MALDI imaging at Imabiotech

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ImaBioteh provides a MALDI imaging solution as a fast and robust tool for ADME and pharmacokinetics

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MALDI imaging at Imabiotech

  1. 1. Mass spectrometry Imaging (MSI) <br />An innovative platform for drug and metabolites study<br /> www.imabiotech.com Imagine your next innovations<br />
  2. 2. Introduction<br />IMABIOTECH is a leading French company providing CRO, biotechs and pharmaceutical groups with innovative Mass spectrometry imaging (MSI), customized services and products. <br />IMABIOTECH is a spin-off of University of Lille, and in 2008, founded with Professor SALZET and Professor FOURNIER to bring expertise in the field of MSI<br /> www.imabiotech.com Imagine your next innovations<br />
  3. 3. MS Imaging use<br />Why should do molecular imaging ?<br />Stake of clinical and Pharma research: <br /><ul><li> Bring molecular information
  4. 4. Combine molecular and spatial information in early stage of drug discovery
  5. 5. Fast study of ADME and pharmacokinetics</li></ul> www.imabiotech.com Imagine your next innovations<br />
  6. 6. MSI Technique<br />MSI : in vitro/ex vivo imaging technique which detects surface molecules of histological tissue sections<br />More than thousands simultaneously detected molecules such as drugs, metabolites , lipids and proteins<br /> www.imabiotech.com Imagine your next innovations<br />
  7. 7. Benefits of MSI <br />MS imaging advantages<br /><ul><li>No labeling and non radioactive
  8. 8. Biomolecules or drugs/Metabolites
  9. 9. Large scope of simultaneous detection of elements and molecules (Atom to proteins)
  10. 10. Fast compared to labeling approaches (HIC, autoradiography)
  11. 11. Detailed images
  12. 12. Resolution : 500nm - 100μm
  13. 13. Sensitivity ng/g
  14. 14. Whole body, cells, organs</li></ul>A label free method<br /> www.imabiotech.com Imagine your next innovations<br />
  15. 15. MSI applications <br />Examples of pharmacokinetics of a drug and metabolite (in a single experiment)<br />2 hours post dose<br />6 hours post dose <br />Control T0<br />Its metabolite<br />Many others applications such as :<br /><ul><li> Biomarker discoveries directly on-tissue
  16. 16. Contrast agent evaluation
  17. 17. Chemicals detection
  18. 18. Iron, Lithium of potassium detection
  19. 19. Peptides or lipids</li></ul> www.imabiotech.com Imagine your next innovations<br />Optical image <br />of Kidney<br />Drug localization<br />2 hours post dose<br />6 hours post dose <br />Control T0<br />
  20. 20. MSI applications <br />Larges applications of MSI for :<br /><ul><li>drug ADME/PK studies :
  21. 21. Co-localization of drugs and metabolites (defined by their exact masses)
  22. 22. Research of unknown metabolites
  23. 23. Assess Administration and Formulation
  24. 24. Nanoparticles localization and Drug delivery systems studies
  25. 25. Whole body or organs studies (Brain, Heart, Liver, Kidney, Bones, Muscles… ) </li></ul>Whole mouse body<br />Drug distribution<br />Metabolites distribution<br /> www.imabiotech.com Imagine your next innovations<br />
  26. 26. MSI applications <br />Larges applications of MSI for :<br /><ul><li>biomarkers discoveries in different therapeutic areas :
  27. 27. Oncology
  28. 28. CNS diseases
  29. 29. Infectious diseases
  30. 30. Ophthalmology
  31. 31. Gastroenterology
  32. 32. Pulmonary
  33. 33. Cardiology…</li></ul>Intestinal Disease<br />CNS disease<br />Ophthalmology<br />Cardiology<br />Pulmonary<br />Oncology<br /> www.imabiotech.com Imagine your next innovations<br />
  34. 34. Benefits of MSI <br />Triple benefits of MS imaging in your ADME/PK studies<br /><ul><li> MS Imaging is fast (10 days to assess your drug delivery compared to others techniques 6-12 months)
  35. 35. No radioactive and no labeling are required
  36. 36. MSI technique discriminates the localization of drugs and metabolites
  37. 37. Expertise in MSI </li></ul> www.imabiotech.com Imagine your next innovations<br />
  38. 38. The innovative platform<br />IMABIOTECH an unique CRO Platform in Europe dedicated to MSI imaging<br /><ul><li> From Administration, tissue preparation to MS imaging
  39. 39. ImaBiotech Performs :
  40. 40. More than 40 images within in a week
  41. 41. Organs and whole-body MS imaging
  42. 42. For each molecules injected (>0,2 mg/kg; 0-70KDa)
  43. 43. Distribution of drug and metabolites within 2 week
  44. 44. And pharmacokinetics within 4 weeks</li></ul> www.imabiotech.com Imagine your next innovations<br />
  45. 45. For further information visit our website www.imabiotech.comor contactstauber.jonathan@imabiotech.com<br /> www.imabiotech.com Imagine your next innovations<br />

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