Wirkung von Vitamin D
bei Krebserkrankungen
Stefan Pilz
Department of Internal Medicine, Division of Endocrinology and
Met...
OUTLINE
Vitamin D and sun

Reichrath J. British Journal of Dermatology, 2009; 161: 54-60
Cancer and sunlight

Apperly FL
Cancer Res 1:191-195, 1941
Cancer and sunlight

Apperly FL. Cancer Res 1:191-195, 1941
Solar radiation and colon cancer

Int J Epidemiol 1980; 9:227-231
UV-B and cancer mortality

Cancer 2002;94:1867-1875
OUTLINE
Vitamin D and melanoma
Vitamin D and melanoma
Vitamin D and cancer

47,800 men
4,286 incident cancers
2,025 cancer deaths
Largest study in this field
Vitamin D and cancer mortality

Data from 3299 patients referred for coronary angiography and followed up for 7.7 years

C...
Vitamin D and colorectal cancer

Non-linear dose-response metaanalyses on circulating 25hydroxyvitamin D and risk of
color...
Vitamin D and colorectal cancer

Dose-response meta-analyses of total (dietary + supplemental) vitamin D
intake and risk o...
OUTLINE
Anticancer effects of vitamin D

684-700
Anticancer effects of vitamin D

JNCI J Natl Cancer Inst
(1992) 84(17): 1355-1357
OUTLINE
Vitamin D and cancer incidence

A 4-year, population based, double-blind, randomized, placebo
controlled trial among healt...
WHI-Study
WHI-Study
OUTLINE
Conclusion

Sunlight (ultraviolet-B exposure), which increases vitamin D synthesis
in the skin, is associated with reduced...
Thank you for your attention !
Stefan Pilz - Vitamin D und Krebs
Stefan Pilz - Vitamin D und Krebs
Stefan Pilz - Vitamin D und Krebs
Stefan Pilz - Vitamin D und Krebs
Stefan Pilz - Vitamin D und Krebs
Stefan Pilz - Vitamin D und Krebs
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Stefan Pilz - Vitamin D und Krebs

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Prof. Dr. Stefan Pilz: Sonne, Sonnenschein-Vitamin D und Krebs. Forschungsergebnisse zu Vitamin D und seine Wirkung bei Prävention und Therapie verschiedener Krebsarten. Vortrag beim "Vitamin D-Update 2013" in der Charité Berlin

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Stefan Pilz - Vitamin D und Krebs

  1. 1. Wirkung von Vitamin D bei Krebserkrankungen Stefan Pilz Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Austria Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Amsterdam, The Netherlands
  2. 2. OUTLINE
  3. 3. Vitamin D and sun Reichrath J. British Journal of Dermatology, 2009; 161: 54-60
  4. 4. Cancer and sunlight Apperly FL Cancer Res 1:191-195, 1941
  5. 5. Cancer and sunlight Apperly FL. Cancer Res 1:191-195, 1941
  6. 6. Solar radiation and colon cancer Int J Epidemiol 1980; 9:227-231
  7. 7. UV-B and cancer mortality Cancer 2002;94:1867-1875
  8. 8. OUTLINE
  9. 9. Vitamin D and melanoma
  10. 10. Vitamin D and melanoma
  11. 11. Vitamin D and cancer 47,800 men 4,286 incident cancers 2,025 cancer deaths Largest study in this field
  12. 12. Vitamin D and cancer mortality Data from 3299 patients referred for coronary angiography and followed up for 7.7 years Cumulative Survival 1.00 0.99 HR 0.49 (0.28-0.88) 0.98 (fully adjusted model) 0.97 25-hydroxyvitamin D (ng/ml) 0.96 Q1 (Low) Q2 Q3 Q4 (High) 0.95 0.94 0 2 4 6 8 10 (N=95) Follow-up (years) Pilz S et al, Cancer Epidemiol Biomarkers Prev 2008; 17: 1228-1233
  13. 13. Vitamin D and colorectal cancer Non-linear dose-response metaanalyses on circulating 25hydroxyvitamin D and risk of colorectal cancer
  14. 14. Vitamin D and colorectal cancer Dose-response meta-analyses of total (dietary + supplemental) vitamin D intake and risk of colorectal and colon cancer
  15. 15. OUTLINE
  16. 16. Anticancer effects of vitamin D 684-700
  17. 17. Anticancer effects of vitamin D JNCI J Natl Cancer Inst (1992) 84(17): 1355-1357
  18. 18. OUTLINE
  19. 19. Vitamin D and cancer incidence A 4-year, population based, double-blind, randomized, placebo controlled trial among healthy postmenopausal women (n=1179) receiving 1400-1500 mg calcium/d (Ca-only), calcium plus 1100 IU vitamin D/d (Ca + D), or placebo Entire study cohort Free of cancer at 1 years of intervention RR 0.23*** RR 0.40** ** P=0.01 *** P=0.005 Lappe J, et al. Am J Clin Nutr 2007;85:1586-91
  20. 20. WHI-Study
  21. 21. WHI-Study
  22. 22. OUTLINE
  23. 23. Conclusion Sunlight (ultraviolet-B exposure), which increases vitamin D synthesis in the skin, is associated with reduced cancer risk Vitamin D exerts various anti-carcinogenic effects Observational and interventional studies have partially but not consistently shown an association of a poor vitamin D status with increased cancer risk Whether vitamin D supplementation is effective in the prevention and treatment of cancer remains to be further evaluated in large-scale randomized controlled trials but the promising data on vitamin D regarding cancer and various other health outcomes strongly argue that it is reasonable to prevent and treat vitamin D deficiency
  24. 24. Thank you for your attention !
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