Presented by: Jessica M. Lacki
<ul><li>It causes changes in mood, judgement, personality, makes it difficult to communicate or cope with day to day tasks...
<ul><li>Alzheimer’s Disease  is the most common dementia.  </li></ul><ul><li>Damaged tissue builds up in the brain and for...
<ul><li>U.S scientists say that they have successfully reversed the effects of Alzheimer’s with experimental drugs </li></ul>
<ul><li>Originally tested on mice </li></ul><ul><li>Helped restore long term memory and ability to learn new tasks </li></ul>
<ul><li>The drugs are  HDAC inhibitors , and they reshape DNA scaffolding. </li></ul>
<ul><li>As mentioned before, they reshape DNA scaffolding </li></ul><ul><li>Use histone deacetylase 2 (HDAC2); which helps...
<ul><li>Alzheimer’s  </li></ul><ul><li>All forms of Dimentia </li></ul><ul><li>Huntington’s Disease </li></ul>
<ul><li>Unfortunately, no. </li></ul><ul><li>Scientists are not yet sure that it is safe to use on humans. </li></ul>
<ul><li>The genetic engineers of the drug think that it may take a little over a decade (ten years) for it to be ready </l...
<ul><li>“ We need to do more research to investigate whether developing treatments that control this gene could benefit pe...
<ul><li>http://news.bbc.co.uk/2/hi/health/8033422.stm </li></ul>
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Trial Drugs

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Trial Drugs

  1. 1. Presented by: Jessica M. Lacki
  2. 2. <ul><li>It causes changes in mood, judgement, personality, makes it difficult to communicate or cope with day to day tasks </li></ul><ul><li>It usually gets worse over time, which means that you have to rely on other people more and more. </li></ul>
  3. 3. <ul><li>Alzheimer’s Disease is the most common dementia. </li></ul><ul><li>Damaged tissue builds up in the brain and forms deposits called ‘plaques’ and ‘tangles’- cause the cells around them to die </li></ul><ul><li>Vascular dementia , where the arteries supplying blood to the brain become blocked which leads to small strokes when parts of the brain die as they are starved of oxygen. </li></ul><ul><li>Lewy body dementia is caused by small protein deposits in the brain, and symptoms closely resembles Parkinson’s disease </li></ul><ul><li>Fronto-temporal dementia is caused by damage to the front of the brain and is more likely to cause personality change </li></ul>
  4. 4. <ul><li>U.S scientists say that they have successfully reversed the effects of Alzheimer’s with experimental drugs </li></ul>
  5. 5. <ul><li>Originally tested on mice </li></ul><ul><li>Helped restore long term memory and ability to learn new tasks </li></ul>
  6. 6. <ul><li>The drugs are HDAC inhibitors , and they reshape DNA scaffolding. </li></ul>
  7. 7. <ul><li>As mentioned before, they reshape DNA scaffolding </li></ul><ul><li>Use histone deacetylase 2 (HDAC2); which helps regulate the expression of a plethora of genes </li></ul><ul><li>Increases the brains ability to change in response to experience and memory formation </li></ul>
  8. 8. <ul><li>Alzheimer’s </li></ul><ul><li>All forms of Dimentia </li></ul><ul><li>Huntington’s Disease </li></ul>
  9. 9. <ul><li>Unfortunately, no. </li></ul><ul><li>Scientists are not yet sure that it is safe to use on humans. </li></ul>
  10. 10. <ul><li>The genetic engineers of the drug think that it may take a little over a decade (ten years) for it to be ready </li></ul>
  11. 11. <ul><li>“ We need to do more research to investigate whether developing treatments that control this gene could benefit people with Alzheimer's” </li></ul><ul><li>Rebecca Wood of the Alzheimer's Research Trust </li></ul>
  12. 12. <ul><li>http://news.bbc.co.uk/2/hi/health/8033422.stm </li></ul>
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