Redesigning healthcare, biohacking our lives (IMEC ITF2014)

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On our way to redesign healthcare, we will learn to combine different layers of our biological code (now in reading but soon in writing mode), data from visible and invisible sensors, and the connected Internet of Bodies/Things. These guardian angels will open up unseen opportunities for the way we deal with ourselves in health and disease. With DNA soon becoming the new software, combining biology, electronics, attractive design & smart communication will provide the tools to (bio)hack our lives.
Appropriate use of different (nano)technologies will convert us into health consumers, with our doctors as (virtual) coaches. This will move us away from current curative healthcare to precise, preventive and even augmented healthcare. But smart technologies and the data they generate, are just a tool. When not trusted by the established care provider, when not integrated and available in a personal data platform, healthcare will only be pseudo modernized. The real magic happens when these tools allow you to engage and change behaviour. But even in a rapidly automating world, we can’t automate such change. Or can we?

Redesigning healthcare, biohacking our lives (IMEC ITF2014)

  1. 1. Redesigning healthcare, biohacking our lives Prof. Dr. Koen Kas @kaskoen IMEC ITF2014 June 5, 2014
  2. 2. The Chinese paid their doctor to remain healthy As soon as they got sick, they no longer had to pay
  3. 3. Redesigning healthcare like reinventing the wheel WaterWheel, Cynthia Koenig Bill Gates was a hacker Unix Hacks ended up being MS DOS
  4. 4. While the term “hacker” has had inappropriately negative connotation, “hacking” simply means challenging seemingly entrenched problems by testing innovative concepts and ideas through the rapid building and testing of inchoate and low-cost prototypes. Though, “hacking” has its origins in software development, this approach is now being applied to tackle a range of social issues from education, climate to governance. And soon from healthcare. Technology alone cannot necessarily deliver change. However, well-designed, user- informed digital tools can influence individual behaviour and disrupt traditional cultural norms by making information more accessible, systems more transparent, and ultimately by giving a voice to more people. “Biohacking" is a techno-progressive cultural and intellectual movement which advocates for open access to genetic information and defends the potential of truly democratic technological development. It can also refer to managing one's own biology using a combination of medical, nutritional and electronic techniques. Wikipedia
  5. 5. Current healthcare system has expired 100 € spend on healthcare, 1 € goes to prevention 90 € to last 2 years of our lives
  6. 6. An aging agenda ALARMclock, fig Calico
  7. 7. Chronic disease epidemics INTERFERE today Odra Noel Projected rise chronic diseases 2003-2023
  8. 8. “Doctors pour drugs of which they know little, to cure diseases of which they know less, into patients of whom they know nothing” “There is nothing wrong with his heart, hence it should be the liver” Moliere, French author (1622-1673)
  9. 9. a chronic patient looks after himself Biomarkers Internet of bodies / things (In)visible sensors Guardian angels to the rescue
  10. 10. Age of genomic medicine: predisposed ? - No problem First Warning systems 3.000.000.000 commodity
  11. 11. Personal genomics’ Napster moment ? De-risk conception
  12. 12. Personalised medicine litigation Why we need on the spot tumor detection - liquid biopsies Wagle et al. J. Clin Oncol, 2011
  13. 13. INanoBioGenapsys The era of Personal genome analysers Medic
  14. 14. Age of self monitoring: Wearables - Dermals - Insideables Quantifying smartphones, watches, tricorders, … stickies
  15. 15. Higi The quantified citizen / patient: get your stats, easy entry Healthspot Self-service sexual health express clinic, SoHo, London Be Well Point MD Revolution
  16. 16. The dash Empowerment of citizen - local @home, sports club, car June bracelet CarePredict Hapifork Lumo Qardio
  17. 17. The smartphone (/watch/glass/lens) physician AliveCor ECG iExamine, Welch Allyn iBGStar Blood Glucose Meter Qardio Sensimed Cardiosleeve, Rijuven BasisVital Connect
  18. 18. Sensors in clothing First Warning systems Athos Reebok OM Signal LifeVest LECHAL
  19. 19. Mobisante Baby, baby Bellabeat Sproutling Owlet 3D Babies
  20. 20. MC10 Temporary tattoos - Stick-on skin circuits Rogers & Huang, Northwestern
  21. 21. FDA approved colonoscopy (powering) Submarines, stickies & cyborgs Implantable piezoelectric nanoribbon
  22. 22. Gerijoy pet therapy Communication pending dehydration Son et al., Nature Nanotech 2014 Vittel
  23. 23. Dawn of "personal logging“ era Samsung/IMEC Simband / SAMI To succeed, hardware needs software to make it sing Apple
  24. 24. The cloud gets a brain A trusted 1st or 2nd opinion Doctors prescribing Apps WellDoc
  25. 25. Social, connected & transparent healthcare Digital epidemiology & growing patient awareness D Kinsa
  26. 26. Telehealth by image, facial, voice recognition PEEK
  27. 27. RealView Imaging VirtualWare New imaging modalities - Virtual exercising DevMotion
  28. 28. Sitting is the new smoking … Walkstation, Steelcase Moscow trainstation Paofit
  29. 29. Moves (Facebook) Argus Healthcare becomes attractive, fun, engaging
  30. 30. RaceYourself Motivational games – Digital meets physical
  31. 31. Flappy Bird ->Tappy Fit FitBit If my doctor prescribes a stepcounter – or a walk in the park
  32. 32. Automating behavior: IFTTT & virtual coaches BaseHealth OptimizeMe
  33. 33. Betting on therapy adherence Proteus Digital Health GlowCaps (Vitality) Mango Health
  34. 34. From measuring brainwaves to electroceuticals Emotiv EPOC FOC.US
  35. 35. Gaming fear & anxiety away - Communicating your mood Sensoree Neurowear
  36. 36. Training brain patterns of empathy using brain imaging J. Moll, PlosOne, 2014 Affective brain-computer interfaces
  37. 37. Bionic ear: cohlear implant delivers gene therapy Shepherd & Wise, Univ. Melbourne Osteoid Medical Cast Ultrasound bone fracture healing
  38. 38. Argus II, Second Sight Human computer interfaces Titan arm DekaEkso bionic suit
  39. 39. DNA is the new software/memory: 1 g DNA = 700 terabytes Rothemund, Nature, 2006
  40. 40. Using CAD software, building 3D DNA structures & easily synthesizing them,… Based on TED talk Ido Bachelet, Nano-Center Bar Ilan University, Israel (May 17, 2013) Project Cyborg, Autodesk
  41. 41. … to DNA nanorobots (OFF state) … to ON state Shells loaded with cargo (drug molecules, proteins,…) Ido Bachelet
  42. 42. Nanobots behave like groups of animals Ido Bachelet
  43. 43. Merging bio & digital: nanobots controlable via internet i.e. via my doctors smartphoneIdo Bachelet
  44. 44. BITalino DIY & Biohacker (maker) spaces Glowing Plant e-Health Sensor Shield
  45. 45. Biohacking allows return to the original roots of healthcare * * Modified from a quote by R. Bethencourt, Berkeley BioLabs Some self-funded amateurs “I think the biggest innovations of the 21st century will be at the intersection of biology and technology. A new era is beginning.”
  46. 46. 4 DIMENSiOn AL redesigned future of healthcare DI gital M obile EN gaging S ocial integrated Omics-based quantified A ttractive L ocal Predictive, Personalised/Precise, Participatory, Preventive Not about being sick, but about you staying well & healthy La Sienta Sudios
  47. 47. Contact Prof. Dr. Koen Kas E koen.kas@inbioveritas.com W http://inbioveritas.com/ L be.linkedin.com/in/koenkas T @kaskoen S koenkas

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