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Image Processing (I)

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CURSO: …

CURSO:
Genómica aplicada a la Medicina Clínica
BIOINFORMÁTICA Y NANOMEDICINA

Barcelona
24/11/2010

Published in: Technology, Education

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Transcript

  • 1. Image Processing (I) José Ramón Macías
  • 2. Genome Replication
  • 3. Transcription
  • 4. Translation
  • 5. Signal Transduction
  • 6. Protein Folding
  • 7. Viral Infection
  • 8. Motility
  • 9. Cellular Components
  • 10. researchers use models from structural studies to explain the functions and mechanisms of biological processes at the molecular level
  • 11. many key biological processes are carried out by large macromolecular complexes acting as nanomachines
  • 12. 15m 15x10-9m
  • 13. Image Processing
  • 14. 3D Electron Microscopy
  • 15. Top Side Bottom
  • 16.          N i K k i dkPkXPL 1 1 )|,(,,|log|  X                K k nn i nn in i dkPkXP kPkXP XkP 1' ' )()( )()( )( '|',',','| |,,,| ,|,             0 ,|, ,|, ,|, 1 2 1 )( 1 )( )1( 1 )(               K k N i n i N i i n i n k N i n i dXkP dXXkP VRdXkP                     N i n i N i i n i n k dXkP dXXkP A 1 )( 1 )( )1( ,|, ,|,                         2 2 2 exp 2 1 ,,|     ik M i XA kXP
  • 17. 91,114 particles (resolution: 9.9 Å)
  • 18. 22,176 27,416 25,651 15,871 91,114 particles
  • 19. 64 CPU’s : 3 days1 CPU: 6 months
  • 20. Storage
  • 21. E M D B lectron icroscopy ata ank
  • 22. 10 40 67 117 193 266 363 720 931 2002 2003 2004 2005 2006 2007 2008 2009 2010 since June 2002, the number of structures has increased steadily. “ ”
  • 23. Single Particle Icosahedral Helical Individual Structure 2D Crystal Today: 931 map volume entries
  • 24. Competitors
  • 25. X-Ray Crystallography Requires Crystals High Resolution  3D Electron Microscopy Medium Resolution  Crystals Not required Hybrid Models Fitting
  • 26. 3D-EM model Atomic model
  • 27. Hybrid model
  • 28. Hybrid model 3D-EM model Atomic model
  • 29. Data Integration
  • 30. http://biocomp.cnb.csic.es/das/PeppeR DASx3DEM & PeppeR VisualOmics