INFLAMMATION: REGULATION
DEFECTS IN LEUCOCYTE FUNCTION                       GENETIC• ADHESION DEFECTS-     • LAD1, LAD2     • INTEGRINS AND SELECT...
DEFECTS IN LEUCOCYTE FUNCTION• DEFECT IN MICROBICIDAL ACTIVITY     • CGD-DEFECTS IN NADPH OXIDASE     • REC BACTERIAL INFE...
Outcomes of acute  inflammation
resolution• Restoration of site to normal• Usually occurs when     1. Limited or short lived     2. Little tissue destruct...
fibrosis• Connective tissue replacement• Occurs in cases of 1. Extensive destruction 2. Tissues incapable of regeneration ...
suppuration• When causative agent is pyogenic bacteria• Events
CHRONIC INFLAMMATION• When inflammation can not be resolved• In cases of      1. Persistence of agent      2. Interference...
MORPHOLOGICAL PATTERNS• SEROUS     • THIN FLUID     • Eg BLISTER OF BURN• FIBRINOUS     •   MORE SEV INJURY     •   FIBROG...
MORPHOLOGICAL PATTERNS• SUPPURATIVE/ PURULENT    • SOME PYOGENIC BACTERIA    • LARGE AMTS OF PUS    • ABSCESS-LOCALIZED CO...
SEROUS EXUDATE• Bullous Pemphigoid,• Serous Inflammation                                        Dermis                    ...
FIBRINOUS EXUDATEpericardial cavityshows fibrinouspericarditis withstrands of stringy palefibrin between visceraland parie...
FIBRINOUS INFLAMMATION                       Fibrinous exudate                   pericardiumURAEMIC PERICARDITIS
PURULENT EXUDATE          • Exuded yellowish fluid            fluid in this opened            pericardial cavity also     ...
SUPPURATIVE INFLAMMATIONA                                      BA: purulent exudate obscuring the sulci in pyogenic mening...
ABSCESS   • rounded abscesses (the     purulent material has     drained out after sectioning     to leave a cavity) in th...
ABSCESS    • Diverticulitis of Colon      with abscess formation     Abscess     Sulfur granules of     actinomycoses    L...
ULCER               GrossGastroscopicView                       Microscopic view
4.outcomes and morphology dr ashutosh kumar
4.outcomes and morphology dr ashutosh kumar
4.outcomes and morphology dr ashutosh kumar
4.outcomes and morphology dr ashutosh kumar
4.outcomes and morphology dr ashutosh kumar
4.outcomes and morphology dr ashutosh kumar
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4.outcomes and morphology dr ashutosh kumar

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Transcript of "4.outcomes and morphology dr ashutosh kumar"

  1. 1. INFLAMMATION: REGULATION
  2. 2. DEFECTS IN LEUCOCYTE FUNCTION GENETIC• ADHESION DEFECTS- • LAD1, LAD2 • INTEGRINS AND SELECTIN RECEPTORS DEFECTIVE • REC BACTERIAL INFECTIONS AND IMPAIRED HEALING• DEFECTS IN PHAGOLYSOSOME FUNCTION • CHEDIAK HIGASHI SYN • AR • DEFECTIVE TRANSFER OF LYSOSOMAL ENZYMES
  3. 3. DEFECTS IN LEUCOCYTE FUNCTION• DEFECT IN MICROBICIDAL ACTIVITY • CGD-DEFECTS IN NADPH OXIDASE • REC BACTERIAL INFECTIONS• MPO DEF ACQUIRED-VARIOUS ASPECTS LIKE PHAGO,CHEMO ETC AFFECTED• DM• MALIGNANCY• MALNUTRITION• ANEMIA
  4. 4. Outcomes of acute inflammation
  5. 5. resolution• Restoration of site to normal• Usually occurs when 1. Limited or short lived 2. Little tissue destruction• Events
  6. 6. fibrosis• Connective tissue replacement• Occurs in cases of 1. Extensive destruction 2. Tissues incapable of regeneration 3. Abundant fibrin exudation
  7. 7. suppuration• When causative agent is pyogenic bacteria• Events
  8. 8. CHRONIC INFLAMMATION• When inflammation can not be resolved• In cases of 1. Persistence of agent 2. Interference with healing
  9. 9. MORPHOLOGICAL PATTERNS• SEROUS • THIN FLUID • Eg BLISTER OF BURN• FIBRINOUS • MORE SEV INJURY • FIBROGEN LEAKAGE CON TO FIBRIN • LINING OF BODY CAVITIES-MENINGES,PERICARDIUM • COR VILLOSUM/ BREAD AND BUTTER APP • MICRO-EOSINOPHILIC MESHWORK
  10. 10. MORPHOLOGICAL PATTERNS• SUPPURATIVE/ PURULENT • SOME PYOGENIC BACTERIA • LARGE AMTS OF PUS • ABSCESS-LOCALIZED COLLECTION OF PUS WITHIN A CAVITY• ULCER • LOCAL DEFECT IN SKIN OR MUCOSA • Eg PEPTIC ULCER
  11. 11. SEROUS EXUDATE• Bullous Pemphigoid,• Serous Inflammation Dermis Blister fluid Serous Exudate
  12. 12. FIBRINOUS EXUDATEpericardial cavityshows fibrinouspericarditis withstrands of stringy palefibrin between visceraland parietalpericardium
  13. 13. FIBRINOUS INFLAMMATION Fibrinous exudate pericardiumURAEMIC PERICARDITIS
  14. 14. PURULENT EXUDATE • Exuded yellowish fluid fluid in this opened pericardial cavity also contains a large number of acute inflammatory cells. So it is a purulent exudate
  15. 15. SUPPURATIVE INFLAMMATIONA BA: purulent exudate obscuring the sulci in pyogenic meningitis.B: purulent peritonitis D/T rupture of the colon.
  16. 16. ABSCESS • rounded abscesses (the purulent material has drained out after sectioning to leave a cavity) in the lung.
  17. 17. ABSCESS • Diverticulitis of Colon with abscess formation Abscess Sulfur granules of actinomycoses Lots of neutrophils
  18. 18. ULCER GrossGastroscopicView Microscopic view
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