The unique immune
monitoring service
center for your drug
development
www.cimna.org

Immunomonitoring for drug development
 Immune response analysis:
a real added value to strengthen your pipeline
 Regulatory environment
New requirements of EMEA and FDA for a better understanding of:
• drug mechanisms of action
• scientific context
• initial drug dose evaluation
 Industrial environment
• Obtain necessary information for GO/NO GO decisions
• Strategic discovery of Biomarkers
www.cimna.org

CIMNA unique integrated Immunomonitoring center
 CIMNA is a niche service provider specialized in
immunology
 We offer an access to a high-quality one-stop shop:
 EXPERTISE (board of experts in Immunology)
 State of the Art Technologies
 QUALITY Services
 Project Management
www.cimna.org

CIMNA organisation
1300sqm of Laboratories, +60 employees, 1 location (Nantes, France)
www.cimna.org

Scientific Committee
 A high-level scientific committee ensuring best adequacy and
interpretation of information for the specific needs of our partners
 Chairman: Prof. Régis JOSIEN
 TECHNOLOGY EXPERTS
• Cytomics: Dr. Marie RIMBERT
• Transcriptomics : Dr. Rémi HOULGATTE
• Repertoire: Dr. Marina GUILLET
• Statistics: Dr. Nadine GODFROID
 EXPERTS BY THERAPEUTIC AREA
• Transplantation : Prof. Jean-Paul SOULILLOU
• Autoimmunity/inflammation: Prof. Mohamed HAMIDOU
• Oncology & Immunotherapy: Prof. Marc BONNEVILLE
• Neuroimmunology: Dr. David LAPLAUD
• Allergy: Prof. Antoine MAGNANT
www.cimna.org

Cytomic unit
 ELISPOT
• antigen-specific cytokine-secreting T cells (vaccin
development, autoimmunity, infectious disease, cancer,
transplantation) GBEA
• antigen-specific CTL
• antigen-specific antibody producing B cells
 POLYCHROMATIC FLOW CYTOMETRY
• immune cells (T, B, NK, DC, Mono.)
• T cell subsets (naive, effector, central memory, effector
memory)
• Counting of antigen-specific T cells with tetramers
• Intracellular cytokine staining to assess T cell function
 MULTIPLEX BEAD ARRAY ASSAYS
• Multiple cytokine/chemokine quantification (immune
response, inflammation, cytokine storm, etc..).
• Multiple auto-antibody titration
 ELISA
• Cytokine/chemokine dosage
• Immunoglobulin dosage
• Auto-antibody detection and titration
www.cimna.org

T cell repertoire & qPCR unit
 TcLandscape
• Transcriptomic approach to the analysis of T cell receptor
populations.
• Qualitative analysis of the TCR Vb Gene usage and CDR3 ISO
Length distribution combined with qPCR on TCR mRNA 17025
transcripts
 Indications:
• Immune response detection & characterization
• Targeting immune populations for functional analyses
• Improvements in understanding disease
• Screening drug candidates for their effect on T cell
mobilization
• Diversity analysis (Epitope spreading, Clonality testing)
• Potential beneficial activity in animal models
 T Cell mobilization signature
 qPCR unit
• Customized service using our real-time PCR platform (ABI
7900HT)
• ISO 17025 compliant
• Easy and rapid transfer of your protocol to ISO 17025 www.cimna.org

Transcriptomics Unit
 Microarrays services
 DNA Chip (Agilent, Affimetrix) ISO
9001
 miRNA expression
 SNP genotyping
 BioInformatics & biostatistics (21CFR part11)
Clinical operations Unit
 Methodology
 Regulations
 CO, Monitoring
 Data Management GCP
 Biostatistics
 Medical writing
 Web Randomization
www.cimna.org

The unique immune
monitoring service
center
www.cimna.org