Muscular Distrophy- Cancer causationPresentation Transcript
Scientists closer to finding treatment for life-threatening hereditary disease. And Cancer in a single catastrophe: Chromosome crisis common in cancer causation. Laura Andrea Gómez Marín Medicine Student UPB Medellín-Colombia
Many traditional diseases that today doesn´t have a cure yet.
Possible new techniques like gene therapy becomes in a hope to
Scientists at Royal Holloway University of London, had reported new results base in gene-therapy that consist in an exon skipping, related with Duchenne Muscular Distrophy (DMD).
DMD is characterized by
a progressive muscle
weakness that is caused
by the missing of the
This treatment involves short strand of synthetic DNA (antisense oligonucleotide) that can restore production of the protein dystrophin .
Because of that this study provides further evidence
that could trasform the
symptoms into a less
Knowing the complications in young boys with DMD, the opportunity to use gene-therapy in order to find a posible treatment to reduced complications in those patients is an excellent alternative.
Scientists of the Wellcome Trust Sanger Institute, found that in some cancers chromosomes can suffer structural changes.
In this crisis chromosomes
basically explode and DNA
repair machinery tries to
stick chromosomes back
But it fails, in consequence
occurs hundreds of genomic
mutations that is a considerable
road to cancer.
This report is very interesting as long as the knowledge of structural changes in chromosomes allows to identificated some causes of chromosomes mutations.
Technology allows to improve procedures that in medicine are related with the treatment of cancer and DMD.
Exon skipping gene therapy allows muscular dystrophy patients have great promise as a long term treatment.
As long as medical researches can know more aspects related to chromosomes crisis more alternatives will be available to focus on one specific therapy.
Scientists closer to finding treatment for life-threatening hereditary disease. Science Daily. January 5, 2011.
Cancer in a single catastrophe: Chromosome crisis common in cancer causation. Science Daily. January 10,2011.