Trabajo plegable biomol
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Trabajo plegable biomol

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Trabajo plegable biomol Presentation Transcript

  • 1. “RESEARCHERS DISCOVER DNA ‘REPAIR’ ENZYME THAT COULD ENHANCE CANCER TREATMENTS” AND “NEW MECHANISM FOR HUMAN GENE EXPRESSION DISCOVERED” Juan Sebastián Parada Zuluaga Medicine student III semester Molecular Biology
  • 2. INTRODUCTION The news are about replication of genetic information, an important molecule involved in this process and it relation with cancer; discoveries at same process and it possible treatment associated with neurodegenerative diseases.
  • 3. RESEARCHERS DISCOVER DNA ‘REPAIR’ ENZYME THAT COULD ENHANCE CANCER TREATMENTS
  • 4. RESEARCHERS DISCOVER DNA ‘REPAIR’ ENZYME THAT COULD ENHANCE CANCER TREATMENTS NEIL1 is a protein associated with the replication process. It´s part of the pre-replication complex protein group. The pre-replication complex can bind to the single strands and copy them back into double strands.
  • 5. RESEARCHERS DISCOVER DNA ‘REPAIR’ ENZYME THAT COULD ENHANCE CANCER TREATMENTS DNA replication is an unprotected process, making it more vulnerable to reactive molecules that will damage the structure and function. If this occurs, the genetic information will be altered, producing different diseases associated with specific mutation on DNA. ROS
  • 6. RESEARCHERS DISCOVER DNA ‘REPAIR’ ENZYME THAT COULD ENHANCE CANCER TREATMENTS The damages on DNA are frecuently along the cell division by reactive molecules. NEIL1 immediatly, recognize the mutation and binds to the damaged site, stoping all the process. When the replication stops, the next step is the regression of the replication fork.
  • 7. RESEARCHERS DISCOVER DNA ‘REPAIR’ ENZYME THAT COULD ENHANCE CANCER TREATMENTS In cancer cells, cancer drugs may be more effective if NEIL1 expression is blocked or inihibited. If the genome is damaged and if it´s not repaired, the cell will be more susceptible to external agents and die easily. So, if the DNA is repairable, resistance to disease increases, and the activity of DNA repair is who prevents efficiency against cancer.
  • 8. RESEARCHERS DISCOVER DNA ‘REPAIR’ ENZYME THAT COULD ENHANCE CANCER TREATMENTS PERSONAL OBSERVATION Identify cell process is of utmost importance for development of science and biotechnology. Knowing the different cellular processes, show us possibilities to interact with genome for creation of favorable mechanisms to manage different pathologies and oncology treatment, improving the global health.
  • 9. NEW MECHANISM FOR HUMAN GENE EXPRESSION DISCOVERED  
  • 10. NEW MECHANISM FOR HUMAN GENE EXPRESSION DISCOVERED • CACNA1A  is a gene that codifies to  calcium channel protein in nerve cells. • In  spinocerebellar  ataxia  type-6  (SCA6),  researchers  found  mutation  of this gene, but not difunctionality or  alteration of the channel.
  • 11. NEW MECHANISM FOR HUMAN GENE EXPRESSION DISCOVERED Looking  for  other  reason,  researchers  focused on α1ACT; a  free-floating  fragment  of  the  CACNA1A calcium channel protein  known  to  express  extra  copies  of  glutamine in SCA6 cells.
  • 12. NEW MECHANISM FOR HUMAN GENE EXPRESSION DISCOVERED α1ACT origin  is  the  same  mRNA  sequence as the CACNA1A calcium  channel.  Mutated α1ACT appeared to be toxic  to nerve, finding the explanation this  rare case.
  • 13. NEW MECHANISM FOR HUMAN GENE EXPRESSION DISCOVERED Now, the team are investigating  other examples of human genes  with the same characteristics to  understand the new mechanism and  develop treatments to combat the  disease. They are looking for achieve the  inhibition of production of the mutant  α1ACT in spinocerebellar ataxia  type-6  to stop the progression of  the disease.
  • 14. NEW MECHANISM FOR HUMAN GENE EXPRESSION DISCOVERED PERSONAL OBSERVATION Its not just a mutated protein identification: the knowledge of a new kind of cellular process is a great find, that could open the door to researches for the advance and knowledge about the genome. Knowing those Altered process is a principal part to looking for treatments, or better the cure for diseases. Now there´s a future solution for SCA6.
  • 15. UTILIDAD MÉDICA
  • 16. UTILIDAD MÉDICA Achieve a better understanding of cell replication process is essential for the future of genetic research and therefore, for medical progress in search of fighting diseases current.
  • 17. BIBLIOGRAPHY • Grush, Loren. Researchers discover DNA ‘repair’ enzyme that could enhance cancer treatments. FOX NEWS HEALTH; 2013 [cited 2013 July 30]; Available at : http://www.foxnews.com/health/2013/07/30/researchers-discover- dna-repair-enzyme-that-could-enhance-cancer-treatments/ • New Mechanism for Human Gene Expression Discovered. Science Daily; 2013 [cited 2013 July 3]; Available at: http://www.sciencedaily.com/releases/2013/07/130703120554.htm