Clinical Drug Information


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  • Clinical Drug Information

    1. 1. Clinical Drug Information Julie Whelan Fall 2007
    2. 2. Objectives <ul><li>Drug Names --Discuss the importance of drug nomenclature. </li></ul><ul><li>Looks </li></ul><ul><li>What resources will help in selecting the best drug for this particular patient? </li></ul><ul><li>Where can I find detailed dosing information including pediatric, geriatric, renal and hepatic failure? </li></ul><ul><li>Calculators and nomograms. </li></ul><ul><li>Interactions --Describe sources for drug/drug interaction information? Drug/lab, drug food, drug ethanol, drug disease interactions? </li></ul><ul><li>Where can you find adverse drug reaction ADR) and toxicity information? </li></ul><ul><li>Safety in pregnancy & lactation ? </li></ul><ul><li>Where to find warnings and how to report an ADR . </li></ul><ul><li>Describe PDA programs useful for quick ready reference. </li></ul>
    3. 3. Name Game Brand name generic name Laboratory name CAS Registry # NDC # Foreign names Molecular Formula
    4. 4. One Drug <ul><li>51146-56-6 </li></ul><ul><li>Deltaran, Dolomin, Amersol, Menadol </li></ul><ul><li>RD-13621, U-18573 </li></ul><ul><li>2-(4-Isobutylphenyl)propionic acid </li></ul><ul><li>C13H18O2 </li></ul><ul><li>Anti-inflammatory </li></ul><ul><li>NSAID </li></ul><ul><li>ibuprofen </li></ul>
    5. 5. PubChem <ul><li>Three Databases PubChem Substance, (Compound and BioAssay) </li></ul><ul><ul><ul><li>search by common name, systematic name, molecular weight and more. </li></ul></ul></ul><ul><ul><ul><li>Be as specific as possible. </li></ul></ul></ul><ul><ul><ul><li>Compounds not in PubMed database, have matches. </li></ul></ul></ul><ul><ul><ul><li>Duplicates exist so look for a record with some detail and especially with the literature link on the right-hand side. </li></ul></ul></ul><ul><ul><ul><li>This means there are PubMed citations link to do this substance. </li></ul></ul></ul><ul><ul><ul><li>Identify the common name. Search for it in PubMed using the links menu off of literature. </li></ul></ul></ul>
    6. 6. Sources for Names <ul><li>Brand names </li></ul><ul><ul><li>Micromedex, formulary, PDR, Clinical Pharmacology, USPDI, Mosby’s Drug Consult </li></ul></ul><ul><li>Generic names- all of above + F&C, ADI, MI </li></ul><ul><li>Registry #- Merck Index, ChemID, CAS </li></ul><ul><li>Molecular Forumula- Merck Index, ChemID, SciFinder </li></ul><ul><li>NDC#- Orange Book, Mosby’s </li></ul><ul><li>Foreign Names- Martindales (Mmdx), EMBASE, Index Nominum </li></ul><ul><li>Laboratory names,Investigational #-USAN dictionary, PubMed/EMBASE, Merck Index </li></ul>
    7. 7. Tour of Major Resources <ul><li>Micromedex </li></ul><ul><li>AHFS </li></ul><ul><li>Clinical Pharmacology </li></ul><ul><li>Dynamed </li></ul>
    8. 8. Non-subscription Resources <ul><li>LactMed </li></ul><ul><li> </li></ul><ul><li>MassMedline </li></ul><ul><li>Needy Meds </li></ul>
    9. 9. More Resources <ul><li>Med Watch http:// </li></ul><ul><li>RSS feed possible </li></ul><ul><li>Weekly Morbidity and Mortality Reports </li></ul><ul><li> </li></ul>
    10. 10. PDA- Quick References <ul><li>Available to you </li></ul><ul><ul><li>ePocrates Pro - HMS </li></ul></ul><ul><ul><li>Mobile Micromedex - HMS </li></ul></ul><ul><ul><li>LexiDrugs- Partners </li></ul></ul><ul><ul><li>CPOnHand- HMS </li></ul></ul>
    11. 11. How do they perform? <ul><li>Knollmann, BC Personal digital assistant-based drug reference software as tools to improve rational prescribing : benchmark criteria and performance </li></ul><ul><ul><li>Clin Pharmacol Ther 2005; 78:7-18. </li></ul></ul><ul><li>Galt KA Personal digital assistant-based drug information sources: potential to improve medication safety </li></ul><ul><ul><li>J Med Libr Assoc 93(2) April 2005. 229-236 </li></ul></ul>
    12. 12. Results <ul><li>Both compared 11 products </li></ul><ul><ul><li>Galt eliminated all but 3 for detailed analysis </li></ul></ul><ul><li>Assigned points for meeting quality benchmarks </li></ul><ul><li>Benchmarks included: </li></ul><ul><ul><li>Currency, EB dosing, dosage forms, side effects, ADRs, interactions, H/DS, comprehensiveness, accuracy, mechanism </li></ul></ul><ul><ul><li>Special features-calculators, cost, ID, pharmacokinetics, IV compatibility </li></ul></ul><ul><li>Used specific DI queries to develop ratings </li></ul>
    13. 13. The Winners Are! <ul><li>For Safety </li></ul><ul><ul><li>Lexi-Drugs </li></ul></ul><ul><ul><li>Mobile MDX </li></ul></ul><ul><ul><li>ePocrates RxPro </li></ul></ul><ul><li>For Rational Prescribing </li></ul><ul><ul><li>Lexi Drugs </li></ul></ul><ul><ul><li>CP onHand </li></ul></ul><ul><ul><li>PDRDrugs </li></ul></ul><ul><ul><li>A2ZDrugs </li></ul></ul><ul><ul><li>Pepid PDC </li></ul></ul><ul><ul><li>ePocrates RxPro </li></ul></ul><ul><ul><li>DRDrugs </li></ul></ul><ul><ul><li>Mobile MDX </li></ul></ul>
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