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Doxycycline-tetracycline
 

Doxycycline-tetracycline

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pharmacodynamics of tetracycline

pharmacodynamics of tetracycline

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    Doxycycline-tetracycline Doxycycline-tetracycline Presentation Transcript

    • Amin ullah Daavi Roll no 215
    • Introduction. Chemical structure of doxycycline. Mechanism of action. Resistance. Antimicrobial activity. Clinical uses. Adverse effect. Contraindication.
    •  Doxycycline is a synthetic broad spectrum antibiotic drug derived from tetracycline which inhibit protein synthesis.
    • A. Short acting(6-8 hours)  Chlortetracycline  Oxytetracycline B. Intermediate acting (12 hrs)  Demeclocycline  Methacycline C. Long acting(16-18 hours)  Doxycycline  Minocycline
    • Doxycycline reversiably bind to 30s subunit at A site Block the binding of aminoacyl t-RNA to m-RNA inhibit the addition of new aminoacid to growing peptide chain Stop the translation process
    • Mechanism of resistance. Impaired influx or increase efflux Ribosomal protein production that interfere the binding of doxycycline Enzymatic inactivation
    • Tet (AE)efflux pump Resistance. Tet(M) efflux pump Resistance. Tet(K) efflux pump susceptible.
    • Doxycycline are sensitive against  Many gram-positive and gram-negative bacteria.  Bacillus anthracis.  Staphylococcus aureus.  Listeria monocytogenes.  Mycoplasma pneumoniae.  Chlamydiae and spirochetes.  Rickettsiae .  Vibrio cholera.  Neisseria gonorrhoea.  Haemophilus influenzae.
    •  Doxycyline is the drug of choice in infaction caused by  Mycoplasma Pneumonia.  Rickettsiae Rocky mountain spotted fever and rickettsial pox.  Chlamydia Trachoma and peittacosis.  Vibrio Cholera.  Bacillus anthracis Anthrax.  Spirochetes Lyme’s disease.
    • Doxycycline use in a regimen for treatment of gastic ulcer caused by helicobacter pylori Also with amino glycoside for plague, tularemia and brocellosis
    • A. Gastrointestinal adverse effects Nausea vomiting and diarrhea. B. Bony structures and teeth During pregnancy it can deposited in fetal teeth leading to fluorescence ,discoloration and enamel dysplasia. C. Liver toxicity Hepatic toxicity leading to hepatic necrosis.
    • D. Kidney toxicity. E. Local tissue toxicity. F. Vestibular toxicity. G. Photosensitizat ion.
    • Hypersensitivity Pregnancy Infants and children
    • Basic and clinical pharmacology (11th edition) Chapter 44(796-799) Lippincoatt’s illustrated reviews Pharmacology (4th edition) chapter 32(373-376)  httpwww.drugs.comdoxycycline.html