A linear motif atlas for phosphorylation-dependent signaling

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Advances in Bioinformatics, Heidelberg, Germany, March 6-8, 2009

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A linear motif atlas for phosphorylation-dependent signaling

  1. 1. A linear motif atlas for phosphorylation-dependent signaling
  2. 2. location
  3. 6. signaling networks
  4. 7. phosphoproteomics
  5. 8. Linding, Jensen, Ostheimer et al., Cell , 2007
  6. 9. in vivo phosphosites
  7. 10. kinases are unknown
  8. 11. sequence motifs
  9. 12. Miller, Jensen et al., Science Signaling , 2008
  10. 13. sequence specificity
  11. 14. kinase-specific
  12. 15. in vitro
  13. 16. context
  14. 17. association networks
  15. 18. Linding, Jensen, Ostheimer et al., Cell , 2007
  16. 19. NetworKIN
  17. 20. Linding, Jensen, Ostheimer et al., Cell , 2007
  18. 21. sequence motifs
  19. 22. NetPhorest
  20. 23. Miller, Jensen et al., Science Signaling , 2008
  21. 24. data organization
  22. 25. Miller, Jensen et al., Science Signaling , 2008
  23. 26. automated pipeline
  24. 27. compilation of datasets
  25. 28. redundancy reduction
  26. 29. training and evaluation
  27. 30. classifier selection
  28. 31. motif atlas
  29. 33. 179 kinases
  30. 34. 93 SH2 domains
  31. 35. 8 PTB domains
  32. 36. BRCT domains
  33. 37. WW domains
  34. 38. 14-3-3 proteins
  35. 39. phosphatases
  36. 40. model organisms
  37. 41. biological applications
  38. 42. disease-related kinases
  39. 43. Miller, Jensen et al., Science Signaling , 2008
  40. 44. cell-cycle kinases
  41. 45. variation and signaling
  42. 46. augmented browsing
  43. 47. Reflect
  44. 49. Acknowledgments <ul><li>NetworKIN.info </li></ul><ul><ul><li>Rune Linding </li></ul></ul><ul><ul><li>Gerard Ostheimer </li></ul></ul><ul><ul><li>Francesca Diella </li></ul></ul><ul><ul><li>Karen Colwill </li></ul></ul><ul><ul><li>Jing Jin </li></ul></ul><ul><ul><li>Pavel Metalnikov </li></ul></ul><ul><ul><li>Vivian Nguyen </li></ul></ul><ul><ul><li>Adrian Pasculescu </li></ul></ul><ul><ul><li>Jin Gyoon Park </li></ul></ul><ul><ul><li>Leona D. Samson </li></ul></ul><ul><ul><li>Rob Russell </li></ul></ul><ul><ul><li>Peer Bork </li></ul></ul><ul><ul><li>Michael Yaffe </li></ul></ul><ul><ul><li>Tony Pawson </li></ul></ul><ul><li>Reflect.ws </li></ul><ul><ul><li>Sean O’Donoghue </li></ul></ul><ul><ul><li>Evangelos Pafilis </li></ul></ul><ul><ul><li>Heiko Horn </li></ul></ul><ul><ul><li>Michael Kuhn </li></ul></ul><ul><ul><li>Nigel Brown </li></ul></ul><ul><ul><li>Reinhardt Schneider </li></ul></ul><ul><li>NetPhorest.info </li></ul><ul><ul><li>Martin Lee Miller </li></ul></ul><ul><ul><li>Francesca Diella </li></ul></ul><ul><ul><li>Claus Jørgensen </li></ul></ul><ul><ul><li>Michele Tinti </li></ul></ul><ul><ul><li>Lei Li </li></ul></ul><ul><ul><li>Marilyn Hsiung </li></ul></ul><ul><ul><li>Sirlester A. Parker </li></ul></ul><ul><ul><li>Jennifer Bordeaux </li></ul></ul><ul><ul><li>Thomas Sicheritz-Pontén </li></ul></ul><ul><ul><li>Marina Olhovsky </li></ul></ul><ul><ul><li>Adrian Pasculescu </li></ul></ul><ul><ul><li>Jes Alexander </li></ul></ul><ul><ul><li>Stefan Knapp </li></ul></ul><ul><ul><li>Nikolaj Blom </li></ul></ul><ul><ul><li>Peer Bork </li></ul></ul><ul><ul><li>Shawn Li </li></ul></ul><ul><ul><li>Gianni Cesareni </li></ul></ul><ul><ul><li>Tony Pawson </li></ul></ul><ul><ul><li>Benjamin E. Turk </li></ul></ul><ul><ul><li>Michael B. Yaffe </li></ul></ul><ul><ul><li>Søren Brunak </li></ul></ul>

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