Gigantism

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Gigantism

  1. 1. GigantismTable 4Kevin Knox, KaleyMiller, Hailey Ray, AshleySpaulding
  2. 2. Symptoms• Pretty big people (usually two standard deviations above normal height should be)• Delayed puberty• Double vision or difficulty with side vision
  3. 3. • Headaches• Increased sweating• Irregular periods (females)• Large hands and feet with large fingers and toes
  4. 4. • Release of breast milk• Thickening of facial features• Weakness• Bulging forehead
  5. 5. Causes• ***Excess of growth hormone ***(Acromegaly)• Most commonly: Noncancerous(adenoma) tumor of the pituitary gland• Carney complex
  6. 6. Possible solutions• Medications that reduce growth hormone release such as somatostain analogs• Dopamine aganoists but they are the least effective
  7. 7. Radiationtherapy can beused to bring thegrowth hormonelevel back tonormal but ittake 5 to 10 yearsto take full effectand often effectsother pituitaryhormones
  8. 8. • Removal of tumor on pituitary through endonasal surgery (through nose)
  9. 9. Exams and Tests• CT or MRI scans• Failure to suppress serum growth hormone (GH) levels after an oral glucose challenge (maximum 75g)• High prolactin levels• Increased insulin growth factor-I (IGF-I) levels
  10. 10. Miscellaneous• Female to male ratio of 1:2 (twice as common in males)• Commonly occurs with Acromegaly• App

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