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Physiological changes 09
1.
Physiological Aging Changes IMMUNE neurohumoral
response white blood cell reserve (secondary to bone marrow/splenic sclerosis) “Sluggish” T cell response SENSORY salivation taste buds for sweet & salty: most tastes are bitter / sour visual acuity sensitivity to sound response to pain thirst sensation motor skills Changes in dentition CARDIOVASCULAR myocardial irritability dysrhythmias, e.g. PVC’s/PAC’s A/V blocks maximal heart rate sinus rate arterial compliance systolic blood pressure cardiac output circulation time cutaneous/tissue perfusion BODY COMPOSITION lean muscle mass subcutaneous fat overall body fat sweat glands skin pigmentation serum protein binding CENTRALNERVOUSSYSTEM neuronal density reflexes sympathetic response proprioception barorecptor response (postural hypotension) RENAL bladder capacity renal blood flow glomerular filtration renal clearance of drugs & metabolites RESPIRATORY tidal volume vital capacity residual volume lung capacity compliance response to hypoxemia/hypercapnia GASTROINTESTINAL gastrointestinal absorption gastric emptying hepatic blood flow / drug clearance drug absorption motility transit time METABOLIC basal metabolic rate risk for hypothermia temperature regulation response ENDOCRINE or thyroid function Hypo/hyperthyroidism insulin sensitivity ORTHOPEDIC Osteopenia risk of fractures range of motion ligamentous stiffness Sources: Graf, C. (2006).Functional decline in hospitalized older adults. ANJ, 106(1), 58-67; Mick, DJ, Ackerman, MH. (2004). Critical care nursing for older adults: pathophysiological and functional considerations. Nurs Clin N Am, 39, 473-493; Watters, JM. (2002). Surgery in the elderly. Journal canadien de chirurgie, 45(2), 104-108. Delirium in the Older Person: A Medical Emergency. (2006). VIHA. www.viha.ca/mhas/resources/delirium/ Physiological Aging Changes.v3 08.07; 01.09
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