Elements of aPrincipia PosthumanHuman Body 2.0 Redesign,  Democracy, and Next- generation Intelligence                    ...
About Melanie Swan     Founder DIYgenomics, futurist and applied      genomics expert     Current projects: MelanieSwan....
CONTACT presentations     Data Visualization in Second Life      (2008)     Future of Life Sciences: the Great      Conv...
The future is notoriously hard to predict                        Positional nanoassembly                        Young lady...
Simple models for thinking about the future                      Past                            Present   FutureMarch 31,...
The role of time in thinking: GPS for the Mind exercise                                                                   ...
GPS for the Mind exercise                                                            Image: Salvador Dali       CONTACT G...
Agenda     Context for Principia Posthuman     Elements of a Principia Posthuman         Quantitative: science, human b...
Aspen rhizome   Elements of a Principia Posthuman                                                                  Image: ...
Agenda     Context for Principia Posthuman     Elements of a Principia Posthuman         Quantitative: science, human b...
Miniaturization trend, next node: microdots                  10-100 years ago    2000s      2050s        2100+            ...
(Kuhnian paradigms,  Information transmission eras                        Foucauldian epistemes)     Analog               ...
Prominent artificial intelligence erasEnumeration             Biomimicry      Big data         ?       1950s              ...
Big data: personal health informatics                                                 DNA:                                ...
Biology is an information technology                                        DNA sequencing:                               ...
Biology is the information technology                             Organ regeneration (urethra)                     Algal b...
Agenda     Context for Principia Posthuman     Elements of a Principia Posthuman         Quantitative: science, human b...
Agency: collective intelligence computing                               Crowdsourcing                                     ...
Mobile is the platform     Explosive growth                                                                              ...
Participatory health activity landscape        (Light)                                    Level of Engagement             ...
Concepts in participatory health                                Citizen science                      Quantified self-     ...
Citizen science definition     Performing scientific investigation      without professional training in the field       ...
Citizen science health – why now?     Tools         Plummeting cost of genome sequencing         Availability of consum...
    Goal: personalized knowledge through      quantified self-tracking     Format: monthly ‘show n tell’ meetups     Ou...
Quantified self study examples       Food consumption (1 yr)1 and the Butter Mind study2       Study       Low-cost hom...
Health social networks and collaboration                                      Health social                               ...
Agenda     Context for Principia Posthuman     Elements of a Principia Posthuman         Quantitative: science, human b...
Professionalizing participative health: Philosophical validation     Towards an epistemology of citizen science         ...
Ontological shift                                         Image credit: http://efx3.com                        Old thinkin...
Genome politics and regulation     Our world is not Gattaca       Personal genomics has        destigmatized health issu...
Role of participative health: future medicine                                            1. Continuous health information ...
Health self-management                                   A new model of health and health careMarch 31, 2012        Source...
Biotechnicity and computational philosophy                                                                                ...
Agenda     Context for Principia Posthuman     Elements of a Principia Posthuman         Quantitative: science, human b...
GPS for the Mind exercise                                                            Image: Salvador Dali       CONTACT G...
GPS for the Mind results                                                            Image: Salvador Dali       Past, pres...
Aspen rhizome   Elements of a Principia Posthuman                                                                  Image: ...
Principia                                         Posthuman                                         Thank you!            ...
DIYgenomics participant-organized studies    7 studies in open enrollment (vitamin deficiency, aging, and     mental perf...
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Principia posthuman

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Elements of a Principia Posthuman Human Body 2.0 Redesign, Democracy, and Next-generation Intelligence

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Principia posthuman

  1. 1. Elements of aPrincipia PosthumanHuman Body 2.0 Redesign, Democracy, and Next- generation Intelligence Image credit: Natasha Vita-More, Primo Posthuman Melanie Swan MS Futures Group +1-650-681-9482 @LaBlogga, @DIYgenomicsMarch 31, 2012, Sunnyvale CA www.MelanieSwan.comSlides: http://slideshare.net/LaBlogga m@melanieswan.com
  2. 2. About Melanie Swan  Founder DIYgenomics, futurist and applied genomics expert  Current projects: MelanieSwan.com  Education: MBA Finance, Wharton; BA French/Economics, Georgetown Univ  Work experience: Fidelity, JP Morgan, iPass, RHK/Ovum, Arthur Andersen  Sample publications:  Swan, M. Crowdsourced Health Research Studies: An Important Emerging Complement to Clinical Trials in the Public Health Research Ecosystem. J Med Internet Res 2012, Mar;14(2):e46.  Swan, M. Scaling crowdsourced health studies: the emergence of a new form of contract research organization. Personalized Medicine 2012, Mar;9(2):223-234.  Swan, M. Steady advance of stem cell therapies. Rejuvenation Res 2011, Dec;14(6):699-704.  Swan, M., Hathaway, K., Hogg, C., McCauley, R., Vollrath, A. Citizen science genomics as a model for crowdsourced preventive medicine research. J Participat Med 2010, Dec 23; 2:e20.  Swan, M. Multigenic Condition Risk Assessment in Direct-to-Consumer Genomic Services. Genet Med 2010, May;12(5):279-88.  Swan, M. Emerging patient-driven health care models: an examination of health social networks, consumer personalized medicine and quantified self-tracking. Int J Environ Res Public Health 2009, 2, 492-525.March 31, 2012 Source: http://melanieswan.com/publications.htm 2Principia Posthuman
  3. 3. CONTACT presentations  Data Visualization in Second Life (2008)  Future of Life Sciences: the Great Convergence of Life and Technology (2009)  Revolutionizing Biology with Personal Genomes (2010)  Principia Posthuman (2012) Slides: http://slideshare.net/LaBlogga Image credit: Natasha Vita-More, Primo PosthumanMarch 31, 2012 3Principia Posthuman
  4. 4. The future is notoriously hard to predict Positional nanoassembly Young lady’s illustrated primerMarch 31, 2012 4Principia Posthuman
  5. 5. Simple models for thinking about the future Past Present FutureMarch 31, 2012 Image: http://www.sydmead.com 5Principia Posthuman
  6. 6. The role of time in thinking: GPS for the Mind exercise Image: http://www.mindtime.com  Plot time orientation: certainty, possibility, probability www.mindtimemaps.com/start/contact probability certainty possibilityMarch 31, 2012 Source: Fortunato, VJ and Furey, JT. The theory of MindTime: The relationships between Future, Past, and Present thinking and psychological well-being and distress. Personality and Individual Differences. January 2011, 50(1), pp. 20-4. http://www.miindtime.com 6Principia Posthuman
  7. 7. GPS for the Mind exercise Image: Salvador Dali  CONTACT GPS for the Mind exercise (4 minutes)  Sign up for a free account at www.mindtimemaps.com (use an anonymous name if you prefer)  Complete the GPS for the Mind exercise at the community site: www.mindtimemaps.com/start/contact  Results: return to the community site www.mindtimemaps.com/start/contact and click on the Groups icon, then CONTACT to see the resultsMarch 31, 2012 Source: http://www.mindtimemaps.comPrincipia Posthuman 7
  8. 8. Agenda  Context for Principia Posthuman  Elements of a Principia Posthuman  Quantitative: science, human body 2.0 redesign  Qualitative: social constructs, democracy  Concepts: philosophy, next-generation intelligence  ConclusionMarch 31, 2012Principia Posthuman
  9. 9. Aspen rhizome Elements of a Principia Posthuman Image: http://integral-options.blogspot.com Philosophy Next-generation Concepts Concerned with: Understanding intelligence Art, aesthetics, economics, politics,Qualitative societal design Democracy Concerned with: Experience Science and technology Human BodyQuantitative Concerned with: Characterization 2.0 Redesign March 31, 2012 9 Principia Posthuman
  10. 10. Agenda  Context for Principia Posthuman  Elements of a Principia Posthuman  Quantitative: science, human body 2.0 redesign  Qualitative: social constructs, democracy  Concepts: philosophy, next-generation intelligence  ConclusionMarch 31, 2012Principia Posthuman
  11. 11. Miniaturization trend, next node: microdots 10-100 years ago 2000s 2050s 2100+ Room(s) size Handheld Invisible Non matter- based?ComputingmachineryInformation storage DNAsequencing March 31, 2012 11 Principia Posthuman
  12. 12. (Kuhnian paradigms, Information transmission eras Foucauldian epistemes) Analog Digital Life code ?17,300 years ago 1455 & 1950-2000 2000-2100 2100+Painting, scrolls Press, Transistor DNA ? March 31, 2012 12 Principia Posthuman
  13. 13. Prominent artificial intelligence erasEnumeration Biomimicry Big data ? 1950s 1990s+ 2000s+ 2100+Expert syst, CYC NLP, HTM, NCC Google, Watson ? March 31, 2012 13 Principia Posthuman
  14. 14. Big data: personal health informatics DNA: SNP mutations RNA expression profiling Health 2.0: Proteomics DNA: Structural Personal health variation informatics Epigenetics Microbiomics MetabolomicsMarch 31, 2012 Academic papers re: integrated health data streams: Auffray C, et al. Looking back at genomic medicine in 2011. Genome Med. 2012 Jan 30;4(1):9. Chen R et al. Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell. 2012 Mar 16;148(6):1293-307. 14Principia Posthuman
  15. 15. Biology is an information technology DNA sequencing: 10x/yr improvement I love you010010010010000001101100011011110111011001100101001000 00011110010110111101110101 I hate you010010010010000001101000011000010111010001100101001000 00011110010110111101110101 Image credit: http://pubs.acs.org/cen/_img/87/i50/8750cover2_law.gifMarch 31, 2012 15Principia Posthuman
  16. 16. Biology is the information technology Organ regeneration (urethra) Algal biofuel Image credit: Anthony Atala lab Image credit: http://www.rexresearch.comArtificial cell booted to life Whole organ decellularization and DNA nanotechnology latch Image credit: J. Craig Venter Institute recellularization (heart) box for drug delivery Image credit: Thomas Matthiesen Image credit: Aarhus UniversityMarch 31, 2012 16Principia Posthuman
  17. 17. Agenda  Context for Principia Posthuman  Elements of a Principia Posthuman  Quantitative: science, human body 2.0 redesign  Qualitative: social constructs, democracy  Concepts: philosophy, next-generation intelligence  ConclusionMarch 31, 2012 17Principia Posthuman
  18. 18. Agency: collective intelligence computing Crowdsourcing Concierge research Consumer genomics Citizen science Health 2.0: Consumer blood tests Crowdsourced health computing DIYbio labs Continuous Ambient mental sampling performance Quantified self- optimization trackingMarch 31, 2012 18Principia Posthuman
  19. 19. Mobile is the platform  Explosive growth Image credit: http://www.psfk.com  US: more cell phones (328 m) than people (315 m) 1  One billion+ worldwide smartphone users by 20132  App downloads: 5 bn in 2010 versus 300 mn in 20094  Health-related apps: 7,0004  81% physicians using smartphones 20123  Studies: thousands recruited in months2  Intimate continuous interaction platform Image credit: tehgaygeek.blogspot.com  Phone loss noticed within 5 minutes vs. 1 hour for wallet loss  Kids chat with Siri as virtual friend 1 Kang C. Number of cell phones exceeds US population. Washington Post. October 11, 2011.March 31, 2012 2 Dufau S. Smart phone, smart science: how the use of smartphones can revolutionize research in cognitive science. PLoS One. 2011. 3Kiser K. 25 ways to use your smartphone. Physicians share their favorite uses and apps. Minn Med. 2011. 19Principia Posthuman 4 Boulos MN. How smartphones are changing the face of mobile and participatory healthcare. Biomed Eng Online. 2011.
  20. 20. Participatory health activity landscape (Light) Level of Engagement (Intense) Social Mobile PHRs Consumer media health apps (personal genomics Citizen Quantified science self-tracking health records) DIYbio (do-it-yourself biology)March 31, 2012 Image credit: Getty Images 20Principia Posthuman
  21. 21. Concepts in participatory health Citizen science Quantified self- tracking DIYbio (do-it-yourself http://ezramagazine.cornell.edu biology) http://thecoolgadgets.com http://www.iab.keio.ac.jpMarch 31, 2012 21Principia Posthuman
  22. 22. Citizen science definition  Performing scientific investigation without professional training in the field Image credit: http://www.southernfriedscience.com Institutional science research Citizen science health and biology Citizen science: 200+ organizations1March 31, 2012 1 http://scienceforcitizens.net/finder 22Principia Posthuman
  23. 23. Citizen science health – why now?  Tools  Plummeting cost of genome sequencing  Availability of consumer blood tests  Online bioinformatics tools  Education and support  Local DIYbio labs, online forums Image credit: http://diybionyc.blogspot.com Image credits: http://www.biocurious.orgMarch 31, 2012 23Principia Posthuman
  24. 24.  Goal: personalized knowledge through quantified self-tracking  Format: monthly ‘show n tell’ meetups  Outcome: optimality and improvement  Example: personalized interventions for depression, low energy, sleep quality Image credit: http://www.nationalpost.com Image credit: Quantified SelfMarch 31, 2012 Source: Swan, M. Overview of Crowdsourced Health Research Studies. 2012. Forthcoming. 24Principia Posthuman
  25. 25. Quantified self study examples  Food consumption (1 yr)1 and the Butter Mind study2  Study  Low-cost home-administered blood, urine, saliva tests Cholestech LDX OrSense continuous non-invasive ZRT Labs driedhome cholesterol test glucose monitoring blood spot tests March 31, 2012 1 Source: http://flowingdata.com/2011/06/29/a-year-of-food-consumption-visualized 2 Source: http://quantifiedself.com/2011/01/results-of-the-buttermind-experiment 25 Principia Posthuman
  26. 26. Health social networks and collaboration Health social Health networks collaboration (global & local) communities Source: Extended from Swan, M. Emerging patient-driven health care models: an examination of health social networks, consumerMarch 31, 2012 personalized medicine and quantified self-tracking. Int. J. Environ. Res. Public Health 2009, 2, 492-525. 26Principia Posthuman
  27. 27. Agenda  Context for Principia Posthuman  Elements of a Principia Posthuman  Quantitative: science, human body 2.0 redesign  Qualitative: social constructs, democracy  Concepts: philosophy, next-generation intelligence  ConclusionMarch 31, 2012Principia Posthuman
  28. 28. Professionalizing participative health: Philosophical validation  Towards an epistemology of citizen science  Provide a structure and context for participant-derived health knowledge  Q1: Are new kinds of knowledge are being formed through group collaborations such as wikipedia and health social networks?  Q2: How to characterize the knowledge generated by traditional medicine, self-experimentation, and health collaboration communities? Image credit: http://inkingrey.comMarch 31, 2012 28Principia Posthuman
  29. 29. Ontological shift Image credit: http://efx3.com Old thinking: My health is the responsibility of my physician New thinking: My health is my responsibility … and I have the tools to make managing it easyMarch 31, 2012 29Principia Posthuman
  30. 30. Genome politics and regulation  Our world is not Gattaca  Personal genomics has destigmatized health issues  Issues: human cloning, sex selection, genetic privacy, non-discrimination  UN Convention on Human Rights and Biomedicine 1997 (Ch IV Human Genome) Image credit: http://www.sonypictures.com  U.S. Genetic Information Nondiscrimination Act (GINA) 2008  Biocitizenry, health as a human right Image credit: http://sciencephoto.comMarch 31, 2012 30Principia Posthuman
  31. 31. Role of participative health: future medicine 1. Continuous health information climate Automated digital health monitoring, self-tracking devices, and mobile apps providing personalized recommendations 2. Peer collaboration and health advisors Health social networks, crowdsourced studies, health advisors, wellness coaches, preventive care plans, Individual boutique physicians, genetics coaches, aestheticians, medical tourism 3. Public health system Deep expertise of traditional health system for disease and trauma treatmentMarch 31, 2012 Source: Extended from Swan, M. Emerging patient-driven health care models: an examination of health social networks, consumer personalized medicine and quantified self-tracking. Int. J. Environ. Res. Public Health 2009, 2, 492-525. 31Principia Posthuman
  32. 32. Health self-management A new model of health and health careMarch 31, 2012 Source: Extended from Swan, M. Emerging patient-driven health care models: an examination of health social networks, consumer personalized medicine and quantified self-tracking. Int. J. Environ. Res. Public Health 2009, 2, 492-525, Figure 1. 32Principia Posthuman
  33. 33. Biotechnicity and computational philosophy Metaphysical shift: new ways of being Concepts •Meaning of health and health outcomes •Sense of self and group identity, biocitizenryImage credit: http://stemcellresources.org Epistemic advance: new knowledge generation •Content: New data streams, larger data sets, more granular data, higher Qualitative order magnitude science •Process: New algorithms and new models Computational tools of health-related philosophical discovery •Hardware and software devices and algorithms: quantitative health data streams, health- related smartphone applications, personal electronic health records, quantified self- tracking devices •Crowdsourced human computing networks: crowdsourced disease prediction, health social networks, quantified self n=1 health self-experimentation, crowdsourced health research studies, DIYbio labsQuantitative March 31, 2012 Source: Swan, M. Biotechnicity 2.0: Computation-enabled Philosophical Advance in the Epistemology of Human Biology and the Ontology of Bioidentity. 2012. Submitted. 33 Principia Posthuman
  34. 34. Agenda  Context for Principia Posthuman  Elements of a Principia Posthuman  Quantitative: science, human body 2.0 redesign  Qualitative: social constructs, democracy  Concepts: philosophy, next-generation intelligence  ConclusionMarch 31, 2012 34Principia Posthuman
  35. 35. GPS for the Mind exercise Image: Salvador Dali  CONTACT GPS for the Mind exercise (4 minutes)  Sign up for a free account at www.mindtimemaps.com (use an anonymous name if you prefer)  Complete the GPS for the Mind exercise at the community site: www.mindtimemaps.com/start/contact  Results: return to the community site www.mindtimemaps.com/start/contact and click on the Groups icon, then CONTACT to see the resultsMarch 31, 2012 Source: http://www.mindtimemaps.comPrincipia Posthuman 35
  36. 36. GPS for the Mind results Image: Salvador Dali  Past, present, future  Self, group, countryMarch 31, 2012 Source: http://www.mindtimemaps.comPrincipia Posthuman 36
  37. 37. Aspen rhizome Elements of a Principia Posthuman Image: http://integral-options.blogspot.com Philosophy Next-generation Concepts Concerned with: Understanding intelligence Art, aesthetics, economics, politics,Qualitative societal design Democracy Concerned with: Experience Science and technology Human BodyQuantitative Concerned with: Characterization 2.0 Redesign March 31, 2012 37 Principia Posthuman
  38. 38. Principia Posthuman Thank you! Questions? Image: AmericanThinker.com Image: Natasha Vita-More, Primo Posthuman Melanie Swan MS Futures GroupSlides: http://slideshare.net/LaBlogga +1-650-681-9482 @LaBlogga, @DIYgenomics www.MelanieSwan.comCreative Commons 3.0 license m@melanieswan.com
  39. 39. DIYgenomics participant-organized studies 7 studies in open enrollment (vitamin deficiency, aging, and mental performance); 5 in design (oncology, calcinosis)March 31, 2012 Source: Swan, M., Crowdsourced health research studies. J Med Internet Res 2012, Mar;14(2):e46 39Principia Posthuman
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