The unique immune
 monitoring service
center for your drug
   development



                www.cimna.org
Immunomonitoring for drug development

   Immune response analysis:
    a real added value to strengthen your pipeline

 ...
CIMNA unique integrated Immunomonitoring center


   CIMNA is a niche service provider specialized in
    immunology

  ...
CIMNA organisation

1300sqm of Laboratories, +60 employees, 1 location (Nantes, France)




                              ...
Scientific Committee

   A high-level scientific committee ensuring best adequacy and
    interpretation of information f...
Cytomic unit

   ELISPOT
        • antigen-specific cytokine-secreting T cells (vaccin
          development, autoimmunit...
T cell repertoire & qPCR unit
   TcLandscape
         • Transcriptomic approach to the analysis of T cell receptor
      ...
Transcriptomics Unit
           Microarrays services
             DNA Chip (Agilent, Affimetrix)           ISO
         ...
The unique immune
 monitoring service
      center



               www.cimna.org
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Cimna Slide Show October 2009

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CIMNA, the unique immune monitoring service center for your drug development.

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Cimna Slide Show October 2009

  1. 1. The unique immune monitoring service center for your drug development www.cimna.org
  2. 2. Immunomonitoring for drug development  Immune response analysis: a real added value to strengthen your pipeline  Regulatory environment New requirements of EMEA and FDA for a better understanding of: • drug mechanisms of action • scientific context • initial drug dose evaluation  Industrial environment • Obtain necessary information for GO/NO GO decisions • Strategic discovery of Biomarkers www.cimna.org
  3. 3. CIMNA unique integrated Immunomonitoring center  CIMNA is a niche service provider specialized in immunology  We offer an access to a high-quality one-stop shop:  EXPERTISE (board of experts in Immunology)  State of the Art Technologies  QUALITY Services  Project Management www.cimna.org
  4. 4. CIMNA organisation 1300sqm of Laboratories, +60 employees, 1 location (Nantes, France) www.cimna.org
  5. 5. Scientific Committee  A high-level scientific committee ensuring best adequacy and interpretation of information for the specific needs of our partners  Chairman: Prof. Régis JOSIEN  TECHNOLOGY EXPERTS • Cytomics: Dr. Marie RIMBERT • Transcriptomics : Dr. Rémi HOULGATTE • Repertoire: Dr. Marina GUILLET • Statistics: Dr. Nadine GODFROID  EXPERTS BY THERAPEUTIC AREA • Transplantation : Prof. Jean-Paul SOULILLOU • Autoimmunity/inflammation: Prof. Mohamed HAMIDOU • Oncology & Immunotherapy: Prof. Marc BONNEVILLE • Neuroimmunology: Dr. David LAPLAUD • Allergy: Prof. Antoine MAGNANT www.cimna.org
  6. 6. Cytomic unit  ELISPOT • antigen-specific cytokine-secreting T cells (vaccin development, autoimmunity, infectious disease, cancer, transplantation) GBEA • antigen-specific CTL • antigen-specific antibody producing B cells  POLYCHROMATIC FLOW CYTOMETRY • immune cells (T, B, NK, DC, Mono.) • T cell subsets (naive, effector, central memory, effector memory) • Counting of antigen-specific T cells with tetramers • Intracellular cytokine staining to assess T cell function  MULTIPLEX BEAD ARRAY ASSAYS • Multiple cytokine/chemokine quantification (immune response, inflammation, cytokine storm, etc..). • Multiple auto-antibody titration  ELISA • Cytokine/chemokine dosage • Immunoglobulin dosage • Auto-antibody detection and titration www.cimna.org
  7. 7. T cell repertoire & qPCR unit  TcLandscape • Transcriptomic approach to the analysis of T cell receptor populations. • Qualitative analysis of the TCR Vb Gene usage and CDR3 ISO Length distribution combined with qPCR on TCR mRNA 17025 transcripts  Indications: • Immune response detection & characterization • Targeting immune populations for functional analyses • Improvements in understanding disease • Screening drug candidates for their effect on T cell mobilization • Diversity analysis (Epitope spreading, Clonality testing) • Potential beneficial activity in animal models  T Cell mobilization signature  qPCR unit • Customized service using our real-time PCR platform (ABI 7900HT) • ISO 17025 compliant • Easy and rapid transfer of your protocol to ISO 17025 www.cimna.org
  8. 8. Transcriptomics Unit  Microarrays services  DNA Chip (Agilent, Affimetrix) ISO 9001  miRNA expression  SNP genotyping  BioInformatics & biostatistics (21CFR part11) Clinical operations Unit  Methodology  Regulations  CO, Monitoring  Data Management GCP  Biostatistics  Medical writing  Web Randomization www.cimna.org
  9. 9. The unique immune monitoring service center www.cimna.org

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