Hypothyroidism Definition Causes of hypothyroidism Clinical manifestations of hypothyroidism Laboratory evaluation Autoimmune hypothyroidism
Definition The thyroid gland produce 2 related hormones, thyroxine (T4) and triiodothyronine(T3) These hormones help to maintain thermogenic and metabolic homeostasis in the adult. Hypothyroidism results specially from glandular destruction and underproduction of thyroid hormones.
Laboratory evaluation Dyslipidemia with elevated cholesterol and triglycerides Anemia TSH ↑ and FT4 nle: subclinical hypothyroidism TSH ↑ and FT4↓:clinical hypothyroidism TSH nle or ↓ and FT4 ↓:secondary hypothyroidism
Autoimmune hypothyroidism Autoimmune hypothyroidism may be associated with a goiter (Hashimoto’s disease) or ,at the later stages of the disease, minimal residual thyroid tissue (atrophic thyroiditis) First preceded by subclinical hypothyroidism with normal thyroid hormones levels and elevated TSH Later ,FT4 levels fall and TSH levels rise further Female >male Anti TPO +++