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Presentation of Can

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  • 1. • CAN GmbH – Center for Applied Nanotechnology GmbH• Concepts from Science to Industry• Dr. Frank Schröder-Oeynhausen Centrum für Angewandte Nanotechnologie (CAN) GmbH 1
  • 2. Nanotechnologyin Germany Center for Applied Nanotechnology (CAN) GmbH 2
  • 3. Nanotechnologyin Hamburg Borstel: Lübeck: UKSH UKE, HPI: Nanobiomedicine Lasercenter, Nanobiomedicine, Nanobiomedicine Molecular Imaging University HH: Nanoparticle synthesis, Nanomaterials, Nanobiochemistry, Energy Research, DESY: Catalysis, Characterisation, Nanostructures, Dynamics on the Nanoanalytics, CAN GmbH nanometer scale Nanodevices, EMBL: Theory of NanosystemsActivity: Nanobiochemistry of proteins GKSS: huge Membranes, Medium Nanomaterials TUHH: small BNI: Nanomaterials for Nanobiomedicine Transport Systems, CNTs, Polymers, Fuel Cell Systems Center for Applied Nanotechnology (CAN) GmbH
  • 4. Nanotechnology PropertiesSurface tovolume ratio102 size100 1 nm 1µm 1mm 1m10-210-410-610-8 Optically transparent Center for Applied Nanotechnology (CAN) GmbH
  • 5. Company ProfileMissionOur main expertise is on the production andfunctionalization of nanoparticulate and nanocompositematerials, encapsulation of active ingredients as well asdevelopment of nanoparticle-based biological andmedical markers for the cosmetics-, consumables- andpharma industry.We produce nanoparticles of highest quality, offerscontract research and development services in the area ofnanotechnology and participates in national andinternational research programs. 5 nmMission: We offer nanoparticles for your purpose! Center for Applied Nanotechnology (CAN) GmbH 5
  • 6. Company Profile General Conditions Academia CAN GmbH MarketScience CollaborativePublications ResearchPatentsProject Management Own ProductsStandardizationPrototyping ContractBenchmarking ResearchProducts Center for Applied Nanotechnology (CAN) GmbH 6
  • 7. Company ProfileConceptBusiness Model: Public Private Partnership (PPP)Founded: November 2005Location: HamburgStaff: 25 + 6 (today)Sales: 1.318.000 € (2009)Partners: Verein zur Förderung der Nanotechnologie e.V. (65,2 %) Free and Hanseatic City of Hamburg (24,8 %) University Hamburg (10 %)Subsidiaries: Screening Port Hamburg GmbH. (80,2 %)Head of Supervisory Board: Prof. Dr. Klaus-Peter WitternChief Scientific Officer: Prof. Dr. Horst WellerChief Operation Officer: Dr. Frank Schröder-Oeynhausen Center for Applied Nanotechnology (CAN) GmbH 7
  • 8. Business SegmentsFields of Business Transfer Model:• I. Cosmetics / Flavours: Contract Research Thickener, Emulsions, Encapsulation• II. Medicine / Medical Technology: Nanoparticles for Diagnostics Own Products Drug Delivery Systems International Collaboration Analytics / Toxicity Service Tox-Tests Analyses of Nanostructures Service Analytics Assay Development• III. Technical Applications: Security Labels Contract Research (conf.) Nanostructured Functionalized Layers National Collaboration Center for Applied Nanotechnology (CAN) GmbH 8
  • 9. Business Segment I: CosmeticsNanoparticles• Synthesis of ZnO - and TiO2 - nanoparticles Contract• Modification of nanoparticles ResearchPolymers• Thickener für water- and oilbased systems• Systems for hair-repair• Emulsions• Mucoadhesive polymersEncapsulation• Encapsulation of drugs and flavours• Water/Oil - nanoemulsions Contact: Personal Care: Dr. Marcel Ruppert (ruppert@can-hamburg.de) Hair Care: Dr. Marc Thiry (thiry@can-hamburg.de) Center for Applied Nanotechnology (CAN) GmbH 9
  • 10. Business Segment II: MedicineNanoparticles: Properties Ligands define stability and chemistry: • Biocompatibility • Coupling mechanisms Core defines properties depending on size: • Colour 5 nm • Magnetism • Conductivity • Thermodynamics 5 nm Center for Applied Nanotechnology (CAN) GmbH
  • 11. Business Segment II: MedicineNanoparticles: CANdot® Series AFeatures • Fluorescent Nanoparticles • Emission max: 500 to 620 nm • High reproducible properties • Soluble in water or non-polar organic solvents • High physical and chemical stabilityStructure • CdSe/CdS/ZnS dots • Core-shell-shell structure • Scalable core size • Core and core-shell particles available, too Own Product Center for Applied Nanotechnology (CAN) GmbH 12
  • 12. Business Segment II: MedicineNanoparticles: CANdot® Series MFeatures • Magnetic nanoparticles • Diameter between 5 and 30 nm Own • Small size distribution Product • Soluble in water or non-polar, organic solventsStructure magnet • FeOX nanoparticles • Hydrophobic acids for organic solvents • Hydrophilic polymers for water • Doping possible Center for Applied Nanotechnology (CAN) GmbH 18
  • 13. Business Segment II: MedicineNanoparticles: SynthesisA) Vapour Deposition (PVD / CVD) “Hot Injection Process”B) Sol-Gel TechniqueC) Wet-Chemistry Advantages • universal applicable • well known • broad temperature range Disadvantages • temperature profile hard to control • slow mixing after injection • “up-scaling” difficult Center for Applied Nanotechnology (CAN) GmbH 13
  • 14. Business Segment II: MedicineNanoparticles: SynthesisA) Vapour Deposition (PVD / CVD) “Flow Synthesis”B) Sol-Gel TechniqueC) Wet-Chemistry Center for Applied Nanotechnology (CAN) GmbH 14
  • 15. Business Segment II: MedicineNanoparticles: Synthesis Center for Applied Nanotechnology (CAN) GmbH 15
  • 16. Business Segment II: MedicineNanoparticles: Properties 5 nm Center for Applied Nanotechnology (CAN) GmbH
  • 17. ServiceAnalytics
  • 18. Business Segment II: MedicineToxicity of Nanoparticles quality skin lung ligands intestine shells ICC shape size nanoparticle modification interaction Center for Applied Nanotechnology (CAN) GmbH 19
  • 19. Business Segment II: MedicineToxicity of NanoparticlesExample for studying the interaction between nanoparticles and cell system• Red: Epithelial-cells (lung), stained with Draq5 (nucleus)• Blue: CdSe-CdS nanoparticles with different blockcopolymer-labels, located in the cell cytosol and the cell membrane Service Contact: Toxicity: Dr. Thomas Frahm (frahm@can-hamburg.de) 20 Center for Applied Nanotechnology (CAN) GmbH
  • 20. EU project VIBRANT• The goal of VIBRANT is the development of nano- technology-based systems for diabetes diagnosis and/or therapy. from the pharmaceutical industry.• CAN and UHH will provide a contrast agent providing a stable and high signal intensity, which is highly specific to the cell type, but low toxicity,http://www.fp7-vibrant.eu/Ultimately, VIBRANT will deliver β-cell specific, functionally optimizednanoconstructs and defined know-howfor in vivo applications in non-human Ihr Ansprechpartner:primates and humans with regard to Dr. Theo Schotten (schotten@can-hamburg.de)quantification of BCM, imaging of
  • 21. Specific coupling agent The Nanocontainer Superparamagnetic particleQuantum Dots Biocompatible Shell Anchor/Linker Ligand ~ 20 - 300 nm Micelle or Vesicle Centrum für Angewandte Nanotechnologie GmbH
  • 22. Outline• EU Framework 7 Large Scale Project• Idea and coordination: CAN GmbH• Duration: 7/2009 to 6/2013• Grant: 8 Mio EUR• Scientists from nine research institutes from five EU-countries (Belgium, Spain, Denmark, Sweden and Germany• Industrial Advisory Board: big pharma.http://www.fp7-vibrant.eu/ InternationalIhr Ansprechpartner:Dr. Theo Schotten (schotten@can-hamburg.de) collaboration
  • 23. The “Axis of Excellence”* International collaboration *) R = 0.989! ;-)
  • 24. Business Segment III: Technical ApplicationsSecurity LabelsCANdots® Series X as Security Labels: Contract• Activation of the host lattice by doping with rare-earth elements• Reproducible Shape of Particles (spheres to ellipsoids, synthesis specific) Research• Reproducible Size of Particles (7 to 40 nm, material- and synthesis specific) (conf.)• Physical und Chemical Stability (photo stabilized, inert to high temperatures, acids, bases und organic solvents) Contact: Polymers: Dr. Jan Niehaus (niehaus@can-hamburg.de) Center for Applied Nanotechnology (CAN) GmbH 25
  • 25. Business Segment III: Technical ApplicationsNew Concept of a Solar Cell Quantum Dot- Carbon Nanotube Composites B.Hernandez-Juárez, C. Klinke, A.Kornowski, H. Weller Institute of Physical Chemistry. Universität Hamburg. Center for Applied Nanotechnology (CAN) GmbH
  • 26. Business Segment III: Technical ApplicationsNew Concept of a Solar Cell Collaboration e.g. Photovoltaics h+ with Academia e e- e e e e e h CB VB conductive polymer Center for Applied Nanotechnology (CAN) GmbH
  • 27. Business Model:Collaborative Research ProjectsExample: VIBRANT, EU-Project• EU Framework 7 – NMP – Large Scale Project Nanosciences, Nanotechnologies, Materials and New Production Technologies• Goal of the project: Development of marker systems for diabetes diagnostics• Coordination: CAN GmbH• Timeframe: 7/2009 to 6/2013• Budget: about 8 Mio EUR• Scientists from nine research institutes from five EU-countries (Belgium, Spain, Denmark, Sweden and Germany)• Industrial Advisory Board• Internet: www.fp7-vibrant.eu• Coordination of the application process (two step process) Centrum für Angewandte Nanotechnologie (CAN) GmbH 28
  • 28. Business Model:Patents, ProductsIntellectual Property Rights owned by CAN1. Method for producing alkaline earth sulfate nanoparticles (Basolute I)2. Process for preparing dispersible sulfate nanoparticles (Basolute II)3. Luminescent core/shell nanoparticles4. Core/shell nanoparticles suitable for (F)RET-assays5. Synthesis of nanoparticles comprising metal(III)vanadate6. Security printing liquid and method using nanoparticles7. Paramagnetic nanoparticles8. Synthesis of nanoparticles (Dotnan)9. X-Ray opaque dental nanomaterials10. Postsynthetic polyacid/base modification of nanoparticles11. InP nanoparticles and method for their manufacture12. Reactor for the synthesis of nanoparticles CANdots Series A13. … CANdots Series X Center for Applied Nanotechnology (CAN) GmbH 29
  • 29. Business Model:Contract ResearchFirst Contact• Discussion on ideas / problems / requests• Non Disclosure Agreement (NDA)ConceptAgreement on:• R&D goals• Timeframe• Budget• Patent- and License issues• Other partners• Legal issuesContracts• Small jobs (< 10 T€)• Feasibility Studies (< 50 T€)• R&D Contracts (> 50 T€) Centrum für Angewandte Nanotechnologie (CAN) GmbH 30
  • 30. Business Model:ServiceConsulting and Service• Studies• SurveysCAN-Analytics• Scanning Electron Microscopy (SEM / TEM)• Static and Dynamic Light Scattering (SLS / DLS)• X-Rax Scattering (SAXS / WAXS)• Atomic Force Microscopy (AFM)• Infrared Spectroscopy• Mass-Spectrometry (MS, MALDI-MS)• Absorption Spectroscopy (UV-Vis, NIR)• Fluorescence Optical Microscopy• Confocal Laser-Scanning Microscopy• Electron Spin Resonance-Spectroscopy• SQUID Magnetometry• Chromatography• Rheology Center for Applied Nanotechnology (CAN) GmbH 31
  • 31. CAN GmbH:PartnerUniversity of HamburgCooperation ContractsCompanies:Beiersdorf AG www.beiersdorf.comEppendorf AG www.eppendorf.comBODE Chemie GmbH www.bode-chemie.deMerck KGaA www.merck.deBayer AG www.bayer.deInstitutions:Free and Hansestadt Hamburg http://fhh.hamburg.de/Hamburger Sparkasse www.haspa.deHamburg Chamber of Commerce www.hk24.deInnovationsstiftung Hamburg www.innovationsstiftung.deLife Science Agentur Norgenta www.norgenta.deCenter of Competence Hansenanotec www.nanoscience.de/hansenanotec/ Center for Applied Nanotechnology (CAN) GmbH 32
  • 32. CAN GmbH:… get in contact !Center for Applied Nanotechnology (CAN) GmbHGrindelallee 11720146 HamburgGermanyT +49 40 42838 – 4983F +49 40 42838 – 5797E fso@can-hamburg.dewww.can-hamburg.de Center for Applied Nanotechnology (CAN) GmbH 33

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