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University of Maryland Baltimore

University of Maryland Baltimore
Experimental Therapeutics Symposium 2009



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    Twaddell Twaddell Presentation Transcript

    • Olga Ioffe, MD William S. Twaddell, MD Directors Pathology and Biorepository Shared Service Molecular & Structural Biology Hormone Responsive Cancers Viral Oncology (Developing) Tumor Immunology (Developing) Experimental Therapeutics High Throughput Screening Clinical Research Biopolymer Biostatistics Translational Tissue/ Biorepository Proteomics Flow Cytometry
    • New Leadership
      • Olga Ioffe, M.D.
        • Sub-specialty: Gyn and Breast pathology
      • William (Sandy) Twaddell, M.D.
        • Sub-specialty: Gastrointestinal/liver pathology
    • Current Vision
      • Tissue Biorepository services for both prospective and archived materials
      • Consultation with designated pathologists for both protocol development and tissue evaluation
      • Technical support and expertise for routine histological and immunohistochemical analyses of research specimens
      • Access to samples which support innovative technologies for the molecular analysis of cancer, including prepared DNA and/or RNA, and focused development of normal and tumor cell lines
      • All ordering and billing online through Bioresco
        • https://cf.umaryland.edu/freezer/promo_pbr.cfm
    • Current Vision
      • Tissue procurement and processing services
        • Blood, bone marrow and fluid processing
        • Track surgeries
        • Expedite processing and banking of excess tissues and tumors, including cells and fluids
        • Program/investigator specific procurement and processing (freeze, fix, tissue culture, fractionation)
        • Quality control
    • Current Vision
      • Translational research support
        • Histology:
          • tissue processing and embedding
          • Sectioning and staining
          • Tissue Microarray construction
        • Immunohistochemistry: antibody work-up, control tissues, automated processing
        • Image analysis: quantitative IHC
        • Pathology consultation/interpretation
        • Linkage of archived tissue to clinical data
        • Assist with IRB issues and study design
        • Photomicrography
    • 181 255 Head/neck 139 155 Colon 167 153 Esophagus 482 502 Lung 290 314 Breast 45 78 Pancreas 113 145 Gyn 209 256 Kidney n/a 950 Lymphocytes Normal Cancer Source
    • Pathology Biorepository and Research Core (PBRC) University of Maryland School of Medicine Olga Ioffe, MD, Co-Director William S. Twaddell, MD, Co-Director General Contact: Phone: 410-328-5525; Fax: 410-328-5508 Histology: Kimberly Tuttle: [email_address] Tissue Services: Jennifer Fuhrman: [email_address]
      • Tissue Services
      • procurement of tumor and corresponding non-tumor tissues from surgical resections
      • tissues may be obtained fresh or snap frozen in liquid nitrogen or OCT medium
      • Archival formalin-fixed paraffin embedded tissues are available
      • Clinico-pathologic data available
      • Histology Services
      • Processing tissue
      • Paraffin embedding
      • Cutting paraffin blocks
      • Cutting OCT frozen blocks
      • Unstained sections or routine Hematoxylin and Eosin staining
      • Special stains
      • Decalcify bone/tissue
      • Immunohistochemisrty including work-up of new antibodies
      • Tissue Microarrays
      • Digital image analysis
      • The Core is always willing to expand its services to meet your histology needs. From special stains to study work-ups. If the core does not currently offer a service that you need, please call.