Evolutionary self-organization in molecular networks Lars Juhl Jensen EMBL Heidelberg

huh?

what is self-organization?

patterns emerge

no blueprint

a simple example

an EMBO meeting

fill it with scientists

no seating plan

yet patterns emerge

always the same pattern

but the details vary greatly

social networks

network dynamics

same at the cellular level

protein networks

evolutionary timescale

self-organization

global topology

degree distribution

scale-free networks

hierarchical networks

local topology

network motifs

always the same pattern

but the details vary greatly

cell cycle

S. cerevisiae

synchronized cell culture

microarray time series

periodically expressed genes

protein interactions

temporal network

dynamic and static

de Lichtenberg et al., Science, 2005

just-in-time assembly

not self-organization

evolved via self-organization

cross-species comparison

S. cerevisiae

S. pombe

H. sapiens

A. thaliana

microarray time series

periodically expressed genes

orthology assignment

regulation is not conserved

individual genes

look at a different scale

protein complexes

always the same pattern

but the details vary greatly

multi-level regulation

co-evolution

transcriptional regulation

posttranslational regulation

always the same pattern

but the details vary greatly

Acknowledgments Ulrik de Lichtenberg Thomas Skøt Jensen Søren Brunak Peer Bork