SlideShare a Scribd company logo
1 of 106
Download to read offline
Protein interaction networks from yeast to human Lars Juhl Jensen EMBL Heidelberg
Current Opinion in Structural Biology, 2005
STRING
 
integrate diverse evidence
functional interactions
Bork et al., Current Opinion in Structural Biology, 2005
hundreds of proteomes
evolution
 
 
statistics
(the original sin)
prokaryotes
genomic context methods
gene fusion
 
gene neighborhood
 
phylogenetic profiles
 
 
 
 
Cell Cellulosomes Cellulose
eukaryotes
integrate diverse datasets
Jensen et al., Drug Discovery Today: Targets, 2004
curated knowledge
MIPS Munich Information center for Protein Sequences
KEGG Kyoto Encyclopedia of Genes and Genomes
STKE Signal Transduction Knowledge Environment
Reactome
literature mining
co-mentioning
NLP Natural Language Processing
M EDLINE
SGD Saccharomyces Genome Database
The Interactive Fly
OMIM Online Mendelian Inheritance in Man
primary experimental data
microarray expression data
GEO Gene Expression Omnibus
physical protein interactions
BIND Biomolecular Interaction Network Database
MINT Molecular Interactions Database
GRID General Repository for Interaction Datasets
DIP Database of Interacting Proteins
HPRD Human Protein Reference Database
problems
many sources
(different gene identifiers)
many types of evidence
questionable quality
not directly comparable
spread over many species
huge synonyms lists
calculate raw quality scores
calibrate vs. gold standard
KEGG Kyoto Encyclopedia of Genes and Genomes
von Mering et al., Nucleic Acids Research, 2005
transfer based on orthology
combine all evidence
Bork et al., Current Opinion in Structural Biology, 2005
Networ-Kin™ Phospho-peptide data (from MS) Predict the kinase class (NetPhosK and Scansite)
the human interactome
yeast two-hybrid
1936 13 4 4 1385 65 18465 Stelzl  et al. Rual  et al. Small-scale studies
32 0 3 4 18 4 23 Stelzl  et al. Rual  et al. Small-scale studies
62 8 39 Small-scale studies Stelzl  et al. Rual  et al. 852 17 473 432 69 260
3.5% and 21% sensitivity
in a couple of years
the human interactome
100% = 1/5?
the yeast interactome
five years ago
yeast two-hybrid
1150 117 117 72 4053 118 4469 Uetz  et al. Ito  et al. Small-scale studies
162 53 34 72 180 29 338 Uetz  et al. Ito  et al. Small-scale studies
511 189 616 Small-scale studies Uetz  et al. Ito  et al. 439 178 759 897 190 1347
19% and 12% sensitivity
three years ago
complex purification and MS
14186 784 1178 287 19492 230 3475 Gavin  et al. Ho  et al. Small-scale studies
2341 125 656 287 2725 42 149 Gavin  et al. Ho  et al. Small-scale studies
4431 1465 5041 Small-scale studies Gavin  et al. Ho  et al. 14913 1071 632 8047 517 746
63% and 41% sensitivity
today
combining all available data
scoring and filtering
 
de Lichtenberg et al., Science, 2005
de Lichtenberg et al., Science, 2005
de Lichtenberg et al., Science, 2005
de Lichtenberg et al., Science, 2005
de Lichtenberg et al., Science, 2005
the challenge
how to get from here …
1936 13 4 4 1385 65 18465 Stelzl  et al. Rual  et al. Small-scale studies
…  to there …
de Lichtenberg et al., Science, 2005
yeast two-hybrid
complex purification and MS
scoring and filtering
Acknowledgments ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Thank you!

More Related Content

What's hot

Large-scale data and text mining
Large-scale data and text miningLarge-scale data and text mining
Large-scale data and text miningLars Juhl Jensen
 
STRING - Protein networks from data and text mining
STRING - Protein networks from data and text miningSTRING - Protein networks from data and text mining
STRING - Protein networks from data and text miningLars Juhl Jensen
 
Systems biology: Bioinformatics on complete biological system
Systems biology: Bioinformatics on complete biological systemSystems biology: Bioinformatics on complete biological system
Systems biology: Bioinformatics on complete biological systemLars Juhl Jensen
 
Protein association networks with STRING
Protein association networks with STRINGProtein association networks with STRING
Protein association networks with STRINGLars Juhl Jensen
 
From systems biology
From systems biologyFrom systems biology
From systems biologybrnbarcelona
 
STRING - Modeling of biological systems through cross-species data integ...
STRING - Modeling of biological systems through cross-species data integ...STRING - Modeling of biological systems through cross-species data integ...
STRING - Modeling of biological systems through cross-species data integ...Lars Juhl Jensen
 
Large-scale integration of data and text
Large-scale integration of data and textLarge-scale integration of data and text
Large-scale integration of data and textLars Juhl Jensen
 
Network biology - Large-scale integration of data and text
Network biology - Large-scale integration of data and textNetwork biology - Large-scale integration of data and text
Network biology - Large-scale integration of data and textLars Juhl Jensen
 
Gene association networks - Large-scale integration of data and text
Gene association networks - Large-scale integration of data and textGene association networks - Large-scale integration of data and text
Gene association networks - Large-scale integration of data and textLars Juhl Jensen
 
STRING/STITCH tutorial
STRING/STITCH tutorialSTRING/STITCH tutorial
STRING/STITCH tutorialbiocs
 
The STRING database - Quality scores for heterogeneous interaction data
The STRING database - Quality scores for heterogeneous interaction dataThe STRING database - Quality scores for heterogeneous interaction data
The STRING database - Quality scores for heterogeneous interaction dataLars Juhl Jensen
 
Network biology: Large-scale data integration and text mining
Network biology: Large-scale data integration and text miningNetwork biology: Large-scale data integration and text mining
Network biology: Large-scale data integration and text miningLars Juhl Jensen
 
Network biology: Large-scale data integration and text mining
Network biology: Large-scale data integration and text miningNetwork biology: Large-scale data integration and text mining
Network biology: Large-scale data integration and text miningLars Juhl Jensen
 
Gene association networks - Large-scale integration of data and text
Gene association networks - Large-scale integration of data and textGene association networks - Large-scale integration of data and text
Gene association networks - Large-scale integration of data and textLars Juhl Jensen
 
Network biology: Large-scale data and text mining
Network biology: Large-scale data and text miningNetwork biology: Large-scale data and text mining
Network biology: Large-scale data and text miningLars Juhl Jensen
 
Cellular network biology: Proteome-wide analysis of heterogeneous data
Cellular network biology: Proteome-wide analysis of heterogeneous dataCellular network biology: Proteome-wide analysis of heterogeneous data
Cellular network biology: Proteome-wide analysis of heterogeneous dataLars Juhl Jensen
 
proteomics and system biology
proteomics and system biologyproteomics and system biology
proteomics and system biologyNawfal Aldujaily
 
Whole genome taxonomic classi cation for prokaryotic plant pathogens
Whole genome taxonomic classication for prokaryotic plant pathogensWhole genome taxonomic classication for prokaryotic plant pathogens
Whole genome taxonomic classi cation for prokaryotic plant pathogensLeighton Pritchard
 

What's hot (20)

Large-scale data and text mining
Large-scale data and text miningLarge-scale data and text mining
Large-scale data and text mining
 
The STRING database
The STRING databaseThe STRING database
The STRING database
 
STRING - Protein networks from data and text mining
STRING - Protein networks from data and text miningSTRING - Protein networks from data and text mining
STRING - Protein networks from data and text mining
 
Systems biology: Bioinformatics on complete biological system
Systems biology: Bioinformatics on complete biological systemSystems biology: Bioinformatics on complete biological system
Systems biology: Bioinformatics on complete biological system
 
The STRING database
The STRING databaseThe STRING database
The STRING database
 
Protein association networks with STRING
Protein association networks with STRINGProtein association networks with STRING
Protein association networks with STRING
 
From systems biology
From systems biologyFrom systems biology
From systems biology
 
STRING - Modeling of biological systems through cross-species data integ...
STRING - Modeling of biological systems through cross-species data integ...STRING - Modeling of biological systems through cross-species data integ...
STRING - Modeling of biological systems through cross-species data integ...
 
Large-scale integration of data and text
Large-scale integration of data and textLarge-scale integration of data and text
Large-scale integration of data and text
 
Network biology - Large-scale integration of data and text
Network biology - Large-scale integration of data and textNetwork biology - Large-scale integration of data and text
Network biology - Large-scale integration of data and text
 
Gene association networks - Large-scale integration of data and text
Gene association networks - Large-scale integration of data and textGene association networks - Large-scale integration of data and text
Gene association networks - Large-scale integration of data and text
 
STRING/STITCH tutorial
STRING/STITCH tutorialSTRING/STITCH tutorial
STRING/STITCH tutorial
 
The STRING database - Quality scores for heterogeneous interaction data
The STRING database - Quality scores for heterogeneous interaction dataThe STRING database - Quality scores for heterogeneous interaction data
The STRING database - Quality scores for heterogeneous interaction data
 
Network biology: Large-scale data integration and text mining
Network biology: Large-scale data integration and text miningNetwork biology: Large-scale data integration and text mining
Network biology: Large-scale data integration and text mining
 
Network biology: Large-scale data integration and text mining
Network biology: Large-scale data integration and text miningNetwork biology: Large-scale data integration and text mining
Network biology: Large-scale data integration and text mining
 
Gene association networks - Large-scale integration of data and text
Gene association networks - Large-scale integration of data and textGene association networks - Large-scale integration of data and text
Gene association networks - Large-scale integration of data and text
 
Network biology: Large-scale data and text mining
Network biology: Large-scale data and text miningNetwork biology: Large-scale data and text mining
Network biology: Large-scale data and text mining
 
Cellular network biology: Proteome-wide analysis of heterogeneous data
Cellular network biology: Proteome-wide analysis of heterogeneous dataCellular network biology: Proteome-wide analysis of heterogeneous data
Cellular network biology: Proteome-wide analysis of heterogeneous data
 
proteomics and system biology
proteomics and system biologyproteomics and system biology
proteomics and system biology
 
Whole genome taxonomic classi cation for prokaryotic plant pathogens
Whole genome taxonomic classication for prokaryotic plant pathogensWhole genome taxonomic classication for prokaryotic plant pathogens
Whole genome taxonomic classi cation for prokaryotic plant pathogens
 

Viewers also liked

Protein interaction networks
Protein interaction networksProtein interaction networks
Protein interaction networksLars Juhl Jensen
 
Initial Training Slides
Initial Training SlidesInitial Training Slides
Initial Training Slidesapollohealing
 
Protein–protein interaction networks
Protein–protein interaction networksProtein–protein interaction networks
Protein–protein interaction networksLars Juhl Jensen
 
Beyond Journalism Chicago
Beyond Journalism ChicagoBeyond Journalism Chicago
Beyond Journalism ChicagoMark Deuze
 
From protein interaction networks to human phenotypes
From protein  interaction networks to human phenotypesFrom protein  interaction networks to human phenotypes
From protein interaction networks to human phenotypesbiocs
 
PhD viva - 11th November 2015
PhD viva - 11th November 2015PhD viva - 11th November 2015
PhD viva - 11th November 2015Kevin Keraudren
 
Identifying, annotating, and filtering arguments and opinions on the social w...
Identifying, annotating, and filtering arguments and opinions on the social w...Identifying, annotating, and filtering arguments and opinions on the social w...
Identifying, annotating, and filtering arguments and opinions on the social w...jodischneider
 
Specificity and Evolvability in Eukaryotic Protein Interaction Networks
Specificity and Evolvability in Eukaryotic Protein Interaction NetworksSpecificity and Evolvability in Eukaryotic Protein Interaction Networks
Specificity and Evolvability in Eukaryotic Protein Interaction Networkspedrobeltrao
 
Using structural information to predict protein-protein interaction and enyzm...
Using structural information to predict protein-protein interaction and enyzm...Using structural information to predict protein-protein interaction and enyzm...
Using structural information to predict protein-protein interaction and enyzm...Neil Saunders
 
Towards Biomedical Data Integration for Analyzing the Evolution of Cognition
Towards Biomedical Data Integration for Analyzing the Evolution of CognitionTowards Biomedical Data Integration for Analyzing the Evolution of Cognition
Towards Biomedical Data Integration for Analyzing the Evolution of CognitionAmrapali Zaveri, PhD
 
Towards Social semantic journalism
Towards Social semantic journalismTowards Social semantic journalism
Towards Social semantic journalismBahareh Heravi
 
Harrower Heravi RDA P4 Social media
Harrower Heravi RDA P4 Social mediaHarrower Heravi RDA P4 Social media
Harrower Heravi RDA P4 Social mediadri_ireland
 
Combining sequence motifs and protein interactions to unravel complex phospho...
Combining sequence motifs and protein interactions to unravel complex phospho...Combining sequence motifs and protein interactions to unravel complex phospho...
Combining sequence motifs and protein interactions to unravel complex phospho...Lars Juhl Jensen
 
Linked data in the digital humanities skills workshop for realising the oppo...
Linked data in the digital humanities  skills workshop for realising the oppo...Linked data in the digital humanities  skills workshop for realising the oppo...
Linked data in the digital humanities skills workshop for realising the oppo...jodischneider
 
Protein-Protein Interaction using SVM based kernel,Jacob Coefficient and Gene...
Protein-Protein Interaction using SVM based kernel,Jacob Coefficient and Gene...Protein-Protein Interaction using SVM based kernel,Jacob Coefficient and Gene...
Protein-Protein Interaction using SVM based kernel,Jacob Coefficient and Gene...Ronak Shah
 
Aidan's PhD Viva
Aidan's PhD VivaAidan's PhD Viva
Aidan's PhD VivaAidan Hogan
 
Leveraging Wikipedia-based Features for Entity Relatedness and Recommendations
Leveraging Wikipedia-based Features for Entity Relatedness and RecommendationsLeveraging Wikipedia-based Features for Entity Relatedness and Recommendations
Leveraging Wikipedia-based Features for Entity Relatedness and RecommendationsNitish Aggarwal
 
Data Café — A Platform For Creating Biomedical Data Lakes
Data Café — A Platform For Creating Biomedical Data LakesData Café — A Platform For Creating Biomedical Data Lakes
Data Café — A Platform For Creating Biomedical Data LakesPradeeban Kathiravelu, Ph.D.
 
Sabrina Kirrane INSIGHT Viva Presentation
Sabrina Kirrane INSIGHT Viva Presentation Sabrina Kirrane INSIGHT Viva Presentation
Sabrina Kirrane INSIGHT Viva Presentation Sabrina Kirrane
 
2016 07 12_purdue_bigdatainomics_seandavis
2016 07 12_purdue_bigdatainomics_seandavis2016 07 12_purdue_bigdatainomics_seandavis
2016 07 12_purdue_bigdatainomics_seandavisSean Davis
 

Viewers also liked (20)

Protein interaction networks
Protein interaction networksProtein interaction networks
Protein interaction networks
 
Initial Training Slides
Initial Training SlidesInitial Training Slides
Initial Training Slides
 
Protein–protein interaction networks
Protein–protein interaction networksProtein–protein interaction networks
Protein–protein interaction networks
 
Beyond Journalism Chicago
Beyond Journalism ChicagoBeyond Journalism Chicago
Beyond Journalism Chicago
 
From protein interaction networks to human phenotypes
From protein  interaction networks to human phenotypesFrom protein  interaction networks to human phenotypes
From protein interaction networks to human phenotypes
 
PhD viva - 11th November 2015
PhD viva - 11th November 2015PhD viva - 11th November 2015
PhD viva - 11th November 2015
 
Identifying, annotating, and filtering arguments and opinions on the social w...
Identifying, annotating, and filtering arguments and opinions on the social w...Identifying, annotating, and filtering arguments and opinions on the social w...
Identifying, annotating, and filtering arguments and opinions on the social w...
 
Specificity and Evolvability in Eukaryotic Protein Interaction Networks
Specificity and Evolvability in Eukaryotic Protein Interaction NetworksSpecificity and Evolvability in Eukaryotic Protein Interaction Networks
Specificity and Evolvability in Eukaryotic Protein Interaction Networks
 
Using structural information to predict protein-protein interaction and enyzm...
Using structural information to predict protein-protein interaction and enyzm...Using structural information to predict protein-protein interaction and enyzm...
Using structural information to predict protein-protein interaction and enyzm...
 
Towards Biomedical Data Integration for Analyzing the Evolution of Cognition
Towards Biomedical Data Integration for Analyzing the Evolution of CognitionTowards Biomedical Data Integration for Analyzing the Evolution of Cognition
Towards Biomedical Data Integration for Analyzing the Evolution of Cognition
 
Towards Social semantic journalism
Towards Social semantic journalismTowards Social semantic journalism
Towards Social semantic journalism
 
Harrower Heravi RDA P4 Social media
Harrower Heravi RDA P4 Social mediaHarrower Heravi RDA P4 Social media
Harrower Heravi RDA P4 Social media
 
Combining sequence motifs and protein interactions to unravel complex phospho...
Combining sequence motifs and protein interactions to unravel complex phospho...Combining sequence motifs and protein interactions to unravel complex phospho...
Combining sequence motifs and protein interactions to unravel complex phospho...
 
Linked data in the digital humanities skills workshop for realising the oppo...
Linked data in the digital humanities  skills workshop for realising the oppo...Linked data in the digital humanities  skills workshop for realising the oppo...
Linked data in the digital humanities skills workshop for realising the oppo...
 
Protein-Protein Interaction using SVM based kernel,Jacob Coefficient and Gene...
Protein-Protein Interaction using SVM based kernel,Jacob Coefficient and Gene...Protein-Protein Interaction using SVM based kernel,Jacob Coefficient and Gene...
Protein-Protein Interaction using SVM based kernel,Jacob Coefficient and Gene...
 
Aidan's PhD Viva
Aidan's PhD VivaAidan's PhD Viva
Aidan's PhD Viva
 
Leveraging Wikipedia-based Features for Entity Relatedness and Recommendations
Leveraging Wikipedia-based Features for Entity Relatedness and RecommendationsLeveraging Wikipedia-based Features for Entity Relatedness and Recommendations
Leveraging Wikipedia-based Features for Entity Relatedness and Recommendations
 
Data Café — A Platform For Creating Biomedical Data Lakes
Data Café — A Platform For Creating Biomedical Data LakesData Café — A Platform For Creating Biomedical Data Lakes
Data Café — A Platform For Creating Biomedical Data Lakes
 
Sabrina Kirrane INSIGHT Viva Presentation
Sabrina Kirrane INSIGHT Viva Presentation Sabrina Kirrane INSIGHT Viva Presentation
Sabrina Kirrane INSIGHT Viva Presentation
 
2016 07 12_purdue_bigdatainomics_seandavis
2016 07 12_purdue_bigdatainomics_seandavis2016 07 12_purdue_bigdatainomics_seandavis
2016 07 12_purdue_bigdatainomics_seandavis
 

Similar to Protein interaction networks from yeast to human

Data integration and functional association networks
Data integration and functional association networksData integration and functional association networks
Data integration and functional association networksLars Juhl Jensen
 
Integration of heterogeneous data
Integration of heterogeneous dataIntegration of heterogeneous data
Integration of heterogeneous dataLars Juhl Jensen
 
Protein networks as a scaffold for structuring other data
Protein networks as a scaffold for structuring other dataProtein networks as a scaffold for structuring other data
Protein networks as a scaffold for structuring other dataLars Juhl Jensen
 
Unraveling signal transduction networks through data integration
Unraveling signal transduction networks through data integrationUnraveling signal transduction networks through data integration
Unraveling signal transduction networks through data integrationLars Juhl Jensen
 
Exploring proteins, chemicals and their interactions with STRING and STITCH
Exploring proteins, chemicals and their interactions with STRING and STITCHExploring proteins, chemicals and their interactions with STRING and STITCH
Exploring proteins, chemicals and their interactions with STRING and STITCHbiocs
 
Unraveling signaling networks by data integration
Unraveling signaling networks by data integrationUnraveling signaling networks by data integration
Unraveling signaling networks by data integrationLars Juhl Jensen
 
Using networks to derive function
Using networks to derive functionUsing networks to derive function
Using networks to derive functionLars Juhl Jensen
 
Networks of proteins and diseases
Networks of proteins and diseasesNetworks of proteins and diseases
Networks of proteins and diseasesLars Juhl Jensen
 
Evolutionary plasticity of cell-cycle regulation
Evolutionary plasticity of cell-cycle regulationEvolutionary plasticity of cell-cycle regulation
Evolutionary plasticity of cell-cycle regulationLars Juhl Jensen
 
Integration of heterogeneous data
Integration of heterogeneous dataIntegration of heterogeneous data
Integration of heterogeneous dataLars Juhl Jensen
 
Large-scale data and text mining
Large-scale data and text miningLarge-scale data and text mining
Large-scale data and text miningLars Juhl Jensen
 
Just-in-time assembly: Transcriptional and post-translational cell-cycle regu...
Just-in-time assembly: Transcriptional and post-translational cell-cycle regu...Just-in-time assembly: Transcriptional and post-translational cell-cycle regu...
Just-in-time assembly: Transcriptional and post-translational cell-cycle regu...Lars Juhl Jensen
 
Unraveling cellular phosphorylation networks using computational biology
Unraveling cellular phosphorylation networks using computational biologyUnraveling cellular phosphorylation networks using computational biology
Unraveling cellular phosphorylation networks using computational biologyLars Juhl Jensen
 
Network biology - A basis for large-scale biomedica data mining
Network biology - A basis for large-scale biomedica data miningNetwork biology - A basis for large-scale biomedica data mining
Network biology - A basis for large-scale biomedica data miningLars Juhl Jensen
 
From phosphoproteomics to signaling networks
From phosphoproteomics to signaling networksFrom phosphoproteomics to signaling networks
From phosphoproteomics to signaling networksLars Juhl Jensen
 
Visualization of large-scale protein and disease networks
Visualization of large-scaleprotein and disease networksVisualization of large-scaleprotein and disease networks
Visualization of large-scale protein and disease networksLars Juhl Jensen
 
Systems biology: Large-scale biomedical data mining
Systems biology: Large-scale biomedical data miningSystems biology: Large-scale biomedical data mining
Systems biology: Large-scale biomedical data miningLars Juhl Jensen
 

Similar to Protein interaction networks from yeast to human (20)

Data integration and functional association networks
Data integration and functional association networksData integration and functional association networks
Data integration and functional association networks
 
Integration of heterogeneous data
Integration of heterogeneous dataIntegration of heterogeneous data
Integration of heterogeneous data
 
Protein networks as a scaffold for structuring other data
Protein networks as a scaffold for structuring other dataProtein networks as a scaffold for structuring other data
Protein networks as a scaffold for structuring other data
 
Unraveling signal transduction networks through data integration
Unraveling signal transduction networks through data integrationUnraveling signal transduction networks through data integration
Unraveling signal transduction networks through data integration
 
Network biology
Network biologyNetwork biology
Network biology
 
Exploring proteins, chemicals and their interactions with STRING and STITCH
Exploring proteins, chemicals and their interactions with STRING and STITCHExploring proteins, chemicals and their interactions with STRING and STITCH
Exploring proteins, chemicals and their interactions with STRING and STITCH
 
Unraveling signaling networks by data integration
Unraveling signaling networks by data integrationUnraveling signaling networks by data integration
Unraveling signaling networks by data integration
 
Using networks to derive function
Using networks to derive functionUsing networks to derive function
Using networks to derive function
 
Networks of proteins and diseases
Networks of proteins and diseasesNetworks of proteins and diseases
Networks of proteins and diseases
 
Evolutionary plasticity of cell-cycle regulation
Evolutionary plasticity of cell-cycle regulationEvolutionary plasticity of cell-cycle regulation
Evolutionary plasticity of cell-cycle regulation
 
Integration of heterogeneous data
Integration of heterogeneous dataIntegration of heterogeneous data
Integration of heterogeneous data
 
Network biology
Network biologyNetwork biology
Network biology
 
Large-scale data and text mining
Large-scale data and text miningLarge-scale data and text mining
Large-scale data and text mining
 
Just-in-time assembly: Transcriptional and post-translational cell-cycle regu...
Just-in-time assembly: Transcriptional and post-translational cell-cycle regu...Just-in-time assembly: Transcriptional and post-translational cell-cycle regu...
Just-in-time assembly: Transcriptional and post-translational cell-cycle regu...
 
Unraveling cellular phosphorylation networks using computational biology
Unraveling cellular phosphorylation networks using computational biologyUnraveling cellular phosphorylation networks using computational biology
Unraveling cellular phosphorylation networks using computational biology
 
Network biology - A basis for large-scale biomedica data mining
Network biology - A basis for large-scale biomedica data miningNetwork biology - A basis for large-scale biomedica data mining
Network biology - A basis for large-scale biomedica data mining
 
Data and Text Mining
Data and Text MiningData and Text Mining
Data and Text Mining
 
From phosphoproteomics to signaling networks
From phosphoproteomics to signaling networksFrom phosphoproteomics to signaling networks
From phosphoproteomics to signaling networks
 
Visualization of large-scale protein and disease networks
Visualization of large-scaleprotein and disease networksVisualization of large-scaleprotein and disease networks
Visualization of large-scale protein and disease networks
 
Systems biology: Large-scale biomedical data mining
Systems biology: Large-scale biomedical data miningSystems biology: Large-scale biomedical data mining
Systems biology: Large-scale biomedical data mining
 

More from Lars Juhl Jensen

One tagger, many uses: Illustrating the power of dictionary-based named entit...
One tagger, many uses: Illustrating the power of dictionary-based named entit...One tagger, many uses: Illustrating the power of dictionary-based named entit...
One tagger, many uses: Illustrating the power of dictionary-based named entit...Lars Juhl Jensen
 
One tagger, many uses: Simple text-mining strategies for biomedicine
One tagger, many uses: Simple text-mining strategies for biomedicineOne tagger, many uses: Simple text-mining strategies for biomedicine
One tagger, many uses: Simple text-mining strategies for biomedicineLars Juhl Jensen
 
Extract 2.0: Text-mining-assisted interactive annotation
Extract 2.0: Text-mining-assisted interactive annotationExtract 2.0: Text-mining-assisted interactive annotation
Extract 2.0: Text-mining-assisted interactive annotationLars Juhl Jensen
 
Network visualization: A crash course on using Cytoscape
Network visualization: A crash course on using CytoscapeNetwork visualization: A crash course on using Cytoscape
Network visualization: A crash course on using CytoscapeLars Juhl Jensen
 
STRING & STITCH : Network integration of heterogeneous data
STRING & STITCH: Network integration of heterogeneous dataSTRING & STITCH: Network integration of heterogeneous data
STRING & STITCH : Network integration of heterogeneous dataLars Juhl Jensen
 
Biomedical text mining: Automatic processing of unstructured text
Biomedical text mining: Automatic processing of unstructured textBiomedical text mining: Automatic processing of unstructured text
Biomedical text mining: Automatic processing of unstructured textLars Juhl Jensen
 
Medical network analysis: Linking diseases and genes through data and text mi...
Medical network analysis: Linking diseases and genes through data and text mi...Medical network analysis: Linking diseases and genes through data and text mi...
Medical network analysis: Linking diseases and genes through data and text mi...Lars Juhl Jensen
 
Network Biology: A crash course on STRING and Cytoscape
Network Biology: A crash course on STRING and CytoscapeNetwork Biology: A crash course on STRING and Cytoscape
Network Biology: A crash course on STRING and CytoscapeLars Juhl Jensen
 
Cellular Network Biology: Large-scale integration of data and text
Cellular Network Biology: Large-scale integration of data and textCellular Network Biology: Large-scale integration of data and text
Cellular Network Biology: Large-scale integration of data and textLars Juhl Jensen
 
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...Lars Juhl Jensen
 
STRING & related databases: Large-scale integration of heterogeneous data
STRING & related databases: Large-scale integration of heterogeneous dataSTRING & related databases: Large-scale integration of heterogeneous data
STRING & related databases: Large-scale integration of heterogeneous dataLars Juhl Jensen
 
Tagger: Rapid dictionary-based named entity recognition
Tagger: Rapid dictionary-based named entity recognitionTagger: Rapid dictionary-based named entity recognition
Tagger: Rapid dictionary-based named entity recognitionLars Juhl Jensen
 
Network Biology: Large-scale integration of data and text
Network Biology: Large-scale integration of data and textNetwork Biology: Large-scale integration of data and text
Network Biology: Large-scale integration of data and textLars Juhl Jensen
 
Medical text mining: Linking diseases, drugs, and adverse reactions
Medical text mining: Linking diseases, drugs, and adverse reactionsMedical text mining: Linking diseases, drugs, and adverse reactions
Medical text mining: Linking diseases, drugs, and adverse reactionsLars Juhl Jensen
 
Network biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textNetwork biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textLars Juhl Jensen
 
Medical data and text mining: Linking diseases, drugs, and adverse reactions
Medical data and text mining: Linking diseases, drugs, and adverse reactionsMedical data and text mining: Linking diseases, drugs, and adverse reactions
Medical data and text mining: Linking diseases, drugs, and adverse reactionsLars Juhl Jensen
 
Network biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textNetwork biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textLars Juhl Jensen
 
Biomarker bioinformatics: Network-based candidate prioritization
Biomarker bioinformatics: Network-based candidate prioritizationBiomarker bioinformatics: Network-based candidate prioritization
Biomarker bioinformatics: Network-based candidate prioritizationLars Juhl Jensen
 

More from Lars Juhl Jensen (20)

One tagger, many uses: Illustrating the power of dictionary-based named entit...
One tagger, many uses: Illustrating the power of dictionary-based named entit...One tagger, many uses: Illustrating the power of dictionary-based named entit...
One tagger, many uses: Illustrating the power of dictionary-based named entit...
 
One tagger, many uses: Simple text-mining strategies for biomedicine
One tagger, many uses: Simple text-mining strategies for biomedicineOne tagger, many uses: Simple text-mining strategies for biomedicine
One tagger, many uses: Simple text-mining strategies for biomedicine
 
Extract 2.0: Text-mining-assisted interactive annotation
Extract 2.0: Text-mining-assisted interactive annotationExtract 2.0: Text-mining-assisted interactive annotation
Extract 2.0: Text-mining-assisted interactive annotation
 
Network visualization: A crash course on using Cytoscape
Network visualization: A crash course on using CytoscapeNetwork visualization: A crash course on using Cytoscape
Network visualization: A crash course on using Cytoscape
 
STRING & STITCH : Network integration of heterogeneous data
STRING & STITCH: Network integration of heterogeneous dataSTRING & STITCH: Network integration of heterogeneous data
STRING & STITCH : Network integration of heterogeneous data
 
Biomedical text mining: Automatic processing of unstructured text
Biomedical text mining: Automatic processing of unstructured textBiomedical text mining: Automatic processing of unstructured text
Biomedical text mining: Automatic processing of unstructured text
 
Medical network analysis: Linking diseases and genes through data and text mi...
Medical network analysis: Linking diseases and genes through data and text mi...Medical network analysis: Linking diseases and genes through data and text mi...
Medical network analysis: Linking diseases and genes through data and text mi...
 
Network Biology: A crash course on STRING and Cytoscape
Network Biology: A crash course on STRING and CytoscapeNetwork Biology: A crash course on STRING and Cytoscape
Network Biology: A crash course on STRING and Cytoscape
 
Cellular networks
Cellular networksCellular networks
Cellular networks
 
Cellular Network Biology: Large-scale integration of data and text
Cellular Network Biology: Large-scale integration of data and textCellular Network Biology: Large-scale integration of data and text
Cellular Network Biology: Large-scale integration of data and text
 
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...
 
STRING & related databases: Large-scale integration of heterogeneous data
STRING & related databases: Large-scale integration of heterogeneous dataSTRING & related databases: Large-scale integration of heterogeneous data
STRING & related databases: Large-scale integration of heterogeneous data
 
Tagger: Rapid dictionary-based named entity recognition
Tagger: Rapid dictionary-based named entity recognitionTagger: Rapid dictionary-based named entity recognition
Tagger: Rapid dictionary-based named entity recognition
 
Network Biology: Large-scale integration of data and text
Network Biology: Large-scale integration of data and textNetwork Biology: Large-scale integration of data and text
Network Biology: Large-scale integration of data and text
 
Medical text mining: Linking diseases, drugs, and adverse reactions
Medical text mining: Linking diseases, drugs, and adverse reactionsMedical text mining: Linking diseases, drugs, and adverse reactions
Medical text mining: Linking diseases, drugs, and adverse reactions
 
Network biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textNetwork biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and text
 
Medical data and text mining: Linking diseases, drugs, and adverse reactions
Medical data and text mining: Linking diseases, drugs, and adverse reactionsMedical data and text mining: Linking diseases, drugs, and adverse reactions
Medical data and text mining: Linking diseases, drugs, and adverse reactions
 
Cellular Network Biology
Cellular Network BiologyCellular Network Biology
Cellular Network Biology
 
Network biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textNetwork biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and text
 
Biomarker bioinformatics: Network-based candidate prioritization
Biomarker bioinformatics: Network-based candidate prioritizationBiomarker bioinformatics: Network-based candidate prioritization
Biomarker bioinformatics: Network-based candidate prioritization
 

Recently uploaded

UiPath Studio Web workshop series - Day 6
UiPath Studio Web workshop series - Day 6UiPath Studio Web workshop series - Day 6
UiPath Studio Web workshop series - Day 6DianaGray10
 
How Accurate are Carbon Emissions Projections?
How Accurate are Carbon Emissions Projections?How Accurate are Carbon Emissions Projections?
How Accurate are Carbon Emissions Projections?IES VE
 
Computer 10: Lesson 10 - Online Crimes and Hazards
Computer 10: Lesson 10 - Online Crimes and HazardsComputer 10: Lesson 10 - Online Crimes and Hazards
Computer 10: Lesson 10 - Online Crimes and HazardsSeth Reyes
 
KubeConEU24-Monitoring Kubernetes and Cloud Spend with OpenCost
KubeConEU24-Monitoring Kubernetes and Cloud Spend with OpenCostKubeConEU24-Monitoring Kubernetes and Cloud Spend with OpenCost
KubeConEU24-Monitoring Kubernetes and Cloud Spend with OpenCostMatt Ray
 
AI Fame Rush Review – Virtual Influencer Creation In Just Minutes
AI Fame Rush Review – Virtual Influencer Creation In Just MinutesAI Fame Rush Review – Virtual Influencer Creation In Just Minutes
AI Fame Rush Review – Virtual Influencer Creation In Just MinutesMd Hossain Ali
 
AI You Can Trust - Ensuring Success with Data Integrity Webinar
AI You Can Trust - Ensuring Success with Data Integrity WebinarAI You Can Trust - Ensuring Success with Data Integrity Webinar
AI You Can Trust - Ensuring Success with Data Integrity WebinarPrecisely
 
Empowering Africa's Next Generation: The AI Leadership Blueprint
Empowering Africa's Next Generation: The AI Leadership BlueprintEmpowering Africa's Next Generation: The AI Leadership Blueprint
Empowering Africa's Next Generation: The AI Leadership BlueprintMahmoud Rabie
 
UiPath Studio Web workshop series - Day 7
UiPath Studio Web workshop series - Day 7UiPath Studio Web workshop series - Day 7
UiPath Studio Web workshop series - Day 7DianaGray10
 
The Data Metaverse: Unpacking the Roles, Use Cases, and Tech Trends in Data a...
The Data Metaverse: Unpacking the Roles, Use Cases, and Tech Trends in Data a...The Data Metaverse: Unpacking the Roles, Use Cases, and Tech Trends in Data a...
The Data Metaverse: Unpacking the Roles, Use Cases, and Tech Trends in Data a...Aggregage
 
Secure your environment with UiPath and CyberArk technologies - Session 1
Secure your environment with UiPath and CyberArk technologies - Session 1Secure your environment with UiPath and CyberArk technologies - Session 1
Secure your environment with UiPath and CyberArk technologies - Session 1DianaGray10
 
Cybersecurity Workshop #1.pptx
Cybersecurity Workshop #1.pptxCybersecurity Workshop #1.pptx
Cybersecurity Workshop #1.pptxGDSC PJATK
 
UWB Technology for Enhanced Indoor and Outdoor Positioning in Physiological M...
UWB Technology for Enhanced Indoor and Outdoor Positioning in Physiological M...UWB Technology for Enhanced Indoor and Outdoor Positioning in Physiological M...
UWB Technology for Enhanced Indoor and Outdoor Positioning in Physiological M...UbiTrack UK
 
IaC & GitOps in a Nutshell - a FridayInANuthshell Episode.pdf
IaC & GitOps in a Nutshell - a FridayInANuthshell Episode.pdfIaC & GitOps in a Nutshell - a FridayInANuthshell Episode.pdf
IaC & GitOps in a Nutshell - a FridayInANuthshell Episode.pdfDaniel Santiago Silva Capera
 
Bird eye's view on Camunda open source ecosystem
Bird eye's view on Camunda open source ecosystemBird eye's view on Camunda open source ecosystem
Bird eye's view on Camunda open source ecosystemAsko Soukka
 
activity_diagram_combine_v4_20190827.pdfactivity_diagram_combine_v4_20190827.pdf
activity_diagram_combine_v4_20190827.pdfactivity_diagram_combine_v4_20190827.pdfactivity_diagram_combine_v4_20190827.pdfactivity_diagram_combine_v4_20190827.pdf
activity_diagram_combine_v4_20190827.pdfactivity_diagram_combine_v4_20190827.pdfJamie (Taka) Wang
 
Introduction to Matsuo Laboratory (ENG).pptx
Introduction to Matsuo Laboratory (ENG).pptxIntroduction to Matsuo Laboratory (ENG).pptx
Introduction to Matsuo Laboratory (ENG).pptxMatsuo Lab
 
Meet the new FSP 3000 M-Flex800™
Meet the new FSP 3000 M-Flex800™Meet the new FSP 3000 M-Flex800™
Meet the new FSP 3000 M-Flex800™Adtran
 
Artificial Intelligence & SEO Trends for 2024
Artificial Intelligence & SEO Trends for 2024Artificial Intelligence & SEO Trends for 2024
Artificial Intelligence & SEO Trends for 2024D Cloud Solutions
 
VoIP Service and Marketing using Odoo and Asterisk PBX
VoIP Service and Marketing using Odoo and Asterisk PBXVoIP Service and Marketing using Odoo and Asterisk PBX
VoIP Service and Marketing using Odoo and Asterisk PBXTarek Kalaji
 

Recently uploaded (20)

UiPath Studio Web workshop series - Day 6
UiPath Studio Web workshop series - Day 6UiPath Studio Web workshop series - Day 6
UiPath Studio Web workshop series - Day 6
 
How Accurate are Carbon Emissions Projections?
How Accurate are Carbon Emissions Projections?How Accurate are Carbon Emissions Projections?
How Accurate are Carbon Emissions Projections?
 
Computer 10: Lesson 10 - Online Crimes and Hazards
Computer 10: Lesson 10 - Online Crimes and HazardsComputer 10: Lesson 10 - Online Crimes and Hazards
Computer 10: Lesson 10 - Online Crimes and Hazards
 
KubeConEU24-Monitoring Kubernetes and Cloud Spend with OpenCost
KubeConEU24-Monitoring Kubernetes and Cloud Spend with OpenCostKubeConEU24-Monitoring Kubernetes and Cloud Spend with OpenCost
KubeConEU24-Monitoring Kubernetes and Cloud Spend with OpenCost
 
AI Fame Rush Review – Virtual Influencer Creation In Just Minutes
AI Fame Rush Review – Virtual Influencer Creation In Just MinutesAI Fame Rush Review – Virtual Influencer Creation In Just Minutes
AI Fame Rush Review – Virtual Influencer Creation In Just Minutes
 
AI You Can Trust - Ensuring Success with Data Integrity Webinar
AI You Can Trust - Ensuring Success with Data Integrity WebinarAI You Can Trust - Ensuring Success with Data Integrity Webinar
AI You Can Trust - Ensuring Success with Data Integrity Webinar
 
Empowering Africa's Next Generation: The AI Leadership Blueprint
Empowering Africa's Next Generation: The AI Leadership BlueprintEmpowering Africa's Next Generation: The AI Leadership Blueprint
Empowering Africa's Next Generation: The AI Leadership Blueprint
 
UiPath Studio Web workshop series - Day 7
UiPath Studio Web workshop series - Day 7UiPath Studio Web workshop series - Day 7
UiPath Studio Web workshop series - Day 7
 
The Data Metaverse: Unpacking the Roles, Use Cases, and Tech Trends in Data a...
The Data Metaverse: Unpacking the Roles, Use Cases, and Tech Trends in Data a...The Data Metaverse: Unpacking the Roles, Use Cases, and Tech Trends in Data a...
The Data Metaverse: Unpacking the Roles, Use Cases, and Tech Trends in Data a...
 
Secure your environment with UiPath and CyberArk technologies - Session 1
Secure your environment with UiPath and CyberArk technologies - Session 1Secure your environment with UiPath and CyberArk technologies - Session 1
Secure your environment with UiPath and CyberArk technologies - Session 1
 
Cybersecurity Workshop #1.pptx
Cybersecurity Workshop #1.pptxCybersecurity Workshop #1.pptx
Cybersecurity Workshop #1.pptx
 
UWB Technology for Enhanced Indoor and Outdoor Positioning in Physiological M...
UWB Technology for Enhanced Indoor and Outdoor Positioning in Physiological M...UWB Technology for Enhanced Indoor and Outdoor Positioning in Physiological M...
UWB Technology for Enhanced Indoor and Outdoor Positioning in Physiological M...
 
IaC & GitOps in a Nutshell - a FridayInANuthshell Episode.pdf
IaC & GitOps in a Nutshell - a FridayInANuthshell Episode.pdfIaC & GitOps in a Nutshell - a FridayInANuthshell Episode.pdf
IaC & GitOps in a Nutshell - a FridayInANuthshell Episode.pdf
 
Bird eye's view on Camunda open source ecosystem
Bird eye's view on Camunda open source ecosystemBird eye's view on Camunda open source ecosystem
Bird eye's view on Camunda open source ecosystem
 
20150722 - AGV
20150722 - AGV20150722 - AGV
20150722 - AGV
 
activity_diagram_combine_v4_20190827.pdfactivity_diagram_combine_v4_20190827.pdf
activity_diagram_combine_v4_20190827.pdfactivity_diagram_combine_v4_20190827.pdfactivity_diagram_combine_v4_20190827.pdfactivity_diagram_combine_v4_20190827.pdf
activity_diagram_combine_v4_20190827.pdfactivity_diagram_combine_v4_20190827.pdf
 
Introduction to Matsuo Laboratory (ENG).pptx
Introduction to Matsuo Laboratory (ENG).pptxIntroduction to Matsuo Laboratory (ENG).pptx
Introduction to Matsuo Laboratory (ENG).pptx
 
Meet the new FSP 3000 M-Flex800™
Meet the new FSP 3000 M-Flex800™Meet the new FSP 3000 M-Flex800™
Meet the new FSP 3000 M-Flex800™
 
Artificial Intelligence & SEO Trends for 2024
Artificial Intelligence & SEO Trends for 2024Artificial Intelligence & SEO Trends for 2024
Artificial Intelligence & SEO Trends for 2024
 
VoIP Service and Marketing using Odoo and Asterisk PBX
VoIP Service and Marketing using Odoo and Asterisk PBXVoIP Service and Marketing using Odoo and Asterisk PBX
VoIP Service and Marketing using Odoo and Asterisk PBX
 

Protein interaction networks from yeast to human