lekopoiesis

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hematologi 1

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lekopoiesis

  1. 1. 23 MEI 2011Leukopoiesis
  2. 2. Blood Cytology That fact that we as humans are made up ofmillions of tiny cells. Cytology, more commonly known as cellbiology, studies cell structure, cellcomposition, and the interaction of cells withother cells and the larger environment in whichthey exist. Cytology can also refer to cytopathology, whichanalyzes cell structure to diagnose disease.
  3. 3. KOMPOSISI DARAHPADAT (45%) ERITROSITFungsi : Alat Transportasi LEKOSITFungsi: Pertahanan tubuh TROMBOSITFungsi : Membantu prosespembekuan darahCAIR (55%) Air (90-92%) Protein (Alb,Glo, Fibr) Karbohidrat Vitamin Hormon Enzym Lemak Garam/mineralRata-rata jumlah darah orang dewasasekitar 5 liter atau 7% - 8% dari berat badanDarah terdiri dari dua bagian:
  4. 4. HAEMATOPOIESIS:berarti proses pembentukan darah.Pada manusia hematopoiesis dimulai di yolk sac. padabulan ke 3 gestasi, stem cell berpindah ke liver danspleen sampai bulan ke 7, yang pada akhirnya digantikanoleh BM. Setiap sel darah berasal dari stem cell(pluripotent). Diperkirakan terdapat 1 stem cell dalam10.000 cell dalam BM. Jika pembentukan darah di BMterganggu, sel yang pertama turun adalah netrophil (yangmempunyai masa hidup 6-8 jam), diikuti oleh trombosit(masa hidup 10 hari). Anemia berkembang secaralambat. (masa hidup 120 hari)
  5. 5. Leukopoiesis Leukopoiesis is a form of hematopoiesis inwhich white blood cells (WBC, or leukocytes)are formed in bone marrow located in bonesin adults and hematopoietic organs in thefetus.White blood cells, indeed all bloodcells, are formed from the differentiation ofpluripotent hematopoietic stem cells whichgive rise to several cell lines with more limiteddifferentiation potential.
  6. 6. LeukopoiesisMyeloid Stem CellProductions This stem cell willdifferentiate into either aproerythroblast (andeventually a red bloodcell) or a progenitor cell.The progenitor cell willdifferentiate into amegakaryocyte (andthen a platelet), or amyeloblast ormonoblast.Lymphoid Stem CellProductions Lymphoid stem cellsmature intolymphoblasts, and thenprolymphocytes, andfinally maturelymphocytes, either a BorT cell.Leukopoiesis is a form of haematopoiesis in which white blood cells (WBC) are formedin the bone marrow. WBCs arise from the maturation of hemocytoblasts, which are thegeneral stem cell for all blood cells and platelets, into various pluripotential stem cellswhich can then further differentiate into the different classes of WBCs.
  7. 7. Masa Pembentukan Sel-sel Darah(erytrocyte,Megakaryocyte,Granulocyte,Lympocyte,Monocyte)
  8. 8. Masa Pembentukan Lekosit
  9. 9. Granulopoiesis

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