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MALDI imaging at Imabiotech
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MALDI imaging at Imabiotech

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ImaBioteh provides a MALDI imaging solution as a fast and robust tool for ADME and pharmacokinetics

ImaBioteh provides a MALDI imaging solution as a fast and robust tool for ADME and pharmacokinetics

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    MALDI imaging at Imabiotech MALDI imaging at Imabiotech Presentation Transcript

    • Mass spectrometry Imaging (MSI)
      An innovative platform for drug and metabolites study
      www.imabiotech.com Imagine your next innovations
    • Introduction
      IMABIOTECH is a leading French company providing CRO, biotechs and pharmaceutical groups with innovative Mass spectrometry imaging (MSI), customized services and products.
      IMABIOTECH is a spin-off of University of Lille, and in 2008, founded with Professor SALZET and Professor FOURNIER to bring expertise in the field of MSI
      www.imabiotech.com Imagine your next innovations
    • MS Imaging use
      Why should do molecular imaging ?
      Stake of clinical and Pharma research:
      • Bring molecular information
      • Combine molecular and spatial information in early stage of drug discovery
      • Fast study of ADME and pharmacokinetics
      www.imabiotech.com Imagine your next innovations
    • MSI Technique
      MSI : in vitro/ex vivo imaging technique which detects surface molecules of histological tissue sections
      More than thousands simultaneously detected molecules such as drugs, metabolites , lipids and proteins
      www.imabiotech.com Imagine your next innovations
    • Benefits of MSI 
      MS imaging advantages
      • No labeling and non radioactive
      • Biomolecules or drugs/Metabolites
      • Large scope of simultaneous detection of elements and molecules (Atom to proteins)
      • Fast compared to labeling approaches (HIC, autoradiography)
      • Detailed images
      • Resolution : 500nm - 100μm
      • Sensitivity ng/g
      • Whole body, cells, organs
      A label free method
      www.imabiotech.com Imagine your next innovations
    • MSI applications 
      Examples of pharmacokinetics of a drug and metabolite (in a single experiment)
      2 hours post dose
      6 hours post dose
      Control T0
      Its metabolite
      Many others applications such as :
      • Biomarker discoveries directly on-tissue
      • Contrast agent evaluation
      • Chemicals detection
      • Iron, Lithium of potassium detection
      • Peptides or lipids
      www.imabiotech.com Imagine your next innovations
      Optical image
      of Kidney
      Drug localization
      2 hours post dose
      6 hours post dose
      Control T0
    • MSI applications 
      Larges applications of MSI for :
      • drug ADME/PK studies :
      • Co-localization of drugs and metabolites (defined by their exact masses)
      • Research of unknown metabolites
      • Assess Administration and Formulation
      • Nanoparticles localization and Drug delivery systems studies
      • Whole body or organs studies (Brain, Heart, Liver, Kidney, Bones, Muscles… )
      Whole mouse body
      Drug distribution
      Metabolites distribution
      www.imabiotech.com Imagine your next innovations
    • MSI applications 
      Larges applications of MSI for :
      • biomarkers discoveries in different therapeutic areas :
      • Oncology
      • CNS diseases
      • Infectious diseases
      • Ophthalmology
      • Gastroenterology
      • Pulmonary
      • Cardiology…
      Intestinal Disease
      CNS disease
      Ophthalmology
      Cardiology
      Pulmonary
      Oncology
      www.imabiotech.com Imagine your next innovations
    • Benefits of MSI 
      Triple benefits of MS imaging in your ADME/PK studies
      • MS Imaging is fast (10 days to assess your drug delivery compared to others techniques 6-12 months)
      • No radioactive and no labeling are required
      • MSI technique discriminates the localization of drugs and metabolites
      • Expertise in MSI
      www.imabiotech.com Imagine your next innovations
    • The innovative platform
      IMABIOTECH an unique CRO Platform in Europe dedicated to MSI imaging
      • From Administration, tissue preparation to MS imaging
      • ImaBiotech Performs :
      • More than 40 images within in a week
      • Organs and whole-body MS imaging
      • For each molecules injected (>0,2 mg/kg; 0-70KDa)
      • Distribution of drug and metabolites within 2 week
      • And pharmacokinetics within 4 weeks
      www.imabiotech.com Imagine your next innovations
    • For further information visit our website www.imabiotech.comor contactstauber.jonathan@imabiotech.com
      www.imabiotech.com Imagine your next innovations