Disease Systems Biology

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  • 1. Disease Systems Biology Lars Juhl Jensen
  • 2. protein networks
  • 3. cellular signaling
  • 4. Horn, Schoof et al., in preparation, 2012
  • 5. sequence motif atlas
  • 6. functional associations
  • 7. Szklarczyk, Franceschini et al., Nucleic Acids Research, 2011
  • 8. computational predictions
  • 9. experimental data
  • 10. curated knowledge
  • 11. confidence scores
  • 12. orthology-based transfer
  • 13. Franceschini, Szklarczyk, Frankild et al., Nucleic Acids Research, 2013
  • 14. functional modules
  • 15. Palleja et al., in preparation, 2012
  • 16. literature mining
  • 17. ~22 million abstracts
  • 18. ~4 million full-text articles
  • 19. comprehensive lexicon
  • 20. co-mentioning
  • 21. proteins
  • 22. compartments
  • 23. compartments.jensenlab.org
  • 24. tissues
  • 25. tissues.jensenlab.org
  • 26. diseases
  • 27. diseases.jensenlab.org
  • 28. diseases.jensenlab.org
  • 29. behavioral phenotypes
  • 30. diseases.jensenlab.org
  • 31. medical data mining
  • 32. electronic health records
  • 33. Jensen et al., Nature Reviews Genetics, 2012
  • 34. structured data
  • 35. Jensen et al., Nature Reviews Genetics, 2012
  • 36. unstructured data
  • 37. patient stratification
  • 38. Roque et al., PLoS Computational Biology, 2011
  • 39. comorbidity
  • 40. Roque et al., PLoS Computational Biology, 2011
  • 41. disease trajectories
  • 42. Jensen et al., in preparation, 2012
  • 43. pharmacovigilance
  • 44. Eriksson et al., in preparation, 2012
  • 45. conferences
  • 46. questions?