MALDI imaging at Imabiotech

  • 1,552 views
Uploaded on

ImaBioteh provides a MALDI imaging solution as a fast and robust tool for ADME and pharmacokinetics

ImaBioteh provides a MALDI imaging solution as a fast and robust tool for ADME and pharmacokinetics

  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Be the first to comment
    Be the first to like this
No Downloads

Views

Total Views
1,552
On Slideshare
0
From Embeds
0
Number of Embeds
0

Actions

Shares
Downloads
14
Comments
0
Likes
0

Embeds 0

No embeds

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
    No notes for slide

Transcript

  • 1. Mass spectrometry Imaging (MSI)
    An innovative platform for drug and metabolites study
    www.imabiotech.com Imagine your next innovations
  • 2. Introduction
    IMABIOTECH is a leading French company providing CRO, biotechs and pharmaceutical groups with innovative Mass spectrometry imaging (MSI), customized services and products.
    IMABIOTECH is a spin-off of University of Lille, and in 2008, founded with Professor SALZET and Professor FOURNIER to bring expertise in the field of MSI
    www.imabiotech.com Imagine your next innovations
  • 3. MS Imaging use
    Why should do molecular imaging ?
    Stake of clinical and Pharma research:
    • Bring molecular information
    • 4. Combine molecular and spatial information in early stage of drug discovery
    • 5. Fast study of ADME and pharmacokinetics
    www.imabiotech.com Imagine your next innovations
  • 6. MSI Technique
    MSI : in vitro/ex vivo imaging technique which detects surface molecules of histological tissue sections
    More than thousands simultaneously detected molecules such as drugs, metabolites , lipids and proteins
    www.imabiotech.com Imagine your next innovations
  • 7. Benefits of MSI 
    MS imaging advantages
    • No labeling and non radioactive
    • 8. Biomolecules or drugs/Metabolites
    • 9. Large scope of simultaneous detection of elements and molecules (Atom to proteins)
    • 10. Fast compared to labeling approaches (HIC, autoradiography)
    • 11. Detailed images
    • 12. Resolution : 500nm - 100μm
    • 13. Sensitivity ng/g
    • 14. Whole body, cells, organs
    A label free method
    www.imabiotech.com Imagine your next innovations
  • 15. MSI applications 
    Examples of pharmacokinetics of a drug and metabolite (in a single experiment)
    2 hours post dose
    6 hours post dose
    Control T0
    Its metabolite
    Many others applications such as :
    • Biomarker discoveries directly on-tissue
    • 16. Contrast agent evaluation
    • 17. Chemicals detection
    • 18. Iron, Lithium of potassium detection
    • 19. Peptides or lipids
    www.imabiotech.com Imagine your next innovations
    Optical image
    of Kidney
    Drug localization
    2 hours post dose
    6 hours post dose
    Control T0
  • 20. MSI applications 
    Larges applications of MSI for :
    • drug ADME/PK studies :
    • 21. Co-localization of drugs and metabolites (defined by their exact masses)
    • 22. Research of unknown metabolites
    • 23. Assess Administration and Formulation
    • 24. Nanoparticles localization and Drug delivery systems studies
    • 25. Whole body or organs studies (Brain, Heart, Liver, Kidney, Bones, Muscles… )
    Whole mouse body
    Drug distribution
    Metabolites distribution
    www.imabiotech.com Imagine your next innovations
  • 26. MSI applications 
    Larges applications of MSI for :
    • biomarkers discoveries in different therapeutic areas :
    • 27. Oncology
    • 28. CNS diseases
    • 29. Infectious diseases
    • 30. Ophthalmology
    • 31. Gastroenterology
    • 32. Pulmonary
    • 33. Cardiology…
    Intestinal Disease
    CNS disease
    Ophthalmology
    Cardiology
    Pulmonary
    Oncology
    www.imabiotech.com Imagine your next innovations
  • 34. Benefits of MSI 
    Triple benefits of MS imaging in your ADME/PK studies
    • MS Imaging is fast (10 days to assess your drug delivery compared to others techniques 6-12 months)
    • 35. No radioactive and no labeling are required
    • 36. MSI technique discriminates the localization of drugs and metabolites
    • 37. Expertise in MSI
    www.imabiotech.com Imagine your next innovations
  • 38. The innovative platform
    IMABIOTECH an unique CRO Platform in Europe dedicated to MSI imaging
    • From Administration, tissue preparation to MS imaging
    • 39. ImaBiotech Performs :
    • 40. More than 40 images within in a week
    • 41. Organs and whole-body MS imaging
    • 42. For each molecules injected (>0,2 mg/kg; 0-70KDa)
    • 43. Distribution of drug and metabolites within 2 week
    • 44. And pharmacokinetics within 4 weeks
    www.imabiotech.com Imagine your next innovations
  • 45. For further information visit our website www.imabiotech.comor contactstauber.jonathan@imabiotech.com
    www.imabiotech.com Imagine your next innovations