Sirius T3 Brochure

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SiriusT3 is a new fully automated instrument for pKa, logP, logD, solubility and dissolution measurement.

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Sirius T3 Brochure

  1. 1. Next generation solution for automated physchem measurement
  2. 2. The SiriusT3 is the next generation With a new modular and ultra-miniaturised physchem measurement system from Sirius hardware platform, we have developed a Analytical. It replaces our world renowned new system which meets the needs of the and market leading GLpKa system, which pharmaceutical industry from early over the last decade has been established as discovery all the way through to the industry standard for pKa, logP/D and late stage formulation solubility determinations. and development. The SiriusT3 comprises 3 modules: Dispenser module, which houses Autoloader module, which has a the precision micro dispensers worktable with four for adding water, solvents and 48-position vial trays. The trays acid/base titrants from the are standard footprint, and reagent bottles stored in the easily integrated with existing drawer underneath. The robotics systems. It has a robotic instrument can have up to 6 arm which automatically picks different cosolvents loaded up and move vials to the sample simultaneously (Methanol, Ethanol, position of the Titrator module. DMSO, Acetonitrile, Dioxane, DMF, THF and At the front of the Autoloader module is a others). Also contained within this module is a UV/Vis built-in ultrasonic bath, which can be automatically used to spectrometer and light source, which is connected to a fibre aid the dissolution of poorly soluble compounds. optic dip probe. This provides the same high quality UV/Vis spectroscopic functionality as our well established D-PAS system for the GLpKa. Titrator module, which features a moving arm with the assay probes attached – pH electrode, UV dip probe, overhead stirrer, temperature sensor and capillaries for reagent addition. All of these probes have been miniaturised to fit into 1ml solution volumes. There is a row of buffer and wash positions used for automatically calibrating and cleaning the probes, including a flowing water wash which cleans the electrode with fresh water after each experiment. At the front of the Titrator module is the sample position, which is temperature controlled with a Peltier device (fully controlled by computer), and an additional turbidity sensing device. This is the position where the titration for pKa, logP/D or solubility is performed.
  3. 3. SiriusT3 Titrator Module SiriusT3 Autoloader Module SiriusT3 Dispenser Module SiriusT3 measures multiple physchem properties on a single hardware platform: pKas, logPs, logDs, Kinetic Solubility and Equilibrium Low Throughput Option (thermodynamic) Solubility. SiriusT3 Dispenser Module + SiriusT3 Titrator Module The UV system allows us to also measure pKas by a UV High Throughput Option method, and also determine Molar Extinction co-efficients. SiriusT3 Dispenser Module + SiriusT3 Titrator Module + The flexibility of the platform allows scope for new and SiriusT3 Autoloader Module customized assays to be easily implemented. Both options are available with and without the UV SiriusT3 modular design allows customers a clear upgrade spectroscopy system. route from low to high throughput physchem measurements: The highest throughput assays on the SiriusT3 can measure pKas in under 4 minutes, using just 3µL of 10mM DMSO stock solution. No other system can offer richly detailed measured pKa data at this speed and small sample requirement. The SiriusT3 allows “gold standard” physchem measurements to be performed on sub milligram quantities of material. This revolution allows the best quality data to be obtained even on discovery compounds where sample quantity is a limiting factor. Ordering Information: By obtaining high quality information at an earlier Visit our website for detailed stage in the discovery and development process, information on how to obtain decisions about chemistry changes and SiriusT3 for your laboratory formulation routes can be made early, saving money, and potential problem areas in other assays can be indentified and resolved with ease.
  4. 4. Sirius Analytical Ltd. Riverside, Unit 12, Forest Row Business Park, Forest Row, East Sussex, RH18 5DW, UK Telephone: +44 (0) 1342 820720 Fax: +44 (0) 1342 820725 Email: sirius@sirius-analytical.com web: www.sirius-analytical.com

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