Your SlideShare is downloading. ×
Hypothyroidism Definition Causes of hypothyroidism Clinical manifestations of hypothyroidism Laboratory evaluation Au...
Definition The thyroid gland produce 2 related hormones,  thyroxine (T4) and triiodothyronine(T3) These hormones help to...
Causes of hypothyroidismPrimary hypothyroidism: Autoimmune hypothyroidism: hashimoto’s thyroiditis Iatrogenic: radioacti...
Causes of hypothyroidismTransient hypothyroidism:Silent thyroiditis , including postpartum thyroidtisSubacute thyroiditisW...
Causes of hypothyroidismSecondary hypothyroidism:Hypopituitarism: tumors, pituitary surgery or irradiation, infiltrative d...
Clinical manifestationsSymptoms:   Tiredness, weakness   Dry skin   Feeling cold   Hair loss   Difficulty concentrati...
Signs: Dry skin and cool peripheral extremities Puffy face, hands and feet (myxedema) Diffuse alopecia Bradycardia De...
Laboratory evaluation Dyslipidemia with elevated cholesterol and    triglycerides   Anemia   TSH ↑ and FT4 nle: subclin...
Autoimmune hypothyroidism Autoimmune hypothyroidism may be associated with    a goiter (Hashimoto’s disease) or ,at the l...
Hypothyroidism
Hypothyroidism
Hypothyroidism
Hypothyroidism
Hypothyroidism
Hypothyroidism
Upcoming SlideShare
Loading in...5
×

Hypothyroidism

1,902

Published on

Published in: Education
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total Views
1,902
On Slideshare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
130
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

Transcript of "Hypothyroidism"

  1. 1. Hypothyroidism Definition Causes of hypothyroidism Clinical manifestations of hypothyroidism Laboratory evaluation Autoimmune hypothyroidism
  2. 2. Definition The thyroid gland produce 2 related hormones, thyroxine (T4) and triiodothyronine(T3) These hormones help to maintain thermogenic and metabolic homeostasis in the adult. Hypothyroidism results specially from glandular destruction and underproduction of thyroid hormones.
  3. 3. Causes of hypothyroidismPrimary hypothyroidism: Autoimmune hypothyroidism: hashimoto’s thyroiditis Iatrogenic: radioactive iodine trt, total thyroidectomy, external irradiation Drugs: amiodarone, lithium, antithyroid drugs Congenital hypothyroidism: absent thyroid gland, TSH Rc mutation Iodine deficiency Infiltrative disorders: amyloidosis, sarcoidosis, hemochromatosis…
  4. 4. Causes of hypothyroidismTransient hypothyroidism:Silent thyroiditis , including postpartum thyroidtisSubacute thyroiditisWithdrawal of thyroxine trt
  5. 5. Causes of hypothyroidismSecondary hypothyroidism:Hypopituitarism: tumors, pituitary surgery or irradiation, infiltrative disorders, Sheehan’s syndrome, traumaHypothalamic disease: tumors, trauma, infiltrative disorders , idiopathic
  6. 6. Clinical manifestationsSymptoms: Tiredness, weakness Dry skin Feeling cold Hair loss Difficulty concentrating and poor memory Constipation Weight gain Dyspnea Hoarse voice Dysmenorrhea Paresthesias
  7. 7. Signs: Dry skin and cool peripheral extremities Puffy face, hands and feet (myxedema) Diffuse alopecia Bradycardia Delayed tendon reflex relaxation Carpal tunnel syndrome
  8. 8. Laboratory evaluation Dyslipidemia with elevated cholesterol and triglycerides Anemia TSH ↑ and FT4 nle: subclinical hypothyroidism TSH ↑ and FT4↓:clinical hypothyroidism TSH nle or ↓ and FT4 ↓:secondary hypothyroidism
  9. 9. Autoimmune hypothyroidism Autoimmune hypothyroidism may be associated with a goiter (Hashimoto’s disease) or ,at the later stages of the disease, minimal residual thyroid tissue (atrophic thyroiditis) First preceded by subclinical hypothyroidism with normal thyroid hormones levels and elevated TSH Later ,FT4 levels fall and TSH levels rise further Female >male Anti TPO +++

×