Evolutionary self-organization in molecular networks

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EMBO Workshop on Principles of Self-Organization in Living Matter, European Molecular Biology Laboratory, Heidelberg, Germany, June 2-4, 2006

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Evolutionary self-organization in molecular networks

  1. 1. Evolutionary self-organization in molecular networks Lars Juhl Jensen EMBL Heidelberg
  2. 2. huh?
  3. 3. what is self-organization?
  4. 5. patterns emerge
  5. 6. no blueprint
  6. 7. a simple example
  7. 8. an EMBO meeting
  8. 10. fill it with scientists
  9. 11. no seating plan
  10. 12. yet patterns emerge
  11. 14. always the same pattern
  12. 15. but the details vary greatly
  13. 16. social networks
  14. 18. network dynamics
  15. 19. same at the cellular level
  16. 20. protein networks
  17. 22. evolutionary timescale
  18. 23. self-organization
  19. 24. global topology
  20. 25. degree distribution
  21. 27. scale-free networks
  22. 29. hierarchical networks
  23. 31. local topology
  24. 32. network motifs
  25. 34. always the same pattern
  26. 35. but the details vary greatly
  27. 36. cell cycle
  28. 37. S. cerevisiae
  29. 39. synchronized cell culture
  30. 40. microarray time series
  31. 42. periodically expressed genes
  32. 44. protein interactions
  33. 46. temporal network
  34. 48. dynamic and static
  35. 49. de Lichtenberg et al., Science, 2005
  36. 50. just-in-time assembly
  37. 52. not self-organization
  38. 53. evolved via self-organization
  39. 54. cross-species comparison
  40. 55. S. cerevisiae
  41. 56. S. pombe
  42. 57. H. sapiens
  43. 58. A. thaliana
  44. 59. microarray time series
  45. 61. periodically expressed genes
  46. 63. orthology assignment
  47. 65. regulation is not conserved
  48. 66. individual genes
  49. 67. look at a different scale
  50. 68. protein complexes
  51. 70. always the same pattern
  52. 71. but the details vary greatly
  53. 72. multi-level regulation
  54. 73. co-evolution
  55. 74. transcriptional regulation
  56. 75. posttranslational regulation
  57. 77. always the same pattern
  58. 78. but the details vary greatly
  59. 79. Acknowledgments Ulrik de Lichtenberg Thomas Skøt Jensen Søren Brunak Peer Bork

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