The Dictionary
of Substances
and their Effects
Second Edition
The Dictionary
of Substances
and their Effects
Second Edition
EDITOR
S Gangolli,Consultant,MRC Toxicology Unit,UK
EDITORIA...
PRODUCTIONTEAM
Ken Wilkinson (Staff Editor)
Richard Ellis
Sally Faint
JulieHetherington
Alan Skull
The publishers make no ...
Contents
Volume 1
Foreword
Introduction
Guide to Content
A-B Compounds
Abbreviations
Glossary of Medical and BiologicalTer...
Foreword
The lifestyle of the modern world can only be sustained by the effective utilisation of
chemicals in the protecti...
Introduction
The risk evaluation of the potential adverse effects of a chemical on human health and the
ecosystem, widely ...
A number of important additions have been incorporated in this second edition. Apart from
updating the toxicological data ...
Guide to Content
The data for each chemicalin DOSE are organised as follows:
DOSE No.
Chemical name
Structure/line formula...
Dose No.
Each of the 4123 compounds in DOSE is identified by a unique, sequential alphanumeric
DOSE No. For example, the f...
Uses
Principal uses of the substances are given, with information on other sign
industrial processes.
ficant uses n
Occurr...
The airborne limits of permitted concentrations of hazardous chemicals represent conditions
under which it is believed tha...
The threshold limit values for the USA have been taken from the Threshold Limit Values and
Biological Exposure Indices, 19...
approved for the classification and labelling of substances and preparations dangerous for
supply [Chemicals(Hazard Inform...
Toxicityto other species
Toxicity to species other than mammals, birds, invertebrates and fish (e.g. reptiles,
amphibians,...
Carbonaceous inhibition
Another major biogeochemical process is the recycling of carbon via the decomposition of
complex o...
Mammalian and avian toxicity
Studies on mammalian species are carried out to determine the potential toxicity of
substance...
lrritancy
Chemical substances which cause irritation (itching,inflammation) to skin, eye and mucous
membranes on immediate...
Legislation
Any form of legislation, medical (food and drugs) or environmental from European,
American and worldwide sourc...
Note
The Royal Society of Chemistry (RSC)has only assessed published information in compiling
The Dictionary of Substances...
A-a-C
H
c33YNH2 /
CllH9N3 Mol. Wt. 183.21 CAS Registry No. 26148-68-5
Synonyms 2-amino-a-carboline; 2-amino-9H-pyrido[2,3-...
References
1.
2.
3.
4.
5.
6.
7.
8.
9.
IARCMonograph 1986,40,250.
Ohgaki,H. et a1Carcinogenesisfbndon) 1984,5,815-819.
Ram,...
Mammalian & avian toxicity
Acute data
LD50 intravenous mouse 180mg kg-1(5).
Teratogenicityand reproductive effects
Ingesti...
A3 acenaphthene
C12H10 Mol. Wt. 154.21 CAS Registry No. 83-32-9
Synonyms 1,2-dihydroacenaphthylene; 1,8-ethylenenaphthalen...
Degradation studies
Microbialdegradation from initial aqueous phase concentrationof 1mg 1-1 to non-detectable levelsoccurr...
References
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
31.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
Holcombe, G. W. et al Ec...
Occupational exposure
UN No.2570
Ecotoxicity
Bioaccumulation
Bullhead catfish(BlackRiver, Ohio)and stripedbass (PotomacRiv...
References
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
Health Eflects Assessmentfor Acenaphthylene 1987...
Ecotoxicity
Fish toxicity
LC50 (96hr) rainbow trout, largemouth black bass >1000,1725 mg 1-1, respectively(1).
LC50 (96hr)...
Dietary exposure to 25,100 and 400ppm inhibited brain acetylcholinesteraseactivitybut did not affectplasma
basal luteinisi...
References
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
The PesticideManual 11th...
Mammalian & avian toxicity
Acute data
LDm oral rat, rabbit, mouse 3500-4600mg kg-1 (1-3).
LC5o (4 hr) inhalation rat 4000 ...
Supply classification extremelyflammable, harmful
Risk phrases Extremely flammable-Irritating to eyes and respiratory syst...
whereas 10pg ml-1 induced growth retardation and teratogenic effects.No effectswere seen when 10-day
embryos were exposed ...
23.
24.
25.
26.
27.
28.
29.
30.
31.
32.
33.
Giavini, E. et a1In VitroCell. Dev.Biol.:Anim. 1992,28A(3,Part l),205-210.
Mor...
Other effects
Otheradverseeffects (human)
Poisoning of a family of four at an unspecifiedexposure level has been reported,...
Abiotic removal
The photolytic t1/2 of acetaldoximewas calculated to be 7.3days (5).
Mammalian & avian toxicity
Acute data...
Environmentalfate
Nitrification inhibition
At 100mg 1-1 no inhibition of NH3 oxidation by Nifrosomonasspp. (3).
Mammalian&...
AII acetanilide
NHCOCH3
I
Physical
CsHgNO Mol. Wt. 135.17 CAS RegistryNo. 103-84-4
Synonyms acetylaminobenzene; acetylanil...
LD50 intraperitoneal mouse 500 mg kg-1 (11).
Classifiedas harmful using the acute-toxic-classmethod, an alternative to the...
PhysicaI properties
M. Pt. 17°C B. Pt. 118°C Flashpoint 39°C (closedcup) Specific gravity 1.049at 25°C with respect to wat...
Mammalian & avian toxicity
Acute data
LD50 oral rat 3310mg kg-1 (11).
LC50 (1hr) inhalation guinea pig 5000ppm (12).
LD50 ...
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
Freeman,C. et a1Fertility Sterility 1973,24,884-890.
Barrett, J.et a1Neurobehu...
Invertebratetoxicity
Cell multiplication inhibition test, Pseudomonas putidu 1150mg 1-1, Scenedesmus quadricuuda 3400 mg 1...
AM acetochlor
COCH2CI
"'
CH3CH20CH2
C14H20C1N02 Mol. Wt. 269.77 CAS Registry No. 34256-82-1
Synonyms 2-chloro-N-(ethoxymet...
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B
Upcoming SlideShare
Loading in...5
×

The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B

3,412

Published on

0 Comments
1 Like
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total Views
3,412
On Slideshare
0
From Embeds
0
Number of Embeds
4
Actions
Shares
0
Downloads
304
Comments
0
Likes
1
Embeds 0
No embeds

No notes for slide

The Dictionary of Substances and Their Effects (DOSE): Volume 01 A-B

  1. 1. The Dictionary of Substances and their Effects Second Edition
  2. 2. The Dictionary of Substances and their Effects Second Edition EDITOR S Gangolli,Consultant,MRC Toxicology Unit,UK EDITORIAL ADVISORY BOARD Dr D Anderson, BIBRA International, UK Dr J Chadwick, Health and Safety Executive, UK Professor L Ebdon, University of Plymouth, UK Dr D Gammon, California €PA,USA Professor L King, University of Surrey, UK Dr R McClellan, ChemicalIndustry Institute of Toxicology,USA Professor I Rowland, Universityof Ulster,UK Dr J Solbk, Unilever,UK Dr T Sugimura, National CancerCentre,Japan Professor P van Bladeren, 7"Nutrition and Food Research Institute, TheNetherlands RSeCROYAL SOClEN OF CHEMISTRY
  3. 3. PRODUCTIONTEAM Ken Wilkinson (Staff Editor) Richard Ellis Sally Faint JulieHetherington Alan Skull The publishers make no representation, express or implied, with regard to the accuracy of the information contained in this book and cannot accept any legal responsibility or liability for any errors or omissions that may be made. Volume 1 ISBN 0-85404-808-1 Seven-volume set ISBN 0-85404-803-0 A catalogue record for this book is available from the British Library. 0The Royal Society of Chemistry 1999 All rights reserved Apart from any fair dealing for the purpose of research or private study, or criticism or review as permitted under the terms of the UK Copyright, Designs and Patents Act, 1988, this publication may not be reproduced, stored or transmitted, in anyformor by any means, without the prior permission in writing of The Royal Society of Chemistry, or in the case uf reprographic reproduction only in accordance with the terms of the licences issued by the Copyright Licensing Agency in the UK, or in accordance with the terms of the licences issued by the appropriate Reproduction Rights Organisation outside the UK. Enquiries concerning reproduction outside the terms stated here should be sent to The Royal Society of Chemistry at the address printed on this page. Published by The Royal Society of Chemistry, Thomas Graham House, Science Park, Milton Road, Cambridge, CB4 OWF, UK Typeset by Land & Unwin (Data Sciences)Ltd, Bugbrooke, UK Printed and bound by Bookcraft (Bath)Ltd., UK
  4. 4. Contents Volume 1 Foreword Introduction Guide to Content A-B Compounds Abbreviations Glossary of Medical and BiologicalTerms Glossary of Organism Names Volume 2 Guide to Content C Compounds Volume 3 Guide to Content D Compounds Volume 4 Guide to Content E-J Compounds Volume 5 Guide to Content K-N Cornpounds Volume 6 Guide to Content 0-SCompounds Volume 7 Guide to Content T-Z Compounds Index of ChemicalNames and Synonyms Index of CASRegistry Numbers Index of Molecular Formulae vii ix xi 863-865 1-862 867-88 1 882-889 vii 1-865 vii 1-832 vii 1-892 vii 1-953 vii 1-952 vii 1-712 713-91 4 915-956 957-998
  5. 5. Foreword The lifestyle of the modern world can only be sustained by the effective utilisation of chemicals in the protection of our health, production of our food, manufacture and commerce. Yet these same chemicalsin the wrong place can have potentially harmful effects. To understand the quantitative risks to human health and ecosystems,reliable information is required about the substances and their biological effects.The Dictionary of Substances and their Efiects (DOSE)seeks to provide such information comprehensively yet in an easily accessible format. As our understanding of the complexity of life and the intricate interactions which sustain ecosystems has grown, so has our requirement for information. The toxicologist, ecotoxicologist,and users and suppliers of chemicals need to know the properties, chemistry, biological effects and likely use of substances. Yet too often comprehensive data are difficult to obtain. The first edition of DOSE was hailed as an important breakthrough for those who needed a comprehensive and reliable compilation of data on chemicals with environmental impact. This second edition significantly updates the toxicological data and extends the number of chemicalsto 4123. While regulators might argue that the provision of toxicological data should be the responsibility of chemicalsuppliers, the reality is that often when such data are supplied they are overly brief or ridiculously over-cautious. I recently received a sample labelled "tap water" with the warning that it contained "hydrogen, which is a flammable substance". To have a single compilation of data, collected only from the peer-reviewed literature, and published under the authoritative imprimatur of the Royal Society of Chemistry, is surely the most effectiveanswer to this problem. The editorial team which has brought together this excellent second edition is to be congratulated on its achievement. DOSE will allow users to identify the hazards pertaining to given substances readily. Professor Lord Lewis in his introduction to the first edition emphasised the difference between hazard identification and risk assessment. Lord Lewis stressed the need for training to evaluate risks quantitatively and, in particular, the risks posed by combinations of chemicals.He quoted Paracelsus, the father of toxicology, and his famous dictum often translated as "the dose maketh the poison". In a world reliant on chemicals, but with an environment seriously threatened by anthropological damage, DOSE will enable scientists and regulators to ensure that the dose received by the organism will be far less than poison, indeed below that which has an effect. Professor Les Ebdon Deputy Vice-Chancellor(Academic) University of Plymouth vii Foreword
  6. 6. Introduction The risk evaluation of the potential adverse effects of a chemical on human health and the ecosystem, widely recognised by regulatory agencies as being of vital importance for the protection of man and his environment, requires the assessment of a broad range of information on the chemistry and biological properties of that chemical. Except for certain special human and veterinary medicine and some agrochemicals,relevant data for the vast majority of chemicals traded commercially are either not available or sparsely dispersed in the scientific literature. Thus, the assessment of the health and environmental risks of a chemical would be an onerous task without access to a single comprehensive compilation of relevant information. In the publication of the first edition of The Dictionary of Substances and their €fiects (DOSE), the Royal Society of Chemistry addressed the formidable logistical problems faced by scientists in obtaining the relevant data for the risk assessment of chemicals due to the paucity of publications containing compilations of appropriate data. The aim of this acclaimed publication was to collect and collate relevant chemical and biological data from peer-reviewed scientific literature to provide information for the quantitative risk evaluation of a chemical at its various levels of usage and conditions of exposure. The chemicals in the first edition were selected mainly from sources such as the Authorised and Approved List from the EC’s Classification, Packaging and Labelling Regulations; the EC’s “Black” and “Grey” lists of dangerous substances; the ”Red” list prepared by the UK Department of the Environment; and the Priority Pollutant Lists from the USA and Canada, and the German Pollutant List. Data considered to be of relevance for each of the 4003 chemicals in the first edition included physico-chemical properties; toxic effects on various species in the ecosystem; persistence and degradability in the environment; and toxicity data, encompassing genotoxicity, reproductive effects and toxicokinetic studies in avian and mammalian species,including man. Relevant legislativeinformation was also included. The success of the first edition of DOSE as a unique reference source of essential information for the risk evaluation of chemicals was clearly reflected by sales, encouraging reviews and, most importantly, the favourable comments received from users. Since the publication of the first edition there has been a year on year increase in the numbers of research papers on topics relevant for the risk assessment of chemicals in the literature. These considerations, together with the burgeoning literature on the toxicology of chemicals subsequent to the publication of the first edition, were persuasive factors in influencing the Royal Society of Chemistry to embark on the preparation of the present second edition of DOSE. Relevant information is reported in DOSE if it has been published in the scientific literature, and it is interesting to note that toxicity data on many industrial chemicals are still not available. A recent US Environmental Protection Agency study1 has shown that, of the estimated 3000 high production volume chemicals (i.e. in excess of 1million pounds/annum) produced or imported in the USA, only 7%had a full set of basic toxicity data, and 43% had no toxicity data at all. 1.Pesticide and Toxic Chemical News 1998, 26 (28), 7-8. ix Introduction
  7. 7. A number of important additions have been incorporated in this second edition. Apart from updating the toxicological data for the original compounds in the first edition, the number of compounds has increased to 4123. Special classes of chemicals have been added, including several endocrine disrupting chemicals, a number of pesticides, a few of the high production volume chemicalsfor which data have recently been collected by the OECD, and compounds tested for carcinogenicityby IARC and/or NTP. Risk and safety phrases have been updated, and some headings have been changed to conform with current practice and convention. A new field, Toxicity to other species, has been included, occupational exposure data have been expanded to include values for France, Germany, Sweden and Japan as well as for the UK and USA. RTECS and EINECSnumbers have also been included in the entries. It is my fervent hope that the second edition of DOSE will constitute a scientifically sound foundation and a paradigm for future publications that will be required to satisfy the need for accurate and timely data in this important field. I am grateful to members of the Editorial Advisory Board for their helpful suggestions and advice. I must also place on record my sincere thanks to the staff members of the Royal Society of Chemistry for their invaluable support and cooperation in the preparation of this edition of DOSE. Sharat Gangolli Editor Introduction X
  8. 8. Guide to Content The data for each chemicalin DOSE are organised as follows: DOSE No. Chemical name Structure/line formula Molecular formula Molecular weight CAS Registry No. Synonyms EINECS No. RTECS No. Uses Occurrence Physical properties Melting point Boiling point Flash point Specific gravity Partition coefficient Volatility Solubility Occupational exposure Limit values UN number HAZCHEM code Conveyanceclassification Supply classification Risk phrases Safety phrases Ecotoxicity Fish toxicity Invertebrate toxicity Toxicity to other species Bioaccumulation Environmental fate Nitrification inhibition Carbonaceous inhibition Anaerobic effects Degradation studies Abiotic removal Adsorption and retention Mammalian and avian toxicity Acute data Sub-acuteand sub-chronic data Carcinogenicityand chronic effects Teratogenicity and reproductive effects Metabolism and toxicokinetics Irritancy Sensitisation Genotoxicity Other effects Other adverse effects (human) Any other adverse effects Legislation Other comments References These headings only appear in an item when data have been identified for that heading. The user can, therefore, assume that the absence of a heading means that no relevant data were retrieved from the sources examined. xi Guide to Content
  9. 9. Dose No. Each of the 4123 compounds in DOSE is identified by a unique, sequential alphanumeric DOSE No. For example, the first compound in DOSE, A-a-C,has DOSE No. A2;the last entry, zoxazolamine,has DOSE No. 225. Chemical name In general, the chemical name is the common name of the substance, for example nitrobenzene. If it is not possible to allocate a precise chemical name (i.e.if the substance is of unknown or variable composition,or consistsof biological materials),a short phrase appears instead, for examplechlorinated parafins (C12, 60%). Molecular formula This is the elemental composition of the compound. The elements appear alphabetically for inorganic compounds, i.e. Ag2C03, C12Cr, etc, but for organic compounds, carbon and hydrogen content are shown first followed by the other elements in alphabetical order, i.e. CbHSBr. Molecular weight This is directly calculated from the molecular formula. No molecular weights are given for polymers. CAS Registry No. The CAS Registry No. is a number sequence adopted by the Chemical Abstracts Service (American Chemical Society, Columbus, Ohio, USA) to uniquely identify specific chemical substances. The number contains no information relating to the chemical structure of a substance and is, in effect, a catalogue number relating to one of the millions of unique chemical substances recorded in the CASRegistry.New numbers are assigned sequentiallyto each new compound identified by Chemical Abstracts Service. This information is also provided in the full index of CAS Registry Numbers available at the end of Volume 7. Synonyms For common chemicals, several chemical names and numerous trade names may be applied to describe the chemical in question. Many of these names are identified to aid users on the range of names which have been used to describe each substance. EINECS No. This number is assigned by the European Commission to each record in the EINECS (EuropeanInventory of Existing Commercial Chemical Substances)inventory. The numbers are in the format XXX-XXX-X, for example, 202-726-0 for nitrobenzene. RTECS No. The RTECS (Registry of Toxic Effectsof Chemical Substances)number is a unique identifier assigned by NIOSH (NationalInstitute of OccupationalSafetyand Health in the US) to every substancein the RTECS database. The number is in the format of two alphabetic characters followed by seven numeric characters,forexample, D A 6475000for nitrobenzene. Guide to Content xii
  10. 10. Uses Principal uses of the substances are given, with information on other sign industrial processes. ficant uses n Occurrence Natural occurrences, whether in plants, animals or fungi are reported. Physical properties Melting/Boiling point These data are derived from various sources. Flash point The flash point is the lowest temperature at which the vapours of a volatile combustible substance will sustain combustion in air when exposed to a flame. The flash point information is derived from various sources.Where possible the method of determination of the flash point is given. Specific gravity (density) The specific gravity of each substance has been derived from a variety of sources. Where possible the data have been standardised. Partition coefficient Partition coefficients, important for structure-activity relationship considerations, particularly in the aquatic environment, are indicated. Ideally the n-octanollwater partition coefficient is quoted. The major data source for this measurement is: Sangster,J J. Phys. Chem.ReF Data 1989,18(3),1111-1229 Where no reference is quoted, it can be assumed that the information was derived from this source. VolatiIity The vapour pressure and vapour density are quoted where available. Where possible, the data have been standardised. Solubility Solubility data derived from several sources are quoted for both water and organic solvents where available. Occupational exposure Limit values This field contains the occupational exposure limit values (or threshold limit values) from France, Germany,Japan, Sweden, UK and USA. Guideto Content ... Xlll
  11. 11. The airborne limits of permitted concentrations of hazardous chemicals represent conditions under which it is believed that nearly all workers may be repeatedly exposed day after day without adverse effect. These limits are subject to periodic revision and vary between differentcountries. The term threshold limit relates primarily to the USA, but equivalent terms are available in most industrialised countries. The data relates to concentrations of substances expressed in parts per million (ppm)and milligrams per cubic meter (mgvi3). French exposure limits are published by the French Ministry in Charge of Labour and presented in the report Valeurs limites d’exposition professionnelle aux agents chimiques en France (ND 1945-153-93).The values in DOSE have been taken from the 1998 edition. The FR-VLE values are short-term limits (15minutes), and FR-VME values are long-term limits (8hours). German data currently include the national MAK values where available. The MAK value (Maximale Arbeitsplatz-Konzentration) is defined as the maximum permissible concentration of a chemical compound present in the air within a working area which, according to current knowledge, does not impair the health of the employee or cause undue annoyance. Under those conditions, exposure can be repeated and of long duration over a daily period of eight hours, constituting an average working week of 40 hours. MAK values are published by the Geschaftsstelle der Deutschen Forschungsgemeinschaft, Bonn, in ”Maximum Concentrations at the Workplace and Biological Tolerance Values for Working Materials.” The values in DOSE have been taken from the 1998edition. Japanese exposure limits are those recommended by the Japanese Society of Occupational Health. Unless otherwise indicated, these values are long-term exposure limits (the mean exposure concentration at or below which adverse health effects caused by the substance do not appear in most workers, working 8 hours a day, 40 hours a week under a moderate workload). The values in DOSE were published in 1997. Swedish data can include short-term exposure limit, a level limit, or a ceiling limit. The values in DOSE were adopted in 1996. In the UK occupational limits relating to airborne substances hazardous to health are published by the Health and Safety Executive annually in Guidance Note EH40. The values in the DOSE items have been taken from the 1999edition. There are Maximum Exposure Limits (MEL)in the UK which are subject to regulation and which should not normally be exceeded. They derive from Regulations, Approved Codes of Practice, European Community Directives, or from the Health and Safety Commission. In addition, there are Occupational Exposure Standards (OES) which are considered to represent good practice and realistic criteria for the control of exposure. In an analogous fashion to the USA Threshold Limits, there are long-term limits, expressed as time-weighted average concentrations over an 8-hour working day, designed to protect workers against the effects of long-term exposure. The short-term exposure limit is for a time-weighted average of 15minutes. For those substances for which no short-term limit is listed, it is recommended that a figure of three times the long-term exposure limit averaged over a 15-minute period be used as a guideline for controlling exposure to short-term excursions. Guide to Content xiv
  12. 12. The threshold limit values for the USA have been taken from the Threshold Limit Values and Biological Exposure Indices, 1999 produced by the American Conference of Governmelital Industrial Hygienists, Cincinnati, USA. The limits relate to Threshold Limit - Time Weighted Average, Threshold Limit - Short Term Exposure Limit and Threshold Limit - Ceiling Limit. The Threshold Limit Value -Time Weighted Average (TLV-TWA)allows a time-weighted average concentration for a normal %hour working day and a 40-hour working week, to which nearly all workers may be repeatedly exposed day after day, without adverse effect. The Threshold Limit Value - Short Term Exposure Limit (TLV-STEL) is defined as a 15-minute, time- weighted average which should not be exceeded at any time during a work day, even if the &hour time-weighted average is within the TLV. It is designed to protect workers from chemicals which may cause irritancy, chronic or irreversible tissue damage, or narcosis of sufficient degree to cause the likelihood of accidental injury. Many STELs have been deleted pending further toxicological assessment. With Threshold Limit - Ceiling Values (TLV-C)the concentration should not be exceeded during any part of the working day. UN number The United Nations Number is a four-figure code used to identify hazardous Chemicals and is used for identification of chemicals transported internationally by road, rail, sea and air. In the UK this number is also called the ”SubstanceIdentificationNumber” or “SI Number”. HAZCHEM code The Hazchem Code is used to instruct United Kingdom emergency services on equipment, evacuation and other methods of dealing with transportation incidents. It is administered by the Chemical Industries Association. Conveyance classification The information presented for the transportation of substances dangerous for conveyance by road is derived from the UK’s Approved Carriage List, Health and Safety Commission, UK. Supply classification The information presented for the supply of substances is derived from the UK’s Approved Supply List: information approved for the classification and labelling of substances and preparations dangerous for supply [Chemicals (Hazard Information and Packaging) Regulations 1999(CHIP99)*]Health and Safety Commission,UK. Risk and safety phrases Risk and safety phrases used in connection with DOSE items are approved phrases for describing the risks involved in the use of hazardous chemicals and have validity in the United Kingdom and throughout the countries of the European Community. The approved texts have designated R (Risk) and S (Safety) numbers from which it is possible to provide translations for all approved languages adopted by the European Community. The risk and safety phrases quoted in DOSE relate to the UK’s Approved Supply List: information *At the time of going to press the Health and Safety Commission, UK announced that an amendment (Amendment No. 2) to the CHIP 99 regulations is intended to come into force on 1January 2000. The supply classificationsand the risk and safety phrases reported in this edition of DOSE do not include any changes which are proposed in Amendment No. 2 to CHIP99. Thesechanges are incorporated in the updates to the electronicversions of DOSE released after 1January2000. xv Guideto Content
  13. 13. approved for the classification and labelling of substances and preparations dangerous for supply [Chemicals(Hazard Information and Packaging) Regulations, 1999(CHIP99)] Health and Safety Commission, UK. The risk and safety phrases should be used to describe the hazards of chemicals on data sheets for use and supply; for labelling of containers, storage drums, tanks etc., and for labelling of articles specified as dangerous for conveyanceby road. (Seealso footnote on page xv.) Ecotoxicity Information is presented on the effectsof chemicals on various ecosystems. Results of studies carried out on aquatic species, primarily fish and invertebrates, but also fresh water and marine microorganisms and plants are reported. Persistence and potential for accumulation in the environment and any available information on the harmful effects to non-target species, i.e. the unintentional exposure of terrestrial and/or aquatic species to a toxic substance is given. Ecotoxicologycan be defined as that science involved in the study of the production of harmful effects by substances entering the natural environment, especially effects on populations, communities and ecosystems; or as the study of the effects of chemicals on ecosystems and their non-human components. An essential part of the ecotoxicology is the assessment of movement of potentially toxic imbalance through environmental compartments and through food webs. Ecotoxicology, unlike human toxicology, is more concerned with the effects to populations than to individuals. Human toxicology is based on the extrapolation of data from many species to one species man, whereas ecotoxicology necessitates the extrapolation from a few species to many, or from limited field data to entire ecosystems. Ecotoxicologymust not be confused with environmental toxicology which is the direct effects of environmental chemicals to humans. The term environmental toxicology should only be applied to the study of direct effects of environmental chemicals on human beings. Although the main thrust of preventative toxicology is in the area of human health, it is becoming increasinglyevident that human health is intimately connected with conditions in the natural environment. Chemicals released into the environment far from human habitation may become a health hazard for humans through food chain accumulation. Other chemicals may adversely affectcrop growth or kill economically important fish stocks or bird life. Fish toxicity LC50 values, with duration of exposure, are quoted for two species of freshwater and one marine species if available. Any additional information on bioassay type (static or flow through) and water condition (pH, temperature, hardness or oxygen content) is reported. Invertebratetoxicity LC50values with duration of exposure, are quoted for molluscs and crustaceans. EC50 values, i.e. concentrations which will immobilise 50% of an exposed population, are given for microbes, algae and bacteria. Values which will inhibit microbial or algal growth are reported. Duration of exposure is given when available. Guideto Content xvi
  14. 14. Toxicityto other species Toxicity to species other than mammals, birds, invertebrates and fish (e.g. reptiles, amphibians, plants, seaweeds), is reported here. LD50, LC50 and EC50 values are given with duration of exposure, concentration and as much supplementary information as possible. Bioaccumulation Bioaccumulation, biomagnification and bioconcentration data are quoted primarily for fish, invertebrates, bacteria and algae. Bioaccumulation is the progressive increase in the amount of a chemical in an organism or part of an organism which occurs because the rate of intake exceeds the organism’s ability to remove the substance from its body. Bioconcentration is a process leading to a higher concentration of a chemical in an organism than in its environment. Lastly, biomagnification is a sequence of processes in an ecosystem by which higher concentrations are attained in organisms at higher trophic levels, i.e. at higher levels in the food chain. EnvironmentalFate Degradation data are used to assess the persistence of a chemical substance in the environment, in water, soil and air. If the substance does not persist, information on the degradation products is also desirable. Intermediates may be either harmless or toxic substances which will themselves persist. Degradation occursvia two major routes, microbial degradation utilising microorganisms from a variety of habitats and decomposition by chemical methods. Microbial degradation is associated with the production of elemental carbon, nitrogen and sulfur from complex molecules. Standard biodegradation tests estimate the importance of microbial biodegradation as a persistence factor. Most tests use relatively dense microbial populations adapted to the compound being studied. Rapid degradation results in these tests implies that the compound will degrade under most environmental conditions, although specialised environments where degradation would not occur can exist. Compounds which are not readily degradable are likely to persist over a wide range of environmental situations. Chemical degradation processes include photolysis, hydrolysis, oxidation and removal by reversible/irreversible binding to sediment. Factors which influence degradation rates, such as duration of exposure, temperature, pH, salinity,concentrations of test substance, microbial populations, and other nutrients, must also be taken into account. Due care must also be given when metabolism results in th