expression
    • 100. ageLOC TR90 Summary • Healthy weight management and Body Shaping program. • Based on gene expression science. – Promotes Lean Muscle Maintenance - Appetite Control • Studies on TR90 weight management program resulted in significant weight loss, fat loss and changes in gene expression.
    • 101. Comparison of Genetic Profiles of Adipose Tissue in Identical Twins Pietiläinen et al. PLoS Med. 2008 Mar 11;5(3):e51. Overweight Twin Normal Weight Twin Same DNA Different Expression of Genes Compared to their normal weight twin, overweight twins exhibited down regulation of gene expression pathways related to: • • Fat Regulation (storage versus utilization) Muscle Protein Synthesis
    • 102. Identified Gene Expression Pathways Linked to Fat Storage and Fat Metabolism LifeGen pre-clinical study of Adipose, Gastrocnemius muscle, Hypothalamus
    • 103. Plants altering gene expression Ingredient Effect From PubMed Prickly pear fruit “body silhouette” Potent antioxidant Green tea catechins Thermogenesis (Established) pomegranate Fat reduction related to the presence of anthocyanins, tannins, and very high levels of antioxidants, including polyphenols and flavonoids. Tart cherry Prevents muscle damage increasing total antioxidative capacity, reducing inflammation, lipid peroxidation
    • 104. Green tea, black tea, epigallocatechin: •Modifies body composition •Improves glucose tolerance •DIFFERENTIALLY ALTERS GENE EXPRESSION
    • 105. Gene Expression relates to the Appetite Control Center of the Brain • • • Appetite Control Eating Behavior Regulation of energy intake Ghrelin Leptin Insulin References: 1. 2. 3. 4. 5. 6. 7. 8. 9. Smeets et al. Proceeding of the Nutrition Society. 2012;71:511-520. Guthoff M, et al. J Clin Endocrinol Metab. 2010;95:748-755. De Silva, et al. Cell Metab. 2011;14:700-706. Malik S, et al. Cell Metab. 2008;7:400-409. Farooqi IS, et al. Science. 2007;317:1355 Suzuki K, et al. Experimental Diabetes Research. 2012:1-19. Viquerie N, et al. Diabetologia. 2005;48(1):123-131. Mager et al. European Journal of Endocrinology. 2008;158: Mutch DM, et al. Am J Clin Nutr. 2011;94(6):1399-1409.
    • 106. Eating Plan Based on: Protein Science & Nutrition Science • “3-2-1 eating” plan designed to complement the supplements. • Supports metabolically-active lean muscle and inhibits fat storage. Reference: Wycherley TP, et al. AJCN. 2012;96(6):1281-98.
    • 107. Eating Most of Your Protein with Only One Meal of the Day Limits Duration of Metabolic Burn FAT STORING ZONES FAT BURNING Time in Metabolic Burn Zone = Only 3 hours/day Breakfast Lunch Adapted from: 1.Paddon-Jones and Rassmussen. Curr Opin Clin Nutr Metab Care, 2009;12:86. 2.Layman DL. Nutrition and Metabolism, 2009; 6:12. Dinner
    • 108. Eating Protein with Each Meal Accelerates Metabolic Burn FAT STORING ZONES FAT BURNING Time in Metabolic Burn Zone = 9 hours/day Breakfast Lunch Adapted from: 1.Paddon-Jones and Rassmussen. Curr Opin Clin Nutr Metab Care, 2009;12:86. 2.Layman DL. Nutrition and Metabolism, 2009; 6:12. Dinner
    • 109. So what the heck am I supposed to do with this stuff?
    • 110. A personal close: How do YOU want to age? Me – Jan 2013
    • 111. The “First Guy” on TR90 • Measurements from 10/25/13 (start date) – 11/6/13 • Lost: – ¾” on waist (one belt loop) – 1.25” total – 4.4 lbs • In 10 days
    • 112. Wrapping Up: The “Survival Curve” – Where Are You?
    • 113. “For me, the practice of medicine has opened the door to the greatest adventure in life. Medicine is like a hallway lined with doors, each door opening into a different room, and each room opening into another hallway, again lined with doors. Medicine is always wonderful and never will be finished.” - Charles H. Mayo, M.D.

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