Twaddell

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University of Maryland Baltimore
Experimental Therapeutics Symposium 2009

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Twaddell

  1. 1. Olga Ioffe, MD William S. Twaddell, MD Directors Pathology and Biorepository Shared Service Molecular & Structural Biology Hormone Responsive Cancers Viral Oncology (Developing) Tumor Immunology (Developing) Experimental Therapeutics High Throughput Screening Clinical Research Biopolymer Biostatistics Translational Tissue/ Biorepository Proteomics Flow Cytometry
  2. 2. New Leadership <ul><li>Olga Ioffe, M.D. </li></ul><ul><ul><li>Sub-specialty: Gyn and Breast pathology </li></ul></ul><ul><li>William (Sandy) Twaddell, M.D. </li></ul><ul><ul><li>Sub-specialty: Gastrointestinal/liver pathology </li></ul></ul>
  3. 3. Current Vision <ul><li>Tissue Biorepository services for both prospective and archived materials </li></ul><ul><li>Consultation with designated pathologists for both protocol development and tissue evaluation </li></ul><ul><li>Technical support and expertise for routine histological and immunohistochemical analyses of research specimens </li></ul><ul><li>Access to samples which support innovative technologies for the molecular analysis of cancer, including prepared DNA and/or RNA, and focused development of normal and tumor cell lines </li></ul>
  4. 4. <ul><li>All ordering and billing online through Bioresco </li></ul><ul><ul><li>https://cf.umaryland.edu/freezer/promo_pbr.cfm </li></ul></ul>
  5. 5. Current Vision <ul><li>Tissue procurement and processing services </li></ul><ul><ul><li>Blood, bone marrow and fluid processing </li></ul></ul><ul><ul><li>Track surgeries </li></ul></ul><ul><ul><li>Expedite processing and banking of excess tissues and tumors, including cells and fluids </li></ul></ul><ul><ul><li>Program/investigator specific procurement and processing (freeze, fix, tissue culture, fractionation) </li></ul></ul><ul><ul><li>Quality control </li></ul></ul>
  6. 6. Current Vision <ul><li>Translational research support </li></ul><ul><ul><li>Histology: </li></ul></ul><ul><ul><ul><li>tissue processing and embedding </li></ul></ul></ul><ul><ul><ul><li>Sectioning and staining </li></ul></ul></ul><ul><ul><ul><li>Tissue Microarray construction </li></ul></ul></ul><ul><ul><li>Immunohistochemistry: antibody work-up, control tissues, automated processing </li></ul></ul><ul><ul><li>Image analysis: quantitative IHC </li></ul></ul><ul><ul><li>Pathology consultation/interpretation </li></ul></ul><ul><ul><li>Linkage of archived tissue to clinical data </li></ul></ul><ul><ul><li>Assist with IRB issues and study design </li></ul></ul><ul><ul><li>Photomicrography </li></ul></ul>
  7. 7. 181 255 Head/neck 139 155 Colon 167 153 Esophagus 482 502 Lung 290 314 Breast 45 78 Pancreas 113 145 Gyn 209 256 Kidney n/a 950 Lymphocytes Normal Cancer Source
  8. 8. Pathology Biorepository and Research Core (PBRC) University of Maryland School of Medicine Olga Ioffe, MD, Co-Director William S. Twaddell, MD, Co-Director General Contact: Phone: 410-328-5525; Fax: 410-328-5508 Histology: Kimberly Tuttle: [email_address] Tissue Services: Jennifer Fuhrman: [email_address] <ul><li>Tissue Services </li></ul><ul><li>procurement of tumor and corresponding non-tumor tissues from surgical resections </li></ul><ul><li>tissues may be obtained fresh or snap frozen in liquid nitrogen or OCT medium </li></ul><ul><li>Archival formalin-fixed paraffin embedded tissues are available </li></ul><ul><li>Clinico-pathologic data available </li></ul><ul><li>Histology Services </li></ul><ul><li>Processing tissue </li></ul><ul><li>Paraffin embedding </li></ul><ul><li>Cutting paraffin blocks </li></ul><ul><li>Cutting OCT frozen blocks </li></ul><ul><li>Unstained sections or routine Hematoxylin and Eosin staining </li></ul><ul><li>Special stains </li></ul><ul><li>Decalcify bone/tissue </li></ul><ul><li>Immunohistochemisrty including work-up of new antibodies </li></ul><ul><li>Tissue Microarrays </li></ul><ul><li>Digital image analysis </li></ul><ul><li>The Core is always willing to expand its services to meet your histology needs. From special stains to study work-ups. If the core does not currently offer a service that you need, please call. </li></ul>

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