<ul><li>Advances in medical science: </li></ul>2. Prion Disease Spreads in Sheep Via Mother's . 1.Airborne Pathogens Can Induce Mad Cow Disease, New Findings Suggest. KELLY AGUDELO GIL. Medicine Student, 2011.
The use of molecular biology as a science is a determinant present on diseases in humans lived in both animals, plants and humans, allowing the proper organization and distribution of each of the components of life. One of the pathologies that explains the evolution in molecular biology is Creutzfeldt Jacob, which is caused by a prion that causes brain disorders and result in death, is ingested through the consumption of meat and milk from sheep. Another study finds the increased technology in the study of pathology is the Fish, is a specialized technique to determine abnormalities in the chromosomes, assuming that the world does not stop and science advances.
EXPLANATION OF THE FIRST NEW Creutzfeldt Jacob disease is a rare degenerative brain disorder, symptoms usually start around age 60. Problems with memory, behavior changes, problems with vision and poor muscle coordination quickly lead to “dementia”, coma and death. Most patients die within the first year. There are three major categories of Creutzfeldt Jacob: • Sporadic : which occurs without any known reason. • hereditary : which is familial tendency. • acquired: which occurs through contact with. The prion protein is found naturally in mammals. Spongiform encephalopathy occurs when the normal structure of the prion protein PrP Sc is disturbed, it acts on the normal protein (PrP) and get them to change even the structure, gradually appear deformations of neural cells, the altered prion generates many changes including holes in the cerebral cortex.
EXPLINATION OF THE FIRST NEW Symptoms of Creutzfeldt Jacob disease: Delirium or dementia of rapid development (within a few weeks or months), blurred vision, changes in gait (walking) may have seizures, personality changes, drowsiness, among others. Importantly, these symptoms lead to death .
EXPLINATION OF THE FIRST NEW The present relationship between liver diseases and neurological diseases has been a boom, an example of which is the pathology of Jacob Kreutzfeldt which the nitrogenous bases to degrade the prion in the brain causes a deficiency of carbamoyl phosphate and ornithine transcarbamylase, indicating an alteration of the urea cycle and therefore an accumulation of cellular nitrogen, hyperammonemia, exacerbating the situation of the patient.
EXPLINATION OF THE FIRST NEW TREATMENT: There is no known cure for this disease. It may be necessary to put the patient under care during the early stages of the disease. It may require medications such as sedatives, antipsychotics, and others to control aggressive behaviors. The fact of providing a safe environment, control aggressive or agitated, and meet physiologic needs may require monitoring and assistance either at home or in an institution. Counseling can help the family cope with the changes required for home care. Visiting nurses or aides, volunteer services, homemakers, the adult protective services and other community resources may be helpful for the care of a person with Creutzfeldt-Jakob disease. .
EXPLINATION OF THE SECOND NEW SPONGIFORM ENCEPHALOPATHY: FATAL INSOMNIA Fatal familial insomnia is one of the transmissible spongiform encephalopathies, neurodegenerative disorders characterized by abnormal protein associated with: the prion protein PrP. It is manifest personality disorders such as apathy or disinterest, well, have eyestrain, afternoon fever, hypertension, sweating, tearing, tachycardia and tachypnea. Men suffering from impotence. In many cases, these early symptoms are attributed to emotional stress. Characteristically, both insomnia and autonomic hyperactivity progressively worse, patients are deprived of sleep at night and are sleepy during the day .
EXPLINATION OF THE SECOND NEW The nervous and hormonal system has been developed for all the systems to a joint activity effectively. Both systems differ in how quickly to trigger a response, nervous system makes it fast, and hormones more slowly. The central nervous system is protected by the skull and spine. Respect to its origin we must say that is ectodermal. Central nervous system, protected by the meninges and all of it contained in the bone, many cells specialize in support functions that form the glia. He has more peripheral neurotransmitters such as dopamine, serotonin, gamma-amino butyric acid, acetylcholine and noradrenaline, is the center of action for interference since prions at the synapse and make an income from their human DNA contaminated material.
PRION DIAGNOSIS The definitive diagnosis is established by brain biopsy or autopsy showing a spongiform brain tissue (hence this illness is part of spongiform encephalopathy's). However, if it is you want to exclude with certainty a cause of treatable brain disease, brain biopsy to be a risky procedure, and not change the prognosis and treatment should confirm the existence of Creutzfeldt-Jakob, this is not performed routinely. Yes there is a specific pathological study of the brain at autopsy in these patients. There is currently no diagnostic test for certain disease, so it is important to suspect the disease reached a complete examination and a thorough neurological examination and rule out other diseases with dementia who are potentially treatable. Neuroimaging (CT / MRI) or cerebrospinal fluid are usually normal or nonspecific changes. The electroencephalogram may, however, reveal some changes that may suggest the diagnosis
IMUM SYSTEM The immune system is the body's defense against infectious organisms and other invaders. Through a series of steps called "immune response", the immune system attacks organisms and substances that invade the body systems and cause disease. The immune system consists of a network of cells, tissues and organs that work together to protect the body. The above are white blood cells of two basic types, which combine to find and destroy the substances or organisms that cause diseases such as prions introduced as new genomic sequences become mediators antigen- antibody.
The vital functions of being human lies in their ability to interact with it is therefore vitally important to get an idea of the functioning of the body, were tested in different sciences and technologies such as molecular biology, which performs electrophoresis in chromosome banding, Q, R, T and others that identify abnormalities in the development and capacity of the genome. MEDICINE UTILITY
Histocompatibility complex in meidicina and biology are essential to interpret the semiology of the patient and that according to the type of organism that is attacking the body with specific characteristics, such as allergy, malaise, rash, between pray . In addition to the type of immunizations I will try to make the agency can verify the correct functioning of the human immunology. MEDICINE UTILITY
Borne diseases contact with toxic substances, animals and even apparently clean media can cause pathologies that lead to risk their lives such as Creutzfeldt Jacob, in which the consumption of sheep meat involves the acquisition and generates a prion mutates the brain and trasncurre to death, so the doctor must make a good interview and send useful laboratory tests to diagnosis the patient appropriately.
MEDICINE UTILITY For Medicine, empathy is the most important factor that leads to diagnostic as complicated as the tendency of a prion in the body, therefore the kindness and the way in which he will explain to the patient subjects of research provides greater confidence and an index of increased security in terms of pathologies.