Perkembangan pengetahuan tentang
• Semakin banyak fakta terungkap
seiring dengan perkembangan
pengetahuan tentang metabolisme dan
• Sifat, teknik assessment, spektrum
gejala dan upaya penanggulangan
Amplification of action
• Defined as the percent of the consumed mineral
that enters via the intestinal absorptive cells and
is used for its intended purpose.
• Bioavailibility includes not only how much of a
consumed minerals enters the body, but also
how much is retained and available for use.
Requirement and Allowance
The lowest continuing intake of a nutrient that will
maintain a specified criterion of adequacy
RDA (recommended dietary allowance)
The average daily amount of a nutrient considered
adequate to meet the known nutrient needs of
practically all healthy people.
Interactions among the trace minerals are common
and often lead to nutrient imbalances.
An excess of one may cause a deficiency of another.
A deficiency of one may open the way for another to
cause a toxic reaction.
A deficiency of one may exacerbate the problems
associated with the deficiency of another.
Interlocking gear system
is used primarily to detect subclinical deficiency states
is becoming increasingly important with the growing
emphasis on preventive medicine
can be used to supplement other methods
often affected by biological and technical factors
• Static biochemical test
• Functional test