Propossal Summer 09

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  • 1. Proposal Research
    Title:
    • Lupus in pregnant women
    Abstract:
    This proposal investigation gives me the opportunity to do a research about the different types of lupus and if some of these types affects directly the pregnancy in women within lupus diagnostic. Pregnant women with a lupus diagnostic have the risks that she or the baby can be negatively affected by this disease and also the mother and the bay can be expose to die. So the problem of this proposal is to find why women with a lupus diagnostic can be pregnant or why the women have to decide between her life and the baby’s life. Basically, the purpose of this is that people being to familiarize with the effects of lupus disease, especially meanwhile the pregnancy. Therefore, have to examine the different effects that can be present meanwhile the pregnancy to know how these can affects the baby’s development or the mother life; and definitely search different alternatives to combat these risks.
    As the search going up, a possibility to being to control the pregnancy was find, basically is to find an enzyme to control the preeclampsia, the major risk for the baby meanwhile the pregnancy, that have as a goal find a enzyme that serve like a control to all these enzymes that are in a hyperactive manner and also normalize the electrocutes in the blood. So these, conduce us to the proposal’s hypothesis that is that Lupus affects directly all the possibilities to survive of the mother or the baby and with the help of an enzyme, the Lupus can be controlled. Additionally, have the possibility to use this enzyme to control the Lupus neonatal that the baby, after the birthing, can be get from the mother.
    Introduction:
    Lupus is an autoimmune disorder that affects our Immune System. As is of your knowledge he Immune System works as a catcher in a baseball game, because the catcher’s function is to catch all the “bad balls”; so the Immune System is similar because this catch all the bacterium and viruses that enter in our body prevent that these bacterium and viruses infect our organs. In other words, Lupus is a disease that catches these viruses and bacterium and invaded our organs with these. Exists 5 types of Lupus: Lupus eritematoso, the most common; Lupus cutaneo and discoide, that are like an intensive rash on skin; Secondary Lupus, that is from medicines and Lupus Neonatal, that is a lupus that the mother transfer to the baby and the baby can die for that. Also, Lupus is a disease that affects more women than men and the women that affects are in their reproductive age between 20 to 35 years.
    Lupus risks are:
    • 40% women with lupus increase her risks during the pregnancy
    • 2. 20% pregnant women get preeclampsia
    • 3. 50% babies born premature
    • 4. Presence of antibodies in blood
    • 5. Baby born dead
    Basically, these are the major risks that the mother and the baby exposed. Definitely, Lupus is a rare disease and it’s difficult to works with this because it’s not clearly what the cause of this disease is. Many scientists that work in HYPERLINK " http://dialnet.unirioja.es/servlet/revista?tipo_busqueda=CODIGO&clave_revista=10706" Rheumatic disease clinics of North America, believe that the principal cause of lupus can be a genetic component, but this is not completely clearly.
    Methodology:
    For this proposal will be to use animals first, animals like cats, because cats are very similar to the humans and also can have many babies from one birthing. So first have to ask for some permission like the vertebrates’ permissions to work with cats and then when have to work with humans ask for the respective permissions too.
    When I can have the cats I going to divide in three groups: the control group that going to be normal cats or cats without lupus; the experimental group that going to be pregnant cats with lupus and the third one going to be cats with lupus but not pregnant. That because I want to compare the behavior of the enzyme in this three groups; how this enzyme affects, if is positive or negative. So, after the enzyme is injected and being to working, I going to examine or monitoring each month the different groups. The monitoring is going to evaluate the behavior of the lupus, if the disease advances or control or minimizes, if the preeclampsia control and the hyperactive enzymes control and be normal. All these things going to be evaluate and when the babies born, have to evaluate how many lives, die or acquire Lupus Neonatal and also if the mother die or her disease advance. So, depend of my results after the pregnancy, I going to develop a treatment with less risk for the mother and develop a treatment to cure the lupus neonatal that the baby can get meanwhile the pregnancy, as I said.
    References:
    HYPERLINK " http://dialnet.unirioja.es/servlet/autor?codigo=2129555" Andrea L. Sestak, HYPERLINK " http://dialnet.unirioja.es/servlet/autor?codigo=2129556" Swapan K. Nath, HYPERLINK " http://dialnet.unirioja.es/servlet/autor?codigo=2129557" John B. Harley; HYPERLINK " http://dialnet.unirioja.es/servlet/revista?tipo_busqueda=CODIGO&clave_revista=10706" Rheumatic disease clinics of North America, ISSN 0889-857X, HYPERLINK " http://dialnet.unirioja.es/servlet/listaarticulos?tipo_busqueda=EJEMPLAR&revista_busqueda=10706&clave_busqueda=181501" Nº. 2, 2005 (Ejemplar dedicado a: Lupus eritematoso sistémico / HYPERLINK " http://dialnet.unirioja.es/servlet/autor?codigo=2129546" Murray B. Urowitz (ed. lit.)) , pags. 191-208
    WOFSY D, SEAMAN WE: Successful Treatment of Autoimmunity in NZB/NZW F1 Mice with Monoclonal Antibody to L3T4. J Exp Med 1985, 161:378-391.
    Friedman EA, Rutherford JW. Pregnancy and lupus erythematosus. Obstet Gynecol 1956; 8: 601.
    Nossent HC, Swakk TJG. Systemic lupus erythematosus.VI Analysis of the interrelationship with pregnancy. J Rheumatol 1990; 17: 771.
    http://www.lupusresearchinstitute.org
    http://medicine.ucsf.edu/lupus
    RISE Program
    Lupus in Pregnant Women
    Karla Irenisse Velázquez Soto
    Biol. 3009