Biblio 1 official
Upcoming SlideShare
Loading in...5
×
 

Like this? Share it with your network

Share

Biblio 1 official

on

  • 234 views

 

Statistics

Views

Total Views
234
Views on SlideShare
227
Embed Views
7

Actions

Likes
0
Downloads
0
Comments
0

1 Embed 7

http://juancarlosrise.wordpress.com 7

Accessibility

Upload Details

Uploaded via as Microsoft Word

Usage Rights

© All Rights Reserved

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Processing…
Post Comment
Edit your comment

Biblio 1 official Document Transcript

  • 1. Juan Carlos Torres Sánchez #804-11-9230 BIOL 3095Ranganathan S, Williams E, Ganchev P, Gopalakrishnan V, Lacomis D, Urbinelli à L,Newhall K, Cudkowicz ME, Brown Jr. RH and Bowser R. 2005. Proteomic profilingof cerebrospinal fluid identifies biomarkers for amyotrophic lateral sclerosis. Journalof Neurochemestry. 95:1461–1471This review is about Amyotrophic Lateral Sclerosis (ALS) and profiling biomarkersfor this disease. ALS is a neurodegenerative disease that causes damage to motorneurons located in the cerebral cortex, brainstem and spinal cord. To help detectspecific biomarkers in this research,they used cerebrospinal fluid (CSF) from ALSpatients and from the control subjects using surface-enhanced laser desorption/ionization-time of flight mass spectrometry (SELDI-TOF-MS). This technique hasbetter precision in identifying biomarkers. Three biomarkers were found in the results,transthyretin, cystatin C, and carboxy-terminal fragment of neuroendocrine protein7B2. Two of these biomarkers were validated, showing a section of CSF biomarkersof ALS patients. This study is very useful because it displays the correlation of howimportant it is to find biomarkers for ALS patients and how cystain C can be a greatbiomarker for that disease.