• CAN GmbH – Center for Applied Nanotechnology GmbH• Concepts from Science to Industry•   Dr. Frank Schröder-Oeynhausen   ...
Nanotechnologyin Germany                 Center for Applied Nanotechnology (CAN) GmbH   2
Nanotechnologyin Hamburg                                                        Borstel:                       Lübeck: UKS...
Nanotechnology  PropertiesSurface tovolume ratio102                                                    size100        1 nm...
Company ProfileMissionOur main expertise is on the production andfunctionalization of nanoparticulate and nanocompositemat...
Company Profile General Conditions                     Academia             CAN GmbH                  MarketScience       ...
Company ProfileConceptBusiness Model:       Public Private Partnership (PPP)Founded:              November 2005Location:  ...
Business SegmentsFields of Business                                                           Transfer Model:• I. Cosmetic...
Business Segment I: CosmeticsNanoparticles• Synthesis of ZnO - and TiO2 - nanoparticles                                   ...
Business Segment II: MedicineNanoparticles: Properties                                         Ligands define stability an...
Business Segment II: MedicineNanoparticles: CANdot® Series AFeatures            •   Fluorescent Nanoparticles            •...
Business Segment II: MedicineNanoparticles: CANdot® Series MFeatures            •   Magnetic nanoparticles            •   ...
Business Segment II: MedicineNanoparticles: SynthesisA)   Vapour Deposition (PVD / CVD)                    “Hot Injection ...
Business Segment II: MedicineNanoparticles: SynthesisA)   Vapour Deposition (PVD / CVD)                         “Flow Synt...
Business Segment II: MedicineNanoparticles: Synthesis                   Center for Applied Nanotechnology (CAN) GmbH   15
Business Segment II: MedicineNanoparticles: Properties       5 nm                   Center for Applied Nanotechnology (CAN...
ServiceAnalytics
Business Segment II: MedicineToxicity of Nanoparticles                                                      quality       ...
Business Segment II: MedicineToxicity of NanoparticlesExample for studying the interaction between nanoparticles and cell ...
EU project VIBRANT• The goal of VIBRANT is the development of nano-    technology-based systems for diabetes diagnosis    ...
Specific coupling agent    The Nanocontainer                                                     Superparamagnetic particl...
Outline•   EU Framework 7 Large Scale Project•   Idea and coordination: CAN GmbH•   Duration: 7/2009 to 6/2013•   Grant: 8...
The “Axis of Excellence”*                                 International                                 collaboration     ...
Business Segment III: Technical ApplicationsSecurity LabelsCANdots® Series X as Security Labels:                          ...
Business Segment III: Technical ApplicationsNew Concept of a Solar Cell                                    Quantum Dot-   ...
Business Segment III: Technical ApplicationsNew Concept of a Solar Cell                                                   ...
Business Model:Collaborative Research ProjectsExample: VIBRANT, EU-Project•   EU Framework 7 – NMP – Large Scale Project  ...
Business Model:Patents, ProductsIntellectual Property Rights owned by CAN1.    Method for producing alkaline earth sulfate...
Business Model:Contract ResearchFirst Contact• Discussion on ideas / problems / requests• Non Disclosure Agreement (NDA)Co...
Business Model:ServiceConsulting and Service• Studies• SurveysCAN-Analytics• Scanning Electron Microscopy (SEM / TEM)• Sta...
CAN GmbH:PartnerUniversity of HamburgCooperation ContractsCompanies:Beiersdorf AG                         www.beiersdorf.c...
CAN GmbH:… get in contact !Center for Applied Nanotechnology (CAN) GmbHGrindelallee 11720146 HamburgGermanyT +49 40 42838 ...
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Presentation of Can

  1. 1. • CAN GmbH – Center for Applied Nanotechnology GmbH• Concepts from Science to Industry• Dr. Frank Schröder-Oeynhausen Centrum für Angewandte Nanotechnologie (CAN) GmbH 1
  2. 2. Nanotechnologyin Germany Center for Applied Nanotechnology (CAN) GmbH 2
  3. 3. Nanotechnologyin Hamburg Borstel: Lübeck: UKSH UKE, HPI: Nanobiomedicine Lasercenter, Nanobiomedicine, Nanobiomedicine Molecular Imaging University HH: Nanoparticle synthesis, Nanomaterials, Nanobiochemistry, Energy Research, DESY: Catalysis, Characterisation, Nanostructures, Dynamics on the Nanoanalytics, CAN GmbH nanometer scale Nanodevices, EMBL: Theory of NanosystemsActivity: Nanobiochemistry of proteins GKSS: huge Membranes, Medium Nanomaterials TUHH: small BNI: Nanomaterials for Nanobiomedicine Transport Systems, CNTs, Polymers, Fuel Cell Systems Center for Applied Nanotechnology (CAN) GmbH
  4. 4. Nanotechnology PropertiesSurface tovolume ratio102 size100 1 nm 1µm 1mm 1m10-210-410-610-8 Optically transparent Center for Applied Nanotechnology (CAN) GmbH
  5. 5. Company ProfileMissionOur main expertise is on the production andfunctionalization of nanoparticulate and nanocompositematerials, encapsulation of active ingredients as well asdevelopment of nanoparticle-based biological andmedical markers for the cosmetics-, consumables- andpharma industry.We produce nanoparticles of highest quality, offerscontract research and development services in the area ofnanotechnology and participates in national andinternational research programs. 5 nmMission: We offer nanoparticles for your purpose! Center for Applied Nanotechnology (CAN) GmbH 5
  6. 6. Company Profile General Conditions Academia CAN GmbH MarketScience CollaborativePublications ResearchPatentsProject Management Own ProductsStandardizationPrototyping ContractBenchmarking ResearchProducts Center for Applied Nanotechnology (CAN) GmbH 6
  7. 7. Company ProfileConceptBusiness Model: Public Private Partnership (PPP)Founded: November 2005Location: HamburgStaff: 25 + 6 (today)Sales: 1.318.000 € (2009)Partners: Verein zur Förderung der Nanotechnologie e.V. (65,2 %) Free and Hanseatic City of Hamburg (24,8 %) University Hamburg (10 %)Subsidiaries: Screening Port Hamburg GmbH. (80,2 %)Head of Supervisory Board: Prof. Dr. Klaus-Peter WitternChief Scientific Officer: Prof. Dr. Horst WellerChief Operation Officer: Dr. Frank Schröder-Oeynhausen Center for Applied Nanotechnology (CAN) GmbH 7
  8. 8. Business SegmentsFields of Business Transfer Model:• I. Cosmetics / Flavours: Contract Research Thickener, Emulsions, Encapsulation• II. Medicine / Medical Technology: Nanoparticles for Diagnostics Own Products Drug Delivery Systems International Collaboration Analytics / Toxicity Service Tox-Tests Analyses of Nanostructures Service Analytics Assay Development• III. Technical Applications: Security Labels Contract Research (conf.) Nanostructured Functionalized Layers National Collaboration Center for Applied Nanotechnology (CAN) GmbH 8
  9. 9. Business Segment I: CosmeticsNanoparticles• Synthesis of ZnO - and TiO2 - nanoparticles Contract• Modification of nanoparticles ResearchPolymers• Thickener für water- and oilbased systems• Systems for hair-repair• Emulsions• Mucoadhesive polymersEncapsulation• Encapsulation of drugs and flavours• Water/Oil - nanoemulsions Contact: Personal Care: Dr. Marcel Ruppert (ruppert@can-hamburg.de) Hair Care: Dr. Marc Thiry (thiry@can-hamburg.de) Center for Applied Nanotechnology (CAN) GmbH 9
  10. 10. Business Segment II: MedicineNanoparticles: Properties Ligands define stability and chemistry: • Biocompatibility • Coupling mechanisms Core defines properties depending on size: • Colour 5 nm • Magnetism • Conductivity • Thermodynamics 5 nm Center for Applied Nanotechnology (CAN) GmbH
  11. 11. Business Segment II: MedicineNanoparticles: CANdot® Series AFeatures • Fluorescent Nanoparticles • Emission max: 500 to 620 nm • High reproducible properties • Soluble in water or non-polar organic solvents • High physical and chemical stabilityStructure • CdSe/CdS/ZnS dots • Core-shell-shell structure • Scalable core size • Core and core-shell particles available, too Own Product Center for Applied Nanotechnology (CAN) GmbH 12
  12. 12. Business Segment II: MedicineNanoparticles: CANdot® Series MFeatures • Magnetic nanoparticles • Diameter between 5 and 30 nm Own • Small size distribution Product • Soluble in water or non-polar, organic solventsStructure magnet • FeOX nanoparticles • Hydrophobic acids for organic solvents • Hydrophilic polymers for water • Doping possible Center for Applied Nanotechnology (CAN) GmbH 18
  13. 13. Business Segment II: MedicineNanoparticles: SynthesisA) Vapour Deposition (PVD / CVD) “Hot Injection Process”B) Sol-Gel TechniqueC) Wet-Chemistry Advantages • universal applicable • well known • broad temperature range Disadvantages • temperature profile hard to control • slow mixing after injection • “up-scaling” difficult Center for Applied Nanotechnology (CAN) GmbH 13
  14. 14. Business Segment II: MedicineNanoparticles: SynthesisA) Vapour Deposition (PVD / CVD) “Flow Synthesis”B) Sol-Gel TechniqueC) Wet-Chemistry Center for Applied Nanotechnology (CAN) GmbH 14
  15. 15. Business Segment II: MedicineNanoparticles: Synthesis Center for Applied Nanotechnology (CAN) GmbH 15
  16. 16. Business Segment II: MedicineNanoparticles: Properties 5 nm Center for Applied Nanotechnology (CAN) GmbH
  17. 17. ServiceAnalytics
  18. 18. Business Segment II: MedicineToxicity of Nanoparticles quality skin lung ligands intestine shells ICC shape size nanoparticle modification interaction Center for Applied Nanotechnology (CAN) GmbH 19
  19. 19. Business Segment II: MedicineToxicity of NanoparticlesExample for studying the interaction between nanoparticles and cell system• Red: Epithelial-cells (lung), stained with Draq5 (nucleus)• Blue: CdSe-CdS nanoparticles with different blockcopolymer-labels, located in the cell cytosol and the cell membrane Service Contact: Toxicity: Dr. Thomas Frahm (frahm@can-hamburg.de) 20 Center for Applied Nanotechnology (CAN) GmbH
  20. 20. EU project VIBRANT• The goal of VIBRANT is the development of nano- technology-based systems for diabetes diagnosis and/or therapy. from the pharmaceutical industry.• CAN and UHH will provide a contrast agent providing a stable and high signal intensity, which is highly specific to the cell type, but low toxicity,http://www.fp7-vibrant.eu/Ultimately, VIBRANT will deliver β-cell specific, functionally optimizednanoconstructs and defined know-howfor in vivo applications in non-human Ihr Ansprechpartner:primates and humans with regard to Dr. Theo Schotten (schotten@can-hamburg.de)quantification of BCM, imaging of
  21. 21. Specific coupling agent The Nanocontainer Superparamagnetic particleQuantum Dots Biocompatible Shell Anchor/Linker Ligand ~ 20 - 300 nm Micelle or Vesicle Centrum für Angewandte Nanotechnologie GmbH
  22. 22. Outline• EU Framework 7 Large Scale Project• Idea and coordination: CAN GmbH• Duration: 7/2009 to 6/2013• Grant: 8 Mio EUR• Scientists from nine research institutes from five EU-countries (Belgium, Spain, Denmark, Sweden and Germany• Industrial Advisory Board: big pharma.http://www.fp7-vibrant.eu/ InternationalIhr Ansprechpartner:Dr. Theo Schotten (schotten@can-hamburg.de) collaboration
  23. 23. The “Axis of Excellence”* International collaboration *) R = 0.989! ;-)
  24. 24. Business Segment III: Technical ApplicationsSecurity LabelsCANdots® Series X as Security Labels: Contract• Activation of the host lattice by doping with rare-earth elements• Reproducible Shape of Particles (spheres to ellipsoids, synthesis specific) Research• Reproducible Size of Particles (7 to 40 nm, material- and synthesis specific) (conf.)• Physical und Chemical Stability (photo stabilized, inert to high temperatures, acids, bases und organic solvents) Contact: Polymers: Dr. Jan Niehaus (niehaus@can-hamburg.de) Center for Applied Nanotechnology (CAN) GmbH 25
  25. 25. Business Segment III: Technical ApplicationsNew Concept of a Solar Cell Quantum Dot- Carbon Nanotube Composites B.Hernandez-Juárez, C. Klinke, A.Kornowski, H. Weller Institute of Physical Chemistry. Universität Hamburg. Center for Applied Nanotechnology (CAN) GmbH
  26. 26. Business Segment III: Technical ApplicationsNew Concept of a Solar Cell Collaboration e.g. Photovoltaics h+ with Academia e e- e e e e e h CB VB conductive polymer Center for Applied Nanotechnology (CAN) GmbH
  27. 27. Business Model:Collaborative Research ProjectsExample: VIBRANT, EU-Project• EU Framework 7 – NMP – Large Scale Project Nanosciences, Nanotechnologies, Materials and New Production Technologies• Goal of the project: Development of marker systems for diabetes diagnostics• Coordination: CAN GmbH• Timeframe: 7/2009 to 6/2013• Budget: about 8 Mio EUR• Scientists from nine research institutes from five EU-countries (Belgium, Spain, Denmark, Sweden and Germany)• Industrial Advisory Board• Internet: www.fp7-vibrant.eu• Coordination of the application process (two step process) Centrum für Angewandte Nanotechnologie (CAN) GmbH 28
  28. 28. Business Model:Patents, ProductsIntellectual Property Rights owned by CAN1. Method for producing alkaline earth sulfate nanoparticles (Basolute I)2. Process for preparing dispersible sulfate nanoparticles (Basolute II)3. Luminescent core/shell nanoparticles4. Core/shell nanoparticles suitable for (F)RET-assays5. Synthesis of nanoparticles comprising metal(III)vanadate6. Security printing liquid and method using nanoparticles7. Paramagnetic nanoparticles8. Synthesis of nanoparticles (Dotnan)9. X-Ray opaque dental nanomaterials10. Postsynthetic polyacid/base modification of nanoparticles11. InP nanoparticles and method for their manufacture12. Reactor for the synthesis of nanoparticles CANdots Series A13. … CANdots Series X Center for Applied Nanotechnology (CAN) GmbH 29
  29. 29. Business Model:Contract ResearchFirst Contact• Discussion on ideas / problems / requests• Non Disclosure Agreement (NDA)ConceptAgreement on:• R&D goals• Timeframe• Budget• Patent- and License issues• Other partners• Legal issuesContracts• Small jobs (< 10 T€)• Feasibility Studies (< 50 T€)• R&D Contracts (> 50 T€) Centrum für Angewandte Nanotechnologie (CAN) GmbH 30
  30. 30. Business Model:ServiceConsulting and Service• Studies• SurveysCAN-Analytics• Scanning Electron Microscopy (SEM / TEM)• Static and Dynamic Light Scattering (SLS / DLS)• X-Rax Scattering (SAXS / WAXS)• Atomic Force Microscopy (AFM)• Infrared Spectroscopy• Mass-Spectrometry (MS, MALDI-MS)• Absorption Spectroscopy (UV-Vis, NIR)• Fluorescence Optical Microscopy• Confocal Laser-Scanning Microscopy• Electron Spin Resonance-Spectroscopy• SQUID Magnetometry• Chromatography• Rheology Center for Applied Nanotechnology (CAN) GmbH 31
  31. 31. CAN GmbH:PartnerUniversity of HamburgCooperation ContractsCompanies:Beiersdorf AG www.beiersdorf.comEppendorf AG www.eppendorf.comBODE Chemie GmbH www.bode-chemie.deMerck KGaA www.merck.deBayer AG www.bayer.deInstitutions:Free and Hansestadt Hamburg http://fhh.hamburg.de/Hamburger Sparkasse www.haspa.deHamburg Chamber of Commerce www.hk24.deInnovationsstiftung Hamburg www.innovationsstiftung.deLife Science Agentur Norgenta www.norgenta.deCenter of Competence Hansenanotec www.nanoscience.de/hansenanotec/ Center for Applied Nanotechnology (CAN) GmbH 32
  32. 32. CAN GmbH:… get in contact !Center for Applied Nanotechnology (CAN) GmbHGrindelallee 11720146 HamburgGermanyT +49 40 42838 – 4983F +49 40 42838 – 5797E fso@can-hamburg.dewww.can-hamburg.de Center for Applied Nanotechnology (CAN) GmbH 33

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