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Bio3 0910 Lec2 Controls Cd Ks
Bio3 0910 Lec2 Controls Cd Ks
Bio3 0910 Lec2 Controls Cd Ks
Bio3 0910 Lec2 Controls Cd Ks
Bio3 0910 Lec2 Controls Cd Ks
Bio3 0910 Lec2 Controls Cd Ks
Bio3 0910 Lec2 Controls Cd Ks
Bio3 0910 Lec2 Controls Cd Ks
Bio3 0910 Lec2 Controls Cd Ks
Bio3 0910 Lec2 Controls Cd Ks
Bio3 0910 Lec2 Controls Cd Ks
Bio3 0910 Lec2 Controls Cd Ks
Bio3 0910 Lec2 Controls Cd Ks
Bio3 0910 Lec2 Controls Cd Ks
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Bio3 0910 Lec2 Controls Cd Ks

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  • 1. Cell Cycle Controls<br />Biology 3 Kawashima<br />Philippine Science High School<br />SY 2009-2010<br />
  • 2. Key Terms and Concepts<br />Checkpoints<br />Cyclins<br />Cyclin-dependent kinases<br />
  • 3.
  • 4. G1 Checkpoint<br />Also known as “Restriction Point” in mammalian cells<br />Cells that go through G1 usually complete the cell cycle<br />Cells that do not receive the go-signal exit the cell cycle<br />Quiescent non-dividing stage called G0 phase<br />
  • 5. G1 checkpoint<br />Continue with G1 and proceed to S<br />Exit cycle; switch to nondividing state<br />
  • 6. G2 Checkpoint<br />MPF or maturation promoting factor drives the cell past the G2 checkpoint<br />MPF is a protein complex composed of cyclins and cyclin-dependent kinases (Cdk)<br />Accumulated cyclin in G2 associate with cyclin-dependent kinases<br />
  • 7.
  • 8.
  • 9. M Phase Checkpoint<br />Ensures that chromosomes are properly attached to mitotic spindle (composed of microtubules)<br />Anaphase promoting complex (APC) is inactive until kinetochores have interacted with microtubules<br />Activation of APC indirectly triggers breakdown of cyclins<br />
  • 10.
  • 11.
  • 12.
  • 13. External Signals Affect Regulation<br />

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