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Acenano calcium   130800
 

Acenano calcium 130800

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The key to taking calcium supplement is the amount of calcium absorbed and bioavailability. ...

The key to taking calcium supplement is the amount of calcium absorbed and bioavailability.
Acenano Calcium has finest and narrowest particle size distribution in the market now, which maximize calcium absorption and bioavailability with lesser dosage.

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    Acenano calcium   130800 Acenano calcium 130800 Presentation Transcript

    • Ace Environment Pte Ltd Jul 13 Making Nano Powders Maintaining “As-Is” Ingredients Acenano Calcium Essential
    • Ace Environment Pte Ltd An Overlooked Market – Bone Health In USA, fracture due to osteoporosis:  1 in 3 women over 50 years & 1 in 2 over 60 years  1 in 5 men over 50 years & 1 in 3 over 60 years  10 million people over 50 years suffer from osteoporosis & 33 million have low bone density (osteopenia) In USA and Europe  The cost of treating osteoporosis fractures is ~USD48 billion annually  Cost burden of osteoporosis is forecast to USD131.5 billion by 2050 worldwide
    • Ace Environment Pte Ltd An Overlooked Market – Bone Health China  300% osteoporosis cases increase in the last 30 years Hong Kong  Women aged 65 over - 45% Osteoporosis / 42% Osteoponia Men aged 65 over - 13% Osteoporosis / 47% Osteopenia Total healthcare cost projected US$128 million by 2010 Japan  estimated 10 million osteoporosis patients Malaysia  51.8% urban Malaysian menopause aged women has mild osteoporosis There are no effective preventive products for the US$2 billion Calcium supplement market that promise increase in Bone Mineral Density (BMD) Figures taken from International Osteoporosis Foundation
    • Ace Environment Pte Ltd Current RDI (Reference Daily Intake) : 1,000mg If daily diet : (600mg) Lack of calcium intake : 400mg In USA, studies show that  44% boys and 58% girls ages 6-11  64% boys and 87% girls ages 12-19  55% men and 78% of women ages 20+ not meeting recommended intake for calcium Are We Taking Enough Calcium? RDA (Recommended Dietary Allowance) ---------------------------- 9~18 year 1,300mg 19~50 year 1,000mg 51+ year 1,200mg Pregnancy 1,300mg In the long run, inadequate calcium intake will causes low bone density which if untreated can lead to osteoporosis. Need Calcium Supplement!
    • Ace Environment Pte Ltd Taking Calcium Supplement Take more calcium supplement = more calcium absorption? Studies show that average 23%~27% of consumed elementary calcium will be absorbed (~10% of calcium carbonate) ie. Take 1,200mg Calcium carbonate, ~120mg elementary calcium will be absorbed How about the remaining unabsorbed calcium? Constipation? Intestinal Bloating? Kidney stone? The key to taking Calcium supplement is “The amount of calcium absorbed and bioavailability”
    • Ace Environment Pte Ltd What is good powder? 1. Fine (small size) 2. High purity 3. Narrow particle size distribution 4. Small agglomeration between primary particles 5. Good “flowability” (for better compaction and screen printing) 6. Stability against atmosphere 7. Homogeneous composition 8. Spherical morphology
    • Ace Environment Pte Ltd AceNano Calcium Essential  Very narrow particle size distribution  Near “Spherical” shape particle  Produced by world’s first 4D Dry Nano Pulverization Technology – Whole process is executed under DRY environment, doesn’t use WATER, impose no HEAT. Small agglomeration, good “flowability”, maintain “AS-IS” ingredients  Ebonite charged Calcium particle (an electrostatic charging process)  Micronized Calcium Carbonate from purest oyster shells  Finest calcium powder in the market now
    • Ace Environment Pte Ltd Nano Calcium Process 1st Ebonite Charge 4D Nano Pulverization 2nd Ebonite Charge Additive Vitamin D3, Proteins Purified cellulose (Optional) CaCO3 (Oyster Shell) Ebonite Charge (Electrostatic charging process) improves the bioavailability without the loss of nutrients, taste, smell, color. Grade “A - B” Two or more times of Nano pulverization Process Grade “C ”
    • Ace Environment Pte Ltd Calcium Nano Particle Acenano Calcium  Spherical shape Typical Calcium Carbonate  Needle shape  10µm to 100µm Grade A (Ca Essential)  30nm to 1µm 65%± 5%  More than 3µm <5% Grade B (Ca 7030)  30nm to 1µm 50%± 5%  More than 3µm <5%
    • Ace Environment Pte Ltd Guaranteed purity source of calcium carbonate supply Calcium Carbonate Source Free from mercury, arsenic, barium, cadmium, lead, chromium, silver & selenium Contains about 40% of Calcium
    • Ace Environment Pte Ltd Calcium Absorption Group Calcium content (mg) Absorption rate (%) Intake Discharge Calcium Carbonate 5.026 ±0.022 4.355 ±0.029 13.35 Nanocalcium L16 5.047 ±0.006 2.740 ±0.033 45.60 Nanocalcium L20 5.091 ±0.002 2.738 ±0.007 46.20 Nanocalcium L24 5.044 ±0.005 2.751 ±0.013 45.46 The calcium absorption of nano calcium is about 3.5 times of calcium carbonate  Calcium intake & discharge content  Internal absorption rate of SD rats after intake of calcium carbonate & nano calcium
    • Ace Environment Pte Ltd Effects of Nano Calcium Supplemented Milk on Bone Mineral Metabolism Animal Study (Korea)  Twenty four 7 weeks-old Sprague-Dawley female rats divided into 4 groups  Duration : 18 weeks  All rats were fed with 20mg/daily of milk containing different types of calcium supplement for 18 weeks  Nano calcium size 30nm~900nm  Water supply unlimited
    • Ace Environment Pte Ltd Observations:  There was a significant difference in calcium content of femoral weight in OVX4 compared to other groups.  Femoral bone mineral density was significantly greater in OVX4 than the other groups.  The OVX4 group also showed highest stiffness, maximum energy in femur and trabecular bone area. Conclusion: NANO CALCIUM supplement milk is proved as the most effective for the improvement and prevention from OSTEOPOROSIS being induced from bone Animal Study (Korea) The study was conducted by Department of Food Science and Technology, Sejong University, Korea
    • Ace Environment Pte Ltd Human Study – Open Label (Korea) Sub Pre- treatment After- treatment Duration 1 -3.86 -1.93 9 m 15 days 2 -2.11 -2.02 3 months 3 -2.81 -2.64 2 months 4 -0.75 +0.93 2 months 5 -0.16 +0.23 8 m 8 days 6 -0.81 -0.56 2 months 7 -4.76 -3.76 13 m 27 days 8 -1.59 -1.45 3 months 9 -3.88 -3.87 3 months 10 -1.59 -1.45 3 months Sub Pre- treatment After- treatment Duration 11 -3.41 -3.17 3 months 12 -3.15 -3.00 3 m 19 days 13 -1.55 -1.42 5 m 23 days 14 -0.91 -0.73 8 months 15 -2.13 -0.85 13 months 16 -4.74 -1.99 24 months 17 -1.54 -0.5 26 months 18 -1.69 +0.47 30 months Ave. -2.27 -1.32 9 months Result of BMD T-score for individual subjects (DEXA scan), aged 42 ~ 72 T-score :  -1 to 1 : Normal/healty bone density  -1 to -2.5 : Low bone density, may lead to osteoporosis  Below -2.5 : Have osteoporosis. The greater the negative number, the more severe the osteoporosis
    • Ace Environment Pte Ltd Human Study – Open Label (Korea) Results  Average pre-treatment BMD T-score of -2.27 increased to -1.32, an increase of 0.95 or nearly 10%. (1 SD difference in T-score equals a 10-15% increase of bone density).  The longer they take nano calcium, the increase in BMD is more pronounced!
    • Ace Environment Pte Ltd Clinical Study (USA)  49-subjects from Orange County, CA, USA  Double blind, placebo controlled (CaCO3)  19 in Bisphosphonate (Fosamax, Boniva, Actonnel)  30 in Non-Bisphosphonate  BMD per DEXA-SCAN (GE Lunar Prodigy System ) at 0 and 4th Month  Inclusion : BMD T-score < - 1.0  Dosage: 800mg/Day + Vitamin D3 800IU/Day  No change in life style(exercise), diet regime
    • Ace Environment Pte Ltd Clinical Study (USA) Bisphosphonate 19 Participants Disqualified 4 Nonbisphosphonate 30 Total Participants 53 Total Eligible Participants 49 Calcium 7030 15 CaCO3 15 Calcium 7030 10 CaCO3 9 Study Design
    • Ace Environment Pte Ltd Clinical Study (USA) T-score Change Calcium 7030 : +0.19 (2.3%) Placebo (CaCO3) : 0.00 T-score Change Calcium 7030 : +0.16 (2%) Placebo (CaCO3) : -0.11 DEXA Study Results (49 Subjects)
    • Ace Environment Pte Ltd Clinical Study (USA) A Cautious Hypothesis  T-Score increase 0.16 (=2%) in BMD for Non-Bisphosphonate Group T-Score increase 0.19 (=2.3%) in BMD for Bisphosphonate Group in 4 months, with 800mg/day of Calcium 7030, it is a significant improvement, without changing lifestyle patterns, suggesting possible reversal of BMD loss.  The increase in BMD could potentially be more pronounced with prolonged intake and/or increased dosage. The finest Calcium Nano powder to its fullest extend via Ebonite Charging to achieve maximum bioavailability
    • Ace Environment Pte Ltd Other Products  NEBDAI  Nano Red ginseng  Nano Mulberry leaf  Nano Green tea OEM more than 70 different types of nano powder for our clients in  Healthcare & biomedical  Electronic & semiconductor  Cosmetic  Other industries Other Nano Products & Services
    • Ace Environment Pte Ltd