Gigantism
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Gigantism

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Gigantism Gigantism Presentation Transcript

  • GigantismTable 4Kevin Knox, KaleyMiller, Hailey Ray, AshleySpaulding
  • Symptoms• Pretty big people (usually two standard deviations above normal height should be)• Delayed puberty• Double vision or difficulty with side vision
  • • Headaches• Increased sweating• Irregular periods (females)• Large hands and feet with large fingers and toes
  • • Release of breast milk• Thickening of facial features• Weakness• Bulging forehead
  • Causes• ***Excess of growth hormone ***(Acromegaly)• Most commonly: Noncancerous(adenoma) tumor of the pituitary gland• Carney complex
  • Possible solutions• Medications that reduce growth hormone release such as somatostain analogs• Dopamine aganoists but they are the least effective
  • Radiationtherapy can beused to bring thegrowth hormonelevel back tonormal but ittake 5 to 10 yearsto take full effectand often effectsother pituitaryhormones
  • • Removal of tumor on pituitary through endonasal surgery (through nose)
  • Exams and Tests• CT or MRI scans• Failure to suppress serum growth hormone (GH) levels after an oral glucose challenge (maximum 75g)• High prolactin levels• Increased insulin growth factor-I (IGF-I) levels
  • Miscellaneous• Female to male ratio of 1:2 (twice as common in males)• Commonly occurs with Acromegaly• App