04 17-06

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04 17-06

  1. 1. Circulation and Gas Exchange Chapter 42 (all)<br />4-17-06<br />
  2. 2. Overview: Trading with the Environment<br />Every organism must exchange materials with its environment (whether it be nutrients or gases (oxygen and carbon dioxide)<br />And this exchange ultimately occurs at the cellular level<br />
  3. 3. In unicellular organisms<br />These exchanges occur directly with the environment across the cell membrane. Diffusion is adequate for necessary rapid exchange.<br />For most of the cells making up multicellular organisms direct exchange with the environment is not possible because diffusion distances are too great! Therefore specialized exchange and transport systems have evolved!<br />
  4. 4. Gills as exchange sites in aquatic animals!<br />Figure 42.1<br />The feathery gills projecting from a salmon<br />Are an example of a specialized exchange system found in animals<br />Gill arch with filaments which have lamellae on both sides!<br />Surface area of gill equal body skin surface area!<br />
  5. 5. Transport systems<br />Functionally connect the organs of exchange with the body cells where nutrients and oxygen required!<br />Most complex animals have internal transport systems providing a conduit between the evironment and the cell cytoplasm!<br />
  6. 6. Invertebrate Circulation<br />The wide range of invertebrate body size and form is paralleled by a great diversity in circulatory systems. Water vascular system in star fish, open circulatory systems in insects and closed circulatory systems in earth worms and squids.<br />
  7. 7. Gastrovascular Cavities<br />Simple animals, such as cnidarians<br />Have a body wall only two cells thick that encloses a gastrovascular cavity (recall sea anemone sac with a mouth!)<br />The gastrovascular cavity<br />Functions in both digestion and distribution of substances throughout the body. Also gas exchange for cells lining the cavity.<br />
  8. 8. Circularcanal<br />Radial canal<br />Mouth<br />5 cm<br />Figure 42.2<br />Some cnidarians, such as jellies<br />Have elaborate gastrovascular cavities with canals radiating off the central sac!<br />
  9. 9. Open and Closed Circulatory Systems<br />More complex animals<br />Have one of two types of circulatory systems: open or closed<br />Both of these types of systems have three basic components<br />A circulatory fluid (blood)<br />A set of tubes (blood vessels)<br />A muscular pump (the heart)<br />
  10. 10. Heart<br />Hemolymph in sinusessurrounding ograns<br />Ostia<br />Anterior vessel<br />Lateral vessels<br />Tubular heart<br />Figure 42.3a<br />(a) An open circulatory system<br />Open circulatory systems<br />In insects, other arthropods, and most molluscs<br />Blood bathes the organs and tissues directly in an open circulatory system<br />Valves in heart so blood flow is unidirectional <br />No interstitial space or fluid!<br />
  11. 11. Closed Circulatory System <br />Heart<br />Interstitialfluid<br />Small branch vessels in each organ<br />Dorsal vessel(main heart)<br />Ventral vessels<br />Auxiliary hearts<br />(b) A closed circulatory system<br />Figure 42.3b<br />In a closed circulatory system<br />Blood is confined to vessels and is distinct from the interstitial fluid<br />Closed systems<br />are more efficient at transporting circulatory fluids to tissues and cells.<br />Earthworm an annelid is the first time we see a closed circulatory system!<br />
  12. 12. Survey of Vertebrate Circulation<br />Humans and other vertebrates have a closed circulatory system often called the cardiovascular system.<br />Blood flows in a closed cardiovascular system consisting of blood vessels and a two- to four-chambered heart.<br />Arteries carry blood from heart to capillaries<br />The capillaries are the sites of chemical exchange between the blood and interstitial fluid<br />Veins collect blood from capillaries and return blood to the heart.<br />Types of hearts!<br />
  13. 13. Lung capillaries<br />Lung capillaries<br />Lung and skin capillaries<br />Gill capillaries<br />AMPHIBIANS<br />REPTILES (EXCEPT BIRDS)<br />MAMMALS AND BIRDS<br />FISHES <br />Right systemicaorta<br />Pulmonarycircuit<br />Pulmocutaneouscircuit<br />Artery<br />Pulmonarycircuit<br />Gillcirculation<br />Heart:ventricle (V)<br />Left <br />Systemicaorta<br />A<br />A<br />A<br />A<br />A<br />A<br />Atrium (A)<br />V<br />V<br />V<br />V<br />V<br />Left <br />Right<br />Left <br />Left <br />Right<br />Right<br />Systemiccirculation<br />Systemic circuit<br />Systemic circuit<br />Vein<br />Systemic capillaries<br />Systemic capillaries<br />Systemic capillaries<br />Systemic capillaries<br />Figure 42.4<br />Vertebrate circulatory systems<br />
  14. 14. Fishes- two chambered heart!<br />A fish heart has two main chambers<br />One ventricle and one atrium and blood pumped from the ventricle through the gills<br /> where it is loaded with oxygen and unloadsf CO2. It then travels through the dorsal aorta to the organs and tissues thru capillary beds and is returned to the heart as venous blood. Where does heart get its oxygen? Enough remains in the venous blood. In some active species (Tuna fishes) a branch off the ventral aorta supplies oxygenated blood to the heart. <br />
  15. 15. Amphibians<br />Frogs and other amphibians have a three-chambered heart, with two atria and one ventricle<br />The ventricle pumps blood into a forked artery that splits the ventricle’s output into the pulmocutaneous circuit (lung and skin) and the systemic circuit. Thus a certain amount of mixing of oxygenated and oxygen poor blood occures. <br />
  16. 16. Reptiles (Except Birds)<br />Reptiles have double circulation<br />With a pulmonary circuit (lungs) and a systemic circuit<br />Turtles, snakes, and lizards<br />Have a three-chambered heart. <br />
  17. 17. Mammals and Birds<br />In all mammals and birds<br />The ventricle is completely divided into separate right and left chambers<br />The left side of the heart pumps and receives only oxygen-rich blood<br />While the right side receives and pumps only oxygen-poor blood<br />
  18. 18. A powerful four-chambered heart<br />Was an essential adaptation of the endothermic way of life characteristic of mammals and birds. Reason is because of metabolism being almost 10 times greater than the ectotherms!<br />
  19. 19. A powerful four-chambered heart was an essential adaptation of the endothermic way of life characteristic of mammals and birds. Reason is because of metabolism being almost 10 times greater than the ectotherms!<br />Double circulation in mammals depends on the anatomy and pumping cycle of the heart (Good model).<br />Heart valves dictate a one-way flow of blood through the heart.<br />Blood begins its flow<br />With the right ventricle pumping blood to the lungs<br />In the lungs<br />The blood loads O2 and unloads CO2<br />
  20. 20. Oxygen-rich blood from the lungs<br />Enters the heart at the left atrium and is pumped to the body tissues by the left ventricle<br />Blood returns to the heart<br />Through the right atrium<br />
  21. 21. Capillaries of<br />head and <br />forelimbs <br />Anterior<br />vena cava<br />Aorta<br />Pulmonary<br />artery<br />Pulmonary<br />artery<br />9<br />6<br />3<br />3<br />7<br />8<br />Capillaries<br />of right lung<br />Capillaries<br />of left lung<br />2<br />4<br />11<br />Pulmonary <br />vein<br />Pulmonary <br />vein<br />Left atrium<br />5<br />1<br />Right atrium<br />10<br />Left ventricle<br />Right ventricle<br />Aorta<br />Posterior<br />vena cava<br />Capillaries of<br />abdominal organs<br />and hind limbs<br />Figure 42.5<br />The mammalian cardiovascular system<br />See text for description of sequential events<br />
  22. 22. The Mammalian Heart: A Closer Look<br />Pulmonary artery<br />Aorta<br />Pulmonaryveins<br />Pulmonaryartery<br />Anterior vena cava<br />Leftatrium<br />Right atrium<br />Pulmonaryveins<br />Atrioventricularvalve<br />Semilunarvalve<br />Semilunarvalve<br />Atrioventricularvalve<br />Posterior vena cava<br />Right ventricle<br />Figure 42.6<br />Left ventricle<br />A closer look at the mammalian heart<br />Provides a better understanding of how double circulation works<br />In fetus ductus artieriosus shunts blood from pulmonary artery into the aorta. Closes off at birth when the lungs inflate!<br />
  23. 23. The heart contracts and relaxes<br />In a rhythmic cycle called the cardiac cycle<br />The contraction, or pumping, phase of the cycle<br />Is called systole<br />The relaxation, or filling, phase of the cycle<br />Is called diastole<br />
  24. 24. Atrial systole; ventricular diastole<br />2<br />Semilunarvalvesclosed<br />0.1 sec<br />Semilunarvalvesopen<br />0.3 sec<br />0.4 sec<br />AV valvesopen<br />Atrial and ventricular diastole<br />AV valvesclosed<br />1<br />3<br />Ventricular systole; atrial diastole<br />Figure 42.7<br />The cardiac cycle: filling of chambers longest!<br />
  25. 25. The heart rate, also called the pulse<br />Is the number of beats per minute<br />The cardiac output<br />Is the volume of blood pumped into the systemic circulation per minute and depends on the rate of contraction and the stroke volume (how much blood is “loaded” into the ventricle during diastole).<br />
  26. 26. Maintaining the Heart’s Rhythmic Beat<br />Some cardiac muscle cells are self-excitable (myogenic)<br />Meaning they contract without any signal from the nervous system (heart transplant).<br />A region of the heart called the sinoatrial (SA) node, or pacemaker sets the rate and timing at which all cardiac muscle cells contract<br />Impulses from the SA node spread across the atria to the atrioventricular (AV) node<br />At the AV node, the impulses are delayed and then travel down bundle fiber to the the Purkinje fibers that make the ventricles contract<br />
  27. 27. The impulses that travel during the cardiac cycle<br />Can be recorded as an electrocardiogram (ECG or EKG)<br />
  28. 28. Signals pass<br />to heart apex.<br />Signals spread<br />throughoutventricles.<br />Pacemaker generates wave of signals in the atriato contract. <br />Signals are delayed<br />at AV node.<br />Bundlebranches<br />AV node<br />SA node(pacemaker)<br />Purkinjefibers<br />Heartapex<br />ECG<br />2<br />1<br />3<br />4<br />Figure 42.8<br />The control of heart rhythm<br />The impulses that travel during the cardiac cycle can be recorded as an electrocardiogram (EKG)<br />
  29. 29. The pacemaker is influenced by<br />Nerves, hormones, body temperature, and exercise<br />
  30. 30. Blood Circulation<br />The same physical principles that govern the movement of water in plumbing systems<br />Also influence the functioning of animal circulatory systems.<br />Structure of circulatory system is a network of vessels that are differ in structure to accommodate function.<br />
  31. 31. 5,0004,000<br />3,000<br />2,000<br />1,000<br />0<br />Area (cm2)<br />5040<br />30<br />20<br />10<br />0<br />Velocity (cm/sec)<br />120100<br />80<br />60<br />40<br />20<br />0<br />Systolicpressure<br />Pressure (mm Hg)<br />Diastolicpressure<br />Aorta<br />Veins<br />Arteries<br />Venules<br />Capillaries<br />Arterioles<br />Venae cavae<br />Figure 42.11<br />The velocity of blood flow varies in the circulatory system<br />And is slowest in the capillary beds as a result of the high resistance and large total cross-sectional area<br />
  32. 32. Vein<br />Artery<br />Valve<br />Endothelium<br />Basementmembrane<br />Smoothmuscle<br />100 µm<br />Endothelium<br />Connectivetissue<br />Endothelium<br />Smoothmuscle<br />Capillary<br />Connectivetissue<br />Artery<br />Vein<br />Venule<br />Arteriole<br />Figure 42.9<br />All blood vessels<br />Are built of similar tissues<br />Have three similar layers<br />Basement membrane composed of mucopolysaccharides and collagen fibers. Not a barrier to diffusion of molecules.<br />Arteries have thicker walls to accommodate the high pressure of blood pumped from the heart. Veins thinner walls.<br />
  33. 33. Direction of blood flowin vein (toward heart)<br />Valve (open)<br />Skeletal muscle<br />Valve (closed)<br />Figure 42.10<br />In the thinner-walled veins<br />Blood flows back to the heart mainly as a result of muscle action<br />
  34. 34. Blood Flow Velocity<br />Physical laws governing the movement of fluids through pipes<br />Influence blood flow and blood pressure<br />
  35. 35. Blood pressure<br />Is the hydrostatic pressure that blood exerts against the wall of a vessel<br />Systolic pressure<br />Is the pressure in the arteries during ventricular systole<br />Is the highest pressure in the arteries<br />Diastolic pressure<br />Is the pressure in the arteries during diastole<br />Is lower than systolic pressure<br />
  36. 36. 1<br />3<br /> A typical blood pressure reading for a 20-year-oldis 120/70. The units for these numbers are mm of mercury (Hg); a blood pressure of 120 is a force that can support a column of mercury 120 mm high.<br />4<br /> The cuff is loosened further until the blood flows freely through the artery and the sounds below the cuff disappear. The pressure at this point is the diastolic pressure remaining in the artery when the heart is relaxed.<br />Blood pressure<br />reading: 120/70<br />Pressurein cuff above 120<br />Pressurein cuff below 120<br />Pressurein cuff below 70<br />Rubber cuffinflatedwith air<br />120<br />120<br />70<br />Sounds stop<br />Sounds audible instethoscope<br />Artery<br />Arteryclosed<br /> A stethoscope is used to listen for sounds of blood flow below the cuff. If the artery is closed, there is no pulse below the cuff. The cuff is gradually deflated until blood begins to flow into the forearm, and sounds from blood pulsing into the artery below the cuff can be heard with the stethoscope. This occurs when the blood pressure is greater than the pressure exerted by the cuff. The pressure at this point is the systolic pressure.<br /> A sphygmomanometer, an inflatable cuff attached to apressure gauge, measures blood pressure in an artery.The cuff is wrapped around the upper arm and inflated until the pressure closes the artery, so that no blood flows past the cuff. When this occurs, the pressure exerted by the cuff exceeds the pressure in the artery.<br />2<br />Figure 42.12<br />Blood pressure<br />Can be easily measured in humans<br />
  37. 37. Blood pressure is determined partly by cardiac output<br />And partly by peripheral resistance due to variable constriction of the arterioles (anaphylactic shock). <br />For high blood pressure try and reduce peripheral resistance using smooth muscle relaxants!<br />
  38. 38. Capillary Function<br />Capillaries in major organs are usually filled to capacity<br />But in many other sites, the blood supply varies. Homeostatic mechanisms involved to keep blood pressure constant! <br />
  39. 39. Control of Blood Flow Through Capillaries<br />Two mechanisms<br />Regulate the distribution of blood in capillary beds<br />In one mechanism<br />Contraction of the smooth muscle layer in the wall of an arteriole constricts the vessel<br />
  40. 40. Thoroughfare<br />channel<br />Precapillary sphincters<br />(a) Sphincters relaxed<br />Venule<br />Arteriole<br />Capillaries<br />(b) Sphincters contracted<br />Venule<br />Arteriole<br />(c) Capillaries and larger vessels (SEM) <br />Figure 42.13 a–c<br />20 m<br />In a second mechanism<br />Precapillary sphincters control the flow of blood between arterioles and venules<br />
  41. 41. The critical exchange of substances between the blood and interstitial fluid<br />Takes place across the thin endothelial walls of the capillaries<br />
  42. 42. Tissue cell<br />INTERSTITIAL FLUID<br />Net fluid<br />movement in<br />Net fluid<br />movement out<br />Capillary<br />Capillary<br />Red<br />blood<br />cell<br />15 m<br />At the venule end of a capillary, blood pressure is less than osmotic pressure, and fluid flows from the interstitial fluid into the capillary.<br />Direction of <br />blood flow<br />At the arterial end of a<br />capillary, blood pressure is<br />greater than osmotic pressure,<br />and fluid flows out of the<br />capillary into the interstitial fluid.<br />Blood pressure<br />Osmotic pressure<br />Inward flow<br />Pressure<br />Outward flow<br />Venule end<br />Arterial end of capillary<br />Figure 42.14<br />The difference between blood pressure and osmotic pressure<br />Drives fluids out of capillaries at the arteriole end and into capillaries at the venule end<br />Osmotic pressure in capillary due to plasma proteins!<br />
  43. 43. Fluid Return by the Lymphatic System<br />The lymphatic system<br />Returns fluid to the body from the capillary beds<br />Aids in body defense because it passes through lymph nodes where white blood cells take out any pathogens or foreign material!<br />Fluid reenters the circulation<br />Directly at the venous end of the capillary bed and indirectly through the lymphatic system<br />
  44. 44. Blood<br />Separatedbloodelements<br />The cellular elements of mammalian blood<br />Cellular elements 45%<br />Functions<br />Cell type<br />Numberper L (mm3) of blood<br />Erythrocytes(red blood cells)<br />Transport oxygenand help transportcarbon dioxide<br />5–6 million<br />Defense andimmunity<br />Leukocytes(white blood cells)<br />5,000–10,000<br />Lymphocyte<br />Basophil<br />Eosinophil<br />Neutrophil<br />Monocyte<br />Platelets<br />250,000400,000 <br />Blood clotting<br />Figure 42.15<br />
  45. 45. Plasma<br />Blood plasma is about 90% water<br />Among its many solutes are<br />Inorganic salts in the form of dissolved ions, sometimes referred to as electrolytes<br />
  46. 46. Plasma 55%<br />Constituent<br />Major functions<br />Solvent for<br />carrying other<br />substances<br />Water<br />(blood electrolytes)<br />Sodium<br />Potassium<br />CalciumMagnesium<br />Chloride<br />Bicarbonate<br />Osmotic balance<br />pH buffering, and<br />regulation of <br />membrane<br />permeability<br />Separatedbloodelements<br />Plasma proteins<br />Albumin<br />Fibringen<br />Immunoglobulins<br />(antibodies)<br />Osmotic balance,<br />pH buffering<br />Clotting<br />Defense<br />Substances transported by blood<br />Nutrients (such as glucose, fatty acids, vitamins)<br />Waste products of metabolism<br />Respiratory gases (O2 and CO2)<br />Hormones<br />Figure 42.15<br />The composition of mammalian plasma<br />
  47. 47. Erythrocytes<br />Red blood cells, or erythrocytes<br />Are by far the most numerous blood cells<br />Transport oxygen throughout the body<br />Platelets function in blood clotting<br />
  48. 48. Blood Clotting<br />3<br />The clotting process begins when the endothelium of a vessel is damaged, exposing connective tissue in the vessel wall to blood. Platelets<br />adhere to collagen fibers in <br />the connective tissue and release a substance that<br />makes nearby platelets sticky.<br />The platelets form a plug that provides<br />emergency protection<br />against blood loss.<br />This seal is reinforced by a clot of fibrin when vessel damage is severe. Fibrin is formed via amultistep process: Clotting factors released fromthe clumped platelets or damaged cells mix withclotting factors in the plasma, forming an activation cascade that converts a plasma proteincalled prothrombin to its active form, thrombin.Thrombin itself is an enzyme that catalyzes the final step of the clotting process, the conversion of fibrinogen to fibrin. The threads of fibrin become interwoven into a patch (see colorized SEM).<br />2<br />1<br />Collagen fibers<br />Fibrin clot<br />Plateletplug<br />Red blood cell<br />Platelet releases chemicalsthat make nearby platelets sticky<br /> Clotting factors from: Platelets Damaged cells Plasma (factors include calcium, vitamin K)<br />Prothrombin<br />Thrombin <br />Fibrin<br />Figure 42.17<br />Fibrinogen<br />5 µm<br />A cascade of complex reactions<br />Converts fibrinogen to fibrin, forming a clot<br />A baby aspirin per day makes the platelets lazy!<br />Hemophiliacs<br />

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