Plegable.

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Plegable.

  1. 1. CHROMOSOMES AND CHROMATINE. <ul><li>Juan Fernando </li></ul><ul><li>Restrepo Hincapié. </li></ul><ul><li>Medicine student. </li></ul><ul><li>Universidad Pontifica Bolivariana. </li></ul>
  2. 2. FOLDING.
  3. 3. FOLDING
  4. 4. Systematic analysis of the methylation status of histones H2A. A complete description of all proteins in an organism .
  5. 5. METHYLATION OF H2AR29 IS A NOVEL REPRESSIVE PRMT6 TARGET. (20 de julio de 2011)
  6. 6. METHYLATION OF H2AR29 IS A NOVEL REPRESSIVE PRMT6. Post-translational modifications of histones have an important role in regulating all nuclear processes that occur in chromatin. they have identified and functionally characterized two methylation sites in the new H2A: R11 (H2AR11) and R29 (H2AR29). Depending on the type of modification and / or modified residue may be involved in the activation or silencing of genes.
  7. 7. METHYLATION OF H2AR29 IS A NOVEL REPRESSIVE PRMT6. H2AR29me2 as a new player in gene repression mediated by PRMT6.
  8. 8. OBSERVATION. the study of genes and histones is an important step in understanding how post-translational modifications can regulate gene expression.
  9. 9. <ul><li>CIPF scientists participating in an international project for proteomics. </li></ul><ul><li>(Abril 25 DE 2011) </li></ul>
  10. 10. CIPF scientists participating in an international project for proteomics. CIPF participates in the international Human Proteome Project (HPP), to detect the proteins encoded by the 20,300 human genes, quantify and define the changes involved in different pathologies. Scientists look for the difference between a cell and another in the proteins expressed.
  11. 11. CIPF scientists participating in an international project for proteomics. The purpose is to determine what proteins are in each moment in each of the different cell types. The long term goal is to integrate the knowledge extracted from both the human genome and the proteome, in order to apply the diagnosis, prognosis and treatment of various pathologies.
  12. 12. OBSERVATION.
  13. 13. MEDICAL UTILITY.
  14. 14. MEDICAL UTILITY. they can study the errors in the transcription of genes and their protein production consequences and a phenotype to humans so well that having studied this topic can find a solution for these bugs and corrected.
  15. 15. MEDICAL UTILITY. Proteomics has te objetive to generate a comprehensive map of human proteins in their biological context for the diagnosis, prevention, treatment and cure of diseases to improve health globally.
  16. 16. BIBLIOGRAPHY. <ul><li>-Tanja Waldmann and others. Methylation of H2AR29 is a novel repressive PRMT6 target, 20 de julio de 2011, Disponible en: PUBMED.GOV, (Base de datos en línea). </li></ul><ul><li>  </li></ul><ul><li>- http://www.noticias.com, CIPF scientists participating in an international project for proteomics. Abr 25, 2011 </li></ul>
  17. 17. <ul><li>GRACIAS… </li></ul>

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