Drug Innovation 2.0Why we Need Knowledge Metrics for Democratic Action<br />Joerg Kurt Wegner<br />2009<br />Tibotec<br />
J.K. Wegner, 2009, Tibotec<br />information<br />You<br />We want to innovate with novel information<br />
J.K. Wegner, 2009, Tibotec<br />Innovate with … … knowledge = people + information<br />people + information<br />You<br /...
J.K. Wegner, 2009, Tibotec<br />For getting knowledge (=people+information) you needknowledge = people + informationEnable...
Use metrics for improving your peer collaboration<br />J.K. Wegner, 2009, Tibotec<br />Knowledge(=people+information) crea...
Peers are the metric ! Embrace and use “web 2.0” !<br />J.K. Wegner, 2009, Tibotec<br />Content<br />Filter<br />
Drug Innovation 2.0 challenges<br />Negative group dynamics<br />Information overload<br />Data silos<br />J.K. Wegner, 20...
People are scared ?Use a contribution revision for helping people<br />Ensure compliance<br />Educate contributors<br />J....
Are we hiding knowledge (=people+information)?Create knowledge and measure progress!<br />After information makes sense do...
Improve knowledge(people+information) collaboration<br />Stop shouting from skyscrapers,<br />allow “people-centric” feedb...
Drug Innovation 2.0 challenges<br />Negative group dynamics<br /><ul><li> Peer cycles are creating innovative knowledge
 Support people with revisioning
 Improve your knowledge(=people+information) creation factor
 Knowledge collaboration must be measured and improved</li></ul>Information overload<br />Data silos<br />J.K. Wegner, 200...
The knowledge gap is increasing,caused by information overload !<br />information<br />knowledge<br />gap<br />Articles<br...
Information overloadand a knowledgegapare a majorrisk<br />41% / day 	managing e-mail<br />25% / day 	finding information<...
Knowledge workers have too much information, do too little sharing. Stop this ! Leverage !<br />Keeping nothing does not c...
Drug Innovation 2.0 challenges<br />Negative group dynamics<br />Information overload<br /><ul><li> Too much information/w...
 Leverage knowledge collaborations by measuring and improving knowledge(=people+information) growth </li></ul>Data silos<b...
Aspirin was found as drug in 1899. At that time, the puzzle was simple.<br />J.K. Wegner, 2009, Tibotec<br />
Today, information is spread over growing silos.Drug puzzles are complex, collaboration is key!<br />Regulations<br />-OMI...
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Drug Innovation 2.0 – Why we Need Knowledge Metrics for Democratic Action

In this presentation we share three current challenges for innovation in drug design. 1) Group dynamics – Scientific collaboration typically occurs through networks. Inefficient collaboration and networking can lead to tunnel vision; innovation opportunities through more distant networks may be overlooked. Knowledge metrics can encourage new and productive networks, by appropriately rewarding contributing network members. 2) Information overload – Information and knowledge are not the same thing. We have too much (unstructured) information and we lack the time required to structure this information into knowledge. Knowledge metrics can encourage the ranking, structuring, and accessing of information on a reward-per-use basis. 3) Data silos – Data silos caused by technical or license hurdles, can reduce the number of efficient collaboration options. Knowledge metrics should clearly reward barrier-breaking and silo-bridging efforts, and favor new and diverse over redundant information…Drug designers, lawyers and computer scientists have a unique opportunity to take on these challenges – drug innovation 2.0!

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  • Experts still needed, Nature, Vol 457 | Issue no. 7225 | 1 January 2009But … too much emphasis on a single metric aspect (quantity, quality, cost) is likely to create an imbalance in the team’s motivations, leading to a dysfunctional project.h-index – Hirsch, PNAS, 2005, 102, 16521. DOI 10.1073/pnas.0507655102e-index – Zhang,PLoS ONE, 2009, 4, e5429.g-index – Egghe, 2006 – (5) Zhang,PLoS ONE, 2009, 4, e5429.a-index – (7) Zhang,PLoS ONE, 2009, 4, e5429.R-index – (11) Zhang,PLoS ONE, 2009, 4, e5429.Bad metrics: peer review, number of contributions, number of links to contributions.Pay for delivered value or usage (free-market scenario), not only access (IP scenario)Waterfall versus pragmatic Jean-Pierre Garnier, “Rebuilding the R&D Engine in Big Pharma”, Harvard Business Review (May 2008), DOI: 10.1225/R0805DA better way of stimulating genuine innovation would be to reward scientists for “what they do, not for what the restof the company does”, as Jean-Pierre Garnier, outgoing chief executive of GlaxoSmithKline recently noted. GSKhas overhauled its incentive scheme and now pays its researchers a bonus only when a candidate molecule reaches theproof-of-concept stage or when they solve major problems, such as figuring out how to make a previously insoluble compound soluble.
  • keep personal information out of your blog keep politics out of your bloghttp://scienceroll.com/2008/03/15/dangers-of-web-20-in-medicine/do not be a dig, every time you are one, people can link to it ... you can be uninformed, wrong, ... but please be respectful.and yes, nowadays there is a lot of caching, history, and tracking ...... moderation is keyRegulatory authorities will collect more and better data on compliance.Cosohttp://en.wikipedia.org/wiki/COSO#COSO_Guidance_on_Monitoring_Internal_Control_SystemsGovernance, Risk, Compliance (GRC)
  • keep personal information out of your blog keep politics out of your blogdo not be a dig, every time you are one, people can link to it ... you can be uninformed, wrong, ... but please be respectful.and yes, nowadays there is a lot of caching, history, and tracking ...... moderation is keyRegulatory authorities will collect more and better data on compliance.Cosohttp://en.wikipedia.org/wiki/COSO#COSO_Guidance_on_Monitoring_Internal_Control_SystemsGovernance, Risk, Compliance (GRC)
  • Blogs, BackType
  • Rational decision exampleKeeping Found Things Found, Page 103 and 114http://www.basexblog.com/2008/12/19/information-overload-now-900-billion-what-is-your-organizations-exposure/In 2009 it is predicted that 41% of your time will be spent managing e-mail.” The Radicati Group According to our latest research Information Overload costs the U.S. economy a minimum of $900 billion per year in lowered employee productivity and reduced innovation.  Despite its heft, this is a fairly conservative number and reflects the loss of 25% of the knowledge worker’s day to the problem.  The total could be as high as $1 trillion.Information overload describes an excess of information that results in the loss of ability to make decisions, process information, and prioritize tasks.  It remains a key challenge for companies that operate in the knowledge economy but it is nothing new. Indeed, it was very much on the minds of thought leaders of an earlier information age centuries ago, including Roger Bacon, Samuel Johnson, and KonradGeßner whose 1545 Bibliotheca universalis warned of the “confusing and harmful abundance of books” and promulgated reading strategies for coping with the overload of information.In modern times, information overload was first mentioned in 1962, in an article entitled “Operation Basic: The Retrieval of Wasted Knowledge” by Gertram M. Gross.  The problem was predicted by Alvin Toffler in Future Shock (1970), and in 1989, Richard Saul Wurman warned of it in his book, Information Anxiety.Workers spend up to 50 percent of their day managing information, according to a recent survey conducted by Basex of more than 3,000 knowledge workers, and streamlining these processes can have a significant impact on productivity.  But determining the extent of the problem is the first step.eMail is brokenhttp://www.xobni.com/http://www.postbox-inc.com/http://nutshellmail.comhttp://www.OtherInbox.com/http://andreas-wpv.blogspot.com/2009/02/does-facebook-privacy-and-copyright.htmlhttp://www.marketingprofs.com/9/questions-to-ask-before-you-hit-send-stern.asp?adref=znnpbsc4539http://www.ccbetty.comhttp://www.deathbyemail.com/2008/12/is-the-future-of-email-at-yahoo.htmlhttp://andreas-wpv.blogspot.com/2009/02/doesfacebook-privacy-and-copyright.htmlhttp://getreal.corante.com/archives/2005/02/11/eight_years_of_email_stats_pass_1.phphttp://www.flickr.com/photos/threadsy/3474179018/http://www.theproductivityparadox.com/blog/2008/10/10/update-to-my-experience-with-otherinbox/http://procmail.org/
  • Managers in US and UK loose ~25% of their time by looking for informationhttp://www.informationweek.com/news/global-cio/showArticle.jhtml?articleID=196800921http://miningdrugs.blogspot.com/2006/09/even-if-online-what-is-missing-for.htmlKeep Found Things Found Page 91 and 93 and 127Keep nothingKeep Found Things Found , Page 135
  • Idea based on the story of MendeleevKeeping Found Things Found, page 255
  • Idea based on the story of MendeleevKeeping Found Things Found, page 255
  • European Science Foundation. Population Surveys and Biobanking. May 2008
  • http://biobank.org/CMFiles/GA_BioBank06_24_08withoutAppendix38MXC-6242008-9552.ppt
  • Drug Innovation 2.0 (Slides)

    1. 1. Drug Innovation 2.0Why we Need Knowledge Metrics for Democratic Action<br />Joerg Kurt Wegner<br />2009<br />Tibotec<br />
    2. 2. J.K. Wegner, 2009, Tibotec<br />information<br />You<br />We want to innovate with novel information<br />
    3. 3. J.K. Wegner, 2009, Tibotec<br />Innovate with … … knowledge = people + information<br />people + information<br />You<br />knowledge you need, but do not have, yet !<br />
    4. 4. J.K. Wegner, 2009, Tibotec<br />For getting knowledge (=people+information) you needknowledge = people + informationEnable this by collaborating with your peers !<br />information<br />people<br />Friend of a Friend<br />You<br />TopicGuru<br />
    5. 5. Use metrics for improving your peer collaboration<br />J.K. Wegner, 2009, Tibotec<br />Knowledge(=people+information) creation cycle<br />
    6. 6. Peers are the metric ! Embrace and use “web 2.0” !<br />J.K. Wegner, 2009, Tibotec<br />Content<br />Filter<br />
    7. 7. Drug Innovation 2.0 challenges<br />Negative group dynamics<br />Information overload<br />Data silos<br />J.K. Wegner, 2009, Tibotec<br />
    8. 8. People are scared ?Use a contribution revision for helping people<br />Ensure compliance<br />Educate contributors<br />J.K. Wegner, 2009, Tibotec<br />§<br />
    9. 9. Are we hiding knowledge (=people+information)?Create knowledge and measure progress!<br />After information makes sense do not hide it in a silo, e.g. eMail<br /> Share content - Three paragraph text <br /> Filter/organize - Hard to find information<br /> Compete – Make contributions transparent<br />J.K. Wegner, 2009, Tibotec<br />
    10. 10. Improve knowledge(people+information) collaboration<br />Stop shouting from skyscrapers,<br />allow “people-centric” feedback.<br />Ensure there is a driving oligarchy, <br />e.g. people with “knowledge sharing” as <br />job objective.<br />J.K. Wegner, 2009, Tibotec<br />
    11. 11. Drug Innovation 2.0 challenges<br />Negative group dynamics<br /><ul><li> Peer cycles are creating innovative knowledge
    12. 12. Support people with revisioning
    13. 13. Improve your knowledge(=people+information) creation factor
    14. 14. Knowledge collaboration must be measured and improved</li></ul>Information overload<br />Data silos<br />J.K. Wegner, 2009, Tibotec<br />
    15. 15. The knowledge gap is increasing,caused by information overload !<br />information<br />knowledge<br />gap<br />Articles<br />knowledge<br />Year<br />J.K. Wegner, 2009, Tibotec<br />source: NCBI PubMed<br />
    16. 16. Information overloadand a knowledgegapare a majorrisk<br />41% / day managing e-mail<br />25% / day finding information<br />This costs ~$900 billion per year in <br />lowered employee productivity and <br />reduced innovation.  <br />J.K. Wegner, 2009, Tibotec<br />
    17. 17. Knowledge workers have too much information, do too little sharing. Stop this ! Leverage !<br />Keeping nothing does not cost anything?<br />But you can not control what you do not know!<br />Keeping is a challenge, but leveraging helps. <br />Which metric helps you optimize?<br />J.K. Wegner, 2009, Tibotec<br />
    18. 18. Drug Innovation 2.0 challenges<br />Negative group dynamics<br />Information overload<br /><ul><li> Too much information/work for a single person
    19. 19. Leverage knowledge collaborations by measuring and improving knowledge(=people+information) growth </li></ul>Data silos<br />J.K. Wegner, 2009, Tibotec<br />
    20. 20. Aspirin was found as drug in 1899. At that time, the puzzle was simple.<br />J.K. Wegner, 2009, Tibotec<br />
    21. 21. Today, information is spread over growing silos.Drug puzzles are complex, collaboration is key!<br />Regulations<br />-OMICS<br />x5from 100k <br />to 500k<br />Last 10 years<br />Patients<br />Literature<br />x1.6from 500k <br />to 800k<br />Last 10 years<br />J.K. Wegner, 2009, Tibotec<br />
    22. 22. Defragmenting data silos is key foraccelerating research<br />Standardization, e.g. for Biobanking data<br /> People must be able to accesspeople silos<br /><ul><li>e.g. Twitter</li></ul> Integration<br />J.K. Wegner, 2009, Tibotec<br />
    23. 23. Legal barriers to data silos ? Get over it, we need to build bridges !<br />Private-Public <br />partnership<br />J.K. Wegner, 2009, Tibotec<br />
    24. 24. Drug Innovation 2.0 challenges<br />Negative group dynamics<br />Information overload<br />Data silos<br /><ul><li> Not using knowledge, does not help patients !
    25. 25. Build legal data silo bridges for knowledge(people+information)
    26. 26. Measure and improve silo bridging efforts (defragmentation)</li></ul>J.K. Wegner, 2009, Tibotec<br />
    27. 27. Drug Innovation 2.0 – Measure and improve !knowledge = people + information<br />Negative group dynamics<br />Encourage people by measuring efficiency and helping them to learn, to compete, to share, and to build trust.<br />Information overload<br />Not keeping is easy! <br />Keeping is a challenge, but crowd-sourcing, “people-need”, and “people-centric” solutions can create knowledge networks.<br />Data silos<br />There are many challenges: standardization, semantics, security, integration, and legal aspects. <br />Helping patients requires building silo bridges !<br />J.K. Wegner, 2009, Tibotec<br />
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