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Sintesis de novo
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Sintesis de novo

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Síntesis de novo.

Síntesis de novo.

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  • 1. Mmmmmmm…..Triglicéridos
  • 2. GeneralidadesSíntesis de ácidos grasosRegulación
  • 3. •Se lleva a cabo a partir de Acetil CoA•Cito sol•Reserva energética•Almacenamiento en adipositos
  • 4. •Síntesis de Malonil CoA•Elongación
  • 5. 1• catalizada por la acetil-CoA carboxilasaUtiliza: •Acetil CoA •Bicarbonato •ATP •Biotina
  • 6. AcetilMalonil CoA CoA
  • 7. •Ocurre a través de cuatro reacciones recurrentes•Llevada a cabo por la ácido graso sintetaza.
  • 8. 1•Llevada a cabo por β-Cetoacil-ACP sintetasaAcetil CoA+ Malonil ACP = Acetoacetil ACP –Co2
  • 9. Sinte Acetil Aceto-AcetilMalonil CoA CoA 2 CoA CO
  • 10. • 2•Llevada a cabo por β-Cetoacil-ACP reductasaAcetoacetil ACP+ NADPH+H = D-3-Hidroxibutiril ACP
  • 11. NADPH D-3 Aceto-Acetil Hidroxibutiril CoA ACP
  • 12. 3•Llevada a cabo por 3-Hidroxiacil-ACP deshidratasa D-3-Hidroxibutiril ACP = Crotonil-ACP, -H2O
  • 13. D-3 CrotinilHidroxibutiril ACP ACP
  • 14. • 4•Llevada a cabo por Enoil-ACP reductasa Crotonil-ACP + NADPH = Butiril ACP + NADP*
  • 15. NADPH Crotinil Butiril ACP
  • 16. Agrega Malonil ACP•Se vuelve a iniciar el ciclo de la elongación•Siguen agregando 2 carbonos por ciclo•Hasta formar ácido palmítico de 16 carbonos, el cual se une a una CoA y forma palmitoil CoA
  • 17. 1. 4 carbonos2. +2 carbonos = 6 carbonos3. +2 carbonos = 8 carbonos4. +2 carbonos = 10 carbonos5. +2 carbonos = 12 carbonos6. +2 carbonos = 14 carbonos7. +2 carbonos = 16 carbonos• 8 acetil CoA• 7 ATP´S• 14 NADPH
  • 18. •Insulina y glucagon•Palmitonil CoA

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