Juan Carlos Torres Sánchez #804-11-9230 BIOL 3095Blasco H, Corcia P, Moreau C, Veau S, Fournier C, Vourc’h P, Emond Patrick,Gordon P, PradatPF, Praline J, Devos D, Desbarats L and Andres CR. 2010. H-NMR-Based Metabolomic Profiling of CSF in Early Amyotrophic Lateral Sclerosis. PlosOne. 5(10):e13223Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of motor neurons.Patients usually live 2-5 years after symptom onset with an unknown cause. In thisresearch,samples were collected from the cerebral spinal fluid (CSF) of ALS patientsand from subjects that did not have a neurodegenerative disease. Metabolomicsstudies were performed on the samples using NMR (Nuclear Magnetic Resonance)spectroscopy to find biomarkers in the early stages of the disease, and to evaluatecertain biochemical factors that are involved in ALS. The researchers are aware thatthis study only focused on nuclear magnetic resonance (NMR), but to achieve asuperior result, the combinations of different approache is better. The resultsdemonstrated that H NMR spectroscopy combined with other analysis techniquescould detect certain changes in the concentration of some CSF metabolites in ALS.The mechanisms involved in amyotrophic lateral sclerosis are very complex and nonehave been identified as useful biomarkers that can substitutefor the patient’sroutinecheck up.