Unraveling signaling networks by large-scale data integration

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    Unraveling signaling networks by large-scale data integration - Presentation Transcript

    1. Unraveling signaling networks by large-scale data integration
    2. Lars Juhl Jensen
    3.  
    4. function prediction
    5.  
    6.  
    7. data integration
    8.  
    9. cell-cycle regulation
    10.  
    11. signaling networks
    12. phosphoproteomics
    13. Linding, Jensen, Ostheimer et al., Cell , 2007
    14. in vivo phosphosites
    15. kinases are unknown
    16. sequence motifs
    17. Miller, Jensen et al., Science Signaling , 2008
    18. sequence specificity
    19. kinase-specific
    20. in vitro
    21. context
    22. association networks
    23. Linding, Jensen, Ostheimer et al., Cell , 2007
    24. NetworKIN
    25. Linding, Jensen, Ostheimer et al., Cell , 2007
    26. sequence motifs
    27. NetPhorest
    28. Miller, Jensen et al., Science Signaling , 2008
    29. data organization
    30. Miller, Jensen et al., Science Signaling , 2008
    31. automated pipeline
    32. compilation of datasets
    33. training and evaluation
    34. motif atlas
    35.  
    36. association networks
    37. STRING
    38. functional associations
    39. 630 genomes
    40. genomic context
    41. Korbel et al., Nature Biotechnology , 2004
    42. primary experimental data
    43. Jensen & Bork, Science , 2008
    44. curated knowledge
    45. Letunic & Bork, Trends in Biochemical Sciences , 2008
    46. literature mining
    47.  
    48. probabilistic integration
    49. transfer by orthology
    50. Frishman et al., Modern Genome Annotation , 2009
    51. STITCH
    52. Kuhn et al., Nucleic Acids Research , 2008
    53. kinase inhibitor screens
    54. Fedorov et al., PNAS , 2007
    55. experimental design
    56. text–data integration
    57. Reflect
    58. augmented browsing
    59.  
    60. Acknowledgments
      • NetworKIN.info
        • Rune Linding
        • Gerard Ostheimer
        • Francesca Diella
        • Karen Colwill
        • Jing Jin
        • Pavel Metalnikov
        • Vivian Nguyen
        • Adrian Pasculescu
        • Jin Gyoon Park
        • Leona D. Samson
        • Rob Russell
        • Peer Bork
        • Michael Yaffe
        • Tony Pawson
      • STITCH.embl.de
        • Michael Kuhn
        • Christian von Mering
        • Monica Campillos
        • Peer Bork
      • NetPhorest.info
        • Martin Lee Miller
        • Francesca Diella
        • Claus Jørgensen
        • Michele Tinti
        • Lei Li
        • Marilyn Hsiung
        • Sirlester A. Parker
        • Jennifer Bordeaux
        • Thomas Sicheritz-Pontén
        • Marina Olhovsky
        • Adrian Pasculescu
        • Jes Alexander
        • Stefan Knapp
        • Nikolaj Blom
        • Peer Bork
        • Shawn Li
        • Gianni Cesareni
        • Tony Pawson
        • Benjamin E. Turk
        • Michael B. Yaffe
        • Søren Brunak
      • STRING.embl.de
        • Christian von Mering
        • Michael Kuhn
        • Manuel Stark
        • Samuel Chaffron
        • Philippe Julien
        • Tobias Doerks
        • Jan Korbel
        • Berend Snel
        • Martijn Huynen
        • Peer Bork
      • Reflect.ws
        • Sean O’Donoghue
        • Evangelos Pafilis
        • Heiko Horn
        • Michael Kuhn
        • Nigel Brown
        • Reinhardt Schneider

    + Lars Juhl JensenLars Juhl Jensen, 11 months ago

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