NECROTIZING
SIALOMETAPLASIA
Necrotizing Sialometaplasia
• Uncommon locally destructive
inflammatory condition of the
salivary glands.
• Cause: unknown...
ISCHEMIA AND LOCAL INFARCTION
LEADING TO NECROTIZING
SIALOMETAPLASIA

OXYGEN

No blood supply
No oxygen

No ATP
No glucose
Predisposing factors:
–Traumatic injuries
–Dental injections
–Ill fitting dentures
–Upper respiratory
infections

–Adjacen...
CLINICAL FEATURES
• Most frequently develops in the
palatal salivary glands
• Hard palate > soft palate
***2/3 of palatal ...
Unilateral
Bilateral
Midline
in location
CLINICAL FEATURES
• Has also been reported in other
minor salivary gland sites and
occasionally in the parotid gland.
• Su...
CLINICAL FEATURES
• Most common in adults and in men
• The condition appears initially as a
non-ulcerated swelling often
a...
CLINICAL FEATURES
HISTOPATHOLOGIC FEATURES
• Microscopic appearance of
necrotizing sialometaplasia is
characterized by acinar necrosis in
ea...
HISTOPATHOLOGIC FEATURES
Treatment
• The lesion is self-limiting in most
instances and heals uneventfully.
Xerostomia
Xerostomia
• Refers to subjective sensation of
a “dry mouth”
• Frequently but not always
associated with salivary gland
hy...
Xerostomia
CAUSES
• DEVELOPMENTAL
-Salivary gland aplasia
• WATER OR METABOLITE LOSS impaired
fluid intake
-impaired fluid intake
-he...
CAUSES
• IATROGENIC
-medications
• LOCAL FACTORS
-decreased mastication
-smoking
-mouth breathing
CAUSES
• SYSTEMIC DISEASES
-Sjogren’s syndrome
-diabetes mellitus
-diabetes insipidus
-sarcoiadosis
-HIV infection
-Graft-...
Upcoming SlideShare
Loading in...5
×

Necrotizing sialometaplasia

549

Published on

Published in: Health & Medicine
0 Comments
1 Like
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total Views
549
On Slideshare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
23
Comments
0
Likes
1
Embeds 0
No embeds

No notes for slide

Necrotizing sialometaplasia

  1. 1. NECROTIZING SIALOMETAPLASIA
  2. 2. Necrotizing Sialometaplasia • Uncommon locally destructive inflammatory condition of the salivary glands. • Cause: unknown but they believe it is the result of ischemia of the salivary tissue that leads to local infaction.
  3. 3. ISCHEMIA AND LOCAL INFARCTION LEADING TO NECROTIZING SIALOMETAPLASIA OXYGEN No blood supply No oxygen No ATP No glucose
  4. 4. Predisposing factors: –Traumatic injuries –Dental injections –Ill fitting dentures –Upper respiratory infections –Adjacent tumors –Previous tumors ***However many cases occur without any known predisposing factors.
  5. 5. CLINICAL FEATURES • Most frequently develops in the palatal salivary glands • Hard palate > soft palate ***2/3 of palatal cases are unilateral, with the rest being bilateral or midline in location
  6. 6. Unilateral
  7. 7. Bilateral Midline in location
  8. 8. CLINICAL FEATURES • Has also been reported in other minor salivary gland sites and occasionally in the parotid gland. • Submandibular and sublingual glands are rarely affected.
  9. 9. CLINICAL FEATURES • Most common in adults and in men • The condition appears initially as a non-ulcerated swelling often associated with pain or paresthesia with crater-like ulcer that can range from less than 1cm to more than 5cm in diameter appearing within 2 to 3 weeks.
  10. 10. CLINICAL FEATURES
  11. 11. HISTOPATHOLOGIC FEATURES • Microscopic appearance of necrotizing sialometaplasia is characterized by acinar necrosis in early lesions, followed by associated squamous metaplasia of the salivary ducts.
  12. 12. HISTOPATHOLOGIC FEATURES
  13. 13. Treatment • The lesion is self-limiting in most instances and heals uneventfully.
  14. 14. Xerostomia
  15. 15. Xerostomia • Refers to subjective sensation of a “dry mouth” • Frequently but not always associated with salivary gland hypofunction.
  16. 16. Xerostomia
  17. 17. CAUSES • DEVELOPMENTAL -Salivary gland aplasia • WATER OR METABOLITE LOSS impaired fluid intake -impaired fluid intake -hemorrhage -vomiting or diarrhea
  18. 18. CAUSES • IATROGENIC -medications • LOCAL FACTORS -decreased mastication -smoking -mouth breathing
  19. 19. CAUSES • SYSTEMIC DISEASES -Sjogren’s syndrome -diabetes mellitus -diabetes insipidus -sarcoiadosis -HIV infection -Graft-versus-host disease -psychogenic disorder
  1. A particular slide catching your eye?

    Clipping is a handy way to collect important slides you want to go back to later.

×