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Bioengineering: making life from scratch
 

Bioengineering: making life from scratch

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An overview of bioengineering and synthetic biology; definition, history, key research findings, scientists, current initiatives and future outlook.

An overview of bioengineering and synthetic biology; definition, history, key research findings, scientists, current initiatives and future outlook.

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    Bioengineering: making life from scratch Bioengineering: making life from scratch Presentation Transcript

    • Bioengineering: making life from scratch Melanie Swan MS Futures Group +1-650-681-9482 [email_address] http://www.melanieswan.com Slides: http://slideshare.net/LaBlogga/slideshows NIH, Bethesda MD September 25, 2008 Must build it to understand it
    • Synthetic biology Novel biological system
    • The new biology: virtuous feedback loop Model and simulate Investigate and experiment Build
    • Bio-SPICE Biological Simulation Program for Intra- and Inter-Cellular Evaluation http://biospice.org Model and simulate
    • Registry of Standard Biological Parts Build http://partsregistry.org
    • Parts Registry: select measurement device http://partsregistry.org
    • Parts Registry: obtain part sequence DNA Synthesizer http://partsregistry.org
    • The story of biocomputing
      • Mapping genes to proteins -> life can be engineered
      • Genes can be turned on and off -> gene as binary switch
      • Systemic understanding of DNA -> genes as circuits
      • Cell noisiness -> need for stable and predictable circuits
    • Repressilator schema “ Noisy” cells Michael Elowitz Stanislas Leibler Repressilator A synthetic oscillatory network of transcriptional regulators Michael B. Elowitz & Stanislas Leibler Nature. 2000 Jan 20;403(6767):335-38. http://www.nature.com/nature/journal/v403/n6767/full/403335a0.html
    • Construction of a genetic toggle switch in Escherichia coli Gardner TS, Cantor CR, Collins JJ Nature. 2000 Jan 20;403(6767):339-42. http://www.ncbi.nlm.nih.gov/pubmed/10659857 Toggle switch induction threshold Toggle switch plasmid Gardner Cantor Collins Genetic toggle switch
    • Open wetware Drew Endy
      • Parts Registry
      • BioBricks Foundation
      • iGEM competition
      http://openwetware.org/ http://bbf.openwetware.org/ http://www.igem.org/ http://partsregistry.org
    • Genome Craig Venter Synthetic life
      • Synthetic life
      • Fourth-generation biofuels
      Mycoplasma genitalium Bacterial image Genetic map
    • Further applications of bioengineering Coli-roid microbial camera Landmine sensing plant: Arabidopsis thaliana Amorphous computing Cellular colonies Natural genetic engineering Ciliate
    • Summary Model and simulate Investigate and experiment Build
    • Thank you Melanie Swan MS Futures Group +1-650-681-9482 [email_address] http://www.melanieswan.com Slides: http://slideshare.net/LaBlogga/slideshows NIH, Bethesda MD September 25, 2008