JPCL jz2016473 Knecht Presentation

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JPCL jz2016473 Knecht Presentation

  1. 1. Nanotechnology Meets Biology: Peptide-based Methods for theFabrication of Functional Materials Beverly D. Briggs and Marc R. Knecht University of MiamiJ. Phys. Chem. Lett. 2012, 3, 405-418. 1
  2. 2. Motivation • Mimicking Nature’s specificity, size and shape control of nanoparticle (NP) formation can be achieved. • Through this control, nanoparticle synthesis can be engineered for specialized applications. • Traditional methods for nanoparticle fabrication include high temperatures and harsh conditions. • Biomimetic techniques offer eco- friendly methods for fabrication under ambient conditions and temperatures. Proprietary and Confidential 2 American Chemical Society
  3. 3. Cell Surface/Phage Display Biocombinatorial isolation methods are utilized to identify peptides that bind to non-natural targets. Sarikaya, et. al., Nat. Mater., 2003  These techniques allow for identification of peptides with the ability to bind materials for technological applications.Proprietary and Confidential 3American Chemical Society
  4. 4. Palladium and Platinum Both Pd and Pt have applications in catalysis, energy storage, and gas sensing. • Q7 and Pd4 – spherical NP size control, isolated with Pd specificity. • R5 – originally isolated for SiO2 from diatoms, but also acts as a template for shaped particle formation. Chiu, C.-Y., et. al., Nanoscale, 2010. Bhandari, R., et. al., ACS Catal., 2011.• BP7A – preferentially binds to {110} surface, forming multipods.• T7 and S7 – preferentially bind to {100} and {111}, respectively, controls NP shape as well.• Cha – peptide binds to {100} and forms nanocubes. Proprietary and Confidential 4 American Chemical Society Chiu, C., et. al., Nat. Chem., 2011.
  5. 5. Gold and Silver Carter, C. J., Au and Ag NPs possess visible et. al., ACS plasmons, making them relevant for Nano, 2010. optics, biosensing, and catalysis. • E5 and FlgA3 – can impart chiral properties on achiral Au particles. • A3 – conjugated with organic molecules, leads to self assembly of unique Au NP helices and hollow spheres. • AG4 – used to create hybrid Au peptide spheres. • E6, D6, and EEEE – generates Ag particles that require only light for reduction and act as a template for nanowires in Li ion batteries. • Ge8 – mediates the formation of Ag nanoparticles, which, when immobilized, result in curled structures. Proprietary and Confidential American Chemical Society Chen, C.-L., et. al., J. Am. Chem. Soc., 2008. Song, C., et. al., J. Am. Chem. Soc., 2010.
  6. 6. Metal Oxides The electronic structure of ZnO, TiO2, and BaTiO3 make them applicable for optics, photovoltaics, and catalysis. • Z1 – shown to form ZnO hexagonal plates without secondary reagents. • G-12 and GT-16 – shown to preferentially bind to the (0001) ZnO surface. Ahmad, G., et. al., J. Am. Chem. Soc., 2008.• Ti-1 and Ti-1 (RKK) – demonstrates that basic residues • BT1 and BT2 – revealed to form are important in TiO2 NP formation. tetragonal BaTiO3 crystals with• Ti (Si) – 1 – isolated to bind and ferroelectric properties. generate TiO2 and not SiO2. Proprietary and Confidential 6 American Chemical Society
  7. 7. Conclusions: Acknowledgments:• Peptides can mediate the We graciously acknowledge the formation of a variety of National Science Foundation (Grants DMR-1145175 and technologically significant CBET-1157431) for financial materials. assistance. Further support from• Composition-specific the University of Miami is also acknowledged. interactions are important for NP formation, although peptide templates can also be used.• New techniques are needed to further probe the properties of biomimetic particles.Proprietary and Confidential 7American Chemical Society

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