Protein and disease networks

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Protein and disease networks

  1. 1. Protein and disease networks Lars Juhl Jensen
  2. 2. three parts
  3. 3. temporal networks
  4. 4. association networks
  5. 5. disease networks
  6. 6. Part 1temporal networks
  7. 7. protein interactions
  8. 8. Jensen & Bork, Science, 2008
  9. 9. Jeong et al., Nature, 2001
  10. 10. static view
  11. 11. cell cycle
  12. 12. Nobel Prize press release, 2001
  13. 13. temporal expression
  14. 14. dynamic nodes
  15. 15. a single number
  16. 16. circular layout
  17. 17. M G1G2 S
  18. 18. distorts statistics
  19. 19. de Lichtenberg, Jensen et al., Science, 2005
  20. 20. color scale
  21. 21. relax the network
  22. 22. static nodes
  23. 23. de Lichtenberg, Jensen et al., Science, 2005
  24. 24. no general solution
  25. 25. Part 2association networks
  26. 26. STRING
  27. 27. large-scale data mining
  28. 28. interactive network
  29. 29. drill down
  30. 30. text mining
  31. 31. co-expression
  32. 32. customization
  33. 33. external payload
  34. 34. pretty networks
  35. 35. Part 3disease networks
  36. 36. national discharge registry
  37. 37. 6.2 million individuals
  38. 38. 119 million diagnoses
  39. 39. correlated diseases
  40. 40. heatmap
  41. 41. too many nodes
  42. 42. significance filter
  43. 43. network
  44. 44. too many edges
  45. 45. clustering
  46. 46. hyper-cluster visualization
  47. 47. global overview
  48. 48. sufficient detail
  49. 49. not simple
  50. 50. AcknowledgmentsInteractive networks Temporal networks Damian Szklarczyk Ulrik de Lichtenberg Andrea Franceschini Søren Brunak Michael Kuhn Peer Bork Milan Simonovic Alexander Roth Disease networks Pablo Minguez Anders Boeck Tobias Doerks Jensen Manuel Stark Søren Brunak Jean Muller Peer Bork Christian von Mering
  51. 51. larsjuhljensen

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