Personalized Medicine and You!

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Realize preventive medicine through predictive risk profiling, determining baseline markers of wellness and variability, and engaging in personalized pre-clinical interventions

Personalized Medicine and You!

  1. 1. Personalized Medicine and You! Melanie Swan Founder DIYgenomicsHealth Technology Forum +1-650-681-9482 @DIYgenomicsSeptember 27, 2012, San Francisco, CA www.DIYgenomics.orgSlides: http://slideshare.net/LaBlogga m@melanieswan.com
  2. 2. The Realization of Preventive Medicine Condition Lifecycle 80% Pre-Clinical 20% Clinical Telemedicine Health Collaboration Hospital Re-admit Social Health Media Communities Reduction Programs Disease Risk Personal Health Consumer Prevention Personalized Records (PHRs) Genomics Crowdsourced Molecular eHealth Participatory Health Studies Diagnostics Initiatives Medicine Health Social Personalized P4 Networks Cancer Health Medicine Wellness Treatment Coach Higher-deductible Profiling insurance Mobile Quantified Self- Home Monitoring Health Apps tracking Devices Biosensors Programs (Light) Engagement (Heavy) Swan, M. Health 2050: The Realization of Personalized Medicine through Crowdsourcing, the Quantified Self, and the ParticipatorySeptember 27, 2012 Biocitizen. J Pers Med 2012, 2(3), 93-118. 2DIYgenomics.org
  3. 3. Health Social Networks and Collaboration Health Health Social Collaboration Networks Communities Source: Extended from Swan, M. Emerging patient-driven health care models: an examination of health social networks, consumerSeptember 27, 2012 personalized medicine and quantified self-tracking. Int. J. Environ. Res. Public Health 2009, 2, 492-525. 3DIYgenomics.org
  4. 4. DIYgenomics: Research Model  Goal: preventive medicine  Realize preventive medicine through predictive risk profiling, determining baseline markers of wellness and variability, and engaging in personalized pre-clinical interventions  Generalized hypothesis  One or more polymorphisms may result in out-of-bounds baseline levels of phenotypic markers which may be ameliorated through personalized intervention Genotype + Phenotype + Intervention = OutcomeVitamin B Study: MTHFR SNPs + Vitamin B & Homocysteine Blood Test + Vitamin B = Personalized Outcomes September 27, 2012 Source: Swan, M., Hathaway, K., Hogg, C., McCauley, R., Vollrath, A. Citizen science genomics as a model for crowdsourced preventive medicine research. J Participat Med. 2010, Dec 23; 2:e20. 4 DIYgenomics.org
  5. 5. Big Data: Integrating Health Data Streams New Data Streams Traditional Data Streams Quantified Self Data Streams Genome SNP mutations Personal and Family Self-reported data: Structural variation Health History health, exercise, Epigenetics food, mood journals, etc. Microbiome Prescription History Transcriptome Mobile App Data Lab Tests: History Metabolome and Current Quantified Self Proteome Demographic Data Device Data Diseasome Standardized Biosensor Data Instrument Objective Metrics Environmentome Response Swan, M. Health 2050: The Realization of Personalized Medicine through Crowdsourcing, the Quantified Self, and the ParticipatorySeptember 27, 2012 Biocitizen. J Pers Med 2012, 2(3), 93-118. 5DIYgenomics.org Legend: Consumer-available
  6. 6. Sensor Mania! Wearable ElectronicsSmartwatch (Pebble) and Smartring (ElectricFoxy) Electronic tattoos (mc10), $1 blood API (Sano Intelligence), and Electronic T-shirt (Carre) Dried blood spot testing (ZRT Lab) Image credit: Cisco Continuous Monitors (Medtronic) The Brain: 24/7 Consumer EEG, Eye-tracking, Emotion Mapping, Augmented Reality Glasses September 27, 2012 Source: Swan, M. Sensor Mania! The Internet of Things, Objective Metrics, and the Quantified Self 2.0. J Sens Actuator Netw 2012, submitted. 6 DIYgenomics.org
  7. 7. Operated on: DIYgenomics Memory StudySeptember 27, 2012 7DIYgenomics.org
  8. 8. 13 DIYgenomicsGenotype + Phenotype + Intervention Studies in Open = Outcome Enrollment  Sleep, Genomics, and Caffeine  20 sleep SNPs + 3 standardized sleep instruments + myZeo + caffeine intervention  Empathy  OXTR SNP + IRI (Interpersonal Reactivity Index) + Personal Virtual Coach  Microbiome  Human gut disease risk SNPs + Microbiome Sequencing + Questionnaire + Probiotic  Diabesity prevention  Diabetes & obesity risk SNPs + Hemoglobin & other blood tests + Glucometer tracking Full List: http://ww.DIYgenomics.orgSeptember 27, 2012 Source: Swan, M. Sensor Mania! The Internet of Things, Objective Metrics, and the Quantified Self 2.0. J Sens Actuator Netw 2012, submitted. 8DIYgenomics.org
  9. 9. Genotype Phenotype Intervention Outcome + + = DIYgenomics Studies in Design  Predictive Risk Profiling  Immune System and Diseasome  Environmentome (Body Burden and Capacity)  Cancer Risk and Drug Response  Mental Performance Optimization  Creativity  Learning  Flow State Image credit: http://sciencemag.org  Diabesity Prevention  Do you have a Sweet Tooth? Genomics and Dietary PreferenceSeptember 27, 2012 Source: DIYgenomics 9DIYgenomics.org
  10. 10. Personalized Preventive Medicine and You! 1. Continuous health information climate Automated digital health monitoring, self-tracking devices, and mobile apps providing personalized recommendations 2. Peer collaboration and health advisors Health social networks, crowdsourced studies, health advisors, wellness coaches, preventive care plans, Individual boutique physicians, genetics coaches, aestheticians, medical tourism 3. Public health system Deep expertise of traditional health system for disease and trauma treatment Source: Extended from Swan, M. Emerging patient-driven health care models: an examination of health social networks, consumerSeptember 27, 2012 personalized medicine and quantified self-tracking. Int. J. Environ. Res. Public Health 2009, 2, 492-525. 10DIYgenomics.org
  11. 11. DIYgenomics Press Coverage "...accelerating the professionalization of do-it- yourself studies" - March 2012 "Ordinary people are taking control of their health data" - December 2011 "A group called DIYgenomics has banded together to analyse their genomes, and even conduct and participate in small clinical trials" - October 2010 "...early adopters are showing how empowering and beneficial to science personal genetic information can be" - September 2010 "...they wanted to build a model trial that could be easily replicated by citizen scientists anywhere" - March 2011September 27, 2012 11DIYgenomics.org
  12. 12. Crowd-sourced clinical trials Personal genome apps Thank you! Collaborators: International collaborations: Lorenzo Albanello Marat Nepomnyashy Janet Chang Ted Odet JST and Rikengenesis Cindy Chen Roland Parnaso Takashi Kido John Furber Thomas Pickard Minae Kawashima Hong Guo William Reinhardt Jin Yamanaka Kristina Hathaway Greg Smith Laura Klemme Aaron Vollrath University Hospitals of Geneva Priya Kshirsagar Lawrence S. Wong Louis Nahum Lucymarie Mantese Armin Schnider Melanie Swan Founder Raymond McCauley DIYgenomics +1-650-681-9482 @DIYgenomics www.DIYgenomics.orgCreative Commons 3.0 license Slides: http://slideshare.net/LaBlogga m@melanieswan.com

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