An Overview to the service offerings of BioVariance

1. Overview and Introduction
All our offerings are driven by our scientific context platform. It is the base for our
data analyses, that combined with high-quality visualization capabilities form the
two pillars of BioVariance‘s offering in the services area.
We turn complexity into usable data for drug development and thereby ensure that
you can discuss and communicate the key parts of the results quickly within your
project team.
Side effects complexdata Research Services at a Glance
Data Analysis
Visualization
Toxicity
Pathways biological Dr. Josef Scheiber
Sequences networks Garmischer Str. 4/V
80339 München
Tel.: +49 89 / 1 89 65 82-80
Fax: +49 89 / 1 89 65 82-99
Scientific context platform
Disease Xenobiotic josef.scheiber@biovariance.com (Back) Translating complex knowledge
Phenotype
w w w. b i o v a r i a n c e . d e where Xenobiotics meet Human Biology

2. Data Analysis for Drug Discovery Translational Data Analysis Consulting
Target Lead Preclinical Marketed Within this area we enrich all results with knowledge from our scientific context platform.
Tox
identification Finding Development Drug (exemplified in this image are different biological reasons that can lead to the same out-
come.)
We firmly believe that these additional information sources greatly facilitate your decision
Enhanced
analyses making when trying to understand compound effects, e.g. in clinical studies.
and results Knowledge
SNP in Gene A affects
For this area we have a strong focus on exploiting knowledge about marketed drugs affinity of
for earlier stages of Drug Discovery and always aim for testable hypotheses. You Epigenetic modification
can contact us for our expertise in the following areas: causes Complex Biomedical Interaction Data Straightforward visualization of the most relevant facts
side effect and toxicity prediction (starting from chemical structures Protein modification affects Main focus areas are: With our consulting services BioVariance helps to identify the right informatics me-
only, but we can also incorporate other data types) phosphorylation thods and tools to help you solving your scientific challenge. At the interface of Che-
Tertiary NGS analysis mistry and Biology we support you with the following points:
linking biological pathways with additional phenotypes is an off-target of drug X (what do the results mean)
the patient is taking Expression analysis content selection to improve results and interpretation
start from an unwanted toxicity to develop a hypothesis for the reason Pathway based biomarkers
finding additional possible simple visualization methods to improve understanding of complex
Polypharmacology profiles and chemogenomics analyses Food intake affects indications data
transcription factor Patient Stratification
By applying these methods BioVariance‘s clients take a quicker route to better lead hypotheses for Companion broad network of vendors and academia to find the best tool, either
compounds and clinical candidates. a single phenotype, e.g. side effect Diagnostics open source or commercial.