What is medicinal chemistry.ppt

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What is medicinal chemistry.ppt

  1. 1. M.KUMARASAMY COLLEGE OF ENGINEERING
  2. 2. What is medicinal chemistry?The science that deals with the discovery or design of new therapeutic chemicals and the development of these chemicals into useful medicine
  3. 3. A Father of ModernMedicinal ChemistryEdward E. Smissman, University of Kansas Smissman Award of the ACS Division of Medicinal Chemistry named in his honor
  4. 4. Everyday drugs…..Still produce a response; many are addictiveCaffeineSugarNicotineAlcoholFood additivesVitaminsHerbs
  5. 5. cocaineBesides being an extremely addictive and dangerous narcotic, cocaine has some medicinal use. Cocaine has been used as a local anesthetic for eye and nasal surgery.The vasoconstriction helps reduce bleeding and the systemic circulation of cocaine (into the heart, specifically).
  6. 6. The tobacco plant  When tobacco smoke is inhaled, the nicotine passes quickly to every organ of the body. The brain and nervous system are stimulated by small doses and depressed by larger ones. Nicotine increases the heart rate and the blood pressure, and may contribute directly to the excess of thrombosis and atheroma in smokers.
  7. 7. HeroinDiamorphineOne of the best painkillers (“hero”)1898: on market1903: withdrawn (addictive properties)Today: still used
  8. 8. DRUGS "all chemicals other than food that affect living processes." The drug is a medicine. However, if a drug causes a harmful effect on the body, the drug is a poison. The same chemical can be a medicine and a poison depending on conditions of use and the person using it.
  9. 9. DRUGS CLASSIFICATION Drugs can be classified according to various criteria Chemotherapeutic agents - used to cure infectious diseases and cancer. (Sulfa drugs, Antibiotics) Pharmacodynamic agents - used in non-infectious diseases (Cholinergic, Adrenergic, Hallucinogenic, Sedatives) Miscellaneous agents (Narcotic Analgesics, Local Anesthetics)
  10. 10. DRUGS NAMEDrugs have three or more names including a:chemical name- rules of nomenclature of chemical compounds. brand or trade name- selected by the manufacturer generic or common name- common established name
  11. 11. MODE OF DRUG ACTION One major problem of pharmacology is that no drug produces a single effect. primary effect is the desired therapeutic effect. Secondary effects are all other effects beside the desired effect which may be either beneficial or harmful. Drugs are chosen to exploit differences between normal metabolic processes and any abnormalities which may be present.
  12. 12. TYPES OF MEDICINESSiddhaAyurvedhaAllopathyHomeopathyEtc………….
  13. 13. SIDDHAThe father of Siddha Vaidyam or Siddha Medicine. Agasthiya GuruSiddha Medicines are natural and safe without any side effects.Its a way of life formulated by Siddhars through their vision and realisation for getting peace for the mind, health for the physical body .
  14. 14. ANANAS COMOSUS  English Name : Pine apple  Family Name : Bromeliaceae  Chemical constituents : Bromelin  Action : Styptic, Emmenagogue, Anthelmintic, Vermicide,  Diaphoretic, Aperient  Uses in Siddha :  It is useful in vomiting,gastralgia,jaundice .  It’s juice is processed into syrup and it helps in vomiting, excessive thirst, leucorrhoea  and other pitha disorders.
  15. 15. CITRUS AURANTIUM English Name : Sour orange, bitter orange Family Name : Rutaceae Chemical constituent : d-linalool and glucoside hesperidin Action : Refrigerant, Stomachic, Tonic Uses in Siddha : ? It is a blood purifier. ? It reduces secretion of excessive bile and improves digestion and health. ? It also helps in curing cough, diabetes mellitus, chest pain, liver disorder.
  16. 16. ANNONA SQUAMOSA English Name : Custard apple, Sugar apple Family Name : Annonaceae Chemical constituent : Seeds has an acrid principle Action : Coolant, Tonic, Haematinic Uses in Siddha : It is prepared as syrup and it helps to reduce heat in the body.
  17. 17. AYURVEDA "the knowledge for long life" Ayurveda stresses the use of plant- based medicines and treatments. All diseases originate as an inbalance in the digestive system. Up to 80% of people in India use either Ayurveda or other traditional medicines.
  18. 18. PAPAYA Boosts up the immune system. Increases quality of proteins in whole organism. Encourages the renewal of muscle tissue. Papaya can be use also externally as a treatment for skin wounds that don’t heal quickly, for this you can use papaya peel or ointments made out of papaya.
  19. 19. LEMONMouth ulcer and Throat infection.Reduce BodyFat Stomach upsetConstipation Body pain
  20. 20. JACKFRUIT The Chinese consider jackfruit pulp and seeds tonic, cooling and nutritious, and to be "useful in overcoming the influence of alcohol on the system.“ The seed starch is given to relieve biliousness and the roasted seeds are regarded as aphrodisiac. The root is a remedy for skin diseases and asthma
  21. 21. ALLOPATHY"The term allopathy was invented by German physician Samuel Hahnemann ..."Scientific medicine at the beginning of the [19th] century was heroic medicine.“
  22. 22. ACETAMINOPHEN Paracetamol They are widely used for the treatment of inflammatory disorders and painful conditionsParacetamol is a drug used as a painkiller (analgesic) and for reducing fever (antipyretic)Other names are panadol & tylenol in US
  23. 23. Benadryl  Diphenhydramine Hydrochloride  Benadryl is a medication that is used for a variety of different purposes.  It can be used to treat insomnia, sneezing and runny nose due to the common cold.  Healthcare providers may also occasionally recommend off-label uses for Benadryl such as for treating morning sickness, coughing, and autism.
  24. 24. CHEMICAL INREGULAR USE
  25. 25. TULSI TULSI MEANS IN COMPARABLE IT CALLED AS QUEEN OF HERBS TULSI IS AN ANTI-INFLAMMATORY ANDANTI–OXDIANT
  26. 26. TULSI CONTENTS OCIMUM SANCTUM TULSI CONTAINS ASCORBIC ACID CAROTENE ONE FORM OF VITAMIN -C
  27. 27. AMLA  Used in ayurvedha  Contains vitamin C  20 times the amount of vitamin C in oranges  prevents jaundice indigestion   regulates the blood sugar
  28. 28. GUAVA Contains calcium , iron, protien have more amount of vitamin A prevents poor circulation cataracts to help kidney to eliminate the waste reduce the risk of cancer and cholestrol
  29. 29. TURMERIC  Used in sidha  Contains resin,fatty substances  Root contains 10% of glucosoid and turpethin  Contains mixture of phenol compounds called curcumin  Having starch,protien,vitamin A,etc.

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